SE9100142L - En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal - Google Patents

En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal

Info

Publication number
SE9100142L
SE9100142L SE9100142A SE9100142A SE9100142L SE 9100142 L SE9100142 L SE 9100142L SE 9100142 A SE9100142 A SE 9100142A SE 9100142 A SE9100142 A SE 9100142A SE 9100142 L SE9100142 L SE 9100142L
Authority
SE
Sweden
Prior art keywords
substances
diagnostic
extracoral
preparing
removal
Prior art date
Application number
SE9100142A
Other languages
English (en)
Swedish (sv)
Other versions
SE9100142D0 (sv
Inventor
Bengt Sandberg
Hans Olof Sjoegren
Kristina Norrgren
Lars Lindgren
Rune Nilsson
Sven-Erik Strand
Original Assignee
Bengt Sandberg
Hans Olof Sjoegren
Kristina Norrgren
Lars Lindgren
Rune Nilsson
Sven Erik Strand
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bengt Sandberg, Hans Olof Sjoegren, Kristina Norrgren, Lars Lindgren, Rune Nilsson, Sven Erik Strand filed Critical Bengt Sandberg
Priority to SE9100142A priority Critical patent/SE9100142L/xx
Publication of SE9100142D0 publication Critical patent/SE9100142D0/xx
Priority to AT92903020T priority patent/ATE178214T1/de
Priority to PCT/SE1992/000020 priority patent/WO1992012730A1/en
Priority to ES92903020T priority patent/ES2130167T3/es
Priority to DK92903020T priority patent/DK0567514T3/da
Priority to EP92903020A priority patent/EP0567514B1/de
Priority to US08/090,047 priority patent/US6251394B1/en
Priority to DE69228802T priority patent/DE69228802T2/de
Priority to CA002100256A priority patent/CA2100256C/en
Priority to JP50311992A priority patent/JP3471352B2/ja
Publication of SE9100142L publication Critical patent/SE9100142L/xx
Priority to US09/689,421 priority patent/US6723318B1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6893—Pre-targeting systems involving an antibody for targeting specific cells clearing therapy or enhanced clearance, i.e. using an antibody clearing agents in addition to T-A and D-M
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6891—Pre-targeting systems involving an antibody for targeting specific cells
    • A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
    • A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
    • A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Nanotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Anesthesiology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Biophysics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Cardiology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • External Artificial Organs (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SE9100142A 1991-01-17 1991-01-17 En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal SE9100142L (sv)

Priority Applications (11)

Application Number Priority Date Filing Date Title
SE9100142A SE9100142L (sv) 1991-01-17 1991-01-17 En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal
JP50311992A JP3471352B2 (ja) 1991-01-17 1992-01-15 体外除去による診断及び／又は治療剤の高インビボクリアランス方法及び系と上記目的に関する上記剤の用法
DK92903020T DK0567514T3 (da) 1991-01-17 1992-01-15 System til forøget in vivo udskillelse af diagnostiske og/eller terapeutiske midler ved ekstrakorporal depletering af midle
PCT/SE1992/000020 WO1992012730A1 (en) 1991-01-17 1992-01-15 A method and a system for enhanced in vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion, and the use of said agents for said purpose
ES92903020T ES2130167T3 (es) 1991-01-17 1992-01-15 Un sistema para la eliminacion mejorada in vivo de agentes de diagnostico y/o agentes terapeuticos por agotamiento extracorpores de los agentes.
AT92903020T ATE178214T1 (de) 1991-01-17 1992-01-15 System zur verbesserten in-vivo aussonderung diagnostischer und/oder therapeutischer wirkstoffe durch extrakorporales entfernen der wirkstoffe
EP92903020A EP0567514B1 (de) 1991-01-17 1992-01-15 System zur verbesserten in-vivo aussonderung diagnostischer und/oder therapeutischer wirkstoffe durch extrakorporales entfernen der wirkstoffe
US08/090,047 US6251394B1 (en) 1991-01-17 1992-01-15 Method and a system for enhanced in vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion, and the use of said agents for said purpose
DE69228802T DE69228802T2 (de) 1991-01-17 1992-01-15 System zur verbesserten in-vivo aussonderung diagnostischer und/oder therapeutischer wirkstoffe durch extrakorporales entfernen der wirkstoffe
CA002100256A CA2100256C (en) 1991-01-17 1992-01-15 A method and a system for enhanced in vivo clearance of diagnostic and/or therapeutic agents by extracorporeal depletion,and the use of said agents for said purpose
US09/689,421 US6723318B1 (en) 1991-01-17 2000-10-12 Targeting of biomolecules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9100142A SE9100142L (sv) 1991-01-17 1991-01-17 En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal

Publications (2)

Publication Number Publication Date
SE9100142D0 SE9100142D0 (sv) 1991-01-17
SE9100142L true SE9100142L (sv) 1992-07-18

Family

ID=20381639

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9100142A SE9100142L (sv) 1991-01-17 1991-01-17 En metod och ett system foer foerbaettrad in vivo reducering av diagnostiska och/eller terapeutiska substanser medelst extrakorporeal borttagning, och anvaendandet av naemnda substanser foer detta aendamaal

Country Status (10)

Country Link
US (2) US6251394B1 (de)
EP (1) EP0567514B1 (de)
JP (1) JP3471352B2 (de)
AT (1) ATE178214T1 (de)
CA (1) CA2100256C (de)
DE (1) DE69228802T2 (de)
DK (1) DK0567514T3 (de)
ES (1) ES2130167T3 (de)
SE (1) SE9100142L (de)
WO (1) WO1992012730A1 (de)

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US5911969A (en) 1992-06-09 1999-06-15 Neorx Corporation Pretargeting protocols for enhanced localization of active agents to target sites
US6015897A (en) * 1993-12-07 2000-01-18 Neorx Corporation Biotinamido-n-methylglycyl-seryl-o-succinamido-benzyl dota
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AU2191795A (en) * 1994-03-23 1995-10-09 Alexion Pharmaceuticals, Inc. Method for reducing immune and hemostatic dysfunctions during extracorporeal circulation
US6172045B1 (en) 1994-12-07 2001-01-09 Neorx Corporation Cluster clearing agents
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US8951499B2 (en) 1996-02-08 2015-02-10 University Of Washington Trifunctional reagent for conjugation to a biomolecule
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US6533734B1 (en) * 1999-06-11 2003-03-18 The Board Of Trustees Of The University Of Illinois Time-integrated sampler of bodily fluid
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Also Published As

Publication number Publication date
DE69228802D1 (de) 1999-05-06
EP0567514A1 (de) 1993-11-03
JPH06504542A (ja) 1994-05-26
CA2100256C (en) 2004-06-08
JP3471352B2 (ja) 2003-12-02
US6723318B1 (en) 2004-04-20
WO1992012730A1 (en) 1992-08-06
DE69228802T2 (de) 1999-10-14
ATE178214T1 (de) 1999-04-15
CA2100256A1 (en) 1992-07-18
DK0567514T3 (da) 1999-10-18
EP0567514B1 (de) 1999-03-31
SE9100142D0 (sv) 1991-01-17
ES2130167T3 (es) 1999-07-01
US6251394B1 (en) 2001-06-26

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