SG11201700955SA - Mutants of the bacteriophage lambda integrase - Google Patents
Mutants of the bacteriophage lambda integraseInfo
- Publication number
- SG11201700955SA SG11201700955SA SG11201700955SA SG11201700955SA SG11201700955SA SG 11201700955S A SG11201700955S A SG 11201700955SA SG 11201700955S A SG11201700955S A SG 11201700955SA SG 11201700955S A SG11201700955S A SG 11201700955SA SG 11201700955S A SG11201700955S A SG 11201700955SA
- Authority
- SG
- Singapore
- Prior art keywords
- mutants
- bacteriophage lambda
- lambda integrase
- integrase
- bacteriophage
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1241—Nucleotidyltransferases (2.7.7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10311—Siphoviridae
- C12N2795/10322—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1414130.3A GB201414130D0 (en) | 2014-08-08 | 2014-08-08 | Mutants of the bacteriophage lambda integrase |
| PCT/SG2015/050255 WO2016022075A1 (en) | 2014-08-08 | 2015-08-11 | Mutants of the bacteriophage lambda integrase |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201700955SA true SG11201700955SA (en) | 2017-03-30 |
Family
ID=51629549
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201700955SA SG11201700955SA (en) | 2014-08-08 | 2015-08-11 | Mutants of the bacteriophage lambda integrase |
| SG10202005089XA SG10202005089XA (en) | 2014-08-08 | 2015-08-11 | Mutants of the bacteriophage lambda integrase |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10202005089XA SG10202005089XA (en) | 2014-08-08 | 2015-08-11 | Mutants of the bacteriophage lambda integrase |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US10344301B2 (2) |
| EP (1) | EP3177717A4 (2) |
| JP (1) | JP6616822B2 (2) |
| CN (1) | CN108064279B (2) |
| GB (1) | GB201414130D0 (2) |
| SG (2) | SG11201700955SA (2) |
| WO (1) | WO2016022075A1 (2) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201414130D0 (en) * | 2014-08-08 | 2014-09-24 | Agency Science Tech & Res | Mutants of the bacteriophage lambda integrase |
| GB201603577D0 (en) * | 2016-03-01 | 2016-04-13 | Oxford Genetics Ltd | Promoter |
| US11078493B2 (en) | 2016-06-21 | 2021-08-03 | Nanyang Technological University | Site-specific DNA recombination |
| WO2018229226A1 (en) | 2017-06-14 | 2018-12-20 | Technische Universität Dresden | Methods and means for genetic alteration of genomes utilizing designer dna recombining enzymes |
| EP4004558A2 (en) | 2019-07-29 | 2022-06-01 | Larimar Therapeutics, Inc. | Methods of quantifying frataxin and frataxin fusion proteins |
| AU2020321901A1 (en) * | 2019-07-29 | 2022-02-24 | The Trustees Of Indiana University | Materials and methods for treating Friedreich's Ataxia |
| WO2021108659A1 (en) | 2019-11-25 | 2021-06-03 | Larimar Therapeutics, Inc. | Methods for quantifying frataxin activity |
| EP4142768A1 (en) | 2020-04-30 | 2023-03-08 | Larimar Therapeutics, Inc. | Methods for treating myelin associated diseases and mitochondria associated diseases |
| US12390509B2 (en) | 2020-12-12 | 2025-08-19 | Larimar Therapeutics, Inc. | Pharmaceutical composition comprising frataxin fusion protein and methods of use thereof |
| CN117178056A (zh) * | 2021-03-12 | 2023-12-05 | 南洋理工大学 | 用于生产无缝dna载体的方法 |
| WO2023234866A1 (en) * | 2022-05-31 | 2023-12-07 | Nanyang Technological University | Method for production of a eukaryotic host cell or cell line for lambda-integrase-mediated recombination |
| CN118546903A (zh) * | 2023-02-24 | 2024-08-27 | 尧唐(上海)生物科技有限公司 | 能介导大片段dna整合到哺乳动物基因组的酶及其应用 |
| WO2024181932A1 (en) * | 2023-03-02 | 2024-09-06 | Nanyang Technological University | Lambda integrase mutants and methods of their use |
| WO2025006468A2 (en) | 2023-06-26 | 2025-01-02 | University Of Hawaii | Evolved integrases and methods of using the same for genome editing |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2522166C (en) * | 2001-05-30 | 2011-05-03 | Chromos Molecular Systems, Inc. | Lambda integrase mutein for use in recombination |
| AU2002310275B2 (en) * | 2001-05-30 | 2006-08-31 | Glaxo Group Limited | Chromosome-based platforms |
| CN102209778B (zh) * | 2008-11-11 | 2014-10-15 | 丹尼斯科美国公司 | 包含丝氨酸蛋白酶变体的组合物和方法 |
| SG170652A1 (en) | 2009-11-06 | 2011-05-30 | Agency Science Tech & Res | Muteins of the bacteriophage lambda integrases |
| GB201414130D0 (en) * | 2014-08-08 | 2014-09-24 | Agency Science Tech & Res | Mutants of the bacteriophage lambda integrase |
-
2014
- 2014-08-08 GB GBGB1414130.3A patent/GB201414130D0/en not_active Ceased
-
2015
- 2015-08-11 WO PCT/SG2015/050255 patent/WO2016022075A1/en not_active Ceased
- 2015-08-11 JP JP2017506963A patent/JP6616822B2/ja active Active
- 2015-08-11 EP EP15829802.6A patent/EP3177717A4/en active Pending
- 2015-08-11 SG SG11201700955SA patent/SG11201700955SA/en unknown
- 2015-08-11 CN CN201580054345.8A patent/CN108064279B/zh active Active
- 2015-08-11 US US15/502,783 patent/US10344301B2/en active Active
- 2015-08-11 SG SG10202005089XA patent/SG10202005089XA/en unknown
-
2019
- 2019-06-03 US US16/430,410 patent/US11414681B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US20170327847A1 (en) | 2017-11-16 |
| US10344301B2 (en) | 2019-07-09 |
| SG10202005089XA (en) | 2020-07-29 |
| CN108064279A (zh) | 2018-05-22 |
| US20200063165A1 (en) | 2020-02-27 |
| JP6616822B2 (ja) | 2019-12-04 |
| JP2017525355A (ja) | 2017-09-07 |
| CN108064279B (zh) | 2022-03-11 |
| US11414681B2 (en) | 2022-08-16 |
| GB201414130D0 (en) | 2014-09-24 |
| EP3177717A4 (en) | 2017-12-27 |
| WO2016022075A1 (en) | 2016-02-11 |
| EP3177717A1 (en) | 2017-06-14 |
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