SG148823A1 - Pharmaceutical compositions of fibrinolytic agent - Google Patents

Pharmaceutical compositions of fibrinolytic agent

Info

Publication number
SG148823A1
SG148823A1 SG200400542-7A SG2004005427A SG148823A1 SG 148823 A1 SG148823 A1 SG 148823A1 SG 2004005427 A SG2004005427 A SG 2004005427A SG 148823 A1 SG148823 A1 SG 148823A1
Authority
SG
Singapore
Prior art keywords
fibrinolytic agent
pharmaceutical compositions
lyophilized
compositions
lyophilized composition
Prior art date
Application number
SG200400542-7A
Other languages
English (en)
Inventor
Brent S Kendrick
Brian Peterson
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of SG148823A1 publication Critical patent/SG148823A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Inorganic Chemistry (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
SG200400542-7A 1999-10-01 2000-09-29 Pharmaceutical compositions of fibrinolytic agent SG148823A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US09/411,335 US6440414B1 (en) 1999-10-01 1999-10-01 Pharmaceutical compositions of fibrinolytic agent

Publications (1)

Publication Number Publication Date
SG148823A1 true SG148823A1 (en) 2009-01-29

Family

ID=23628514

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200400542-7A SG148823A1 (en) 1999-10-01 2000-09-29 Pharmaceutical compositions of fibrinolytic agent

Country Status (28)

Country Link
US (4) US6440414B1 (de)
EP (2) EP1438967A3 (de)
JP (1) JP2003510369A (de)
KR (1) KR100717435B1 (de)
CN (2) CN100353999C (de)
AT (1) ATE262923T1 (de)
AU (1) AU769313B2 (de)
BG (1) BG106578A (de)
BR (1) BR0014420A (de)
CA (1) CA2385966A1 (de)
CZ (1) CZ20021033A3 (de)
DE (2) DE60009529T2 (de)
DK (1) DK1220685T3 (de)
EA (2) EA004627B1 (de)
ES (2) ES2224917T1 (de)
HK (1) HK1049112B (de)
HU (1) HUP0202654A3 (de)
IL (1) IL148842A0 (de)
MX (1) MXPA02003197A (de)
NO (1) NO20021500L (de)
NZ (4) NZ540967A (de)
PL (1) PL355016A1 (de)
PT (1) PT1220685E (de)
SG (1) SG148823A1 (de)
SK (1) SK4242002A3 (de)
WO (1) WO2001024817A2 (de)
YU (1) YU23302A (de)
ZA (1) ZA200202400B (de)

Families Citing this family (22)

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DK1820516T3 (da) * 1999-02-22 2013-10-28 Univ Connecticut Nye albuminfrie faktor VIII-præparater
US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6261820B1 (en) 1999-10-01 2001-07-17 Amgen Inc. Fibronolytically active polypeptide
US6455269B1 (en) * 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
US7033776B2 (en) 1999-12-17 2006-04-25 Amgen Inc. Method for treatment of indwelling catheter occlusion using fibrinolytic metalloproteinases
DE10149030A1 (de) * 2001-10-05 2003-04-10 Viscum Ag Stabile galenische gefriergetrocknete Arzneimittelzubereitung von rViscumin
WO2003063824A2 (en) * 2002-02-01 2003-08-07 Shimoda Biotech (Pty) Ltd Pharmaceutical composition
WO2003068805A2 (en) * 2002-02-14 2003-08-21 Bayer Pharmaceuticals Corporation Formulation strategies in stabilizing peptides in organic solvents and in dried states
US6803046B2 (en) * 2002-08-16 2004-10-12 Bracco International B.V. Sincalide formulations
AU2005317166B2 (en) * 2004-12-15 2009-09-10 Biovitrum Ab (Publ) Therapeutic formulations of keratinocyte growth factor
CN101309916A (zh) * 2005-11-18 2008-11-19 卫材R&D管理有限公司 制备肉桂酰胺衍生物的方法
US8158152B2 (en) * 2005-11-18 2012-04-17 Scidose Llc Lyophilization process and products obtained thereby
KR100807692B1 (ko) * 2006-11-08 2008-02-28 신라대학교 산학협력단 혈전용해성 메탈로프로테아제 및 이를 포함하는 조성물
EP1958618A1 (de) * 2007-02-15 2008-08-20 Octapharma AG Verfahren zur Gefriertrocknung mit optimierter Rekonstitution von Biopolymeren
MX339060B (es) 2008-11-07 2016-05-09 Baxter Int Formulaciones del factor viii.
KR20120050442A (ko) 2009-07-10 2012-05-18 쓰롬보제닉스 엔.브이. 플라스미노겐 및 플라스민의 변이체
CN102000022A (zh) * 2010-11-23 2011-04-06 郑州大学 注射用重组双功能纤溶酶冻干制剂及其制备方法
EP2661493B1 (de) 2011-01-05 2016-03-30 ThromboGenics N.V. Plasminogen- und plasminvarianten
JP6000353B2 (ja) 2011-08-12 2016-09-28 スロンボジェニックス・ナムローゼ・フェンノートシャップＴｈｒｏｍｂｏＧｅｎｉｃｓ ＮＶ プラスミノーゲンおよびプラスミンの変異体
US20140212405A1 (en) 2013-01-28 2014-07-31 2294719 Ontario Limited Fibrinolytic/Proteolytic Treatment of Myofacial and Neuropathic Pain and Related Conditions
CN107250375A (zh) * 2014-11-06 2017-10-13 科罗拉多州立大学董事会 在血栓溶解剂存在下使用粘弹性分析鉴定新疾病状态
US20220305094A1 (en) * 2019-01-06 2022-09-29 Endo Global Aesthetics Limited Collagenase formulations and methods of producing the same

Citations (2)

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EP0323722A1 (de) * 1987-12-18 1989-07-12 Chiron Corporation Zusammensetzung und Verfahren zur Herstellung von rekombinanter Fibrolase aus Crotalidus venom
EP0689843A1 (de) * 1993-12-17 1996-01-03 Mochida Pharmaceutical Co., Ltd. Lösliches thrombomodulin enthaltende zubereitung

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US5222941A (en) 1990-01-12 1993-06-29 Don Michael T Anthony Method of dissolving an obstruction in a vessel
JPH05184352A (ja) 1990-01-16 1993-07-27 Centro De Ing Genetica Y Biotecnol ピヒア パストリス（Ｐｉｃｈｉａ ｐａｓｔｏｒｉｓ）酵母中での異種遺伝子の発現方法、発現ベクターおよび形質転換微生物
US5709676A (en) 1990-02-14 1998-01-20 Alt; Eckhard Synergistic treatment of stenosed blood vessels using shock waves and dissolving medication
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US6440414B1 (en) 1999-10-01 2002-08-27 Amgen Inc. Pharmaceutical compositions of fibrinolytic agent
US6455269B1 (en) 1999-12-17 2002-09-24 Amgen, Inc. Method for localized administration of fibrinolytic metalloproteinases
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Publication number Priority date Publication date Assignee Title
EP0323722A1 (de) * 1987-12-18 1989-07-12 Chiron Corporation Zusammensetzung und Verfahren zur Herstellung von rekombinanter Fibrolase aus Crotalidus venom
EP0689843A1 (de) * 1993-12-17 1996-01-03 Mochida Pharmaceutical Co., Ltd. Lösliches thrombomodulin enthaltende zubereitung

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* Cited by examiner, † Cited by third party
Title
AMINO ACID SEQUENCE OF FIBROLASE, A DIRECT-ACTING FIBRINOLYTIC ENZYME FROM AGKISTRODON CONTOTRIX CONTORTIX VENOM *
STABILIZATION VS. DEGRADATION OF STAPHYLOCOCCUS AUREUS METALLOPROTEINASE *

Also Published As

Publication number Publication date
WO2001024817A2 (en) 2001-04-12
DE60009529T2 (de) 2005-04-14
WO2001024817A3 (en) 2001-10-18
CZ20021033A3 (cs) 2003-06-18
NZ518007A (en) 2004-03-26
NZ540967A (en) 2007-02-23
US6440414B1 (en) 2002-08-27
US20060246053A1 (en) 2006-11-02
IL148842A0 (en) 2002-09-12
MXPA02003197A (es) 2002-09-30
CN101209347A (zh) 2008-07-02
US7244426B2 (en) 2007-07-17
EP1220685A2 (de) 2002-07-10
HUP0202654A2 (hu) 2002-12-28
KR20020053065A (ko) 2002-07-04
NZ530959A (en) 2005-08-26
ES2218228T3 (es) 2004-11-16
ZA200202400B (en) 2003-05-28
EA004627B1 (ru) 2004-06-24
SK4242002A3 (en) 2003-08-05
HK1049112A1 (en) 2003-05-02
CA2385966A1 (en) 2001-04-12
EP1438967A3 (de) 2005-01-26
EA200400182A1 (ru) 2004-08-26
NO20021500L (no) 2002-05-27
ES2224917T1 (es) 2005-03-16
HK1049112B (en) 2005-01-21
NO20021500D0 (no) 2002-03-26
PL355016A1 (en) 2004-03-22
DE04007657T1 (de) 2005-01-13
DK1220685T3 (da) 2004-08-02
US7138114B2 (en) 2006-11-21
AU769313B2 (en) 2004-01-22
BG106578A (bg) 2003-04-30
EA200200396A1 (ru) 2002-10-31
US20060263347A1 (en) 2006-11-23
EA006600B1 (ru) 2006-02-24
PT1220685E (pt) 2004-08-31
EP1220685B1 (de) 2004-03-31
EP1438967A2 (de) 2004-07-21
US20020192207A1 (en) 2002-12-19
HUP0202654A3 (en) 2003-11-28
DE60009529D1 (de) 2004-05-06
NZ550200A (en) 2008-04-30
KR100717435B1 (ko) 2007-05-14
BR0014420A (pt) 2002-06-11
CN100353999C (zh) 2007-12-12
YU23302A (sh) 2005-06-10
US7311908B2 (en) 2007-12-25
JP2003510369A (ja) 2003-03-18
AU7743000A (en) 2001-05-10
CN1402641A (zh) 2003-03-12
ATE262923T1 (de) 2004-04-15

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