SG10202107367SA - Use of sublingual dexmedetomidine for the treatment of agitation - Google Patents

Use of sublingual dexmedetomidine for the treatment of agitation

Info

Publication number
SG10202107367SA
SG10202107367SA SG10202107367SA SG10202107367SA SG10202107367SA SG 10202107367S A SG10202107367S A SG 10202107367SA SG 10202107367S A SG10202107367S A SG 10202107367SA SG 10202107367S A SG10202107367S A SG 10202107367SA SG 10202107367S A SG10202107367S A SG 10202107367SA
Authority
SG
Singapore
Prior art keywords
agitation
treatment
sublingual dexmedetomidine
dexmedetomidine
sublingual
Prior art date
Application number
SG10202107367SA
Other languages
English (en)
Inventor
Krishnan Nandabalan
Frank Yocca
Sameer Sharma
Original Assignee
Bioxcel Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bioxcel Therapeutics Inc filed Critical Bioxcel Therapeutics Inc
Publication of SG10202107367SA publication Critical patent/SG10202107367SA/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
SG10202107367SA 2016-12-31 2017-12-29 Use of sublingual dexmedetomidine for the treatment of agitation SG10202107367SA (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662441164P 2016-12-31 2016-12-31
US201762471393P 2017-03-15 2017-03-15
US201762542323P 2017-08-08 2017-08-08

Publications (1)

Publication Number Publication Date
SG10202107367SA true SG10202107367SA (en) 2021-08-30

Family

ID=62710955

Family Applications (1)

Application Number Title Priority Date Filing Date
SG10202107367SA SG10202107367SA (en) 2016-12-31 2017-12-29 Use of sublingual dexmedetomidine for the treatment of agitation

Country Status (19)

Country Link
US (7) US11839604B2 (fr)
EP (3) EP4368169A3 (fr)
JP (6) JP6868698B2 (fr)
KR (2) KR20190108104A (fr)
CN (1) CN110337290A (fr)
AU (3) AU2017388759B2 (fr)
BR (1) BR112019013503A2 (fr)
DK (1) DK3562486T3 (fr)
ES (1) ES2980126T3 (fr)
FI (1) FI3562486T3 (fr)
HU (1) HUE067266T2 (fr)
IL (1) IL267689B2 (fr)
MX (3) MX2019007923A (fr)
PL (1) PL3562486T3 (fr)
PT (1) PT3562486T (fr)
SG (1) SG10202107367SA (fr)
TW (3) TWI791479B (fr)
WO (1) WO2018126182A1 (fr)
ZA (1) ZA202006636B (fr)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL267689B2 (en) 2016-12-31 2025-05-01 Bioxcel Therapeutics Inc Use of sublingual dexmedetomidine for the treatment of agitation
EP3813828A4 (fr) * 2018-06-27 2022-03-30 Bioxcel Therapeutics, Inc. Méthodes de traitement de l'agitation faisant appel à du chlorhydrate de dexmédétomidine
BR112020026672A2 (pt) 2018-06-27 2021-03-30 Bioxcel Therapeutics, Inc. Formulações de filme contendo dexmedetomidina e métodos para produzi-las
RU2692247C1 (ru) * 2018-12-06 2019-06-24 федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр имени В.А. Алмазова" Министерства здравоохранения Российской Федерации Способ лечения послеоперационного делирия
BR112022000992A2 (pt) * 2019-07-19 2022-06-14 Arx Llc Regimes de tratamento de dexmedetomidina não sedantes
JP2022549142A (ja) * 2019-09-18 2022-11-24 バイオエクセル セラピューティクス，インコーポレイテッド 激越の出現を検出及び防止するためのシステム及び方法
EP4101448B1 (fr) * 2020-02-07 2026-04-22 Neuroventi Composition comprenant un composé de rilmenidine en tant que principe actif pour le traitement du syndrome de l'x fragile ou de la déficience développementale associée
IL295489A (en) * 2020-02-14 2022-10-01 Bioxcel Therapeutics Inc Systems and methods for detecting and preventing the onset of restlessness
US20240024289A1 (en) * 2020-10-08 2024-01-25 Bioxcel Therapeutics, Inc. Treatment of bipolar disorders and psychosis using dexmedetomidine hydrochloride
JP2024502082A (ja) * 2021-01-04 2024-01-17 バイオエクセル セラピューティクス，インコーポレイテッド デクスメデトミジン治療レジメン
CN116801863A (zh) * 2021-01-04 2023-09-22 比奥克斯塞尔医疗股份有限公司 右美托咪定治疗方案
CN117412747A (zh) * 2021-02-26 2024-01-16 比奥克斯塞尔医疗股份有限公司 用于治疗激越的方法和组合物
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JP2025531884A (ja) * 2022-09-11 2025-09-25 バイオエクセル セラピューティクス，インコーポレイテッド 社会環境における激越の処置方法
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US11806334B1 (en) 2023-01-12 2023-11-07 Bioxcel Therapeutics, Inc. Non-sedating dexmedetomidine treatment regimens
EP4731214A1 (fr) * 2023-06-23 2026-04-29 BioXcel Therapeutics, Inc. Régimes thérapeutiques à dexmédétomidine
WO2026006766A1 (fr) * 2024-06-27 2026-01-02 Applied Cognition, Inc. Compositions, formulations et méthodes de traitement de maladies neurodégénératives
WO2026072029A1 (fr) * 2024-09-24 2026-04-02 Teikoku Pharma Usa, Inc. Dexmédétomidine transdermique pour le traitement de l'agitation
CN119139275B (zh) * 2024-11-05 2025-08-22 中国人民解放军军事科学院军事医学研究院 一种盐酸右美托咪定口溶膜及其制备方法和其应用

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