SE9302006D0 - Protein formulation - Google Patents

Protein formulation

Info

Publication number: SE9302006D0
Authority: SE; Sweden
Prior art keywords: composition; polysorbate; stabilizing agent; factor viii; coagulation factor
Prior art date: 1992-10-02

Application number

SE9302006A

Other languages

English (en)

Inventor

*Oesterberg Thomas

*Fatouros Angelica

Original Assignee

Kabi Pharmacia Ab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-02

Filing date

1993-06-11

Publication date

1993-06-11

1992-10-02 Priority claimed from SE9202878A external-priority patent/SE9202878D0/sv

1993-06-11 Application filed by Kabi Pharmacia Ab filed Critical Kabi Pharmacia Ab

1993-06-11 Priority to SE9302006A priority Critical patent/SE9302006D0/sv

1993-06-11 Publication of SE9302006D0 publication Critical patent/SE9302006D0/sv

1993-10-01 Priority to KR1019940701858A priority patent/KR100303872B1/ko

1993-10-01 Priority to AT93923080T priority patent/ATE198277T1/de

1993-10-01 Priority to EP99121997A priority patent/EP1016673B1/en

1993-10-01 Priority to ES93923080T priority patent/ES2154650T3/es

1993-10-01 Priority to DE69329795T priority patent/DE69329795T2/de

1993-10-01 Priority to JP50895794A priority patent/JP3905921B2/ja

1993-10-01 Priority to DE69333974T priority patent/DE69333974T2/de

1993-10-01 Priority to CZ19941328A priority patent/CZ290342B6/cs

1993-10-01 Priority to AT99121997T priority patent/ATE316981T1/de

1993-10-01 Priority to PCT/SE1993/000793 priority patent/WO1994007510A1/en

1993-10-01 Priority to EP06001883A priority patent/EP1652534A3/en

1993-10-01 Priority to CA002124690A priority patent/CA2124690C/en

1993-10-01 Priority to AU52883/93A priority patent/AU677797C/en

1993-10-01 Priority to MX9306133A priority patent/MX9306133A/es

1993-10-01 Priority to HU9401382A priority patent/HU220194B/hu

1993-10-01 Priority to SK659-94A priority patent/SK282483B6/sk

1993-10-01 Priority to RU94032143A priority patent/RU2136294C1/ru

1993-10-01 Priority to NZ256921A priority patent/NZ256921A/en

1993-10-01 Priority to US08/244,266 priority patent/US5733873A/en

1993-10-01 Priority to PT93923080T priority patent/PT627924E/pt

1993-10-01 Priority to EP93923080A priority patent/EP0627924B1/en

1993-10-01 Priority to DK93923080T priority patent/DK0627924T3/da

1994-06-01 Priority to NO942033A priority patent/NO942033D0/no

1994-06-01 Priority to FI942573A priority patent/FI111443B/sv

1995-06-28 Priority to HU95P/P00473P priority patent/HU211670A9/hu

1997-05-27 Priority to US08/863,198 priority patent/US5919766A/en

2001-02-23 Priority to GR20010400311T priority patent/GR3035472T3/el

Links

239000000203 mixture Substances 0.000 title abstract 5
238000009472 formulation Methods 0.000 title 1
102000004169 proteins and genes Human genes 0.000 title 1
108090000623 proteins and genes Proteins 0.000 title 1
102000001690 Factor VIII Human genes 0.000 abstract 2
108010054218 Factor VIII Proteins 0.000 abstract 2
HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 abstract 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
229940105778 coagulation factor viii Drugs 0.000 abstract 2
-1 polyhydroxyethylene Polymers 0.000 abstract 2
239000003381 stabilizer Substances 0.000 abstract 2
239000004094 surface-active agent Substances 0.000 abstract 2
UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 abstract 1
229920001213 Polysorbate 20 Polymers 0.000 abstract 1
229920001400 block copolymer Polymers 0.000 abstract 1
239000001110 calcium chloride Substances 0.000 abstract 1
229910001628 calcium chloride Inorganic materials 0.000 abstract 1
235000014113 dietary fatty acids Nutrition 0.000 abstract 1
239000003814 drug Substances 0.000 abstract 1
230000000694 effects Effects 0.000 abstract 1
150000002148 esters Chemical class 0.000 abstract 1
239000000194 fatty acid Substances 0.000 abstract 1
229930195729 fatty acid Natural products 0.000 abstract 1
150000004665 fatty acids Chemical class 0.000 abstract 1
229960002885 histidine Drugs 0.000 abstract 1
239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 abstract 1
235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 abstract 1
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
229940068977 polysorbate 20 Drugs 0.000 abstract 1
229920000053 polysorbate 80 Polymers 0.000 abstract 1
229940068968 polysorbate 80 Drugs 0.000 abstract 1
239000011780 sodium chloride Substances 0.000 abstract 1
239000000126 substance Substances 0.000 abstract 1
235000000346 sugar Nutrition 0.000 abstract 1
150000005846 sugar alcohols Chemical class 0.000 abstract 1
150000008163 sugars Chemical class 0.000 abstract 1

Landscapes

Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

SE9302006A 1992-10-02 1993-06-11 Protein formulation SE9302006D0 (sv)

Priority Applications (28)

Application Number	Priority Date	Filing Date	Title
SE9302006A SE9302006D0 (sv)	1992-10-02	1993-06-11	Protein formulation
EP93923080A EP0627924B1 (en)	1992-10-02	1993-10-01	Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
DK93923080T DK0627924T3 (da)	1992-10-02	1993-10-01	Sammensætning, der omfatter koagulationsfaktor VIII formulering, fremgangsmåde til dens fremstilling og anvendelse af et overfladeaktivt middel som stabilisator
EP06001883A EP1652534A3 (en)	1992-10-02	1993-10-01	Composition comprising coagulation factor VIII formulation, process for its preparation and use of a surfactant as stabilizer
MX9306133A MX9306133A (es)	1992-10-02	1993-10-01	Composicion que comprende una formulacion del factor de coagulacion viii, proceso para su preparacion y uso de un surfactante como estabilizador.
EP99121997A EP1016673B1 (en)	1992-10-02	1993-10-01	Composition comprising coagulation factor VIII formulation, process for its preparation and use of a surfactant as stabilizer
ES93923080T ES2154650T3 (es)	1992-10-02	1993-10-01	Composicion que comprende una formulacion con factor de coagulacion viii, procedimiento para su preparacion y uso de un tensioactivo como estabilizador.
DE69329795T DE69329795T2 (de)	1992-10-02	1993-10-01	Zusammensetzung, welche den koagulationsfaktor viii beinhaltet; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator
JP50895794A JP3905921B2 (ja)	1992-10-02	1993-10-01	凝固第▲ｖｉｉｉ▼因子を含む組成物及びその製造方法並びに安定剤としての界面活性剤の使用方法
DE69333974T DE69333974T2 (de)	1992-10-02	1993-10-01	Zusammensetzung, welche den Koagulationsfaktor VIII beinhaltet; Verfahren zu deren Herstellung und die Benutzung eines Oberflächenaktiven Stoffes als Stabilisator
CZ19941328A CZ290342B6 (cs)	1992-10-02	1993-10-01	Kompozice stabilní při skladování, obsahující koagulační faktor VIII a neiontovou povrchově aktivní látku a způsob její výroby
AT99121997T ATE316981T1 (de)	1992-10-02	1993-10-01	Zusammensetzung, welche den koagulationsfaktor viii beinhalted; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator
PCT/SE1993/000793 WO1994007510A1 (en)	1992-10-02	1993-10-01	Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
KR1019940701858A KR100303872B1 (ko)	1992-10-02	1993-10-01	응고인자ⅷ제형을포함하는조성물,이것의제조방법및안정화제로서의계면활성제의사용방법
CA002124690A CA2124690C (en)	1992-10-02	1993-10-01	Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
AU52883/93A AU677797C (en)	1992-10-02	1993-10-01	Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
AT93923080T ATE198277T1 (de)	1992-10-02	1993-10-01	Zusammensetzung, welche den koagulationsfaktor viii beinhaltet; verfahren zu deren herstellung und die benutzung eines oberflächenaktiven stoffes als stabilisator
HU9401382A HU220194B (hu)	1992-10-02	1993-10-01	Koagulációs faktor VIII-at tartalmazó készítmény és eljárás előállítására
SK659-94A SK282483B6 (sk)	1992-10-02	1993-10-01	Stabilná kompozícia koagulačného faktora VIII, spôsob jej prípravy a stabilizácie
RU94032143A RU2136294C1 (ru)	1992-10-02	1993-10-01	Композиция, содержащая препарат коагуляционного фактора viii, способ ее получения и применение поверхностно-активного вещества в качестве стабилизатора
NZ256921A NZ256921A (en)	1992-10-02	1993-10-01	Formulations of coagulation factor viii and a non-ionic surfactant and their preparation
US08/244,266 US5733873A (en)	1992-10-02	1993-10-01	Composition comprising coagulation factor VIII formulation, process for its preparation and use of a surfactant as stabilizer
PT93923080T PT627924E (pt)	1992-10-02	1993-10-01	Formulacao compreendendo o factor de coagulacao viii processo para a sua preparacao e utilizacao de um tensioactivo como estabilizador
FI942573A FI111443B (sv)	1992-10-02	1994-06-01	Förfarande för framställning av en komposition för stabilisering av rekombinantkoaguleringsfaktor VIII
NO942033A NO942033D0 (no)	1992-10-02	1994-06-01	Preparat omfattende koagulasjonsfaktor VIII, fremgangsmåte for fremstilling derav samt anvendelse av et overflateaktivt middel som stabilisator
HU95P/P00473P HU211670A9 (en)	1992-10-02	1995-06-28	Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer
US08/863,198 US5919766A (en)	1992-10-02	1997-05-27	Composition comprising coagulation factor VIII formulation, process for its preparation and use of a surfactant as stabilizer
GR20010400311T GR3035472T3 (en)	1992-10-02	2001-02-23	Composition comprising coagulation factor viii formulation, process for its preparation and use of a surfactant as stabilizer.

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
SE9202878A SE9202878D0 (sv)	1992-10-02	1992-10-02	Protein formulation
SE9302006A SE9302006D0 (sv)	1992-10-02	1993-06-11	Protein formulation

Publications (1)

Publication Number	Publication Date
SE9302006D0 true SE9302006D0 (sv)	1993-06-11

Family

ID=26661537

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE9302006A SE9302006D0 (sv)	1992-10-02	1993-06-11	Protein formulation

Country Status (2)

Country	Link
RU (1)	RU2136294C1 (sv)
SE (1)	SE9302006D0 (sv)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2921180B1 (en) *	1999-02-22	2019-08-14	University of Connecticut	Albumin-free factor VIII formulations
EP1359936B1 (en) *	2001-02-05	2008-02-20	Novo Nordisk Health Care AG	Combined use of factor vii polypeptides and factor viii polypeptides
US8399620B2 (en) *	2007-07-11	2013-03-19	Novo Nordisk A/S	Purification of factor VIII using a mixed-mode or multimodal resin
CN117860874B (zh) *	2024-03-12	2024-07-02	正大天晴药业集团南京顺欣制药有限公司	重组人凝血因子VIIa的药物组合物

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4359463A (en) *	1980-11-26	1982-11-16	Rock Gail A	Stabilization of Factor VIII activity in whole blood or blood plasma
JPS5874617A (ja) *	1981-10-28	1983-05-06	Green Cross Corp:The	人由来血液凝固第７因子含有水溶液の加熱処理方法
DE4111393A1 (de) *	1991-04-09	1992-10-15	Behringwerke Ag	Stabilisierte faktor viii-praeparationen

1993
- 1993-06-11 SE SE9302006A patent/SE9302006D0/sv unknown
- 1993-10-01 RU RU94032143A patent/RU2136294C1/ru active

Also Published As

Publication number	Publication date
RU94032143A (ru)	1996-08-20
RU2136294C1 (ru)	1999-09-10

Publication	Publication Date	Title
JP2608762B2 (ja)	1997-05-14	多汗症の治療剤
ES2154650T3 (es)	2001-04-16	Composicion que comprende una formulacion con factor de coagulacion viii, procedimiento para su preparacion y uso de un tensioactivo como estabilizador.
NO891379D0 (no)	1989-03-31	Anestetisk hudfuktingspreparat og fremgangsmaate for fremstilling derav.
SE7903817L (sv)	1979-11-04	Moranolinderivat
ATE204178T1 (de)	2001-09-15	Methode zur behandlung und vorbeugung von typ-1 diabetis durch orale verabreichung von insulin
ES2153385T3 (es)	2001-03-01	Composicion acuosa a base de hormona del crecimiento humana.
DE69414840D1 (de)	1999-01-07	Akzeptabele pharmazeutische zusammensetzung enthaltend einen alkohol und einen hydrophalischen wirkstoff
ES2102157T3 (es)	1997-07-16	Emulsion agua en aceite para uso cosmetico o farmaceutico.
ATE177640T1 (de)	1999-04-15	Pharmazeutische zusammensetzung zur wund-, narben- und keloidbehandlung
SE9401406D0 (sv)	1994-04-25	Pharmaceutical products for curing tumourous diseases and process for preparing same
JPH08208488A (ja)	1996-08-13	皮膚外用剤
UA41502C2 (uk)	2001-09-17	Стабілізований фармацевтичний препарат, який містить гормон росту і гістидин, кристали гормону росту, що містять гістидин, та спосіб їх одержання
KR870700599A (ko)	1987-12-30	카르복실산유도체, 그의 제조방법, 이화합물을 함유한 약제조성물 및 그의 용도
DE58901002D1 (de)	1992-04-30	Mittel mit zerstoerender wirkung auf maligne tumore, verfahren zu dessen herstellung und praeparation zur anwendung in der therapie von krebskranken.
ES460743A1 (es)	1978-05-01	Procedimiento para la obtencion de preparados medicinales con ph acido.
PE33396A1 (es)	1996-08-19	Composicion para el tratamiento del ansia de nicotina y/o los sintomas de abstinencia de fumar
JP2844103B2 (ja)	1999-01-06	皮膚外用剤
NO306762B1 (no)	1999-12-20	Anvendelse av lanolinderivater sammen med polyetylenglykoletere, blanding derav og transdermalt terapeutisk system
DE69401502D1 (de)	1997-02-27	Arzneizubereitung zum Herstellen eines stabilisierten Pulvers das eine Kombination aus Acetylsalicylsäure und Metoclopramid als Wirkstoff enthält
SE9302006D0 (sv)	1993-06-11	Protein formulation
CS275816B6 (en)	1992-03-18	Cosmetic preparation for use on greasy skin
FR2358893A1 (fr)	1978-02-17	Composition antimicrobienne contenant des 1-imidazolyl-butane-2-ones ou -butane-2-ols halogenes
TW328049B (en)	1998-03-11	Penciclover/propylene glycol composition
ES8200363A1 (es)	1981-11-01	Procedimiento para la obtencion de esteres 4,5-dialquil-3- hidroxi-pirrol-2-carboxilicos
ATE91079T1 (de)	1993-07-15	Salicylsaeurehaltiges mittel gegen schuppende hauterkrankungen.