SE9503672L - Partiklar för fördröjd frisättning - Google Patents

Partiklar för fördröjd frisättning

Info

Publication number
SE9503672L
SE9503672L SE9503672A SE9503672A SE9503672L SE 9503672 L SE9503672 L SE 9503672L SE 9503672 A SE9503672 A SE 9503672A SE 9503672 A SE9503672 A SE 9503672A SE 9503672 L SE9503672 L SE 9503672L
Authority
SE
Sweden
Prior art keywords
core particles
particles
organic solvent
active substance
delayed release
Prior art date
Application number
SE9503672A
Other languages
Unknown language ( )
English (en)
Other versions
SE505146C2 (sv
SE9503672D0 (sv
Inventor
Nils-Ove Gustafsson
Timo Laakso
Peter Fyhr
Monica Joensson
Original Assignee
Biogram Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogram Ab filed Critical Biogram Ab
Priority to SE9503672A priority Critical patent/SE505146C2/sv
Publication of SE9503672D0 publication Critical patent/SE9503672D0/sv
Priority to EP01117830A priority patent/EP1142569B1/en
Priority to IL12405296A priority patent/IL124052A/xx
Priority to ES01117830T priority patent/ES2267637T3/es
Priority to KR1019980702757A priority patent/KR100482262B1/ko
Priority to HK98112027.5A priority patent/HK1011182B/en
Priority to AT96935641T priority patent/ATE228826T1/de
Priority to AU73478/96A priority patent/AU699080B2/en
Priority to EP96935641A priority patent/EP0869774B1/en
Priority to DK96935641T priority patent/DK0869774T3/da
Priority to CZ19981173A priority patent/CZ293059B6/cs
Priority to JP9515728A priority patent/JP2000501380A/ja
Priority to HU9901205A priority patent/HUP9901205A3/hu
Priority to CA 2234615 priority patent/CA2234615C/en
Priority to DE69636177T priority patent/DE69636177T2/de
Priority to AT01117830T priority patent/ATE326953T1/de
Priority to PCT/SE1996/001091 priority patent/WO1997014408A1/en
Priority to PT96935641T priority patent/PT869774E/pt
Priority to ES96935641T priority patent/ES2125209T3/es
Priority to DE0869774T priority patent/DE869774T1/de
Priority to DE69625240T priority patent/DE69625240T2/de
Priority to US09/051,709 priority patent/US6120787A/en
Priority to EP06010350A priority patent/EP1716849A1/en
Publication of SE9503672L publication Critical patent/SE9503672L/sv
Publication of SE505146C2 publication Critical patent/SE505146C2/sv
Priority to NO19981558A priority patent/NO320392B1/no
Priority to HK01108604.0A priority patent/HK1038309B/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1641Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A61K9/1647Polyesters, e.g. poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Manufacturing Of Micro-Capsules (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
SE9503672A 1995-10-19 1995-10-19 Partiklar för fördröjd frisättning SE505146C2 (sv)

Priority Applications (25)

Application Number Priority Date Filing Date Title
SE9503672A SE505146C2 (sv) 1995-10-19 1995-10-19 Partiklar för fördröjd frisättning
EP06010350A EP1716849A1 (en) 1995-10-19 1996-09-03 Coating of small particles
HU9901205A HUP9901205A3 (en) 1995-10-19 1996-09-03 Sustained release particles
DE69636177T DE69636177T2 (de) 1995-10-19 1996-09-03 Umhüllung kleiner Partikel
ES01117830T ES2267637T3 (es) 1995-10-19 1996-09-03 Revestimiento de pequeñas particulas.
KR1019980702757A KR100482262B1 (ko) 1995-10-19 1996-09-03 서방성입자
HK98112027.5A HK1011182B (en) 1995-10-19 1996-09-03 Method for manufacturing sustained release particles
AT96935641T ATE228826T1 (de) 1995-10-19 1996-09-03 Methode zur herstellung von partikeln mit verzoegerter freisetzung
AU73478/96A AU699080B2 (en) 1995-10-19 1996-09-03 Sustained release particles
EP96935641A EP0869774B1 (en) 1995-10-19 1996-09-03 Method for manufacturing sustained release particles
DK96935641T DK0869774T3 (da) 1995-10-19 1996-09-03 Fremgangsmåde til fremstilling af vedvarende frigivende partikler
CZ19981173A CZ293059B6 (cs) 1995-10-19 1996-09-03 Způsob přípravy mikročástic s trvalým uvolňováním
JP9515728A JP2000501380A (ja) 1995-10-19 1996-09-03 持続放出性粒子
EP01117830A EP1142569B1 (en) 1995-10-19 1996-09-03 Coating of small particles
CA 2234615 CA2234615C (en) 1995-10-19 1996-09-03 Sustained release particles
IL12405296A IL124052A (en) 1995-10-19 1996-09-03 Method of preparing parenterally administrable sustained release microparticles and microparticles obtainable thereby
AT01117830T ATE326953T1 (de) 1995-10-19 1996-09-03 Umhüllung kleiner partikel
PCT/SE1996/001091 WO1997014408A1 (en) 1995-10-19 1996-09-03 Sustained release particles
PT96935641T PT869774E (pt) 1995-10-19 1996-09-03 Metodo para a producao de particulas de libertacao retardada
ES96935641T ES2125209T3 (es) 1995-10-19 1996-09-03 Metodo para fabricar particulas de liberacion sostenida.
DE0869774T DE869774T1 (de) 1995-10-19 1996-09-03 Partikel mit verzögerter freisetzung
DE69625240T DE69625240T2 (de) 1995-10-19 1996-09-03 Methode zur herstellung von partikeln mit verzoegerter freisetzung
US09/051,709 US6120787A (en) 1995-10-19 1996-09-03 Sustained release particles
NO19981558A NO320392B1 (no) 1995-10-19 1998-04-06 Fremgangsmate for fremstilling av parenteralt administrerbare mikrokapsler med vedvarende frigivelse, og mikropartikler ifolge denne fremgangsmaten
HK01108604.0A HK1038309B (en) 1995-10-19 1998-11-16 Coating of small particles

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9503672A SE505146C2 (sv) 1995-10-19 1995-10-19 Partiklar för fördröjd frisättning

Publications (3)

Publication Number Publication Date
SE9503672D0 SE9503672D0 (sv) 1995-10-19
SE9503672L true SE9503672L (sv) 1997-04-20
SE505146C2 SE505146C2 (sv) 1997-06-30

Family

ID=20399887

Family Applications (1)

Application Number Title Priority Date Filing Date
SE9503672A SE505146C2 (sv) 1995-10-19 1995-10-19 Partiklar för fördröjd frisättning

Country Status (16)

Country Link
US (1) US6120787A (sv)
EP (3) EP0869774B1 (sv)
JP (1) JP2000501380A (sv)
KR (1) KR100482262B1 (sv)
AT (2) ATE228826T1 (sv)
AU (1) AU699080B2 (sv)
CZ (1) CZ293059B6 (sv)
DE (3) DE869774T1 (sv)
DK (1) DK0869774T3 (sv)
ES (2) ES2125209T3 (sv)
HU (1) HUP9901205A3 (sv)
IL (1) IL124052A (sv)
NO (1) NO320392B1 (sv)
PT (1) PT869774E (sv)
SE (1) SE505146C2 (sv)
WO (1) WO1997014408A1 (sv)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2198854B1 (en) * 1997-09-18 2011-11-30 Pacira Pharmaceuticals, Inc. Sustained-release liposomal anesthetic compositions
US20070212422A1 (en) * 1999-11-10 2007-09-13 Manfred Keller Dry powder for inhalation
US6458387B1 (en) * 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
ES2169980B1 (es) 1999-12-17 2003-11-01 Lipotec Sa Microcapsulas para la liberacion prolongada de farmacos.
IT1318380B1 (it) * 2000-03-09 2003-08-25 Intercos Italiana Polvere cosmetica rivestita.
US6495164B1 (en) * 2000-05-25 2002-12-17 Alkermes Controlled Therapeutics, Inc. I Preparation of injectable suspensions having improved injectability
US7259139B1 (en) * 2000-05-26 2007-08-21 Frohwitter Means for maintenance and/or correction of glucose concentration in blood
US6824822B2 (en) * 2001-08-31 2004-11-30 Alkermes Controlled Therapeutics Inc. Ii Residual solvent extraction method and microparticles produced thereby
JP2004510730A (ja) * 2000-10-06 2004-04-08 ヤゴテック アーゲー 非経口的投与可能な制御放出微粒子調製物
SE517421C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Mikropartiklar, lämpade för parenteral administration, väsentligen bestående av stärkelse med minst 85 % amylopektin och med reducerad molekylvikt, samt framställning därav
SE517422C2 (sv) 2000-10-06 2002-06-04 Bioglan Ab Farmaceutiskt acceptabel stärkelse
EP1335661B1 (en) 2000-10-27 2009-05-06 Baxter Healthcare S.A. Production of microspheres
SE518007C2 (sv) 2000-11-16 2002-08-13 Bioglan Ab Förfarande för framställning av mikropartiklar
US7034037B2 (en) * 2001-06-29 2006-04-25 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable polymeric waxes and rapamycin
US6967234B2 (en) * 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
US7030127B2 (en) * 2001-06-29 2006-04-18 Ethicon, Inc. Composition and medical devices utilizing bioabsorbable polymeric waxes
ATE395042T1 (de) * 2001-08-16 2008-05-15 Baxter Int Darreichungsformen welche mikropartikel und treibgas enthalten
US7105181B2 (en) 2001-10-05 2006-09-12 Jagotec, Ag Microparticles
WO2003068941A2 (en) 2002-02-13 2003-08-21 Duke University Modulation of immune response by non-peptide binding stress response polypeptides
SE0201599D0 (sv) 2002-03-21 2002-05-30 Skyepharma Ab Microparticles
US7326426B2 (en) * 2002-03-29 2008-02-05 Ethicon, Inc. Compositions and medical devices utilizing bioabsorbable liquid polymers
US7005136B2 (en) 2002-03-29 2006-02-28 Ethicon, Inc. Bone replacement materials utilizing bioabsorbable liquid polymers
US7368125B2 (en) * 2002-06-05 2008-05-06 Ethicon, Inc. Amphiphilic polymers for medical applications
US7026374B2 (en) * 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
US7101566B2 (en) * 2002-06-28 2006-09-05 Ethicon, Inc. Polymer coated microparticles for sustained release
AU2003279770A1 (en) 2002-10-01 2004-04-23 Novartis Vaccines And Diagnostics, Inc. Anti-cancer and anti-infectious disease compositions and methods for using same
US6872799B2 (en) 2002-12-18 2005-03-29 Ethicon, Inc. Functionalized polymers for medical applications
US6866860B2 (en) 2002-12-19 2005-03-15 Ethicon, Inc. Cationic alkyd polyesters for medical applications
CA2510319A1 (en) * 2002-12-20 2004-07-15 Thomas J. Smith High pressure compaction for pharmaceutical formulations
US20040120981A1 (en) * 2002-12-20 2004-06-24 Aruna Nathan Crosslinked alkyd polyesters for medical applications
US7060299B2 (en) * 2002-12-31 2006-06-13 Battelle Memorial Institute Biodegradable microparticles that stabilize and control the release of proteins
WO2005000278A1 (en) * 2003-06-26 2005-01-06 Mediolanum Pharmaceuticals Ltd. Subcutaneous implants having limited initial release of the active principle and subsequent linearly varying extended release thereof
TWI357815B (en) * 2003-06-27 2012-02-11 Euro Celtique Sa Multiparticulates
RU2426590C2 (ru) * 2003-07-18 2011-08-20 Бакстер Интернэшнл Инк. Способы изготовления, применение и композиции небольших сферических частиц, приготовленных регулируемым фазовым разделением
US20050142205A1 (en) * 2003-07-18 2005-06-30 Julia Rashba-Step Methods for encapsulating small spherical particles prepared by controlled phase separation
US20070092452A1 (en) * 2003-07-18 2007-04-26 Julia Rashba-Step Methods for fabrication, uses, compositions of inhalable spherical particles
US20050048127A1 (en) * 2003-07-22 2005-03-03 Larry Brown Small spherical particles of low molecular weight organic molecules and methods of preparation and use thereof
KR100453273B1 (ko) * 2003-09-04 2004-10-15 주식회사 펩트론 초음파 이중공급노즐을 이용한 서방성 미립구의 제조 방법
US7456254B2 (en) * 2004-04-15 2008-11-25 Alkermes, Inc. Polymer-based sustained release device
US20060110423A1 (en) * 2004-04-15 2006-05-25 Wright Steven G Polymer-based sustained release device
SI2409707T1 (sl) 2004-04-15 2015-07-31 Alkermes Pharma Ireland Limited Naprava s podaljšanim sproščanjem na osnovi polimerov
DK2072040T3 (da) 2004-05-12 2013-07-29 Baxter Healthcare Sa Terapeutisk anvendelse af nukleinsyremikrokugler
US8333995B2 (en) 2004-05-12 2012-12-18 Baxter International, Inc. Protein microspheres having injectable properties at high concentrations
WO2005112885A2 (en) * 2004-05-12 2005-12-01 Baxter International Inc. Oligonucleotide-containing microspheres, their use for the manufacture of a medicament for treating diabetes type 1
US8728525B2 (en) 2004-05-12 2014-05-20 Baxter International Inc. Protein microspheres retaining pharmacokinetic and pharmacodynamic properties
CA2586846C (en) * 2004-11-10 2013-12-31 Qlt Usa Inc. A stabilized polymeric delivery system
US11246913B2 (en) 2005-02-03 2022-02-15 Intarcia Therapeutics, Inc. Suspension formulation comprising an insulinotropic peptide
US8318210B2 (en) 2005-02-28 2012-11-27 Neos Therapeutics, Lp Compositions and methods of making sustained release liquid formulations
AU2006241145B2 (en) * 2005-04-27 2011-04-28 Baxter Healthcare S. A. Surface-modified microparticles and methods of forming and using the same
US8017152B2 (en) 2005-05-27 2011-09-13 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
EP1726299A3 (en) 2005-05-27 2007-04-18 StratoSphere Pharma AB Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
US9693967B2 (en) 2005-09-07 2017-07-04 Southwest Research Institute Biodegradable microparticle pharmaceutical formulations exhibiting improved released rates
KR20080059175A (ko) * 2005-09-07 2008-06-26 사우스웨스트 리서치 인스티튜트 방출속도가 향상된 생분해성 미립자 약제학적 제제
US20070092553A1 (en) * 2005-10-21 2007-04-26 Pfab Lp Compositions and methods of making rapidly dissolving lonically masked formulations
US20080286375A1 (en) * 2005-11-15 2008-11-20 Amorepacific Corporation Method for Preparing Sustained-Release Microparticles Comprising Sucrose Acetate Isobutyrate
GB0602897D0 (en) * 2006-02-13 2006-03-22 Jagotec Ag Improvements In Or Relating To Dry Powder Inhaler Devices
US20070281031A1 (en) * 2006-06-01 2007-12-06 Guohan Yang Microparticles and methods for production thereof
JP5118139B2 (ja) 2006-08-04 2013-01-16 バクスター・インターナショナル・インコーポレイテッド 新規発症自己免疫性糖尿病を予防および/または逆転させるためのマイクロスフィアに基づく組成物
EP2049081B1 (en) 2006-08-09 2012-11-14 Intarcia Therapeutics, Inc. Osmotic delivery systems and piston assemblies
EP2068845A2 (en) * 2006-10-06 2009-06-17 Baxter International Inc. Microencapsules containing surface-modified microparticles and methods of forming and using the same
GB0622818D0 (en) * 2006-11-15 2006-12-27 Jagotec Ag Improvements in or relating to organic compounds
GB0625303D0 (en) * 2006-12-19 2007-01-24 Jagotec Ag Improvements in and relating to metered dose inhalers
AU2008231093A1 (en) * 2007-03-22 2008-10-02 Alkermes, Inc. Coacervation process
GB0707612D0 (en) 2007-04-19 2007-05-30 Stratosphere Pharma Ab Cores and microcapsules suitable for parenteral administration as well as process for their manufacture
HRP20130259T1 (hr) 2007-04-23 2013-04-30 Intarcia Therapeutics, Inc. Suspenzijske formulacije inzulinotropnih peptida i njihove uporabe
CA2689101C (en) * 2007-05-30 2013-01-22 Neos Therapeutics, Lp Modifying drug release in suspensions of ionic resin systems
WO2008157540A1 (en) * 2007-06-20 2008-12-24 Alkermes, Inc. Quench liquids and washing systems for production of microparticles
DK2240155T3 (da) 2008-02-13 2012-09-17 Intarcia Therapeutics Inc Indretninger, formuleringer og fremgangsmåder til levering af flere gavnlige midler
US8323685B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing compositions containing microparticles
US8367427B2 (en) 2008-08-20 2013-02-05 Baxter International Inc. Methods of processing compositions containing microparticles
US8323615B2 (en) 2008-08-20 2012-12-04 Baxter International Inc. Methods of processing multi-phasic dispersions
SMT201700583T1 (it) 2009-09-28 2018-01-11 Intarcia Therapeutics Inc Instaurazione e/o terminazione rapida di erogazione di farmaci in modo sostanzialmente stazionario
KR101331136B1 (ko) 2011-01-12 2013-11-26 아주대학교산학협력단 약물의 초기 과다 방출 제어를 위한 약물전달 제형 및 이의 제조방법
US20120208755A1 (en) 2011-02-16 2012-08-16 Intarcia Therapeutics, Inc. Compositions, Devices and Methods of Use Thereof for the Treatment of Cancers
SG10201604814WA (en) 2013-03-21 2016-08-30 Eupraxia Pharmaceuticals USA LLC Injectable sustained release composition and method of using the same for treating inflammation in joints and pain associated therewith
US9889085B1 (en) 2014-09-30 2018-02-13 Intarcia Therapeutics, Inc. Therapeutic methods for the treatment of diabetes and related conditions for patients with high baseline HbA1c
US10925639B2 (en) 2015-06-03 2021-02-23 Intarcia Therapeutics, Inc. Implant placement and removal systems
MX2018005035A (es) 2015-10-27 2018-09-06 Eupraxia Pharmaceuticals Inc Formulaciones de liberacion sostenida de anestesicos locales.
RU2760007C2 (ru) 2016-05-16 2021-11-22 Интарсия Терапьютикс, Инк. Полипептиды, селективные к рецепторам глюкагона, и способы их применения
USD860451S1 (en) 2016-06-02 2019-09-17 Intarcia Therapeutics, Inc. Implant removal tool
USD840030S1 (en) 2016-06-02 2019-02-05 Intarcia Therapeutics, Inc. Implant placement guide
CN110225762A (zh) 2017-01-03 2019-09-10 因塔西亚制药公司 包括glp-1受体激动剂的连续施用和药物的共同施用的方法
KR102383448B1 (ko) * 2020-04-20 2022-04-06 한국화학연구원 락트산 또는 글리콜산을 포함하는 미립구형 서방출 제제 및 그의 제조방법

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3117027A (en) * 1960-01-08 1964-01-07 Wisconsin Alumni Res Found Apparatus for coating particles in a fluidized bed
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US4384975A (en) * 1980-06-13 1983-05-24 Sandoz, Inc. Process for preparation of microspheres
US4479911A (en) * 1982-01-28 1984-10-30 Sandoz, Inc. Process for preparation of microspheres and modification of release rate of core material
US4637905A (en) * 1982-03-04 1987-01-20 Batelle Development Corporation Process of preparing microcapsules of lactides or lactide copolymers with glycolides and/or ε-caprolactones
CH661206A5 (fr) * 1983-09-23 1987-07-15 Debiopharm Sa Procede pour la preparation d'un medicament destine au traitement de maladies hormonodependantes.
US4568559A (en) * 1984-02-06 1986-02-04 Biotek, Inc. Composite core coated microparticles and process of preparing same
US4623588A (en) * 1984-02-06 1986-11-18 Biotek, Inc. Controlled release composite core coated microparticles
CA1256638A (en) * 1984-07-06 1989-06-27 Motoaki Tanaka Polymer and its production
JP2551756B2 (ja) * 1985-05-07 1996-11-06 武田薬品工業株式会社 ポリオキシカルボン酸エステルおよびその製造法
US4666704A (en) * 1985-05-24 1987-05-19 International Minerals & Chemical Corp. Controlled release delivery system for macromolecules
SE459005B (sv) * 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
AU7280387A (en) * 1986-04-07 1987-11-09 Rorer International (Overseas) Inc. Method for the preparation of a sustained release pharmaceutical composition and the compostion prepared thereby
SE8701479L (sv) * 1987-04-09 1988-10-10 Carbomatrix Ab Metod foer inneslutning av biologiskt verksamma preparat samt anvaendning daerav
US5019397A (en) * 1988-04-21 1991-05-28 Alza Corporation Aqueous emulsion for pharmaceutical dosage form
US5275819A (en) * 1989-02-06 1994-01-04 Amer Particle Technologies Inc. Drug loaded pollen grains with an outer coating for pulsed delivery
US5019400A (en) * 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
WO1991006287A1 (en) * 1989-11-06 1991-05-16 Enzytech, Inc. Protein microspheres and methods of using them
FR2663207B1 (fr) * 1990-06-15 1993-04-30 Rhone Poulenc Nutrition Animal Procede d'enrobage par un polymere ph sensible de principes actifs.
EP0576675A4 (en) * 1991-03-25 1994-06-01 Fujisawa Pharmaceutical Co Long-acting pharmaceutical preparation
ATE154241T1 (de) * 1991-10-01 1997-06-15 Takeda Chemical Industries Ltd Mikropartikeln-zusammenfassung zur verlängerten freigabe und herstellung derselbe
US5288502A (en) * 1991-10-16 1994-02-22 The University Of Texas System Preparation and uses of multi-phase microspheres
WO1994012158A1 (en) * 1992-12-02 1994-06-09 Alkermes Controlled Therapeutics, Inc. Controlled release growth hormone containing microspheres
US5417982A (en) * 1994-02-17 1995-05-23 Modi; Pankaj Controlled release of drugs or hormones in biodegradable polymer microspheres

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SE505146C2 (sv) 1997-06-30
CZ117398A3 (cs) 1998-09-16
JP2000501380A (ja) 2000-02-08
EP1142569B1 (en) 2006-05-24
DE869774T1 (de) 1999-06-02
KR100482262B1 (ko) 2006-04-14
DE69625240T2 (de) 2003-09-11
AU7347896A (en) 1997-05-07
HUP9901205A2 (hu) 1999-08-30
ES2125209T1 (es) 1999-03-01
NO981558L (no) 1998-04-06
NO981558D0 (no) 1998-04-06
EP0869774A1 (en) 1998-10-14
DK0869774T3 (da) 2003-03-24
EP0869774B1 (en) 2002-12-04
CZ293059B6 (cs) 2004-01-14
ATE326953T1 (de) 2006-06-15
DE69636177D1 (de) 2006-06-29
IL124052A (en) 2000-11-21
EP1142569A3 (en) 2003-05-21
EP1142569A2 (en) 2001-10-10
NO320392B1 (no) 2005-11-28
SE9503672D0 (sv) 1995-10-19
ES2267637T3 (es) 2007-03-16
WO1997014408A1 (en) 1997-04-24
KR19990064267A (ko) 1999-07-26
HK1011182A1 (en) 1999-07-09
US6120787A (en) 2000-09-19
DE69636177T2 (de) 2007-03-29
ATE228826T1 (de) 2002-12-15
EP1716849A1 (en) 2006-11-02
DE69625240D1 (de) 2003-01-16
AU699080B2 (en) 1998-11-19
PT869774E (pt) 2003-04-30
HUP9901205A3 (en) 2001-04-28
ES2125209T3 (es) 2003-07-01

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