SG11202000367RA - Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7] annulene-2-carboxylic acid and its use for the treatment of cancer - Google Patents

Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7] annulene-2-carboxylic acid and its use for the treatment of cancer

Info

Publication number: SG11202000367RA
Authority: SG; Singapore
Prior art keywords: annulene; palbociclib; oxyphenyl; fluoropropyl; pyrrolidin
Prior art date: 2017-07-24

Application number

SG11202000367RA

Other languages

English (en)

Inventor

Monsif Bouaboula

Maysoun Shomali

Fangxian Sun

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2017-07-24

Filing date

2018-07-23

Publication date

2020-02-27

2018-07-23 Application filed by Sanofi Sa filed Critical Sanofi Sa

2020-02-27 Publication of SG11202000367RA publication Critical patent/SG11202000367RA/en

Links

KISZAGQTIXIVAR-VWLOTQADSA-N 6-(2,4-dichlorophenyl)-5-[4-[(3S)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7H-benzo[7]annulene-2-carboxylic acid Chemical compound ClC1=C(C=CC(=C1)Cl)C1=C(C2=C(CCC1)C=C(C=C2)C(=O)O)C1=CC=C(C=C1)O[C@@H]1CN(CC1)CCCF KISZAGQTIXIVAR-VWLOTQADSA-N 0.000 title 1
206010028980 Neoplasm Diseases 0.000 title 1
201000011510 cancer Diseases 0.000 title 1
AHJRHEGDXFFMBM-UHFFFAOYSA-N palbociclib Chemical compound N1=C2N(C3CCCC3)C(=O)C(C(=O)C)=C(C)C2=CN=C1NC(N=C1)=CC=C1N1CCNCC1 AHJRHEGDXFFMBM-UHFFFAOYSA-N 0.000 title 1
229960004390 palbociclib Drugs 0.000 title 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Epidemiology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SG11202000367RA 2017-07-24 2018-07-23 Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7] annulene-2-carboxylic acid and its use for the treatment of cancer SG11202000367RA (en)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US201762536121P	2017-07-24	2017-07-24
EP17305998.1A EP3434272A1 (fr)	2017-07-25	2017-07-25	Combinaison comprenant du palbociclib et 6-(2,4-dichlorophényl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulène-2-acide carboxylique
PCT/EP2018/069901 WO2019020559A1 (fr)	2017-07-24	2018-07-23	Combinaison comprenant du palbociclib et de l'acide 6-(2,4-dichlorophényl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphényl]-8,9-dihydro-7h-benzo [7]annulène-2-carboxylique et son utilisation pour le traitement du cancer

Publications (1)

Publication Number	Publication Date
SG11202000367RA true SG11202000367RA (en)	2020-02-27

Family

ID=59569252

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG11202000367RA SG11202000367RA (en)	2017-07-24	2018-07-23	Combination comprising palbociclib and 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7] annulene-2-carboxylic acid and its use for the treatment of cancer

Country Status (30)

Country	Link
US (2)	US11260057B2 (fr)
EP (2)	EP3434272A1 (fr)
JP (1)	JP6741897B1 (fr)
KR (1)	KR20200031622A (fr)
CN (1)	CN111107851B (fr)
AR (1)	AR112284A1 (fr)
AU (1)	AU2018308871A1 (fr)
BR (1)	BR112020001398A2 (fr)
CA (1)	CA3070754A1 (fr)
CO (1)	CO2020000240A2 (fr)
DK (1)	DK3658147T3 (fr)
ES (1)	ES2906279T3 (fr)
HR (1)	HRP20212030T1 (fr)
HU (1)	HUE057271T2 (fr)
IL (1)	IL272166B2 (fr)
LT (1)	LT3658147T (fr)
MA (1)	MA49673B1 (fr)
MX (1)	MX393852B (fr)
MY (1)	MY195271A (fr)
PH (1)	PH12020500091A1 (fr)
PL (1)	PL3658147T3 (fr)
PT (1)	PT3658147T (fr)
RS (1)	RS62837B1 (fr)
RU (1)	RU2764116C2 (fr)
SG (1)	SG11202000367RA (fr)
SI (1)	SI3658147T1 (fr)
TW (1)	TWI768087B (fr)
UY (1)	UY37818A (fr)
WO (1)	WO2019020559A1 (fr)
ZA (1)	ZA202000145B (fr)

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EP3434272A1 (fr) *	2017-07-25	2019-01-30	Sanofi	Combinaison comprenant du palbociclib et 6-(2,4-dichlorophényl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulène-2-acide carboxylique
BR112021003440A2 (pt)	2018-09-07	2021-05-18	Sanofi	sais de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil) pirrolidin-3-il]oxifenil]-8,9-di-hidro-7h-benzo[7]anuleno-2-carboxilato de metila e seu processo de preparação
CA3146346A1 (fr) *	2019-05-09	2020-11-12	Sanofi	Acide 6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo [7]annulene-2-carboxylique destine a etre utilise chez des patients attei nts d'un cancer du sein metastatique ou avance
EP4037768B1 (fr)	2019-10-01	2023-10-11	Sanofi	Nouveaux composés 6,7-dihydro-5h-benzo[7]annulène, leurs procédés de préparation et leurs utilisations thérapeutiques
AU2020399168A1 (en) *	2019-12-09	2022-07-28	Sanofi	Crystalline form of a 7H-benzo[7]annulene-2-carboxylic acid derivative
TW202146007A (zh) *	2020-02-27	2021-12-16	法商賽諾菲公司	包含阿培利司（ａｌｐｅｌｉｓｉｂ）與６－（２，４－二氯苯基）－５－［４－［（３ｓ）－１－（３－氟丙基）吡咯啶－３－基］氧苯基］－８，９－二氫－７ｈ－苯并［７］輪烯－２－羧酸之組合
TW202233572A (zh)	2020-10-19	2022-09-01	法商賽諾菲公司	新穎之經取代的6,7-二氫-5h-苯並[7]輪烯衍生物，其製備方法及其治療用途
WO2022084280A1 (fr)	2020-10-19	2022-04-28	Sanofi	Composés 6,7-dihydro-5h-benzo[7]annulène substitués et leurs dérivés, processus permettant leur préparation et utilisations thérapeutiques associées
WO2022106711A1 (fr) *	2020-11-23	2022-05-27	Sanofi	Combinaison comprenant de l'abémaciclib et de l'acide 6-(2,4-dichlorophényl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphényl]-8,9-dihydro-7h-benzo[7]annulène-2-carboxylique
TW202302084A (zh) *	2021-03-02	2023-01-16	法商賽諾菲公司	以安森司坦和帕博西尼治療乳癌
TW202304425A (zh) *	2021-04-12	2023-02-01	法商賽諾菲公司	包含瑞博西尼和安森司群（ａｍｃｅｎｅｓｔｒａｎｔ）的組合
KR102815360B1 (ko)	2022-03-03	2025-06-02	인하대학교 산학협력단	암의 예방 또는 치료용 조성물
TW202543650A (zh)	2024-03-08	2025-11-16	美商海爾達醫療運營公司	異雙官能化合物及其在治療疾病中之用途

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ES3039455T3 (en)	2016-11-17	2025-10-21	Sanofi Sa	Novel substituted n-(3-fluoropropyl)-pyrrolidine compounds, processes for their preparation and therapeutic uses thereof
EP3434272A1 (fr) *	2017-07-25	2019-01-30	Sanofi	Combinaison comprenant du palbociclib et 6-(2,4-dichlorophényl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulène-2-acide carboxylique
BR112021003440A2 (pt)	2018-09-07	2021-05-18	Sanofi	sais de 6-(2,4-diclorofenil)-5-[4-[(3s)-1-(3-fluoropropil) pirrolidin-3-il]oxifenil]-8,9-di-hidro-7h-benzo[7]anuleno-2-carboxilato de metila e seu processo de preparação
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2017
- 2017-07-25 EP EP17305998.1A patent/EP3434272A1/fr not_active Ceased
2018
- 2018-07-23 KR KR1020207002003A patent/KR20200031622A/ko not_active Ceased
- 2018-07-23 PT PT187406152T patent/PT3658147T/pt unknown
- 2018-07-23 WO PCT/EP2018/069901 patent/WO2019020559A1/fr not_active Ceased
- 2018-07-23 RS RS20220068A patent/RS62837B1/sr unknown
- 2018-07-23 MX MX2020000917A patent/MX393852B/es unknown
- 2018-07-23 DK DK18740615.2T patent/DK3658147T3/da active
- 2018-07-23 US US16/634,089 patent/US11260057B2/en active Active
- 2018-07-23 EP EP18740615.2A patent/EP3658147B1/fr active Active
- 2018-07-23 SI SI201830528T patent/SI3658147T1/sl unknown
- 2018-07-23 CA CA3070754A patent/CA3070754A1/fr active Pending
- 2018-07-23 CN CN201880048755.5A patent/CN111107851B/zh active Active
- 2018-07-23 LT LTEPPCT/EP2018/069901T patent/LT3658147T/lt unknown
- 2018-07-23 SG SG11202000367RA patent/SG11202000367RA/en unknown
- 2018-07-23 IL IL272166A patent/IL272166B2/en unknown
- 2018-07-23 MA MA49673A patent/MA49673B1/fr unknown
- 2018-07-23 PL PL18740615T patent/PL3658147T3/pl unknown
- 2018-07-23 ES ES18740615T patent/ES2906279T3/es active Active
- 2018-07-23 AU AU2018308871A patent/AU2018308871A1/en not_active Abandoned
- 2018-07-23 JP JP2020503737A patent/JP6741897B1/ja active Active
- 2018-07-23 HR HRP20212030TT patent/HRP20212030T1/hr unknown
- 2018-07-23 MY MYPI2020000179A patent/MY195271A/en unknown
- 2018-07-23 BR BR112020001398-6A patent/BR112020001398A2/pt not_active Application Discontinuation
- 2018-07-23 RU RU2020107416A patent/RU2764116C2/ru active
- 2018-07-23 HU HUE18740615A patent/HUE057271T2/hu unknown
- 2018-07-24 AR ARP180102058 patent/AR112284A1/es not_active Application Discontinuation
- 2018-07-24 TW TW107125442A patent/TWI768087B/zh not_active IP Right Cessation
- 2018-07-24 UY UY0001037818A patent/UY37818A/es not_active Application Discontinuation
2020
- 2020-01-09 ZA ZA2020/00145A patent/ZA202000145B/en unknown
- 2020-01-10 PH PH12020500091A patent/PH12020500091A1/en unknown
- 2020-01-13 CO CONC2020/0000240A patent/CO2020000240A2/es unknown
2022
- 2022-01-19 US US17/579,187 patent/US20220362248A1/en not_active Abandoned

Also Published As

Publication number	Publication date
CA3070754A1 (fr)	2019-01-31
KR20200031622A (ko)	2020-03-24
US11260057B2 (en)	2022-03-01
PH12020500091A1 (en)	2020-09-14
CN111107851B (zh)	2023-05-12
DK3658147T3 (da)	2022-01-31
MA49673A (fr)	2021-03-24
IL272166B (en)	2022-12-01
RU2764116C2 (ru)	2022-01-13
UY37818A (es)	2020-08-31
JP6741897B1 (ja)	2020-08-19
LT3658147T (lt)	2022-01-10
PT3658147T (pt)	2022-02-02
IL272166B2 (en)	2023-04-01
SI3658147T1 (sl)	2022-02-28
ZA202000145B (en)	2021-07-28
CO2020000240A2 (es)	2020-04-24
WO2019020559A1 (fr)	2019-01-31
HRP20212030T1 (hr)	2022-04-01
PL3658147T3 (pl)	2022-03-07
TWI768087B (zh)	2022-06-21
RS62837B1 (sr)	2022-02-28
US20220362248A1 (en)	2022-11-17
CN111107851A (zh)	2020-05-05
EP3658147A1 (fr)	2020-06-03
EP3434272A1 (fr)	2019-01-30
AR112284A1 (es)	2019-10-09
MY195271A (en)	2023-01-11
JP2020526572A (ja)	2020-08-31
EP3658147B1 (fr)	2021-11-10
MA49673B1 (fr)	2022-02-28
IL272166A (en)	2020-03-31
AU2018308871A1 (en)	2020-02-06
RU2020107416A (ru)	2021-08-25
MX393852B (es)	2025-03-24
RU2020107416A3 (fr)	2021-08-25
BR112020001398A2 (pt)	2020-07-28
HUE057271T2 (hu)	2022-04-28
TW201919612A (zh)	2019-06-01
ES2906279T3 (es)	2022-04-18
US20200171033A1 (en)	2020-06-04

Publication	Publication Date	Title
IL272166A (en)	2020-03-31	A combination containing palbociclib and 6-(4,2-dichlorophenyl)-5-[4-[(S3)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-9,8-dihydro-H7-benzo [7] Anolin-2 carboxylic acid and its use in cancer treatment
IL281191A (en)	2021-04-29	Salts of methyl 6-(4,2-dichlorophenyl)-5-[4-[(S3)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-9,8-dihydro-H7-benzo[7 ]anolene-2-carboxylate and processes for their preparation
IL287805A (en)	2022-01-01	6-(2,4-dichlorophenyl)-5-[4-[(3s)-1-(3-fluoropropyl)pyrrolidin-3-yl]oxyphenyl]-8,9-dihydro-7h-benzo[7]annulene -2-carboxylic for use in metastatic or advanced breast cancer patients
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