SE9300013L - Nytt förfarande och mellanprodukter för framställning av pro- läkemedel - Google Patents

Nytt förfarande och mellanprodukter för framställning av pro- läkemedel

Info

Publication number: SE9300013L
Authority: SE; Sweden
Prior art keywords: formula; salt; tranexamic acid; substituted; prodrug
Prior art date: 1992-12-30

Application number

SE9300013A

Other languages

Unknown language ( )

English (en)

Other versions

SE9300013D0 (sv

Inventor

Nilsaake Joensson

Original Assignee

Kabi Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-12-30

Filing date

1992-12-30

Publication date

1994-07-01

1992-12-30 Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab

1992-12-30 Priority to SE9300013A priority Critical patent/SE9300013L/sv

1992-12-30 Publication of SE9300013D0 publication Critical patent/SE9300013D0/sv

1993-12-30 Priority to AU58452/94A priority patent/AU5845294A/en

1993-12-30 Priority to PCT/SE1993/001115 priority patent/WO1994015904A1/en

1994-07-01 Publication of SE9300013L publication Critical patent/SE9300013L/sv

Links

229940002612 prodrug Drugs 0.000 title abstract 3
239000000651 prodrug Substances 0.000 title abstract 3
239000000543 intermediate Substances 0.000 title abstract 2
238000004519 manufacturing process Methods 0.000 title 1
238000000034 method Methods 0.000 title 1
GYDJEQRTZSCIOI-LJGSYFOKSA-N tranexamic acid Chemical compound NC[C@H]1CC[C@H](C(O)=O)CC1 GYDJEQRTZSCIOI-LJGSYFOKSA-N 0.000 abstract 3
150000003839 salts Chemical class 0.000 abstract 2
229960000401 tranexamic acid Drugs 0.000 abstract 2
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000000217 alkyl group Chemical group 0.000 abstract 1
239000007864 aqueous solution Substances 0.000 abstract 1
150000003934 aromatic aldehydes Chemical class 0.000 abstract 1
125000001246 bromo group Chemical group Br* 0.000 abstract 1
239000003054 catalyst Substances 0.000 abstract 1
238000006243 chemical reaction Methods 0.000 abstract 1
125000001309 chloro group Chemical group Cl* 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000005843 halogen group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
CQDGTJPVBWZJAZ-UHFFFAOYSA-N monoethyl carbonate Chemical compound CCOC(O)=O CQDGTJPVBWZJAZ-UHFFFAOYSA-N 0.000 abstract 1
125000001624 naphthyl group Chemical group 0.000 abstract 1
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
239000000243 solution Substances 0.000 abstract 1
239000000725 suspension Substances 0.000 abstract 1
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
- C07C251/24—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to carbon atoms of six-membered aromatic rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/46—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino or carboxyl groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SE9300013A 1992-12-30 1992-12-30 Nytt förfarande och mellanprodukter för framställning av pro- läkemedel SE9300013L (sv)

Priority Applications (3)

Application Number	Priority Date	Filing Date	Title
SE9300013A SE9300013L (sv)	1992-12-30	1992-12-30	Nytt förfarande och mellanprodukter för framställning av pro- läkemedel
AU58452/94A AU5845294A (en)	1992-12-30	1993-12-30	Novel process and intermediates for the preparation of prodrugs
PCT/SE1993/001115 WO1994015904A1 (en)	1992-12-30	1993-12-30	Novel process and intermediates for the preparation of prodrugs

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
SE9300013A SE9300013L (sv)	1992-12-30	1992-12-30	Nytt förfarande och mellanprodukter för framställning av pro- läkemedel

Publications (2)

Publication Number	Publication Date
SE9300013D0 SE9300013D0 (sv)	1992-12-30
SE9300013L true SE9300013L (sv)	1994-07-01

Family

ID=20388467

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9300013A SE9300013L (sv)	1992-12-30	1992-12-30	Nytt förfarande och mellanprodukter för framställning av pro- läkemedel

Country Status (3)

Country	Link
AU (1)	AU5845294A (sv)
SE (1)	SE9300013L (sv)
WO (1)	WO1994015904A1 (sv)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US20050025825A1 (en)	2003-07-31	2005-02-03	Xanodyne Pharmacal, Inc.	Tranexamic acid formulations with reduced adverse effects
KR20110097942A (ko)	2003-08-20	2011-08-31	제노포트 인코포레이티드	아실옥시알킬 카르바메이트 프로드러그, 합성 및 사용 방법
EP2371815A1 (en)	2003-12-30	2011-10-05	XenoPort, Inc.	Sythesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
US7947739B2 (en)	2004-03-04	2011-05-24	Ferring B.V.	Tranexamic acid formulations
US20050244495A1 (en)	2004-03-04	2005-11-03	Xanodyne Pharmaceuticals, Inc.	Tranexamic acid formulations
US8022106B2 (en)	2004-03-04	2011-09-20	Ferring B.V.	Tranexamic acid formulations
US20090215898A1 (en)	2004-03-04	2009-08-27	Xanodyne Pharmaceuticals, Inc.	Tranexamic acid formulations
WO2007002013A2 (en) *	2005-06-20	2007-01-04	Xenoport, Inc.	Acyloxyalkyl carbamate prodrugs of tranexamic acid, methods of synthesis and use
WO2011028234A1 (en)	2009-09-04	2011-03-10	Xenoport, Inc.	Uses of acyloxyalkyl carbamate prodrugs of tranexamic acid
WO2011091164A1 (en)	2010-01-22	2011-07-28	Xenoport, Inc.	Oral dosage forms having a high loading of a tranexamic acid prodrug
CN116284814B (zh) *	2023-01-17	2025-02-14	杭州三式化妆品有限公司	超分子传明酸甘醇酸离子盐及其制备方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4377594A (en) *	1980-06-04	1983-03-22	Kureha Kagaku Kogyo Kabushiki Kaisha	Derivative of 4-(N-(substituted-benzylidene)amino-methyl cyclohexane-1-carboxylic acid
ATE12224T1 (de) *	1981-11-17	1985-04-15	Kabivitrum Ab	Verbindungen mit antifibrinolytischer wirksamkeit.

1992
- 1992-12-30 SE SE9300013A patent/SE9300013L/sv not_active Application Discontinuation
1993
- 1993-12-30 AU AU58452/94A patent/AU5845294A/en not_active Abandoned
- 1993-12-30 WO PCT/SE1993/001115 patent/WO1994015904A1/en not_active Ceased

Also Published As

Publication number	Publication date
WO1994015904A1 (en)	1994-07-21
SE9300013D0 (sv)	1992-12-30
AU5845294A (en)	1994-08-15

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Legal Events

Date

Code

Title

Description

1996-10-07

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