SG148031A1 - Use of cci-779 as an antineoplastic agent - Google Patents

Use of cci-779 as an antineoplastic agent

Info

Publication number: SG148031A1
Authority: SG; Singapore
Prior art keywords: cci; antineoplastic agent; antineoplastic; agent; neoplasms
Prior art date: 2000-11-15

Application number

SG200505237-8A

Other languages

English (en)

Inventor

Gary Dukart

Joseph Gibbons James Jr

Lisa Anne Speicher

Philip Frost

Discafani-Marro Carolyn Mary

Original Assignee

Wyeth Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-15

Filing date

2001-11-13

Publication date

2008-12-31

2001-11-13 Application filed by Wyeth Corp filed Critical Wyeth Corp

2008-12-31 Publication of SG148031A1 publication Critical patent/SG148031A1/en

Links

CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 title abstract 3
229960000235 temsirolimus Drugs 0.000 title abstract 3
229940034982 antineoplastic agent Drugs 0.000 title abstract 2
239000002246 antineoplastic agent Substances 0.000 title abstract 2
206010028980 Neoplasm Diseases 0.000 abstract 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents

Landscapes

Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Urology & Nephrology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SG200505237-8A 2000-11-15 2001-11-13 Use of cci-779 as an antineoplastic agent SG148031A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US24907700P	2000-11-15	2000-11-15

Publications (1)

Publication Number	Publication Date
SG148031A1 true SG148031A1 (en)	2008-12-31

Family

ID=22941961

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200505237-8A SG148031A1 (en)	2000-11-15	2001-11-13	Use of cci-779 as an antineoplastic agent

Country Status (27)

Country	Link
US (3)	US20020091137A1 (de)
EP (1)	EP1335725B1 (de)
JP (4)	JP4472251B2 (de)
KR (1)	KR100827942B1 (de)
CN (2)	CN1678312A (de)
AR (1)	AR031341A1 (de)
AT (1)	ATE393629T1 (de)
AU (2)	AU2731302A (de)
BR (1)	BR0115323A (de)
CA (1)	CA2429020C (de)
CY (1)	CY1108109T1 (de)
DE (1)	DE60133831T2 (de)
DK (1)	DK1335725T3 (de)
EA (1)	EA007096B1 (de)
ES (1)	ES2305134T3 (de)
HU (1)	HUP0400521A3 (de)
IL (2)	IL155871A0 (de)
MX (1)	MXPA03004192A (de)
NO (1)	NO20032181L (de)
NZ (1)	NZ539668A (de)
PL (1)	PL207061B1 (de)
PT (1)	PT1335725E (de)
SG (1)	SG148031A1 (de)
SI (1)	SI1335725T1 (de)
TW (1)	TWI286074B (de)
WO (1)	WO2002040000A2 (de)
ZA (1)	ZA200304603B (de)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5362718A (en)	1994-04-18	1994-11-08	American Home Products Corporation	Rapamycin hydroxyesters
TWI286074B (en) *	2000-11-15	2007-09-01	Wyeth Corp	Pharmaceutical composition containing CCI-779 as an antineoplastic agent
PL409579A1 (pl)	2001-02-19	2015-03-02	Novartis Ag	Leczenie raka
TWI296196B (en) *	2001-04-06	2008-05-01	Wyeth Corp	Antineoplastic combinations
ZA200603888B (en) *	2001-06-01	2007-05-30	Wyeth Corp	Antineoplastic combinations
EA007530B1 (ru) *	2001-06-01	2006-10-27	Уайт	Противоопухолевые комбинации
JP4547911B2 (ja) *	2002-02-01	2010-09-22	アリアド・ファーマシューティカルズ・インコーポレイテッド	リン含有化合物およびその用途
EP1516597A4 (de) *	2002-06-27	2010-11-10	Microport Medical Shanghai Co	Arzneimittel-elutionsstent
NZ537829A (en)	2002-07-30	2006-09-29	Wyeth Corp	Parenteral formulations containing a rapamycin hydroxyester
DE60324609D1 (de) *	2002-09-17	2008-12-18	Wyeth Corp	GRANULIERTE FORMULIERUNG DES RAPAMYCINESTERS CCl-779
AU2003298689A1 (en)	2002-11-21	2004-06-18	Wyeth	Methods for diagnosing rcc and other solid tumors
WO2004072265A2 (en) *	2003-02-11	2004-08-26	Wyeth	Methods for monitoring drug activities in vivo
US7643943B2 (en)	2003-02-11	2010-01-05	Wyeth Llc	Methods for monitoring drug activities in vivo
US20050287532A9 (en) *	2003-02-11	2005-12-29	Burczynski Michael E	Methods for monitoring drug activities in vivo
UA83484C2 (uk) *	2003-03-05	2008-07-25	Уайт	Спосіб лікування раку грудей комбінацією похідного рапаміцину і інгібітора ароматази - летрозолу, фармацевтична композиція
ATE352301T1 (de) *	2003-04-22	2007-02-15	Wyeth Corp	Antineoplastische zusammensetzungen
WO2004097052A2 (en) *	2003-04-29	2004-11-11	Wyeth	Methods for prognosis and treatment of solid tumors
CN1829514A (zh) *	2003-07-25	2006-09-06	惠氏公司	Cci－779冻干制剂
AR046194A1 (es) *	2003-11-04	2005-11-30	Mayo Foundation	Metodo de tratamiento del linfoma de celulas del manto
JP2007517879A (ja) *	2004-01-08	2007-07-05	ワイス	Ｃｃｉ−７７９経口投与用の直接圧縮可能な医薬組成物
AR047988A1 (es) *	2004-03-11	2006-03-15	Wyeth Corp	Combinaciones antineoplásicas de cci-779 y rituximab
ES2364495T3 (es)	2005-02-03	2011-09-05	The General Hospital Corporation	Método para tratar cáncer resistente a gefitinib.
EP1855656A2 (de) *	2005-02-15	2007-11-21	Wyeth	Oral bioverfügbare cci-779-tablettenformulierungen
JP2009514870A (ja)	2005-11-04	2009-04-09	ワイス	ｍＴＯＲインヒビター、ハーセプチン、および／またはＨＫＩ−２７２の抗悪性腫瘍性組み合わせ
RU2487711C2 (ru) *	2005-11-21	2013-07-20	Новартис Аг	Лечение нейроэндокринных опухолей
RU2008121713A (ru) *	2005-12-20	2010-01-27	Вайет (Us)	Контроль стабильности лекарственной формы cci-779 посредством контроля примесей лекарственныхого вещества
DE102006011507A1 (de) *	2006-03-14	2007-09-20	Lts Lohmann Therapie-Systeme Ag	Wirkstoffbeladene Nanopartikel auf Basis hydrophiler Proteine
TW200901989A (en) *	2007-04-10	2009-01-16	Wyeth Corp	Anti-tumor activity of CCI-779 in papillary renal cell cancer
US20090076060A1 (en) *	2007-09-17	2009-03-19	Protia, Llc	Deuterium-enriched temsirolimus
CA2709413C (en) *	2007-10-03	2017-09-12	Genesis Technical Systems Corp.	Dynamic, asymmetric rings
US8022216B2 (en)	2007-10-17	2011-09-20	Wyeth Llc	Maleate salts of (E)-N-{4-[3-chloro-4-(2-pyridinylmethoxy)anilino]-3-cyano-7-ethoxy-6-quinolinyl}-4-(dimethylamino)-2-butenamide and crystalline forms thereof
AU2013205002B2 (en) *	2008-03-21	2016-09-15	The University Of Chicago	Treatment with opioid antagonists and mTOR inhibitors
EP2278966B1 (de) *	2008-03-21	2019-10-09	The University of Chicago	Behandlung mit opioid-antagonisten und mtor-inhibitoren
ES2692769T3 (es)	2008-06-17	2018-12-05	Wyeth Llc	Combinaciones antineoplásicas que contienen HKI-272 y vinorelbina
CN105147713A (zh)	2008-08-04	2015-12-16	惠氏有限责任公司	4-苯胺基-3-氰基喹啉和卡培他滨的抗肿瘤组合
SG174382A1 (en)	2009-04-06	2011-11-28	Wyeth Llc	Treatment regimen utilizing neratinib for breast cancer
US8716307B2 (en) *	2009-05-13	2014-05-06	The Trustees Of The University Of Pennsylvania	Combination antineoplastic therapy
WO2011151704A2 (en) *	2010-06-02	2011-12-08	Fresenius Kabi Oncology Ltd.	Stable pharmaceutical compositions of rapamycin esters
US9745941B2 (en) *	2014-04-29	2017-08-29	Ford Global Technologies, Llc	Tunable starter resistor
KR101965319B1 (ko) *	2015-08-24	2019-04-04	샨시 야바오 헬스 프로덕츠 컴퍼니 리미티드	항종양 약물 제조에서의 다이하이드록시아세톤의 용도
CN111110676A (zh) *	2020-03-07	2020-05-08	天津医科大学总医院	阿帕替尼及联合cci-779在制备肺癌药物中的应用

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ZA737247B (en)	1972-09-29	1975-04-30	Ayerst Mckenna & Harrison	Rapamycin and process of preparation
US3993749A (en)	1974-04-12	1976-11-23	Ayerst Mckenna And Harrison Ltd.	Rapamycin and process of preparation
US4885171A (en)	1978-11-03	1989-12-05	American Home Products Corporation	Use of rapamycin in treatment of certain tumors
US5206018A (en)	1978-11-03	1993-04-27	Ayerst, Mckenna & Harrison, Inc.	Use of rapamycin in treatment of tumors
BE877700A (fr) *	1978-11-03	1980-01-14	Ayerst Mckenna & Harrison	Compositions pharmaceutiques a base de rapamycine pour le traitement de tumeurs carcinogenes
US4401653A (en)	1981-03-09	1983-08-30	Ayerst, Mckenna & Harrison Inc.	Combination of rapamycin and picibanil for the treatment of tumors
US5100899A (en)	1989-06-06	1992-03-31	Roy Calne	Methods of inhibiting transplant rejection in mammals using rapamycin and derivatives and prodrugs thereof
US5078999A (en)	1991-02-22	1992-01-07	American Home Products Corporation	Method of treating systemic lupus erythematosus
US5080899A (en)	1991-02-22	1992-01-14	American Home Products Corporation	Method of treating pulmonary inflammation
US5321009A (en)	1991-04-03	1994-06-14	American Home Products Corporation	Method of treating diabetes
ATE135583T1 (de)	1991-06-18	1996-04-15	American Home Prod	Verwendung von rapamycin zur behandlung von t- zellen lymphom/leukämie bei erwachsenen
ZA924953B (en)	1991-07-25	1993-04-28	Univ Louisville Res Found	Method of treating ocular inflammation
US5286731A (en)	1991-09-17	1994-02-15	American Home Products Corporation	Method of treating immunoinflammatory bowel disease
US5286730A (en)	1991-09-17	1994-02-15	American Home Products Corporation	Method of treating immunoinflammatory disease
US5516781A (en)	1992-01-09	1996-05-14	American Home Products Corporation	Method of treating restenosis with rapamycin
US5288711A (en)	1992-04-28	1994-02-22	American Home Products Corporation	Method of treating hyperproliferative vascular disease
ZA935112B (en)	1992-07-17	1994-02-08	Smithkline Beecham Corp	Rapamycin derivatives
US5362718A (en) *	1994-04-18	1994-11-08	American Home Products Corporation	Rapamycin hydroxyesters
US5561138A (en)	1994-12-13	1996-10-01	American Home Products Corporation	Method of treating anemia
US5496832A (en)	1995-03-09	1996-03-05	American Home Products Corporation	Method of treating cardiac inflammatory disease
JP2004507465A (ja)	2000-08-11	2004-03-11	ワイス	エストロゲン受容体陽性癌腫の治療方法
TWI286074B (en) *	2000-11-15	2007-09-01	Wyeth Corp	Pharmaceutical composition containing CCI-779 as an antineoplastic agent
TWI296196B (en)	2001-04-06	2008-05-01	Wyeth Corp	Antineoplastic combinations
TWI233359B (en)	2001-04-06	2005-06-01	Wyeth Corp	Pharmaceutical composition for treating neoplasm
UA77200C2 (en)	2001-08-07	2006-11-15	Wyeth Corp	Antineoplastic combination of cci-779 and bkb-569

2001
- 2001-11-05 TW TW090127415A patent/TWI286074B/zh not_active IP Right Cessation
- 2001-11-13 EA EA200300566A patent/EA007096B1/ru not_active IP Right Cessation
- 2001-11-13 DK DK01996175T patent/DK1335725T3/da active
- 2001-11-13 CA CA002429020A patent/CA2429020C/en not_active Expired - Lifetime
- 2001-11-13 KR KR1020037006542A patent/KR100827942B1/ko not_active Expired - Lifetime
- 2001-11-13 BR BR0115323-4A patent/BR0115323A/pt not_active Application Discontinuation
- 2001-11-13 SG SG200505237-8A patent/SG148031A1/en unknown
- 2001-11-13 CN CNA018189261A patent/CN1678312A/zh active Pending
- 2001-11-13 JP JP2002542375A patent/JP4472251B2/ja not_active Expired - Lifetime
- 2001-11-13 WO PCT/US2001/047324 patent/WO2002040000A2/en not_active Ceased
- 2001-11-13 CN CN2010101653331A patent/CN102058588A/zh active Pending
- 2001-11-13 US US10/010,584 patent/US20020091137A1/en not_active Abandoned
- 2001-11-13 IL IL15587101A patent/IL155871A0/xx unknown
- 2001-11-13 PT PT01996175T patent/PT1335725E/pt unknown
- 2001-11-13 DE DE60133831T patent/DE60133831T2/de not_active Expired - Lifetime
- 2001-11-13 AU AU2731302A patent/AU2731302A/xx active Pending
- 2001-11-13 HU HU0400521A patent/HUP0400521A3/hu unknown
- 2001-11-13 NZ NZ539668A patent/NZ539668A/en unknown
- 2001-11-13 AT AT01996175T patent/ATE393629T1/de not_active IP Right Cessation
- 2001-11-13 ES ES01996175T patent/ES2305134T3/es not_active Expired - Lifetime
- 2001-11-13 EP EP01996175A patent/EP1335725B1/de not_active Expired - Lifetime
- 2001-11-13 PL PL362740A patent/PL207061B1/pl unknown
- 2001-11-13 SI SI200130829T patent/SI1335725T1/sl unknown
- 2001-11-13 MX MXPA03004192A patent/MXPA03004192A/es active IP Right Grant
- 2001-11-14 AR ARP010105310A patent/AR031341A1/es unknown
2003
- 2003-02-26 US US10/374,644 patent/US7189735B2/en not_active Expired - Lifetime
- 2003-05-12 IL IL155871A patent/IL155871A/en active IP Right Grant
- 2003-05-14 NO NO20032181A patent/NO20032181L/no not_active Application Discontinuation
- 2003-06-12 ZA ZA200304603A patent/ZA200304603B/en unknown
2007
- 2007-02-01 US US11/701,109 patent/US7781446B2/en not_active Expired - Fee Related
- 2007-03-27 AU AU2007201324A patent/AU2007201324B2/en not_active Expired
2008
- 2008-06-02 CY CY20081100573T patent/CY1108109T1/el unknown
2009
- 2009-09-18 JP JP2009216883A patent/JP2010018620A/ja active Pending
2014
- 2014-01-15 JP JP2014005231A patent/JP2014088430A/ja not_active Withdrawn
2015
- 2015-12-10 JP JP2015241449A patent/JP2016094444A/ja not_active Withdrawn

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
RAPAMYCIN ANALOG CCI-779 INHIBITS GROWTH OF HUMAN MEDULLOBLASTOMA XENOGR *
THE EFFECT OF CCI-779, A NOVEL MACROLIDE ANTI-TUMOR AGENT, ON THE GROWTH OF HUMAN TUMOR CELLS IN VITRO AND IN NUDE MOUSE XENOGRAFTS IN VIVO; *

Also Published As

Publication number	Publication date
DE60133831D1 (de)	2008-06-12
EA200300566A1 (ru)	2003-10-30
EP1335725A2 (de)	2003-08-20
US7189735B2 (en)	2007-03-13
ZA200304603B (en)	2004-09-13
US7781446B2 (en)	2010-08-24
JP2014088430A (ja)	2014-05-15
CA2429020C (en)	2009-05-26
PL207061B1 (pl)	2010-10-29
US20070142425A1 (en)	2007-06-21
CA2429020A1 (en)	2002-05-23
CN1678312A (zh)	2005-10-05
DK1335725T3 (da)	2008-06-30
DE60133831T2 (de)	2009-05-20
MXPA03004192A (es)	2003-09-22
WO2002040000A3 (en)	2002-09-06
WO2002040000A2 (en)	2002-05-23
EP1335725B1 (de)	2008-04-30
ES2305134T3 (es)	2008-11-01
CY1108109T1 (el)	2014-02-12
PL362740A1 (en)	2004-11-02
BR0115323A (pt)	2004-02-17
ATE393629T1 (de)	2008-05-15
PT1335725E (pt)	2008-06-19
CN102058588A (zh)	2011-05-18
JP4472251B2 (ja)	2010-06-02
NO20032181D0 (no)	2003-05-14
IL155871A (en)	2012-03-29
IL155871A0 (en)	2003-12-23
AU2007201324B2 (en)	2010-11-18
US20020091137A1 (en)	2002-07-11
JP2010018620A (ja)	2010-01-28
AU2007201324A1 (en)	2007-04-19
JP2004517065A (ja)	2004-06-10
EA007096B1 (ru)	2006-06-30
SI1335725T1 (sl)	2008-08-31
US20030153593A1 (en)	2003-08-14
HUP0400521A2 (hu)	2004-06-28
JP2016094444A (ja)	2016-05-26
AU2731302A (en)	2002-05-27
AR031341A1 (es)	2003-09-17
TWI286074B (en)	2007-09-01
NO20032181L (no)	2003-05-14
NZ539668A (en)	2007-06-29
HUP0400521A3 (en)	2007-05-29
KR20040029309A (ko)	2004-04-06
HK1058008A1 (en)	2004-04-30
KR100827942B1 (ko)	2008-05-13

Publication	Publication Date	Title
SG148031A1 (en)	2008-12-31	Use of cci-779 as an antineoplastic agent
SG170612A1 (en)	2011-05-30	Antineoplastic combinations
MXPA03007140A (es)	2004-05-24	Derivados de carbolina.
MXPA03004644A (es)	2003-09-05	Derivados de fenilacetamdia-pirazol y su uso como agentes antitumorales.
AU6147401A (en)	2001-11-26	Compositions and methods for the treatment of cancer
WO2001070275A3 (en)	2002-01-03	Polyglutamic acid-camptothecin conjugates and methods of preparation
BG108269A (en)	2004-12-30	Pyrazolopyrimidines as therapeutic agents
TW200503753A (en)	2005-02-01	Antineoplastic combinations
SG150559A1 (en)	2009-03-30	Antineoplastic combinations of cci-779 and rituximab
WO2003051300A3 (en)	2003-12-11	Metal complexes and formulations of rifamycin analogues and uses therof
AU2002358199A1 (en)	2003-05-06	Shorts or underpants retaining the sexual organs
SG153647A1 (en)	2009-07-29	Antineoplastic combinations
MXPA03008582A (es)	2003-12-08	Agentes y metodos para tratamiento de cancer.
AR033012A1 (es)	2003-12-03	Combinaciones antineoplasicas
AU4498201A (en)	2001-10-15	Quinolinyl-piperidin-4-ylidene-methyl-benzamide derivatives for the treatment ofpain
WO2002041831A3 (en)	2002-07-18	Inositol derivatives for increasing chloride secretion and inhibiting inflammation
EP1435963A4 (de)	2005-10-26	Cisplatin-formulierungen mit verringerter toxizität und verwendungsverfahren dafür
IL139144A0 (en)	2001-11-25	Mycobacterial inhibitors
WO2003059332A3 (en)	2003-12-04	Use of an anti-microtubule agent for the treatment of uveitis
MXPA03002494A (es)	2004-05-24	Metodo para reducir toxicidad de quimio terapias combinadas.
IL151871A0 (en)	2003-04-10	Restenosis treatment
ZA200107649B (en)	2002-05-14	1-amino-alkylcyclohexanes as trypanocidal agents.
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