SG148183A1 - Succinate and malonate salt of trans-4-(1r,3s)-6-chloro-3-phenylindan-1-yl)- 1,2,2-trimethylpiperazine and the use as a medicament - Google Patents

Succinate and malonate salt of trans-4-(1r,3s)-6-chloro-3-phenylindan-1-yl)- 1,2,2-trimethylpiperazine and the use as a medicament

Info

Publication number
SG148183A1
SG148183A1 SG200808521-9A SG2008085219A SG148183A1 SG 148183 A1 SG148183 A1 SG 148183A1 SG 2008085219 A SG2008085219 A SG 2008085219A SG 148183 A1 SG148183 A1 SG 148183A1
Authority
SG
Singapore
Prior art keywords
phenylindan
trimethylpiperazine
succinate
trans
medicament
Prior art date
Application number
SG200808521-9A
Other languages
English (en)
Inventor
De Diego Heidi Lopez
Ole Nielsen
Lone Munch Ringgard
Henrik Svane
Allan Carsten Dahl
Mark Howells
Benny Bang-Andersen
Lars Ole Lyngsi
Original Assignee
Lundbeck & Co As H
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lundbeck & Co As H filed Critical Lundbeck & Co As H
Publication of SG148183A1 publication Critical patent/SG148183A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D295/00Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C17/00Preparation of halogenated hydrocarbons
    • C07C17/093Preparation of halogenated hydrocarbons by replacement by halogens
    • C07C17/16Preparation of halogenated hydrocarbons by replacement by halogens of hydroxyl groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C25/00Compounds containing at least one halogen atom bound to a six-membered aromatic ring
    • C07C25/18Polycyclic aromatic halogenated hydrocarbons
    • C07C25/22Polycyclic aromatic halogenated hydrocarbons with condensed rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C29/00Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
    • C07C29/132Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group
    • C07C29/136Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH
    • C07C29/143Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring by reduction of an oxygen containing functional group of >C=O containing groups, e.g. —COOH of ketones
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C35/00Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring
    • C07C35/22Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system
    • C07C35/23Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings
    • C07C35/32Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a ring other than a six-membered aromatic ring polycyclic, at least one hydroxy group bound to a condensed ring system with hydroxy on a condensed ring system having two rings the condensed ring system being a (4.3.0) system, e.g. indenols
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D241/00Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/04Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/004Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00Preparation of oxygen-containing organic compounds
    • C12P7/02Preparation of oxygen-containing organic compounds containing a hydroxy group
    • C12P7/22Preparation of oxygen-containing organic compounds containing a hydroxy group aromatic
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07Optical isomers
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07BGENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Medicinal Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG200808521-9A 2003-08-18 2004-08-18 Succinate and malonate salt of trans-4-(1r,3s)-6-chloro-3-phenylindan-1-yl)- 1,2,2-trimethylpiperazine and the use as a medicament SG148183A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200301180 2003-08-18
DKPA200301305 2003-09-11

Publications (1)

Publication Number Publication Date
SG148183A1 true SG148183A1 (en) 2008-12-31

Family

ID=58707237

Family Applications (2)

Application Number Title Priority Date Filing Date
SG200808521-9A SG148183A1 (en) 2003-08-18 2004-08-18 Succinate and malonate salt of trans-4-(1r,3s)-6-chloro-3-phenylindan-1-yl)- 1,2,2-trimethylpiperazine and the use as a medicament
SG200805893-5A SG145723A1 (en) 2003-08-18 2004-08-18 Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG200805893-5A SG145723A1 (en) 2003-08-18 2004-08-18 Trans-1(6-chloro-3-phenylindan-1-yl)-3,3-dimethylpiperazine

Country Status (15)

Country Link
KR (2) KR20060066104A (sr)
CN (1) CN101935305B (sr)
AR (2) AR045279A1 (sr)
AT (1) ATE552247T1 (sr)
DK (1) DK1658277T3 (sr)
EA (2) EA014641B1 (sr)
ES (1) ES2383369T3 (sr)
IS (1) IS8264A (sr)
ME (1) MEP2408A (sr)
MY (2) MY154535A (sr)
PT (1) PT1658277E (sr)
RS (3) RS53369B (sr)
SG (2) SG148183A1 (sr)
SI (1) SI1658277T1 (sr)
TW (2) TWI403505B (sr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI453198B (zh) * 2005-02-16 2014-09-21 Lundbeck & Co As H 製造反式-1-((1r,3s)-6-氯基-3-苯基茚滿-1-基) -3 , 3 -二甲基六氫吡與其鹽類之方法及製造4-((1r , 3s)-6 -氯基-3-苯基茚滿-1-基 )-1,2,2-三甲基六氫吡與其鹽類之方法
PL3135656T3 (pl) 2011-06-20 2019-07-31 H. Lundbeck A/S Deuterowane 1-piperazyno-3-fenyloindany do leczenia schizofrenii
AU2020271908B2 (en) 2019-04-11 2025-12-04 Mei Pharma, Inc. Voruciclib poly morphs and methods of making and using thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE50867B1 (en) * 1980-02-29 1986-08-06 Kefalas As Indane derivatives
DK55192D0 (da) * 1992-04-28 1992-04-28 Lundbeck & Co As H 1-piperazino-1,2-dihydroindenderivater

Also Published As

Publication number Publication date
CN101935305A (zh) 2011-01-05
RS20060121A (sr) 2008-09-29
EA014641B1 (ru) 2010-12-30
HK1096089A1 (en) 2007-05-25
KR20060066104A (ko) 2006-06-15
SG145723A1 (en) 2008-09-29
RS53369B (sr) 2014-10-31
CN101935305B (zh) 2013-04-10
MY149089A (en) 2013-07-15
EA200600441A1 (ru) 2006-08-25
KR20060066094A (ko) 2006-06-15
PT1658277E (pt) 2012-05-25
MEP2408A (xx) 2010-02-10
MY154535A (en) 2015-06-30
EA200600443A1 (ru) 2006-08-25
ES2383369T3 (es) 2012-06-20
TW201111351A (en) 2011-04-01
TWI388550B (zh) 2013-03-11
DK1658277T3 (da) 2012-06-18
TWI403505B (zh) 2013-08-01
KR101227789B1 (ko) 2013-01-30
TW200519098A (en) 2005-06-16
HK1152699A1 (en) 2012-03-09
SI1658277T1 (sl) 2012-10-30
AR045278A1 (es) 2005-10-19
AR045279A1 (es) 2005-10-19
ATE552247T1 (de) 2012-04-15
IS8264A (is) 2006-01-26
RS20060083A (sr) 2008-08-07

Similar Documents

Publication Publication Date Title
IL173788A0 (en) Succinate and malonate salt of trans-4-((1r,3s)-6-chloro-3-phenylindan-1-yl)-1,2,2-trimethylpiperazine and the use as a medicament
EG25011A (en) Amino-piperidin-1-yl-xanthines, the production thereof and the use of the same as medicaments.
AU2003301815A1 (en) Hypodermic needle
IL173204A0 (en) Novel cyanopyrrolidides, methods for the production thereof, and use of the same as medicaments
ZA200407986B (en) Substituted phenylacetamides and their use as glucokinase activators.
AU2003247137A1 (en) Syringe pump
AU2003215209A1 (en) Syringe
AU2003216934A1 (en) Benzoxazinone derivatives, the preparation and use thereof as medicaments
AU2003259457A1 (en) Auto-destructible syringe
AU2003279442A1 (en) 2-thiohydantoine derivative compounds and use thereof for the treatment of diabetes
AU2003224747A1 (en) Technetium-labeled rotenone derivatives, and methods of use thereof
AU2003292263A1 (en) Use of substituted 2-phenylbenzimidazoles as medicaments
AU2003277556A1 (en) Syringe pump
PT1638943E (pt) Novos derivados de imidazoles, sua preparação e sua utilização como medicamento
AU2003274351A1 (en) Substituted pyridyloxyalkylamides and their use as fungicides
PT1532141E (pt) Derivados de 2-pirrolidin-2-il-[1,3,4]-oxadiazole e sua utilização como antidepressivos
SG148183A1 (en) Succinate and malonate salt of trans-4-(1r,3s)-6-chloro-3-phenylindan-1-yl)- 1,2,2-trimethylpiperazine and the use as a medicament
AU2003217942A8 (en) Modulators of leukocyte activation, compositions, and methods of use
AU2003232785A1 (en) Novel anthracene derivatives and the use thereof as a medicament
AU2003294952A1 (en) 3,3-dimethyl-8-oxoisoquinolines for medical purposes, methods for the production thereof, medicaments containing said compounds and the use of the same
AU2002335304A1 (en) The use of berberine as insulin sensitizer
AU2003255727A1 (en) Syringes
PL376886A1 (pl) 2-Merkapto-podstawione triazolopirymidyny, sposoby ich wytwarzania, ich zastosowanie do zwalczania szkodliwych grzybów i zawierające je środki
MY137953A (en) New association of an anti-atherothrombotic agent and an anti-platelet-aggregation agent
AU2003232698A1 (en) Use of a n,n'-dibenzyl-thiourea as medicine