SG164282A1 - Taxane derivatives functionalized at the 14-position and a process for the preparation thereof - Google Patents

Taxane derivatives functionalized at the 14-position and a process for the preparation thereof

Info

Publication number: SG164282A1
Authority: SG; Singapore
Prior art keywords: preparation; taxane derivatives; formula; derivatives functionalized; functionalized
Prior art date: 2002-09-10

Application number

SG200703232-9A

Other languages

English (en)

Inventor

Gabriele Fontana

Ezio Bombardelli

Arturo Battaglia

Eleonora Baldelli

Andrea Guerrini

Maria Luisa Gelmi

Giacomo Carenzi

Donato Pocar

Original Assignee

Indena Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2002-09-10

Filing date

2003-09-05

Publication date

2010-09-29

2003-09-05 Application filed by Indena Spa filed Critical Indena Spa

2010-09-29 Publication of SG164282A1 publication Critical patent/SG164282A1/en

Links

DKPFODGZWDEEBT-QFIAKTPHSA-N taxane Chemical class C([C@]1(C)CCC[C@@H](C)[C@H]1C1)C[C@H]2[C@H](C)CC[C@@H]1C2(C)C DKPFODGZWDEEBT-QFIAKTPHSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 abstract 2
238000006243 chemical reaction Methods 0.000 abstract 1
238000007306 functionalization reaction Methods 0.000 abstract 1
230000008570 general process Effects 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
- C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Animal Behavior & Ethology (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Epoxy Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Crystals, And After-Treatments Of Crystals (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

SG200703232-9A 2002-09-10 2003-09-05 Taxane derivatives functionalized at the 14-position and a process for the preparation thereof SG164282A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
IT001921A ITMI20021921A1 (it)	2002-09-10	2002-09-10	Funzionalizzazione della posizione 14 dei nuclei tassanici e sintesi di nuovi derivati antitumorali.

Publications (1)

Publication Number	Publication Date
SG164282A1 true SG164282A1 (en)	2010-09-29

Family

ID=31986024

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200703232-9A SG164282A1 (en)	2002-09-10	2003-09-05	Taxane derivatives functionalized at the 14-position and a process for the preparation thereof

Country Status (20)

Country	Link
US (1)	US7498452B2 (da)
EP (6)	EP1980557A3 (da)
JP (2)	JP4690039B2 (da)
KR (1)	KR101096918B1 (da)
CN (1)	CN1681799A (da)
AT (1)	ATE398113T1 (da)
AU (1)	AU2003267049B8 (da)
CA (1)	CA2498277C (da)
DE (1)	DE60321577D1 (da)
DK (4)	DK2298754T3 (da)
ES (4)	ES2433580T3 (da)
IL (5)	IL167336A (da)
IT (1)	ITMI20021921A1 (da)
NO (3)	NO332250B1 (da)
PL (4)	PL402323A1 (da)
PT (4)	PT2077264E (da)
RU (1)	RU2320652C2 (da)
SG (1)	SG164282A1 (da)
SI (4)	SI1537093T1 (da)
WO (1)	WO2004024706A2 (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ITMI20012185A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14beta-idrossi-baccatina iii-1,14-carbonato
CN107056767B (zh) *	2015-12-04	2022-07-15	江苏恩华络康药物研发有限公司	用于制备水溶性紫杉烷类衍生物的方法及中间体

Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994022856A1 (en) *	1993-03-26	1994-10-13	The Research Foundation Of The State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5821363A (en) *	1994-01-28	1998-10-13	Pharmacia & Upjohn Company	Antineoplastic use and pharmaceutical compositions containing them
WO2002012215A1 (en) *	2000-08-10	2002-02-14	Indena S.P.A.	Process for the preparation of baccatin iii derivatives

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5504222A (en)	1993-08-20	1996-04-02	The Scripps Research Institute	Transformations of taxol
FR2696464B1 (fr) *	1992-10-05	1994-11-10	Rhone Poulenc Rorer Sa	Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
IL108444A0 (en) *	1993-01-29	1994-04-12	Univ Florida State	C2 taxane derivatives and pharmaceutical compositions containing them
JPH09509431A (ja)	1994-11-04	1997-09-22	フアルマシア・エツセ・ピー・アー	タキサン誘導体
IT1275936B1 (it) *	1995-03-17	1997-10-24	Indena Spa	Derivati della 10-deacetilbaccatina iii e della 10-deacetil-14b- idrossibaccatina iii loro metodo di preparazione e formulazioni
US5811452A (en) *	1997-01-08	1998-09-22	The Research Foundation Of State University Of New York	Taxoid reversal agents for drug-resistance in cancer chemotherapy and pharmaceutical compositions thereof
ITMI991483A1 (it) *	1999-07-06	2001-01-06	Indena Spa	Derivati tassanici e procedimenti per la loro preparazione
AU2001278145B2 (en) *	2000-08-04	2006-09-14	Sensors For Medicine And Science, Inc.	Detection of analytes in aqueous environments
ITMI20012186A1 (it) *	2001-10-19	2003-04-19	Indena Spa	Procedimento per la preparazione della 14-beta-idrossi-baccatina iii-1,14-carbonato

2002
- 2002-09-10 IT IT001921A patent/ITMI20021921A1/it unknown
2003
- 2003-09-05 PT PT91556738T patent/PT2077264E/pt unknown
- 2003-09-05 DK DK10177326.5T patent/DK2298754T3/da active
- 2003-09-05 SI SI200331276T patent/SI1537093T1/sl unknown
- 2003-09-05 RU RU2005106361/04A patent/RU2320652C2/ru not_active IP Right Cessation
- 2003-09-05 SI SI200332239T patent/SI2077264T1/sl unknown
- 2003-09-05 SG SG200703232-9A patent/SG164282A1/en unknown
- 2003-09-05 JP JP2004535440A patent/JP4690039B2/ja not_active Expired - Fee Related
- 2003-09-05 KR KR1020057003994A patent/KR101096918B1/ko not_active Expired - Fee Related
- 2003-09-05 EP EP08157617A patent/EP1980557A3/en not_active Withdrawn
- 2003-09-05 DK DK03747971T patent/DK1537093T3/da active
- 2003-09-05 PL PL402323A patent/PL402323A1/pl unknown
- 2003-09-05 PT PT03747971T patent/PT1537093E/pt unknown
- 2003-09-05 EP EP10177329.9A patent/EP2264019B1/en not_active Expired - Lifetime
- 2003-09-05 EP EP09155673A patent/EP2077264B1/en not_active Expired - Lifetime
- 2003-09-05 AT AT03747971T patent/ATE398113T1/de active
- 2003-09-05 PL PL402332A patent/PL402332A1/pl unknown
- 2003-09-05 PL PL402333A patent/PL402333A1/pl unknown
- 2003-09-05 AU AU2003267049A patent/AU2003267049B8/en not_active Ceased
- 2003-09-05 EP EP10177326.5A patent/EP2298754B9/en not_active Expired - Lifetime
- 2003-09-05 EP EP10177332A patent/EP2281820A3/en not_active Withdrawn
- 2003-09-05 DE DE60321577T patent/DE60321577D1/de not_active Expired - Lifetime
- 2003-09-05 DK DK10177329.9T patent/DK2264019T3/da active
- 2003-09-05 ES ES10177326T patent/ES2433580T3/es not_active Expired - Lifetime
- 2003-09-05 PT PT101773265T patent/PT2298754E/pt unknown
- 2003-09-05 PL PL03375625A patent/PL375625A1/xx unknown
- 2003-09-05 ES ES09155673T patent/ES2398324T3/es not_active Expired - Lifetime
- 2003-09-05 DK DK09155673.8T patent/DK2077264T3/da active
- 2003-09-05 ES ES10177329T patent/ES2432024T3/es not_active Expired - Lifetime
- 2003-09-05 ES ES03747971T patent/ES2307965T3/es not_active Expired - Lifetime
- 2003-09-05 US US10/527,164 patent/US7498452B2/en not_active Expired - Fee Related
- 2003-09-05 SI SI200332306T patent/SI2298754T1/sl unknown
- 2003-09-05 EP EP03747971A patent/EP1537093B1/en not_active Expired - Lifetime
- 2003-09-05 PT PT101773299T patent/PT2264019E/pt unknown
- 2003-09-05 CA CA2498277A patent/CA2498277C/en not_active Expired - Fee Related
- 2003-09-05 SI SI200332292T patent/SI2264019T1/sl unknown
- 2003-09-05 CN CNA038213389A patent/CN1681799A/zh active Pending
- 2003-09-05 WO PCT/EP2003/009866 patent/WO2004024706A2/en not_active Ceased
2005
- 2005-03-09 IL IL167336A patent/IL167336A/en not_active IP Right Cessation
- 2005-04-11 NO NO20051774A patent/NO332250B1/no not_active IP Right Cessation
2009
- 2009-03-26 IL IL197815A patent/IL197815A/en not_active IP Right Cessation
2010
- 2010-07-30 JP JP2010172650A patent/JP2010270145A/ja active Pending
2011
- 2011-05-30 NO NO20110781A patent/NO332366B1/no not_active IP Right Cessation
- 2011-05-30 NO NO20110782A patent/NO332367B1/no not_active IP Right Cessation
- 2011-08-03 IL IL214432A patent/IL214432A/en not_active IP Right Cessation
- 2011-08-03 IL IL214430A patent/IL214430A0/en unknown
- 2011-08-03 IL IL214431A patent/IL214431A/en not_active IP Right Cessation

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994022856A1 (en) *	1993-03-26	1994-10-13	The Research Foundation Of The State University Of New York	Anti-tumor compounds, pharmaceutical compositions, methods for preparation thereof and for treatment
US5821363A (en) *	1994-01-28	1998-10-13	Pharmacia & Upjohn Company	Antineoplastic use and pharmaceutical compositions containing them
WO2002012215A1 (en) *	2000-08-10	2002-02-14	Indena S.P.A.	Process for the preparation of baccatin iii derivatives

Also Published As

Publication number	Publication date
DK1537093T3 (da)	2008-10-27
ITMI20021921A1 (it)	2004-03-11
EP1537093A2 (en)	2005-06-08
CA2498277A1 (en)	2004-03-25
SI2264019T1 (sl)	2013-10-30
RU2320652C2 (ru)	2008-03-27
US20060122258A1 (en)	2006-06-08
EP2298754B1 (en)	2013-08-07
EP2077264A3 (en)	2009-09-16
EP2298754B9 (en)	2013-12-18
ES2432024T3 (es)	2013-11-29
PT1537093E (pt)	2008-09-02
SI2298754T1 (sl)	2013-11-29
ATE398113T1 (de)	2008-07-15
NO20110781L (no)	2005-05-10
PT2298754E (pt)	2013-11-07
JP4690039B2 (ja)	2011-06-01
SI1537093T1 (sl)	2008-10-31
PT2077264E (pt)	2013-01-29
WO2004024706A3 (en)	2004-07-08
IL214430A0 (en)	2011-09-27
ES2398324T3 (es)	2013-03-15
EP2077264B1 (en)	2012-11-14
PT2264019E (pt)	2013-10-28
ES2307965T3 (es)	2008-12-01
EP1537093B1 (en)	2008-06-11
DE60321577D1 (de)	2008-07-24
IL214432A0 (en)	2011-09-27
NO20051774L (no)	2005-05-10
EP1980557A2 (en)	2008-10-15
AU2003267049B2 (en)	2010-02-11
PL402323A1 (pl)	2013-04-02
SI2077264T1 (sl)	2013-03-29
CA2498277C (en)	2011-07-05
AU2003267049A1 (en)	2004-04-30
IL197815A (en)	2013-02-28
NO332250B1 (no)	2012-08-06
PL375625A1 (en)	2005-12-12
DK2298754T3 (da)	2013-11-04
DK2077264T3 (da)	2013-03-04
EP2264019A1 (en)	2010-12-22
NO332367B1 (no)	2012-09-03
PL402333A1 (pl)	2013-04-02
EP1980557A3 (en)	2008-12-31
EP2077264A2 (en)	2009-07-08
NO20110782L (no)	2005-05-10
KR20050035540A (ko)	2005-04-18
EP2298754A1 (en)	2011-03-23
RU2005106361A (ru)	2005-10-10
IL214431A (en)	2014-05-28
JP2010270145A (ja)	2010-12-02
US7498452B2 (en)	2009-03-03
EP2281820A3 (en)	2011-05-04
NO332366B1 (no)	2012-09-03
ES2433580T3 (es)	2013-12-11
WO2004024706A2 (en)	2004-03-25
CN1681799A (zh)	2005-10-12
JP2006503030A (ja)	2006-01-26
AU2003267049B8 (en)	2010-03-04
IL214432A (en)	2014-05-28
EP2281820A2 (en)	2011-02-09
EP2264019B1 (en)	2013-07-24
DK2264019T3 (da)	2013-10-28
IL214431A0 (en)	2011-09-27
PL402332A1 (pl)	2013-04-02
KR101096918B1 (ko)	2011-12-22
IL167336A (en)	2009-11-18

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