SG11201403473QA - Differentiation of human embryonic stem cells into single hormonal insulin positive cells - Google Patents

Differentiation of human embryonic stem cells into single hormonal insulin positive cells

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Publication number
SG11201403473QA
SG11201403473QA SG11201403473QA SG11201403473QA SG11201403473QA SG 11201403473Q A SG11201403473Q A SG 11201403473QA SG 11201403473Q A SG11201403473Q A SG 11201403473QA SG 11201403473Q A SG11201403473Q A SG 11201403473QA SG 11201403473Q A SG11201403473Q A SG 11201403473QA
Authority
SG
Singapore
Prior art keywords
differentiation
embryonic stem
human embryonic
insulin positive
cells
Prior art date
Application number
SG11201403473QA
Inventor
Alireza Rezania
Original Assignee
Janssen Biotech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Biotech Inc filed Critical Janssen Biotech Inc
Publication of SG11201403473QA publication Critical patent/SG11201403473QA/en

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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0676—Pancreatic cells
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/34—Sugars
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/38—Vitamins
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/117—Keratinocyte growth factors (KGF-1, i.e. FGF-7; KGF-2, i.e. FGF-12)
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/15—Transforming growth factor beta (TGF-β)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/155—Bone morphogenic proteins [BMP]; Osteogenins; Osteogenic factor; Bone inducing factor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/16—Activin; Inhibin; Mullerian inhibiting substance
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/10—Growth factors
    • C12N2501/19—Growth and differentiation factors [GDF]
    • C—CHEMISTRY; METALLURGY
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/30—Hormones
    • C12N2501/38—Hormones with nuclear receptors
    • C12N2501/385—Hormones with nuclear receptors of the family of the retinoic acid recptor, e.g. RAR, RXR; Peroxisome proliferator-activated receptor [PPAR]
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/40—Regulators of development
    • C12N2501/41—Hedgehog proteins; Cyclopamine (inhibitor)
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
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    • C12N2501/00—Active agents used in cell culture processes, e.g. differentation
    • C12N2501/70—Enzymes
    • C12N2501/72—Transferases [EC 2.]
    • C12N2501/727—Kinases (EC 2.7.)
    • C—CHEMISTRY; METALLURGY
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    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/02—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from embryonic cells

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  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG11201403473QA 2011-12-22 2012-12-07 Differentiation of human embryonic stem cells into single hormonal insulin positive cells SG11201403473QA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161579351P 2011-12-22 2011-12-22
PCT/US2012/068439 WO2013095953A1 (en) 2011-12-22 2012-12-07 Differentiation of human embryonic stem cells into single hormonal insulin positive cells

Publications (1)

Publication Number Publication Date
SG11201403473QA true SG11201403473QA (en) 2014-10-30

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SG11201403473QA SG11201403473QA (en) 2011-12-22 2012-12-07 Differentiation of human embryonic stem cells into single hormonal insulin positive cells
SG10201608914WA SG10201608914WA (en) 2011-12-22 2012-12-07 Differentiation of human embryonic stem cells into single hormonal insulin positive cells

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Country Status (19)

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US (5) US9388386B2 (en)
EP (1) EP2794857B1 (en)
JP (5) JP6441080B2 (en)
KR (2) KR102090751B1 (en)
CN (1) CN105143446B (en)
AR (1) AR089426A1 (en)
AU (3) AU2012355698B2 (en)
BR (1) BR112014015417A8 (en)
CA (1) CA2860107C (en)
FI (1) FI2794857T3 (en)
HK (1) HK1203552A1 (en)
HR (1) HRP20260251T1 (en)
LT (1) LT2794857T (en)
MX (1) MX2014007744A (en)
PH (1) PH12014501429A1 (en)
PT (1) PT2794857T (en)
RU (2) RU2705001C2 (en)
SG (2) SG11201403473QA (en)
WO (1) WO2013095953A1 (en)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9080145B2 (en) 2007-07-01 2015-07-14 Lifescan Corporation Single pluripotent stem cell culture
DK2185693T3 (en) 2007-07-31 2019-09-23 Lifescan Inc DIFFERENTIZING HUMAN EMBRYONIC STEM CELLS
CA2954431C (en) 2007-11-27 2021-08-24 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
JP5733986B2 (en) 2008-02-21 2015-06-10 ヤンセン バイオテツク，インコーポレーテツド Methods, surface modified plates, and compositions for cell attachment, culture and detachment
EP2942392B1 (en) 2008-06-30 2018-10-03 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
US9234178B2 (en) 2008-10-31 2016-01-12 Janssen Biotech, Inc. Differentiation of human pluripotent stem cells
EP2350265B1 (en) * 2008-10-31 2019-04-17 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
KR101687344B1 (en) 2008-11-20 2016-12-16 얀센 바이오테크 인코포레이티드 Methods and compositions for cell attachment and cultivation on planar substrates
KR101774546B1 (en) 2008-11-20 2017-09-04 얀센 바이오테크 인코포레이티드 Pluripotent stem cell culture on micro-carriers
CN102482643B (en) 2009-07-20 2016-06-29 詹森生物科技公司 The differentiation of human embryo stem cell
US12441985B2 (en) 2009-12-23 2025-10-14 Janssen Biotech, Inc. Methods for making insulin in vivo
SG10201408552YA (en) 2009-12-23 2015-02-27 Janssen Biotech Inc Differentiation of human embryonic stem cells
PH12012501686A1 (en) 2010-03-01 2020-10-19 Janssen Biotech Inc Methods for purifying cells derived from pluripotent stem cells
RU2587634C2 (en) 2010-05-12 2016-06-20 Янссен Байотек, Инк. Differentiation of human embryo stem cells
EP3372672A1 (en) 2010-08-31 2018-09-12 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
PL2853589T3 (en) 2010-08-31 2018-05-30 Janssen Biotech, Inc Differentiation of human embryonic stem cells
FI2794857T3 (en) 2011-12-22 2026-03-25 Janssen Biotech Inc Differentiation of human embryonic stem cells into single hormonal insulin positive cells
CA2866590A1 (en) 2012-03-07 2013-09-12 Janssen Biotech, Inc. Defined media for expansion and maintenance of pluripotent stem cells
EP3450544A1 (en) 2012-06-08 2019-03-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endodrine cells
DK2938723T3 (en) 2012-12-31 2023-02-20 Janssen Biotech Inc DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO PANCREATIC ENDOCRINE CELLS USING HB9 REGULATORS
US10370644B2 (en) 2012-12-31 2019-08-06 Janssen Biotech, Inc. Method for making human pluripotent suspension cultures and cells derived therefrom
BR112015015714A2 (en) 2012-12-31 2017-07-11 Janssen Biotech Inc suspension and agglomeration of human pluripotent cells for differentiation into pancreatic endocrine cells
ES2837763T3 (en) 2012-12-31 2021-07-01 Janssen Biotech Inc Culture of human embryonic stem cells in the air-liquid interface for differentiation into pancreatic endocrine cells
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
CN120796168A (en) * 2013-06-11 2025-10-17 哈佛学院校长同事会 SC-beta cells, compositions and methods for producing the same
RU2016110800A (en) 2013-09-25 2017-10-30 Пронутриа Биосайенсис, Инк. Compositions and compositions for maintaining and increasing muscle mass, strength and effectiveness, and methods for their production and use
WO2015065524A2 (en) * 2013-11-01 2015-05-07 Janssen Biotech, Inc. Suspension and clustering of human pluripotent stem cells for differentiation into pancreatic endocrine cells
WO2015175307A1 (en) * 2014-05-16 2015-11-19 Janssen Biotech, Inc. Use of small molecules to enhance mafa expression in pancreatic endocrine cells
EP3147356B1 (en) * 2014-05-20 2024-03-13 Tokyo Institute of Technology Method for inducing differentiation of insulin-producing cells
EP3147353B1 (en) * 2014-05-21 2022-03-30 Kyoto University Method for producing pancreatic blast cells and pancreatic disease treatment agent containing pancreatic blast cells
US20170304369A1 (en) * 2014-10-08 2017-10-26 Agency For Science, Technology And Research Methods of differentiating stem cells into liver cell lineages
WO2016100921A1 (en) * 2014-12-18 2016-06-23 President And Fellows Of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED β CELLS AND USES THEREOF
EP3234110B1 (en) 2014-12-18 2024-02-28 President and Fellows of Harvard College METHODS FOR GENERATING STEM CELL-DERIVED ß CELLS AND USES THEREOF
WO2016100898A1 (en) 2014-12-18 2016-06-23 President And Fellows Of Harvard College Serum-free in vitro directed differentiation protocol for generating stem cell-derived b cells and uses thereof
CN107614678B (en) 2014-12-18 2021-04-30 哈佛学院校长同事会 Method for producing stem cell-derived beta cells and method for using same
EP3234109A4 (en) * 2014-12-19 2018-06-27 Janssen Biotech, Inc. Suspension culturing of pluripotent stem cells
US10420803B2 (en) * 2016-04-14 2019-09-24 Janssen Biotech, Inc. Differentiation of pluripotent stem cells to intestinal midgut endoderm cells
MD4194548T2 (en) 2016-06-21 2026-02-28 Janssen Biotech Inc Generation of functional beta cells derived from human pluripotent stem cells possessing glucose-dependent mitochondrial respiration and a two-phase insulin secretion response
EP3710021A4 (en) * 2017-11-15 2021-08-11 Semma Therapeutics, Inc. COMPOSITIONS FOR THE MANUFACTURE OF ISLAND CELLS AND METHODS OF USE
US20210214690A1 (en) * 2018-05-07 2021-07-15 President And Fellows Of Harvard College Stem cell-derived alpha cells and methods of generating same
US12421499B2 (en) 2018-05-11 2025-09-23 Cornell University Method of differentiation of human pluripotent stem cells to monohormonal cells
WO2020033879A1 (en) 2018-08-10 2020-02-13 Semma Therapeutics, Inc. Stem cell derived islet differentiation
US12378572B2 (en) 2018-09-07 2025-08-05 Crispr Therapeutics Ag Universal donor cells
WO2020059892A1 (en) * 2018-09-19 2020-03-26 武田薬品工業株式会社 Insulin-producing cells
CN109749986B (en) * 2019-03-13 2021-04-02 武汉大学 Method for obtaining pancreatic precursor cells and pancreatic beta cells by differentiation of human pluripotent stem cells
JP2020146301A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146314A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146298A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146318A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146302A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146305A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146297A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146311A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146304A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146306A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146308A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146307A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146303A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146299A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146309A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146315A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146317A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146312A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146313A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146300A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
JP2020146310A (en) * 2019-03-14 2020-09-17 株式会社三洋物産 Game machine
CN114173837A (en) 2019-05-31 2022-03-11 W.L.戈尔及同仁股份有限公司 Biocompatible film composite
EP3975926A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates, Inc. A biocompatible membrane composite
CA3139292C (en) 2019-05-31 2025-06-10 Viacyte, Inc. Cell encapsulation devices with controlled oxygen diffusion distances
EP3976236A1 (en) 2019-05-31 2022-04-06 W.L. Gore & Associates Inc. A biocompatible membrane composite
PH12022550542A1 (en) 2019-09-05 2023-03-20 Crispr Therapeutics Ag Universal donor cells
CA3150235A1 (en) 2019-09-05 2021-03-11 Alireza Rezania UNIVERSAL DONOR CELLS
CA3158631A1 (en) 2019-10-21 2021-04-29 Orizuru Therapeutics, Inc. Growth inhibitor
JP7721105B2 (en) * 2020-01-17 2025-08-12 国立大学法人京都大学 Method and kit for promoting proliferation of pancreatic endoderm cells
WO2022026932A2 (en) 2020-07-31 2022-02-03 Vertex Pharmaceuticals Incorporated Differentiation of pancreatic endocrine cells
CN112251396B (en) * 2020-10-09 2022-08-16 北京呈诺医学科技有限公司 Culture medium and application thereof, and method for differentiating induced pluripotent stem cells into pancreatic islets
WO2022144855A1 (en) 2020-12-31 2022-07-07 Crispr Therapeutics Ag Universal donor cells
CN113234664B (en) * 2021-05-11 2024-05-10 澳门大学 Preparation method and application of pancreatic progenitor cells
CA3232971A1 (en) 2021-11-01 2023-05-04 George Harb Stem cell derived pancreatic islet differentiation
WO2023201361A1 (en) 2022-04-15 2023-10-19 Aspen Neuroscience, Inc. Methods of classifying the differentiation state of cells and related compositions of differentiated cells
CN114836369B (en) * 2022-05-20 2023-01-17 呈诺再生医学科技(北京)有限公司 Method for differentiating induced pluripotent stem cells into pancreatic islets and application of induced pluripotent stem cells in treatment of type I diabetes
WO2024151541A1 (en) 2023-01-09 2024-07-18 Sana Biotechnology, Inc. Type-1 diabetes autoimmune mouse
EP4716541A2 (en) 2023-05-22 2026-04-01 Sana Biotechnology, Inc. Methods of delivery of islet cells and related methods
WO2025117331A1 (en) 2023-12-01 2025-06-05 Eli Lilly And Company Methods of making stem cell-derived islet-like cells, as well as populations and compositions including the same

Family Cites Families (281)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3209652A (en) 1961-03-30 1965-10-05 Burgsmueller Karl Thread whirling method
AT326803B (en) 1968-08-26 1975-12-29 Binder Fa G MESHWARE AND METHOD OF MANUFACTURING THE SAME
US3935067A (en) 1974-11-22 1976-01-27 Wyo-Ben Products, Inc. Inorganic support for culture media
CA1201400A (en) 1982-04-16 1986-03-04 Joel L. Williams Chemically specific surfaces for influencing cell activity during culture
US4499802A (en) 1982-09-29 1985-02-19 Container Graphics Corporation Rotary cutting die with scrap ejection
US4537773A (en) 1983-12-05 1985-08-27 E. I. Du Pont De Nemours And Company α-Aminoboronic acid derivatives
US4557264A (en) 1984-04-09 1985-12-10 Ethicon Inc. Surgical filament from polypropylene blended with polyethylene
US5089396A (en) 1985-10-03 1992-02-18 Genentech, Inc. Nucleic acid encoding β chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US5215893A (en) 1985-10-03 1993-06-01 Genentech, Inc. Nucleic acid encoding the ba chain prodomains of inhibin and method for synthesizing polypeptides using such nucleic acid
US4737578A (en) 1986-02-10 1988-04-12 The Salk Institute For Biological Studies Human inhibin
US5863531A (en) 1986-04-18 1999-01-26 Advanced Tissue Sciences, Inc. In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework
CA1340581C (en) 1986-11-20 1999-06-08 Joseph P. Vacanti Chimeric neomorphogenesis of organs by controlled cellular implantation using artificial matrices
US5804178A (en) 1986-11-20 1998-09-08 Massachusetts Institute Of Technology Implantation of cell-matrix structure adjacent mesentery, omentum or peritoneum tissue
US5567612A (en) 1986-11-20 1996-10-22 Massachusetts Institute Of Technology Genitourinary cell-matrix structure for implantation into a human and a method of making
NZ229354A (en) 1988-07-01 1990-09-26 Becton Dickinson Co Treating polymer surfaces with a gas plasma and then applying a layer of endothelial cells to the surface
EP0363125A3 (en) 1988-10-03 1990-08-16 Hana Biologics Inc. Proliferated pancreatic endocrine cell product and process
SU1767433A1 (en) 1989-11-27 1992-10-07 Пермский государственный медицинский институт Method of determining insulin resistance of immunogenesis in patients with type 1 diabetes mellitus
US5837539A (en) 1990-11-16 1998-11-17 Osiris Therapeutics, Inc. Monoclonal antibodies for human mesenchymal stem cells
US5795965A (en) 1991-04-25 1998-08-18 Chugai Seiyaku Kabushiki Kaisha Reshaped human to human interleukin-6 receptor
US5449383A (en) 1992-03-18 1995-09-12 Chatelier; Ronald C. Cell growth substrates
GB9206861D0 (en) 1992-03-28 1992-05-13 Univ Manchester Wound healing and treatment of fibrotic disorders
CA2114282A1 (en) 1993-01-28 1994-07-29 Lothar Schilder Multi-layered implant
JP3525221B2 (en) 1993-02-17 2004-05-10 味の素株式会社 Immunosuppressants
AU687386B2 (en) 1993-04-08 1998-02-26 Human Cell Cultures, Inc. Cell culturing method and medium
US5523226A (en) * 1993-05-14 1996-06-04 Biotechnology Research And Development Corp. Transgenic swine compositions and methods
GB9310557D0 (en) 1993-05-21 1993-07-07 Smithkline Beecham Plc Novel process and apparatus
TW257671B (en) 1993-11-19 1995-09-21 Ciba Geigy
US6703017B1 (en) 1994-04-28 2004-03-09 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US6001647A (en) 1994-04-28 1999-12-14 Ixion Biotechnology, Inc. In vitro growth of functional islets of Langerhans and in vivo uses thereof
US5834308A (en) 1994-04-28 1998-11-10 University Of Florida Research Foundation, Inc. In vitro growth of functional islets of Langerhans
US6083903A (en) 1994-10-28 2000-07-04 Leukosite, Inc. Boronic ester and acid compounds, synthesis and uses
EP0800829B2 (en) 1994-12-29 2012-07-25 Chugai Seiyaku Kabushiki Kaisha Use of a pm-1 antibody or of a mh 166 antibody for enhancing the anti-tumor effect of cisplatin or carboplatin
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
US5718922A (en) 1995-05-31 1998-02-17 Schepens Eye Research Institute, Inc. Intravitreal microsphere drug delivery and method of preparation
US5908782A (en) 1995-06-05 1999-06-01 Osiris Therapeutics, Inc. Chemically defined medium for human mesenchymal stem cells
US5681561A (en) 1995-06-07 1997-10-28 Life Medical Sciences, Inc. Compositions and methods for improving autologous fat grafting
CA2277278A1 (en) 1997-01-10 1998-07-16 Life Technologies, Inc. Embryonic stem cell serum replacement
US5965583A (en) 1997-04-24 1999-10-12 Ortho-Mcneil Pharmaceutical, Inc. Substituted imidazoles useful in the treatment of inflammatory disease
DE69837491T2 (en) 1997-07-03 2008-01-17 Osiris Therapeutics, Inc. HUMAN MESENCHYMAL STEM CELLS OF PERIPHERAL BLOOD
PT1015576E (en) 1997-09-16 2005-09-30 Egea Biosciences Llc METHOD FOR COMPLETE CHEMICAL SYNTHESIS AND ASSEMBLY OF GENES AND GENOME
US6670127B2 (en) 1997-09-16 2003-12-30 Egea Biosciences, Inc. Method for assembly of a polynucleotide encoding a target polypeptide
CA2307807C (en) 1997-10-23 2008-09-02 Andrea G. Bodnar Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture
US6372779B1 (en) 1997-12-29 2002-04-16 Ortho Pharmaceutical Corporation Anti-inflammatory compounds
US6328960B1 (en) 1998-03-18 2001-12-11 Osiris Therapeutics, Inc. Mesenchymal stem cells for prevention and treatment of immune responses in transplantation
MY132496A (en) 1998-05-11 2007-10-31 Vertex Pharma Inhibitors of p38
US6413773B1 (en) 1998-06-01 2002-07-02 The Regents Of The University Of California Phosphatidylinositol 3-kinase inhibitors as stimulators of endocrine differentiation
US7410798B2 (en) 2001-01-10 2008-08-12 Geron Corporation Culture system for rapid expansion of human embryonic stem cells
US6667176B1 (en) 2000-01-11 2003-12-23 Geron Corporation cDNA libraries reflecting gene expression during growth and differentiation of human pluripotent stem cells
US6610540B1 (en) 1998-11-18 2003-08-26 California Institute Of Technology Low oxygen culturing of central nervous system progenitor cells
US6413556B1 (en) 1999-01-08 2002-07-02 Sky High, Llc Aqueous anti-apoptotic compositions
EP1144597A2 (en) 1999-01-21 2001-10-17 Vitro Diagnostics, Inc. Immortalized cell lines and methods of making the same
ATE378398T1 (en) 1999-02-11 2007-11-15 Hanmi Pharm Ind Co Ltd PLURIPOTENT EMBRYONAL GERM CELL LINE FROM BIRD
US20020018787A1 (en) 1999-05-21 2002-02-14 Roger V. Kendall Methods and compositions for modulating immune response and for the treatment of inflammatory disease
US6815203B1 (en) 1999-06-23 2004-11-09 Joslin Diabetes Center, Inc. Methods of making pancreatic islet cells
US6333029B1 (en) 1999-06-30 2001-12-25 Ethicon, Inc. Porous tissue scaffoldings for the repair of regeneration of tissue
US6306424B1 (en) 1999-06-30 2001-10-23 Ethicon, Inc. Foam composite for the repair or regeneration of tissue
AU7719300A (en) 1999-09-27 2001-04-30 Ixion Biotechnology, Inc. Reversal of insulin-dependent diabetes by islet-producing stem cells, islet progenitor cells and islet-like structures
US6685936B2 (en) 1999-10-12 2004-02-03 Osiris Therapeutics, Inc. Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation
US20030082155A1 (en) 1999-12-06 2003-05-01 Habener Joel F. Stem cells of the islets of langerhans and their use in treating diabetes mellitus
AU778155B2 (en) 1999-12-13 2004-11-18 Scripps Research Institute, The Markers for identification and isolation of pancreatic islet alpha and beta cell progenitors
US7005252B1 (en) 2000-03-09 2006-02-28 Wisconsin Alumni Research Foundation Serum free cultivation of primate embryonic stem cells
US7439064B2 (en) 2000-03-09 2008-10-21 Wicell Research Institute, Inc. Cultivation of human embryonic stem cells in the absence of feeder cells or without conditioned medium
US6436704B1 (en) 2000-04-10 2002-08-20 Raven Biotechnologies, Inc. Human pancreatic epithelial progenitor cells and methods of isolation and use thereof
US6458589B1 (en) 2000-04-27 2002-10-01 Geron Corporation Hepatocyte lineage cells derived from pluripotent stem cells
EP1302534A4 (en) 2000-06-26 2004-06-16 Renomedix Inst Inc CELL FRACTIONS CONTAINING CELLS CAPABLE OF DIFFERENCING INTO NEURAL CELLS
CN100525768C (en) 2000-10-23 2009-08-12 史密丝克莱恩比彻姆公司 Novel compounds
BR0116468A (en) 2000-12-08 2004-06-29 Ortho Mcneil Pharm Inc Indazolyl-substituted pyrroline compounds as kinase inhibitors
ATE301661T1 (en) 2000-12-08 2005-08-15 Ortho Mcneil Pharm Inc MACROHETEROCYCLIC COMPOUNDS AS KINASE INHIBITORS
US6599323B2 (en) 2000-12-21 2003-07-29 Ethicon, Inc. Reinforced tissue implants and methods of manufacture and use
EP1366148A2 (en) 2001-01-24 2003-12-03 THE GOVERNMENT OF THE UNITED STATES OF AMERICA, represented by THE DEPARTMENT OF HEALTH & HUMAN SERVICES Differentiation of stem cells to pancreatic endocrine cells
ES2571219T3 (en) 2001-01-25 2024-09-23 The United States Of America Represented By The Sec Dep Of Health And Human Services Formulation of boronic acid compounds
US6656488B2 (en) 2001-04-11 2003-12-02 Ethicon Endo-Surgery, Inc. Bioabsorbable bag containing bioabsorbable materials of different bioabsorption rates for tissue engineering
WO2002086107A2 (en) 2001-04-19 2002-10-31 DeveloGen Aktiengesellschaft für entwicklungsbiologische Forschung A method for differentiating stem cells into insulin-producing cells
CN100516204C (en) 2001-04-24 2009-07-22 味之素株式会社 Stem cells and method of separating the same
EP1393066A4 (en) 2001-05-15 2006-01-25 Rappaport Family Inst For Res INSULIN-PRODUCING CELLS DERIVED FROM HUMAN EMBRYONAL STEM CELLS
US6626950B2 (en) 2001-06-28 2003-09-30 Ethicon, Inc. Composite scaffold with post anchor for the repair and regeneration of tissue
KR100418195B1 (en) 2001-07-05 2004-02-11 주식회사 우리기술 Apparatus and method for multi-testing insulation of power cables
GB0117583D0 (en) 2001-07-19 2001-09-12 Astrazeneca Ab Novel compounds
WO2003014313A2 (en) 2001-08-06 2003-02-20 Bresagen, Ltd. Alternative compositions and methods for the culture of stem cells
US6617152B2 (en) 2001-09-04 2003-09-09 Corning Inc Method for creating a cell growth surface on a polymeric substrate
EP1298201A1 (en) 2001-09-27 2003-04-02 Cardion AG Process for the production of cells exhibiting an islet-beta-cell-like state
CA2463914A1 (en) 2001-10-18 2003-04-24 Ixion Biotechnology, Inc. Conversion of liver stem and progenitor cells to pancreatic functional cells
EP1442115B9 (en) 2001-11-15 2009-12-16 Children's Medical Center Corporation Methods of isolation, expansion and differentiation of fetal stem cells from chorionic villus, amniotic fluid, and placenta and therapeutic uses thereof
IL162131A0 (en) * 2001-12-07 2005-11-20 Geron Corp Islet cells from human embryonic stem cells
KR100930139B1 (en) 2001-12-07 2009-12-07 사이토리 테라퓨틱스, 인크. Systems and methods for treating patients with treated lipoasperate cells
AU2002218893A1 (en) 2001-12-21 2003-07-09 Thromb-X Nv Compositions for the in vitro derivation and culture of embryonic stem (es) cell lines with germline transmission capability
JP2005512593A (en) 2001-12-28 2005-05-12 セルアーティス アーベー Establishing a pluripotent human blastocyst-derived stem cell line
US20030162290A1 (en) 2002-01-25 2003-08-28 Kazutomo Inoue Method for inducing differentiation of embryonic stem cells into functioning cells
US20030180268A1 (en) 2002-02-05 2003-09-25 Anthony Atala Tissue engineered construct for supplementing or replacing a damaged organ
US20050208029A1 (en) 2002-04-17 2005-09-22 Akihiro Umezawa Method of forming pancreatic beta cells from mesenchymal cells
US20040161419A1 (en) 2002-04-19 2004-08-19 Strom Stephen C. Placental stem cells and uses thereof
WO2003095452A1 (en) 2002-05-08 2003-11-20 Janssen Pharmaceutica N.V. Substituted pyrroline kinase inhibitors
US20060003446A1 (en) 2002-05-17 2006-01-05 Gordon Keller Mesoderm and definitive endoderm cell populations
WO2003102171A1 (en) 2002-05-28 2003-12-11 Becton, Dickinson And Company Expansion and transdifferentiation of human acinar cells
EP1513830A1 (en) 2002-06-05 2005-03-16 Janssen Pharmaceutica N.V. Bisindolyl-maleimid derivatives as kinase inhibitors
GB0212976D0 (en) 2002-06-06 2002-07-17 Tonejet Corp Pty Ltd Ejection method and apparatus
CN1171991C (en) 2002-07-08 2004-10-20 徐如祥 Culture process of human nerve stem cell
US6877147B2 (en) 2002-07-22 2005-04-05 Broadcom Corporation Technique to assess timing delay by use of layout quality analyzer comparison
US7838290B2 (en) 2002-07-25 2010-11-23 The Scripps Research Institute Hematopoietic stem cells and methods of treatment of neovascular eye diseases therewith
JP2005534345A (en) 2002-07-29 2005-11-17 エス セル インターナショナル ピーティーイー リミテッド Multi-step method for differentiation of insulin positive, glucose responsive cells
WO2004016747A2 (en) 2002-08-14 2004-02-26 University Of Florida Bone marrow cell differentiation
JP2005537803A (en) 2002-09-06 2005-12-15 アムサイト インコーポレーティッド CD56 positive human adult pancreatic endocrine precursor cells
US9969977B2 (en) 2002-09-20 2018-05-15 Garnet Biotherapeutics Cell populations which co-express CD49c and CD90
US20040062753A1 (en) 2002-09-27 2004-04-01 Alireza Rezania Composite scaffolds seeded with mammalian cells
WO2004044158A2 (en) 2002-11-08 2004-05-27 The Johns Hopkins University Human embryonic stem cell cultures, and compositions and methods for growing same
US7144999B2 (en) 2002-11-23 2006-12-05 Isis Pharmaceuticals, Inc. Modulation of hypoxia-inducible factor 1 alpha expression
US20060040385A1 (en) 2002-12-05 2006-02-23 Technion Research & Development Foundation Ltd. Cultured human pancreatic islets, and uses thereof
AU2003303071B2 (en) 2002-12-16 2009-04-23 Technion Research & Development Foundation Ltd. Methods of preparing feeder cells-free, xeno-free human embryonic stem cells and stem cell cultures prepared using same
US20050118148A1 (en) 2002-12-20 2005-06-02 Roland Stein Compositions and methods related to mammalian Maf-A
RU2359671C2 (en) 2003-01-29 2009-06-27 Такеда Фармасьютикал Компани Лимитед Method of obtaining of preparation with covering
EP1588708A4 (en) 2003-01-29 2006-03-01 Takeda Pharmaceutical PROCESS FOR REALIZING COATED PREPARATION
US20070155661A1 (en) 2003-02-14 2007-07-05 The Board Of Trustees Of The Leland Standord Junior University Methods and compositions for modulating the development of stem cells
US20070154981A1 (en) 2003-02-14 2007-07-05 The Board Of Trustees Of The Leland Stanford Junior University Insulin-producing cells derived from stem cells
WO2004087885A2 (en) 2003-03-27 2004-10-14 Ixion Biotechnology, Inc. Method for transdifferentiation of non-pancreatic stem cells to the pancreatic pathway
US20060194315A1 (en) 2003-03-31 2006-08-31 Condie Brian G Compositions and methods for the control, differentiaton and/or manipulation of pluripotent cells through a gamma-secretase signaling pathway
US20090203141A1 (en) 2003-05-15 2009-08-13 Shi-Lung Lin Generation of tumor-free embryonic stem-like pluripotent cells using inducible recombinant RNA agents
WO2005001080A2 (en) 2003-06-27 2005-01-06 Ethicon, Incorporated Postpartum-derived cells for use in treatment of disease of the heart and circulatory system
IL161903A0 (en) 2003-07-17 2005-11-20 Gamida Cell Ltd Ex vivo progenitor and stem cell expansion for usein the treatment of disease of endodermally- deri ved organs
ITRM20030395A1 (en) 2003-08-12 2005-02-13 Istituto Naz Per Le Malattie Infettive Lazz CULTURE GROUND FOR MAINTENANCE, PROLIFERATION AND DIFFERENTIATION OF MAMMALIAN CELLS.
US7569385B2 (en) 2003-08-14 2009-08-04 The Regents Of The University Of California Multipotent amniotic fetal stem cells
US7157275B2 (en) 2003-08-15 2007-01-02 Becton, Dickinson And Company Peptides for enhanced cell attachment and growth
CA2536067A1 (en) 2003-08-27 2005-03-10 Stemcells California, Inc. Enriched pancreatic stem cell and progenitor cell populations, and methods for identifying, isolating and enriching for these populations
WO2005058301A1 (en) 2003-12-17 2005-06-30 Allergan, Inc. Methods for treating retinoid responsive disorders using selective inhibitors of cyp26a and cyp26b
GB0329498D0 (en) 2003-12-19 2004-01-28 Novartis Ag Organic compounds
US20060030042A1 (en) 2003-12-19 2006-02-09 Ali Brivanlou Maintenance of embryonic stem cells by the GSK-3 inhibitor 6-bromoindirubin-3'-oxime
US7625753B2 (en) 2003-12-23 2009-12-01 Cythera, Inc. Expansion of definitive endoderm cells
US20050266554A1 (en) 2004-04-27 2005-12-01 D Amour Kevin A PDX1 expressing endoderm
CN103898047B (en) * 2003-12-23 2020-03-03 维亚希特公司 Definitive endoderm
CN109628371B (en) 2003-12-23 2021-02-19 维亚希特公司 definitive endoderm
US7541185B2 (en) 2003-12-23 2009-06-02 Cythera, Inc. Methods for identifying factors for differentiating definitive endoderm
TWI334443B (en) 2003-12-31 2010-12-11 Ind Tech Res Inst Method of single cell culture of undifferentiated human embryonic stem cells
WO2005065354A2 (en) 2003-12-31 2005-07-21 The Burnham Institute Defined media for pluripotent stem cell culture
US20080241107A1 (en) 2004-01-23 2008-10-02 Copland Iii John A Methods and Compositions For Preparing Pancreatic Insulin Secreting Cells
US7794704B2 (en) 2004-01-23 2010-09-14 Advanced Cell Technology, Inc. Methods for producing enriched populations of human retinal pigment epithelium cells for treatment of retinal degeneration
GB2441530B (en) 2004-02-12 2009-09-23 Univ Newcastle Stem Cells
JP4901471B2 (en) 2004-02-19 2012-03-21 国立大学法人京都大学 Screening method for somatic cell nuclear reprogramming substances
CA2581424A1 (en) 2004-03-09 2005-09-22 Gang Xu Methods for generating insulin-producing cells
JP2007528226A (en) 2004-03-10 2007-10-11 リージェンツ オブ ザ ユニヴァーシティ オブ カリフォルニア Composition and method for propagation of embryonic stem cells
KR101178786B1 (en) 2004-03-23 2012-09-07 다이이찌 산쿄 가부시키가이샤 Method of proliferating pluripotent stem cell
WO2005097980A2 (en) 2004-03-26 2005-10-20 Geron Corporation New protocols for making hepatocytes from embryonic stem cells
AU2005230832B2 (en) 2004-04-01 2010-11-11 Wisconsin Alumni Research Foundation Differentiation of stem cells to endoderm and pancreatic lineage
CN103103158B (en) * 2004-04-27 2016-08-03 韦尔赛特公司 Cell culture medium
AU2005272078B2 (en) 2004-07-09 2011-04-14 Viacyte, Inc. Methods for identifying factors for differentiating definitive endoderm
US8187878B2 (en) 2004-08-13 2012-05-29 University Of Georgia Research Foundation, Inc. Methods for increasing definitive endoderm differentiation of pluripotent human embryonic stem cells with PI-3 kinase inhibitors
WO2006026473A2 (en) 2004-08-25 2006-03-09 University Of Georgia Research Foundation, Inc. METHODS AND COMPOSITIONS UTILIZING MYC AND GSK3ß TO MANIPULATE THE PLURIPOTENCY OF EMBRYONIC STEM CELLS
DE102004043256B4 (en) 2004-09-07 2013-09-19 Rheinische Friedrich-Wilhelms-Universität Bonn Scalable process for culturing undifferentiated stem cells in suspension
ATE549395T1 (en) 2004-09-08 2012-03-15 Wisconsin Alumni Res Found MEDIUM AND CULTURE OF EMBRYONAL STEM CELLS
AU2005282414C1 (en) 2004-09-08 2011-04-07 Wisconsin Alumni Research Foundation Culturing human embryonic stem cells
JP2008538276A (en) 2005-01-28 2008-10-23 ノヴァセラ・リミテッド Methods for embryonic stem cell culture
WO2006083782A2 (en) 2005-01-31 2006-08-10 Es Cell International Pte Ltd. Directed differentiation of embryonic stem cells and uses thereof
WO2006088867A2 (en) 2005-02-15 2006-08-24 Medistem Laboratories, Incorporated Method for expansion of stem cells
AU2006218359A1 (en) 2005-03-04 2006-09-08 John O'neil Adult pancreatic derived stromal cells
GB0505970D0 (en) 2005-03-23 2005-04-27 Univ Edinburgh Culture medium containing kinase inhibitor, and uses thereof
CN103356706B (en) 2005-03-31 2016-01-20 斯丹姆涅恩有限公司 Promote without scar healing or the cosmetic preparation improving skin appearance
CN100425694C (en) 2005-04-15 2008-10-15 北京大学 Method of inducing embryo stem cell to differentiate toward pancreatic cell
WO2006113470A2 (en) 2005-04-15 2006-10-26 Geron Corporation Cancer treatment by combined inhibition of proteasome and telomerase activities
WO2006114098A2 (en) 2005-04-26 2006-11-02 Aarhus Universitet Biocompatible material for surgical implants and cell guiding tissue culture surfaces
WO2006117925A1 (en) * 2005-04-26 2006-11-09 Hitachi Medical Corporation METHOD AND DEVICE FOR REGENERATING PANCREATIC β-CELLS
JP5092124B2 (en) 2005-05-24 2012-12-05 国立大学法人 熊本大学 ES cell differentiation induction method
AU2006202209B2 (en) 2005-05-27 2011-04-14 Lifescan, Inc. Amniotic fluid derived cells
EP1899344A1 (en) 2005-06-10 2008-03-19 Irm, Llc Compounds that maintain pluripotency of embryonic stem cells
WO2006138433A2 (en) 2005-06-14 2006-12-28 The Regents Of The University Of California Induction of cell differentiation by class i bhlh polypeptides
US20080199959A1 (en) 2005-06-21 2008-08-21 Ge Healthcare Bio-Sciences Ab Method For Cell Culture
JP5560391B2 (en) 2005-06-22 2014-07-23 アステリアス バイオセラピューティクス インコーポレイテッド Suspension culture method of human embryonic stem cells
US8778919B2 (en) 2005-06-30 2014-07-15 Janssen Pharmaceutica Nv Cyclic anilino—pyridinotriazines
US20080194021A1 (en) 2005-07-29 2008-08-14 Mays Robert W Use of a Gsk-3 Inhibitor to Maintain Potency of Culture Cells
GB2443370A (en) 2005-07-29 2008-04-30 Australian Stem Cell Ct Ltd Compositions and methods for growth of pluripotent cells
WO2007025234A2 (en) 2005-08-26 2007-03-01 The Trustees Of Columbia University In The City Of New York Generation of pancreatic endocrine cells from primary duct cell cultures and methods of use for treatment of diabetes
EP1962719A4 (en) 2005-08-29 2011-05-04 Technion Res And Dev Of Foundation Ltd CULTURE MEDIA OF STEM CELLS
EP1937801A1 (en) 2005-09-02 2008-07-02 Agency for Science, Technology and Research Method of deriving mesenchymal stem cells
GB2444686B (en) 2005-09-12 2010-08-25 Es Cell Int Pte Ltd Differentiation of pluripotent stem cells using p38 MAPK inhibitors or prostaglandins
US20100322906A1 (en) 2005-10-05 2010-12-23 Osaka University Method for Obtaining Pancreatic Endocrine Cells From Adipose Tissue-Origin Cells
CN101310012B (en) 2005-10-14 2012-05-09 明尼苏达大学董事会 Differentiation of non-embryonic stem cells into cells with pancreatic phenotype
US7732202B2 (en) 2005-10-21 2010-06-08 International Stem Cell Corporation Oxygen tension for the parthenogenic activation of human oocytes for the production of human embryonic stem cells
WO2007051038A2 (en) 2005-10-27 2007-05-03 Cythera, Inc. Pdx1-expressing dorsal and ventral foregut endoderm
US8048999B2 (en) 2005-12-13 2011-11-01 Kyoto University Nuclear reprogramming factor
WO2007082963A1 (en) 2006-01-18 2007-07-26 Fundación Instituto Valenciano De Infertilidad Human embryo stem-cell lines and methods for using same
SG170021A1 (en) 2006-02-23 2011-04-29 Novocell Inc Compositions and methods useful for culturing differentiable cells
US7695965B2 (en) 2006-03-02 2010-04-13 Cythera, Inc. Methods of producing pancreatic hormones
JP6110048B2 (en) 2006-03-02 2017-04-05 ヴィアサイト，インコーポレイテッド Endocrine precursor cells, pancreatic hormone-expressing cells and methods for producing them
AU2007244675A1 (en) 2006-04-28 2007-11-08 Lifescan, Inc. Differentiation of human embryonic stem cells
US8741643B2 (en) 2006-04-28 2014-06-03 Lifescan, Inc. Differentiation of pluripotent stem cells to definitive endoderm lineage
SE534150C2 (en) 2006-05-02 2011-05-10 Wisconsin Alumni Res Found Procedure for differentiating stem cells into cells of the endodermal and pancreatic developmental line
US8685730B2 (en) 2006-05-02 2014-04-01 Wisconsin Alumni Research Foundation Methods and devices for differentiating pluripotent stem cells into cells of the pancreatic lineage
US9598673B2 (en) 2006-05-19 2017-03-21 Creative Medical Health Treatment of disc degenerative disease
US7964402B2 (en) 2006-05-25 2011-06-21 Sanford-Burnham Medical Research Institute Methods for culture and production of single cell populations of human embryonic stem cells
CN101541953A (en) 2006-06-02 2009-09-23 佐治亚大学研究基金会 Pancreatic and liver endoderm cells and tissue by differentiation of definitive endoderm cells obtained from human embryonic stems
US20090298169A1 (en) 2006-06-02 2009-12-03 The University Of Georgia Research Foundation Pancreatic and Liver Endoderm Cells and Tissue by Differentiation of Definitive Endoderm Cells Obtained from Human Embryonic Stems
US8415153B2 (en) 2006-06-19 2013-04-09 Geron Corporation Differentiation and enrichment of islet-like cells from human pluripotent stem cells
CN100494359C (en) 2006-06-23 2009-06-03 中日友好医院 Method for in vitro expansion of neural stem cells in three-dimensional culture
CA2893679C (en) 2006-06-26 2018-10-30 Lifescan, Inc. Conditioned medium for pluripotent stem cell culture
US20080003676A1 (en) 2006-06-26 2008-01-03 Millipore Corporation Growth of embryonic stem cells
WO2008004990A2 (en) 2006-07-06 2008-01-10 Es Cell International Pte Ltd Method for stem cell culture and cells derived therefrom
AU2007277364B2 (en) 2006-07-26 2010-08-12 Viacyte, Inc. Methods of producing pancreatic hormones
DK3441459T3 (en) 2006-08-02 2021-06-07 Technion Res & Dev Foundation PROCEDURES FOR EXPANSION OF EMBRYONAL STEM CELLS IN A SUSPENSION CULTURE
KR101331510B1 (en) 2006-08-30 2013-11-20 재단법인서울대학교산학협력재단 Media compostions containing low concentrations of glucose useful for human embryonic stem cells, differentiation method of human embryonic stem cells into insulin-producing cells or cell clusters using thereof, and insulin-producing cells or cell clusters differentiated thereby
JP2008099662A (en) 2006-09-22 2008-05-01 Institute Of Physical & Chemical Research Stem cell culture method
US20080091234A1 (en) 2006-09-26 2008-04-17 Kladakis Stephanie M Method for modifying a medical implant surface for promoting tissue growth
BRPI0718310A2 (en) 2006-10-17 2013-11-19 Stiefel Laboratories TALAROZOL METABOLITES
WO2008048647A1 (en) 2006-10-17 2008-04-24 Cythera, Inc. Modulation of the phosphatidylinositol-3-kinase pathway in the differentiation of human embryonic stem cells
CA2666789C (en) 2006-10-18 2016-11-22 Yong Zhao Embryonic-like stem cells derived from adult human peripheral blood and methods of use
EP2088190A4 (en) 2006-11-09 2011-01-05 Japan Government METHOD FOR THE CULTURE AND PASSAGE OF PRIMATE EMBRYONIC STRAIN CELL, AND METHOD FOR INDUCING DIFFERENTIATION OF EMBRYONIC STEM CELL
US8217027B2 (en) 2006-12-21 2012-07-10 Abbott Laboratories Sphingosine-1-phosphate receptor agonist and antagonist compounds
WO2008086005A1 (en) 2007-01-09 2008-07-17 University Of South Florida Compositions including triciribine and bortezomib and derivatives thereof and methods of use thereof
CA2676044C (en) 2007-01-30 2019-10-22 University Of Georgia Research Foundation, Inc. Early mesoderm cells, a stable population of mesendoderm cells that has utility for generation of endoderm and mesoderm lineages and multipotent migratory cells (mmc)
GB0703188D0 (en) 2007-02-19 2007-03-28 Roger Land Building Large scale production of stem cells
US20090053182A1 (en) 2007-05-25 2009-02-26 Medistem Laboratories, Inc. Endometrial stem cells and methods of making and using same
WO2009006422A1 (en) 2007-06-29 2009-01-08 Stem Cell Products, Inc. Automated method and apparatus for embryonic stem cell culture
EP2559756B1 (en) 2007-07-01 2019-12-18 Janssen Biotech, Inc. Single pluripotent stem cell culture
EP3957716A1 (en) 2007-07-18 2022-02-23 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
EP2584034B8 (en) 2007-07-31 2017-12-06 Lifescan, Inc. Pluripotent stem cell differentiation by using human feeder cells
DK2185693T3 (en) * 2007-07-31 2019-09-23 Lifescan Inc DIFFERENTIZING HUMAN EMBRYONIC STEM CELLS
MX2010002179A (en) 2007-08-24 2010-04-27 Stichting Het Nl Kanker I Composition.
WO2009061442A1 (en) 2007-11-06 2009-05-14 Children's Medical Center Corporation Method to produce induced pluripotent stem (ips) cells form non-embryonic human cells
CA2954431C (en) * 2007-11-27 2021-08-24 Lifescan, Inc. Differentiation of human embryonic stem cells to pancreatic cells
SG154367A1 (en) 2008-01-31 2009-08-28 Es Cell Int Pte Ltd Method of differentiating stem cells
WO2009096049A1 (en) 2008-02-01 2009-08-06 Kyoto University Differentiated cells originating in artificial pluripotent stem cells
US20100330677A1 (en) 2008-02-11 2010-12-30 Cambridge Enterprise Limited Improved Reprogramming of Mammalian Cells, and Cells Obtained
JP5733986B2 (en) 2008-02-21 2015-06-10 ヤンセン バイオテツク，インコーポレーテツド Methods, surface modified plates, and compositions for cell attachment, culture and detachment
WO2009110215A1 (en) 2008-03-03 2009-09-11 独立行政法人 科学技術振興機構 Method for induction of ciliated cell differentiation
JP2011514169A (en) 2008-03-17 2011-05-06 エージェンシー フォー サイエンス，テクノロジー アンド リサーチ Microcarrier for stem cell culture
RU2359030C1 (en) 2008-03-19 2009-06-20 Общество С Ограниченной Ответственностью "Лаборатория Клеточных Технологий" Method for obtaining endotheliocytes from human embryonic stem cells (versions)
AU2008355123B2 (en) 2008-04-21 2014-12-04 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8338170B2 (en) * 2008-04-21 2012-12-25 Viacyte, Inc. Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells
US8728812B2 (en) 2008-04-22 2014-05-20 President And Fellows Of Harvard College Compositions and methods for promoting the generation of PDX1+ pancreatic cells
US7939322B2 (en) 2008-04-24 2011-05-10 Centocor Ortho Biotech Inc. Cells expressing pluripotency markers and expressing markers characteristic of the definitive endoderm
US8623648B2 (en) 2008-04-24 2014-01-07 Janssen Biotech, Inc. Treatment of pluripotent cells
CA2724839A1 (en) 2008-05-21 2009-11-26 Bioe Llc Differentiation of multi-lineage progenitor cells to pancreatic cells
EP2297319B1 (en) 2008-06-03 2015-10-07 Viacyte, Inc. Growth factors for production of definitive endoderm
US20090298178A1 (en) 2008-06-03 2009-12-03 D Amour Kevin Allen Growth factors for production of definitive endoderm
EP2942392B1 (en) 2008-06-30 2018-10-03 Janssen Biotech, Inc. Differentiation of pluripotent stem cells
DE102008032236A1 (en) 2008-06-30 2010-04-01 Eberhard-Karls-Universität Tübingen Isolation and / or identification of stem cells with adipocytic, chondrocytic and pancreatic differentiation potential
US20100028307A1 (en) 2008-07-31 2010-02-04 O'neil John J Pluripotent stem cell differentiation
WO2010022395A2 (en) 2008-08-22 2010-02-25 President And Fellows Of Harvard College Methods of reprogramming cells
EP2334804B1 (en) 2008-10-07 2013-12-04 True North Therapeutics, Inc. Co-culture compositions and methods
US9234178B2 (en) * 2008-10-31 2016-01-12 Janssen Biotech, Inc. Differentiation of human pluripotent stem cells
EP2350265B1 (en) * 2008-10-31 2019-04-17 Janssen Biotech, Inc. Differentiation of human embryonic stem cells to the pancreatic endocrine lineage
US8008075B2 (en) 2008-11-04 2011-08-30 Viacyte, Inc. Stem cell aggregate suspension compositions and methods of differentiation thereof
JP5390624B2 (en) 2008-11-04 2014-01-15 バイアサイト インク Stem cell assembly suspension composition and differentiation method thereof
JP2012508584A (en) 2008-11-14 2012-04-12 ヴィアサイト，インコーポレイテッド Encapsulation of human pluripotent stem cell-derived pancreatic cells
KR101774546B1 (en) 2008-11-20 2017-09-04 얀센 바이오테크 인코포레이티드 Pluripotent stem cell culture on micro-carriers
ES2633935T3 (en) 2008-12-05 2017-09-26 Inserm - Institut National De La Santé Et De La Recherche Médicale Method and medium for neural differentiation of pluripotent cells
CN103952372B (en) 2009-07-20 2016-10-05 詹森生物科技公司 The differentiation of human embryo stem cell
US8785184B2 (en) 2009-07-20 2014-07-22 Janssen Biotech, Inc. Differentiation of human embryonic stem cells
CN102482643B (en) 2009-07-20 2016-06-29 詹森生物科技公司 The differentiation of human embryo stem cell
WO2011019092A1 (en) 2009-08-12 2011-02-17 Kyoto University Method for inducing differentiation of pluripotent stem cells into neural precursor cells
PL2494035T3 (en) 2009-10-29 2018-07-31 Janssen Biotech, Inc. Pluripotent stem cells
US9018010B2 (en) 2009-11-12 2015-04-28 Technion Research & Development Foundation Limited Culture media, cell cultures and methods of culturing pluripotent stem cells in an undifferentiated state
FI20096288A0 (en) 2009-12-04 2009-12-04 Kristiina Rajala Formulations and Methods for Culturing Stem Cells
CN102712902B (en) 2009-12-23 2019-01-08 詹森生物科技公司 Differentiation of Human Embryonic Stem Cells
SG10201408552YA (en) 2009-12-23 2015-02-27 Janssen Biotech Inc Differentiation of human embryonic stem cells
CA2785966C (en) 2009-12-29 2020-10-27 Takeda Pharmaceutical Company Limited Method for manufacturing pancreatic-hormone-producing cells
TR201000243A2 (en) 2010-01-13 2010-06-21 Akdeni̇z Ahmet Measuring device for measuring and controlling the keyway opening to the shaft
EP2532741B1 (en) 2010-02-03 2018-04-04 Tetsuya Ishikawa Induced hepatic stem cell and process for production thereof, and applications of the cell
PH12012501686A1 (en) * 2010-03-01 2020-10-19 Janssen Biotech Inc Methods for purifying cells derived from pluripotent stem cells
SG10201501513TA (en) 2010-03-02 2015-04-29 Univ Singapore Culture additives to boost stem cell proliferation and differentiation response
CN102959076B (en) 2010-03-31 2015-09-16 斯克里普斯研究所 Reprogramming cells
EP2563908B1 (en) 2010-04-25 2019-01-09 Icahn School of Medicine at Mount Sinai Generation of anterior foregut endoderm from pluripotent cells
RU2587634C2 (en) * 2010-05-12 2016-06-20 Янссен Байотек, Инк. Differentiation of human embryo stem cells
JP5936134B2 (en) 2010-06-15 2016-06-15 国立大学法人京都大学 Selection method of human induced pluripotent stem cells
WO2011160066A1 (en) 2010-06-17 2011-12-22 Regents Of The University Of Minnesota Production of insulin producing cells
US9279103B2 (en) 2010-08-05 2016-03-08 Wisconsin Alumni Research Foundation Simplified basic media for human pluripotent cell culture
KR101877077B1 (en) 2010-08-09 2018-07-10 다케다 야쿠힌 고교 가부시키가이샤 Method of producing pancreatic hormone-producing cells
PL2853589T3 (en) 2010-08-31 2018-05-30 Janssen Biotech, Inc Differentiation of human embryonic stem cells
CN103154237B (en) 2010-08-31 2016-03-16 詹森生物科技公司 The differentiation of multipotential stem cell
MY177150A (en) 2011-02-28 2020-09-08 Stempeutics Res Malaysia Sdn Bhd Isolation and expansion of adult stem cells, their therapeutic composition and uses thereof
US20130274184A1 (en) 2011-10-11 2013-10-17 The Trustees Of Columbia University In The City Of New York Er stress relievers in beta cell protection
US8951798B2 (en) 2011-10-13 2015-02-10 Wisconsin Alumni Research Foundation Generation of cardiomyocytes from human pluripotent stem cells
WO2013055397A1 (en) 2011-10-14 2013-04-18 Children's Medical Center Corporation Inhibition and enhancement of reprogramming by chromatin modifying enzymes
FI2794857T3 (en) 2011-12-22 2026-03-25 Janssen Biotech Inc Differentiation of human embryonic stem cells into single hormonal insulin positive cells
EP2795515A4 (en) 2011-12-22 2015-09-02 Intel Corp Always-available embedded theft reaction subsystem
US10519422B2 (en) 2012-02-29 2019-12-31 Riken Method of producing human retinal pigment epithelial cells
EP3450544A1 (en) 2012-06-08 2019-03-06 Janssen Biotech, Inc. Differentiation of human embryonic stem cells into pancreatic endodrine cells
CN104903440B (en) 2012-09-03 2018-04-06 诺和诺德股份有限公司 Using small molecule pancreas entoderm is produced from multipotential stem cell
DK2938723T3 (en) 2012-12-31 2023-02-20 Janssen Biotech Inc DIFFERENTIATION OF HUMAN EMBRYONIC STEM CELLS TO PANCREATIC ENDOCRINE CELLS USING HB9 REGULATORS
ES2837763T3 (en) 2012-12-31 2021-07-01 Janssen Biotech Inc Culture of human embryonic stem cells in the air-liquid interface for differentiation into pancreatic endocrine cells
US8987471B2 (en) 2013-02-14 2015-03-24 Allergan, Inc. Substituted dihydropyrazoles as sphingosine receptor modulators
US8859286B2 (en) 2013-03-14 2014-10-14 Viacyte, Inc. In vitro differentiation of pluripotent stem cells to pancreatic endoderm cells (PEC) and endocrine cells
CA2906643A1 (en) 2013-03-15 2014-09-25 The Jackson Laboratory Isolation of non-embryonic stem cells and uses thereof
CN120796168A (en) 2013-06-11 2025-10-17 哈佛学院校长同事会 SC-beta cells, compositions and methods for producing the same
CN108699515A (en) 2016-02-24 2018-10-23 诺和诺德股份有限公司 The endocrine progenitor cells generating functionality β cells derived from human pluripotent stem cells

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