SG112092G - New quinazoline derivatives,process for their production and pharmaceutical compositions comprising them - Google Patents

New quinazoline derivatives,process for their production and pharmaceutical compositions comprising them

Info

Publication number: SG112092G
Authority: SG; Singapore
Prior art keywords: pharmaceutical compositions; production; alkyl; quinazoline derivatives; new quinazoline
Prior art date: 1985-10-07

Application number

SG1120/92A

Other languages

English (en)

Original Assignee

Fujisawa Pharmaceutical Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1985-10-07

Filing date

1992-10-27

Publication date

1992-12-24

1992-10-27 Application filed by Fujisawa Pharmaceutical Co filed Critical Fujisawa Pharmaceutical Co

1992-12-24 Publication of SG112092G publication Critical patent/SG112092G/en

Links

239000008194 pharmaceutical composition Substances 0.000 title abstract 2
125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 title 1
125000000217 alkyl group Chemical group 0.000 abstract 3
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 2
MYMOFIZGZYHOMD-UHFFFAOYSA-N Dioxygen Chemical compound O=O MYMOFIZGZYHOMD-UHFFFAOYSA-N 0.000 abstract 1
125000003545 alkoxy group Chemical group 0.000 abstract 1
125000002947 alkylene group Chemical group 0.000 abstract 1
125000003118 aryl group Chemical group 0.000 abstract 1
125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
239000003937 drug carrier Substances 0.000 abstract 1
229910052736 halogen Inorganic materials 0.000 abstract 1
125000001475 halogen functional group Chemical group 0.000 abstract 1
150000002367 halogens Chemical class 0.000 abstract 1
125000000623 heterocyclic group Chemical group 0.000 abstract 1
229910052739 hydrogen Inorganic materials 0.000 abstract 1
239000001257 hydrogen Substances 0.000 abstract 1
125000004435 hydrogen atom Chemical class [H]* 0.000 abstract 1
229910052760 oxygen Inorganic materials 0.000 abstract 1
239000001301 oxygen Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1
125000001424 substituent group Chemical group 0.000 abstract 1
125000000472 sulfonyl group Chemical group *S(*)(=O)=O 0.000 abstract 1
229910052717 sulfur Inorganic materials 0.000 abstract 1
125000004434 sulfur atom Chemical group 0.000 abstract 1
125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/12—Ophthalmic agents for cataracts
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/80—Oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/95—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in positions 2 and 4
- C07D239/96—Two oxygen atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
- C07D285/15—Six-membered rings
- C07D285/16—Thiadiazines; Hydrogenated thiadiazines
- C07D285/18—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines
- C07D285/20—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems
- C07D285/22—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
- C07D285/24—1,2,4-Thiadiazines; Hydrogenated 1,2,4-thiadiazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with oxygen atoms directly attached to the ring sulfur atom
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Diabetes (AREA)
Ophthalmology & Optometry (AREA)
Endocrinology (AREA)
Hematology (AREA)
Obesity (AREA)
Emergency Medicine (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Urology & Nephrology (AREA)
Gastroenterology & Hepatology (AREA)
Reproductive Health (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SG1120/92A 1985-10-07 1992-10-27 New quinazoline derivatives,process for their production and pharmaceutical compositions comprising them SG112092G (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
GB858524663A GB8524663D0 (en)	1985-10-07	1985-10-07	Quinazoline derivatives

Publications (1)

Publication Number	Publication Date
SG112092G true SG112092G (en)	1992-12-24

Family

ID=10586291

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1120/92A SG112092G (en)	1985-10-07	1992-10-27	New quinazoline derivatives,process for their production and pharmaceutical compositions comprising them

Country Status (23)

Country	Link
US (2)	US4734419A (ko)
EP (1)	EP0218999B1 (ko)
JP (3)	JPS6296476A (ko)
KR (1)	KR940007270B1 (ko)
CN (1)	CN1017242B (ko)
AT (1)	ATE60761T1 (ko)
AU (1)	AU596611B2 (ko)
CA (1)	CA1289139C (ko)
DE (1)	DE3677452D1 (ko)
DK (1)	DK158838C (ko)
ES (1)	ES2021266B3 (ko)
FI (1)	FI90234C (ko)
GB (1)	GB8524663D0 (ko)
GR (1)	GR3001502T3 (ko)
HK (1)	HK6993A (ko)
HU (1)	HU196972B (ko)
IE (1)	IE59309B1 (ko)
IL (1)	IL80213A (ko)
NO (1)	NO171785C (ko)
SG (1)	SG112092G (ko)
SU (1)	SU1588283A3 (ko)
UA (1)	UA5562A1 (ko)
ZA (1)	ZA867043B (ko)

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GB8524663D0 (en) *	1985-10-07	1985-11-13	Fujisawa Pharmaceutical Co	Quinazoline derivatives
MX7829A (es) *	1986-08-21	1993-08-01	Pfizer	Quinazolindionas y piridopirimindionas y procedimiento para su preparacion
US4889851A (en) *	1986-11-21	1989-12-26	Fujisawa Pharmaceutical Co, Ltd.	Benzothiadiazine compounds, and pharmaceutical composition comprising the same
US4931440A (en) *	1987-07-29	1990-06-05	Fujisawa Pharmaceutical Company, Ltd.	Uricosuric composition
AU599515B2 (en) *	1987-09-16	1990-07-19	Taiho Pharmaceutical Co., Ltd.	Thienopyrimidine derivatives
JP2621460B2 (ja) *	1988-02-29	1997-06-18	藤沢薬品工業株式会社	利尿または降圧剤
US5324747A (en) *	1992-07-15	1994-06-28	Hoffmann-La Roche Inc.	N-substituted anilines, inhibitors of phospholipases A2
WO1994007867A1 (en) *	1992-09-28	1994-04-14	Pfizer Inc.	Substituted pyrimidines for control of diabetic complications
DE19532052C2 (de) *	1995-08-31	1998-11-19	Clariant Gmbh	Verfahren zur Herstellung von Chinazolinderivaten
DE59606237D1 (de) *	1995-08-31	2001-01-25	Clariant Gmbh	Monoester der carboxymethylenanthranilsäuren und verfahren zu ihrer herstellung
CA2193932C (en) *	1995-12-26	2001-08-21	Shinji Nishii	Process for producing isatoic anhydrides
WO1997024335A1 (en) *	1995-12-28	1997-07-10	Fuji Chemical Industry Co., Ltd.	Process for the preparation of 3-dihalobenzyl-2,4-quinazolinedione derivatives
CA2196510C (en) *	1996-02-01	2000-08-01	Masashi Komatsu	Process for producing dioxoquinazolines
DE19650975A1 (de) *	1996-12-09	1998-06-10	Basf Ag	Neue heterocyclisch substituierte Benzamide und deren Anwendung
SK141899A3 (en) *	1997-04-15	2000-09-12	Csir Corporate Building	Pharmaceutical compositions having appetite suppressant activity
US6444816B1 (en)	1997-10-27	2002-09-03	Dr. Reddy's Research Foundation	Fused 7-oxo-pyrimidinyl compounds, preparation, composition and use thereof
IL137128A0 (en) *	1998-01-30	2001-07-24	R Tech Ueno Ltd	Ophthalmic compositions containing tetrahydroquinazoline derivatives
WO2000043015A1 (fr) *	1999-01-25	2000-07-27	Fujisawa Pharmaceutical Co., Ltd.	Gouttes ophtalmologiques
CA2328877A1 (en)	1999-02-18	2000-08-24	R-Tech Ueno, Ltd.	Composition for treatment of external secretion disorders except hypolacrimation
BR0010402A (pt) *	1999-03-09	2002-01-08	Fujisawa Pharmaceutical Co	Processo para preparação de derivados de quinazolina
US6545004B1 (en)	1999-10-27	2003-04-08	Cytokinetics, Inc.	Methods and compositions utilizing quinazolinones
US7230000B1 (en)	1999-10-27	2007-06-12	Cytokinetics, Incorporated	Methods and compositions utilizing quinazolinones
GB2396815B (en) *	1999-10-27	2004-09-08	Phytopharm Plc	A composition comprising a pregnenone derivative and an NSAID
US6380200B1 (en)	1999-12-07	2002-04-30	Pfizer, Inc.	Combination of aldose reductase inhibitors and selective serotonin reuptake inhibitors for the treatment of diabetic complications
GB2363985B (en) *	2000-06-30	2004-09-29	Phytopharm Plc	Extracts,compounds & pharmaceutical compositions having anti-diabetic activity and their use
AP2001002359A0 (en)	2000-11-30	2001-12-31	Pfizer Prod Inc	Combination of gaba agonists and aldose reductase inhibitors.
JP4273406B2 (ja) *	2001-06-01	2009-06-03	小野薬品工業株式会社	アルドース還元酵素阻害剤を有効成分とする脱髄性疾患または脱髄を伴う疾患治療剤
US7009049B2 (en) *	2002-02-15	2006-03-07	Cytokinetics, Inc.	Syntheses of quinazolinones
EP2316468A1 (en)	2002-02-22	2011-05-04	Shire LLC	Delivery system and methods for protecting and administering dextroamphetamine
US7166595B2 (en) *	2002-05-09	2007-01-23	Cytokinetics, Inc.	Compounds, methods and compositions
AU2003270015A1 (en)	2002-05-09	2003-12-02	Cytokinetics, Inc.	Compounds, compositions, and methods
US20040053948A1 (en) *	2002-05-10	2004-03-18	Cytokinetics, Inc.	Compounds, compositions and methods
WO2003103575A2 (en) *	2002-05-23	2003-12-18	Cytokinetics, Inc.	Compounds, compositions, and methods
CA2489367A1 (en) *	2002-06-14	2003-12-24	Cytokinetics, Inc.	Compounds, compositions, and methods
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EP1539180A4 (en) *	2002-08-21	2006-08-30	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS AND METHODS
WO2004034972A2 (en) *	2002-09-30	2004-04-29	Cytokinetics, Inc.	Compounds, compositions, and methods
JP2007510652A (ja) *	2003-11-03	2007-04-26	サイトキネティクス・インコーポレーテッド	ピリミジン−４−オン化合物、組成物、および方法
WO2005046588A2 (en) *	2003-11-07	2005-05-26	Cytokinetics, Inc.	Compounds, compositions, and methods
EP1692112A4 (en) *	2003-12-08	2008-09-24	Cytokinetics Inc	COMPOUNDS, COMPOSITIONS, AND METHODS
US20070010537A1 (en) *	2004-08-20	2007-01-11	Kazumasa Hamamura	Fused pyramidine derivative and use thereof
US20110092566A1 (en) *	2004-11-19	2011-04-21	Srivastava Satish K	Treatment of cancer with aldose reductase inhibitors
KR101433395B1 (ko) *	2006-07-19	2014-08-26	이 아이 듀폰 디 네모아 앤드 캄파니	3-치환된 2-아미노-5-할로벤즈아미드의 제조 방법
EP2368560A1 (en)	2007-03-12	2011-09-28	Zadec ApS	An anti-diabetic extract of rooibos
CA2685202C (en)	2007-03-23	2017-11-28	The Board Of Regents Of The University Of Texas System	Methods for treating allergic asthma
CA2695331A1 (en) *	2007-08-03	2009-02-12	F. Hoffmann-La Roche Ag	Pyridinecarboxamide and benzamide derivatives as taar1 ligands
US20090270490A1 (en) *	2008-04-24	2009-10-29	The Board Of Regents Of The University Of Texas System	Methods involving aldose reductase inhibition
CN102219759B (zh) *	2010-04-16	2013-07-24	中国科学院上海药物研究所	芳基甲酰胺类化合物及其制备方法、药物组合物和用途
AU2011348074B2 (en)	2010-12-23	2016-04-28	The Board Of Regents Of The University Of Texas System	Methods for treating COPD
EA201591962A1 (ru)	2013-05-10	2016-06-30	Нимбус Аполло, Инк.	Ингибиторы акк и их применение
AU2014262638A1 (en)	2013-05-10	2015-11-26	Gilead Apollo, Llc	ACC inhibitors and uses thereof
AU2014262636A1 (en)	2013-05-10	2015-11-26	Gilead Apollo, Llc	ACC inhibitors and uses thereof
TW201623257A (zh)	2014-05-09	2016-07-01	奧利安公司	藥理活性之喹唑啉二酮衍生物
US12090142B2 (en)	2018-02-22	2024-09-17	Board Of Regents, The University Of Texas System	Combination therapy for the treatment of cancer
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US4016166A (en) *	1973-12-14	1977-04-05	Hisamitsu Pharmaceutical Co., Inc.	1-Nitrophenylquinazoline-2,4(1H,3H)-diones
DE2652144A1 (de) *	1976-11-16	1978-05-18	Merck Patent Gmbh	Neue chinazolindione
CA1161036A (en) *	1980-05-15	1984-01-24	Masayuki Ishikawa	Quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
DE3172006D1 (en) *	1980-05-22	1985-10-03	Masayuki Ishikawa	Novel quinazoline-dione compounds, process for production thereof and pharmaceutical use thereof
JPS58159480A (ja) *	1982-03-17	1983-09-21	Chugai Pharmaceut Co Ltd	新規なフエニルピペラジン誘導体
DD232702A1 (de) *	1982-09-20	1986-02-05	Adw Ddr	Verfahren zur herstellung von 1,2,3,4-tetrahydrochinazolin-2,4-dion-essigsaeuren, deren salzen und estern
US4490374A (en) *	1982-09-30	1984-12-25	Ortho Pharmaceutical Corporation	5,6-Dialkoxy-3,4-optionally substituted-2(1H)quinazolinones, composition and method of use
JPS59186963A (ja) *	1983-04-08	1984-10-23	Chugai Pharmaceut Co Ltd	新規なフエニルピペラジン誘導体
GB8524663D0 (en) *	1985-10-07	1985-11-13	Fujisawa Pharmaceutical Co	Quinazoline derivatives

1985
- 1985-10-07 GB GB858524663A patent/GB8524663D0/en active Pending
1986
- 1986-09-16 US US06/908,005 patent/US4734419A/en not_active Expired - Lifetime
- 1986-09-16 ZA ZA867043A patent/ZA867043B/xx unknown
- 1986-09-23 IE IE252086A patent/IE59309B1/en not_active IP Right Cessation
- 1986-09-25 DK DK459086A patent/DK158838C/da not_active IP Right Cessation
- 1986-09-29 FI FI863917A patent/FI90234C/fi not_active IP Right Cessation
- 1986-10-02 IL IL80213A patent/IL80213A/xx not_active IP Right Cessation
- 1986-10-02 DE DE8686113559T patent/DE3677452D1/de not_active Expired - Lifetime
- 1986-10-02 EP EP86113559A patent/EP0218999B1/en not_active Expired - Lifetime
- 1986-10-02 ES ES86113559T patent/ES2021266B3/es not_active Expired - Lifetime
- 1986-10-02 AT AT86113559T patent/ATE60761T1/de not_active IP Right Cessation
- 1986-10-03 SU SU864028362A patent/SU1588283A3/ru active
- 1986-10-03 CA CA000519759A patent/CA1289139C/en not_active Expired - Lifetime
- 1986-10-03 UA UA4028362A patent/UA5562A1/uk unknown
- 1986-10-06 NO NO863980A patent/NO171785C/no not_active IP Right Cessation
- 1986-10-06 AU AU63589/86A patent/AU596611B2/en not_active Ceased
- 1986-10-06 HU HU864192A patent/HU196972B/hu not_active IP Right Cessation
- 1986-10-06 JP JP61237605A patent/JPS6296476A/ja active Granted
- 1986-10-07 KR KR86008374A patent/KR940007270B1/ko not_active Expired - Fee Related
- 1986-10-07 CN CN86106984A patent/CN1017242B/zh not_active Expired
1987
- 1987-12-08 US US07/130,297 patent/US4883800A/en not_active Expired - Lifetime
1988
- 1988-08-22 JP JP63207571A patent/JPH01125322A/ja active Granted
- 1988-08-22 JP JP63207570A patent/JPH0794447B2/ja not_active Expired - Lifetime
1991
- 1991-02-25 GR GR90401160T patent/GR3001502T3/el unknown
1992
- 1992-10-27 SG SG1120/92A patent/SG112092G/en unknown
1993
- 1993-01-28 HK HK69/93A patent/HK6993A/en not_active IP Right Cessation

Also Published As

Publication number	Publication date
IE59309B1 (en)	1994-02-09
DK459086A (da)	1987-04-08
NO171785C (no)	1993-05-05
JPH01131164A (ja)	1989-05-24
IL80213A (en)	1991-06-30
NO171785B (no)	1993-01-25
CA1289139C (en)	1991-09-17
EP0218999A2 (en)	1987-04-22
JPH01125322A (ja)	1989-05-17
FI90234C (fi)	1994-01-10
HK6993A (en)	1993-02-05
NO863980D0 (no)	1986-10-06
UA5562A1 (uk)	1994-12-28
KR940007270B1 (en)	1994-08-12
CN1017242B (zh)	1992-07-01
IL80213A0 (en)	1987-01-30
AU6358986A (en)	1987-04-09
DK158838C (da)	1991-01-14
GB8524663D0 (en)	1985-11-13
FI90234B (fi)	1993-09-30
NO863980L (no)	1987-04-08
HUT41747A (en)	1987-05-28
KR870003998A (ko)	1987-05-06
EP0218999A3 (en)	1988-01-13
IE862520L (en)	1987-04-07
JPH0794447B2 (ja)	1995-10-11
ATE60761T1 (de)	1991-02-15
US4734419A (en)	1988-03-29
US4883800A (en)	1989-11-28
JPS6296476A (ja)	1987-05-02
JPH05366B2 (ko)	1993-01-05
HU196972B (en)	1989-02-28
FI863917A0 (fi)	1986-09-29
DE3677452D1 (de)	1991-03-14
JPH0482148B2 (ko)	1992-12-25
DK158838B (da)	1990-07-23
DK459086D0 (da)	1986-09-25
AU596611B2 (en)	1990-05-10
ZA867043B (en)	1987-07-29
CN86106984A (zh)	1987-05-20
GR3001502T3 (en)	1992-11-23
EP0218999B1 (en)	1991-02-06
FI863917L (fi)	1987-04-08
SU1588283A3 (ru)	1990-08-23
ES2021266B3 (es)	1991-11-01

Publication	Publication Date	Title
ZA867043B (en)	1987-07-29	New quinazoline derivatives and a process for their production
AU589427B2 (en)	1989-10-12	Pyridonecarboxylic acid derivatives and process for their preparation
IL107426A0 (en)	1994-01-25	Heterocyclic compounds, processes for the preparation thereof, and pharmaceutical compositions containing the same
HUT37128A (en)	1985-11-28	Process for the production of dihydropyridazinone-derivatives, as well as of pharmaceutical preparations containing these derivatives as agent
HUT40101A (en)	1986-11-28	Process for producing quinolin-carboxylic acid derivatives and pharmaceutical compositions containing them as active agents
DK291488A (da)	1988-11-30	Alkansulfonanilidderivater
HUT56089A (en)	1991-07-29	Process for producing quinazoline derivatives and pharmaceutical compositions containing them
DE3477380D1 (en)	1989-04-27	Novel benzothiazepine derivatives, processes for preparing the same and pharmaceutical compositions
FI89594C (fi)	1993-10-25	Foerfarande foer framstaellning av farmakologiskt vaerdefull pyrrolidinfoerening
HUT40658A (en)	1987-01-28	Process for producing benzo/c/-1,5-naphtiridin derivatives and pharmaceutical compositions containing them as active agents
PT84760A (en)	1987-05-01	Heterocyclic compounds