SG166121A1 - Pyrimidine amide compounds as pgds inhibitors - Google Patents

Pyrimidine amide compounds as pgds inhibitors

Info

Publication number
SG166121A1
SG166121A1 SG201007241-1A SG2010072411A SG166121A1 SG 166121 A1 SG166121 A1 SG 166121A1 SG 2010072411 A SG2010072411 A SG 2010072411A SG 166121 A1 SG166121 A1 SG 166121A1
Authority
SG
Singapore
Prior art keywords
amide compounds
compound
pgds inhibitors
pyrimidine amide
pyrimidine
Prior art date
Application number
SG201007241-1A
Other languages
English (en)
Inventor
Suzanne C Aldous
John Ziqi Jiang
Jinqi Lu
Liang Ma
Lan Mu
Harry Randall Munson
Jeffrey Stephen Sabol
Sukanthini Thurairatnam
Christopher Loren Vandeusen
Original Assignee
Aventis Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Inc filed Critical Aventis Pharma Inc
Publication of SG166121A1 publication Critical patent/SG166121A1/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Otolaryngology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
SG201007241-1A 2005-10-04 2006-10-04 Pyrimidine amide compounds as pgds inhibitors SG166121A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US72357005P 2005-10-04 2005-10-04

Publications (1)

Publication Number Publication Date
SG166121A1 true SG166121A1 (en) 2010-11-29

Family

ID=37635758

Family Applications (1)

Application Number Title Priority Date Filing Date
SG201007241-1A SG166121A1 (en) 2005-10-04 2006-10-04 Pyrimidine amide compounds as pgds inhibitors

Country Status (27)

Country Link
US (1) US8202863B2 (fr)
EP (1) EP1937652B1 (fr)
JP (1) JP5452925B2 (fr)
KR (1) KR101457966B1 (fr)
CN (2) CN101282943A (fr)
AR (1) AR056871A1 (fr)
AU (1) AU2006299428B2 (fr)
BR (1) BRPI0616815A2 (fr)
CA (1) CA2624749C (fr)
CR (1) CR9832A (fr)
DO (1) DOP2006000210A (fr)
EC (1) ECSP088335A (fr)
ES (1) ES2514471T3 (fr)
IL (1) IL190411A (fr)
MA (1) MA29925B1 (fr)
MY (1) MY151172A (fr)
NO (1) NO20082000L (fr)
NZ (1) NZ567208A (fr)
PE (2) PE20110118A1 (fr)
RU (1) RU2420519C2 (fr)
SG (1) SG166121A1 (fr)
TN (1) TNSN08104A1 (fr)
TW (1) TWI415839B (fr)
UA (1) UA93213C2 (fr)
UY (1) UY29840A1 (fr)
WO (1) WO2007041634A1 (fr)
ZA (1) ZA200802222B (fr)

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JP2010513458A (ja) 2006-12-19 2010-04-30 ファイザー・プロダクツ・インク H−pgdsの阻害剤としてのニコチンアミド誘導体、およびプロスタグランジンd2の仲介による疾患を治療するためのその使用
CA2679198C (fr) * 2007-02-26 2011-07-12 Pfizer Products Inc. Composes heterocycliques utiles dans le traitement de maladies et de conditions
ES2663517T3 (es) * 2007-08-27 2018-04-13 Dart Neuroscience (Cayman) Ltd Compuestos terapéuticos de isoxazol
MX2010003864A (es) 2007-10-11 2010-06-01 Vertex Pharma Amidas utiles como inhibidores de canales de sodio dependientes de voltaje.
JP5555169B2 (ja) * 2007-10-11 2014-07-23 バーテックス ファーマシューティカルズ インコーポレイテッド 電位開口型ナトリウムチャネルの阻害剤として有用なヘテロアリールアミド
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US8188280B2 (en) * 2008-02-06 2012-05-29 Msd K.K. 3-substituted sulfonyl piperidine derivative
EP2286221A4 (fr) * 2008-05-13 2011-07-06 Cayman Chem Co Procédés d'évaluation de la capacité de composés ou d'agents à déplacer de puissants ligands de la prostaglandine d synthase hématopoïétique
US20110306597A1 (en) 2008-06-18 2011-12-15 James Michael Crawforth Nicotinamide Derivatives
WO2009153720A1 (fr) 2008-06-18 2009-12-23 Pfizer Limited Dérivés de nicotinamide
BRPI0919004A2 (pt) 2008-09-22 2019-09-24 Cayman Chem Co composto de multiheteroarila como inibidores de h-pgds e sua utilização para o tratamento de doenças mediadas por prostaglandina d2
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KR101252335B1 (ko) 2009-07-16 2013-04-08 (주)아모레퍼시픽 피부 노화 방지용 조성물
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AU2010222122B2 (en) 2009-03-09 2013-06-27 Taiho Pharmaceutical Co., Ltd. Piperazine compound capable of inhibiting prostaglandin D synthase
BR112012007635B1 (pt) * 2009-10-08 2019-07-09 Sanofi Compostos derivados de feniloxadiazol como inibidores de pgds, composição farmacêutica compreendendo os mesmos e seus processos de preparação
EP2527340B1 (fr) * 2010-01-22 2016-08-17 Taiho Pharmaceutical Co., Ltd. Composé de pipérazine ayant un effet inhibiteur des prostaglandines
US9320723B2 (en) * 2010-05-03 2016-04-26 University Of Rochester Methods of treating thyroid eye disease
US9199976B2 (en) 2010-06-01 2015-12-01 The University Of Queensland Haematopoietic-prostaglandin D2 synthase inhibitors
WO2012033069A1 (fr) 2010-09-07 2012-03-15 大鵬薬品工業株式会社 Composés de pipéridine inhibiteurs de la prostaglandine d synthase
KR101271223B1 (ko) 2011-01-27 2013-06-07 한국과학기술연구원 아미노피리미딘 유도체 및 이를 포함하는 세포외 신호조절 키나제의 제해제
CN104159587A (zh) 2012-01-06 2014-11-19 南佛罗里达大学 组合物、使用方法、以及治疗方法
WO2014029193A1 (fr) * 2012-08-24 2014-02-27 Sunshine Lake Pharma Co., Ltd. Composés de dihydropyrimidine et leur application dans des produits pharmaceutiques
CN108430992A (zh) 2015-12-17 2018-08-21 阿斯特克斯医疗公司 作为h-pgds抑制剂的喹啉-3-甲酰胺
WO2017160832A1 (fr) * 2016-03-14 2017-09-21 Emory University Dérivés amide-sulfamide, compositions et utilisations associées à l'inhibition de cxcr4
JOP20190072A1 (ar) 2016-10-13 2019-04-07 Glaxosmithkline Ip Dev Ltd مشتقات 1، 3 سيكلوبوتان ثنائي الاستبدال أو آزيتيدين كمثبطات للإنزيم المخلق للبروستاجلاندين d المكون للدم
EP3638672A1 (fr) 2017-06-13 2020-04-22 GlaxoSmithKline Intellectual Property Development Limited Composés chimiques utilisés en tant qu'inhibiteurs de h-pgds
US11357759B2 (en) 2017-10-29 2022-06-14 China Medical University Composition including ADAM9 inhibitor and the use thereof
EP3724197A1 (fr) 2017-12-13 2020-10-21 GlaxoSmithKline Intellectual Property Development Ltd Pyridines fusionnées agissant en tant qu'inhibiteurs de h-pgds
JP7428692B2 (ja) * 2018-03-23 2024-02-06 ステップ ファーマ エス.エー.エス Ctps1阻害剤としてのアミノピリミジン誘導体
JP2022506850A (ja) 2018-11-08 2022-01-17 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド 化学化合物
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JP2023546996A (ja) * 2020-10-23 2023-11-08 ニンバス クロソー, インコーポレイテッド Ctps1阻害剤およびその使用
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Also Published As

Publication number Publication date
AU2006299428B2 (en) 2012-04-26
MY151172A (en) 2014-04-30
UY29840A1 (es) 2007-05-31
JP2009510170A (ja) 2009-03-12
CR9832A (es) 2008-06-18
DOP2006000210A (es) 2007-06-15
KR20080050611A (ko) 2008-06-09
RU2008117170A (ru) 2009-11-10
IL190411A0 (en) 2008-11-03
EP1937652A1 (fr) 2008-07-02
MA29925B1 (fr) 2008-11-03
WO2007041634A1 (fr) 2007-04-12
CN101538246A (zh) 2009-09-23
AR056871A1 (es) 2007-10-31
ZA200802222B (en) 2009-09-30
TW200812977A (en) 2008-03-16
US20080227782A1 (en) 2008-09-18
NZ567208A (en) 2011-03-31
PE20070589A1 (es) 2007-06-22
EP1937652B1 (fr) 2014-07-30
CN101538246B (zh) 2014-07-16
UA93213C2 (en) 2011-01-25
CN101282943A (zh) 2008-10-08
KR101457966B1 (ko) 2014-11-04
ECSP088335A (es) 2008-05-30
AU2006299428A1 (en) 2007-04-12
TWI415839B (zh) 2013-11-21
PE20110118A1 (es) 2011-03-08
JP5452925B2 (ja) 2014-03-26
IL190411A (en) 2013-09-30
US8202863B2 (en) 2012-06-19
TNSN08104A1 (en) 2009-07-14
NO20082000L (no) 2008-06-09
RU2420519C2 (ru) 2011-06-10
BRPI0616815A2 (pt) 2011-07-05
ES2514471T3 (es) 2014-10-28
CA2624749C (fr) 2011-08-16
CA2624749A1 (fr) 2007-04-12

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