SG47522A1 - Tricyclic diazepine vasopressin antagonists and oxytocin antagonists - Google Patents

Tricyclic diazepine vasopressin antagonists and oxytocin antagonists

Info

Publication number
SG47522A1
SG47522A1 SG1996002643A SG1996002643A SG47522A1 SG 47522 A1 SG47522 A1 SG 47522A1 SG 1996002643 A SG1996002643 A SG 1996002643A SG 1996002643 A SG1996002643 A SG 1996002643A SG 47522 A1 SG47522 A1 SG 47522A1
Authority
SG
Singapore
Prior art keywords
opt
substd
antagonists
satd
membered aromatic
Prior art date
Application number
SG1996002643A
Other languages
English (en)
Inventor
Jay D Albright
Marvin F Reich
Fuk-Wah Sum
Efren Guillermo Delos Santos
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of SG47522A1 publication Critical patent/SG47522A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/06—Antiabortive agents; Labour repressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/02—Drugs for disorders of the endocrine system of the hypothalamic hormones, e.g. TRH, GnRH, CRH, GRH, somatostatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Reproductive Health (AREA)
  • Vascular Medicine (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Hospice & Palliative Care (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
  • Pulmonology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG1996002643A 1993-07-29 1994-07-15 Tricyclic diazepine vasopressin antagonists and oxytocin antagonists SG47522A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US10000493A 1993-07-29 1993-07-29

Publications (1)

Publication Number Publication Date
SG47522A1 true SG47522A1 (en) 1998-04-17

Family

ID=22277643

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996002643A SG47522A1 (en) 1993-07-29 1994-07-15 Tricyclic diazepine vasopressin antagonists and oxytocin antagonists

Country Status (28)

Country Link
US (2) US5516774A (de)
EP (1) EP0636625B1 (de)
JP (1) JP3782475B2 (de)
KR (1) KR100347479B1 (de)
CN (2) CN1039908C (de)
AT (1) ATE176234T1 (de)
AU (1) AU683660B2 (de)
BR (1) BR1100563A (de)
CA (1) CA2128956C (de)
CZ (1) CZ291322B6 (de)
DE (1) DE69416211T2 (de)
DK (1) DK0636625T3 (de)
EC (1) ECSP941137A (de)
ES (1) ES2129090T3 (de)
FI (3) FI110944B (de)
GR (1) GR3030069T3 (de)
HU (1) HU220707B1 (de)
IL (1) IL110435A (de)
LV (1) LV12497B (de)
NO (1) NO301827B1 (de)
NZ (1) NZ264115A (de)
PE (1) PE17895A1 (de)
PH (1) PH31469A (de)
PL (1) PL178563B1 (de)
RU (1) RU2126006C1 (de)
SG (1) SG47522A1 (de)
SK (1) SK280836B6 (de)
ZA (1) ZA945603B (de)

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US5968930A (en) * 1993-07-29 1999-10-19 American Cyanamid Company Tricyclic diazepine vasopressin antagonists and oxytocin antagonists
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DE69223573D1 (de) * 1991-09-16 1998-01-29 Merck & Co Inc Hydantoin und Succinimid-substituierte Spiroindanylcamphorsulfonyl als Oxytocin-Antagonisten
EP0533242A3 (en) * 1991-09-16 1993-09-15 Merck & Co. Inc. Substituted derivatives of piperazinylcamphorsulfonyl oxytocin antagonists

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AU6877794A (en) 1995-02-09
LV12497A (en) 2000-06-20
EP0636625B1 (de) 1999-01-27
ZA945603B (en) 1995-03-09
ECSP941137A (es) 1995-02-27
IL110435A0 (en) 1994-10-21
ES2129090T3 (es) 1999-06-01
FI113867B (fi) 2004-06-30
CN1205335A (zh) 1999-01-20
CN1056374C (zh) 2000-09-13
HK1011363A1 (en) 1999-07-09
NZ264115A (en) 1997-10-24
RU94027583A (ru) 1996-07-20
CN1106812A (zh) 1995-08-16
KR950003295A (ko) 1995-02-16
JPH07157486A (ja) 1995-06-20
NO942816D0 (no) 1994-07-28
PL304498A1 (en) 1995-02-06
NO301827B1 (no) 1997-12-15
NO942816L (no) 1995-01-30
KR100347479B1 (ko) 2002-12-06
CA2128956A1 (en) 1995-01-30
BR1100563A (pt) 2000-02-08
HU220707B1 (hu) 2002-04-29
CA2128956C (en) 2004-10-05
DK0636625T3 (da) 1999-09-13
FI943543A0 (fi) 1994-07-28
SK88194A3 (en) 1995-04-12
CZ291322B6 (cs) 2003-02-12
FI20011207L (fi) 2001-06-07
EP0636625A3 (de) 1995-05-17
FI20011206L (fi) 2001-06-07
HU9402219D0 (en) 1994-09-28
LV12497B (lv) 2000-09-20
HUT71495A (en) 1995-11-28
PH31469A (en) 1998-11-03
PE17895A1 (es) 1995-07-18
US5516774A (en) 1996-05-14
CZ179994A3 (en) 1995-02-15
PL178563B1 (pl) 2000-05-31
FI113868B (fi) 2004-06-30
RU2126006C1 (ru) 1999-02-10
US5624923A (en) 1997-04-29
IL110435A (en) 2003-11-23
GR3030069T3 (en) 1999-07-30
DE69416211D1 (de) 1999-03-11
DE69416211T2 (de) 1999-09-02
FI943543L (fi) 1995-01-30
EP0636625A2 (de) 1995-02-01
ATE176234T1 (de) 1999-02-15
CN1039908C (zh) 1998-09-23
FI110944B (fi) 2003-04-30
JP3782475B2 (ja) 2006-06-07
SK280836B6 (sk) 2000-08-14
AU683660B2 (en) 1997-11-20

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