SG48985A1 - Dendrimeric polychelants - Google Patents
Dendrimeric polychelantsInfo
- Publication number
- SG48985A1 SG48985A1 SG1996004854A SG1996004854A SG48985A1 SG 48985 A1 SG48985 A1 SG 48985A1 SG 1996004854 A SG1996004854 A SG 1996004854A SG 1996004854 A SG1996004854 A SG 1996004854A SG 48985 A1 SG48985 A1 SG 48985A1
- Authority
- SG
- Singapore
- Prior art keywords
- conjugated
- site
- polychelants
- macrocyclic chelant
- dendrimeric
- Prior art date
Links
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/595—Polyamides, e.g. nylon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/18—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
- A61K49/189—Host-guest complexes, e.g. cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G83/00—Macromolecular compounds not provided for in groups C08G2/00 - C08G81/00
- C08G83/002—Dendritic macromolecules
- C08G83/003—Dendrimers
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Nanotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Crystallography & Structural Chemistry (AREA)
- Polymers & Plastics (AREA)
- Biophysics (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Medical Informatics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Radiology & Medical Imaging (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Peptides Or Proteins (AREA)
- Polyamides (AREA)
- Medicinal Preparation (AREA)
- Radiation-Therapy Devices (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/772,349 US5914095A (en) | 1989-04-07 | 1991-10-07 | Polychelants containg amide bonds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG48985A1 true SG48985A1 (en) | 1998-05-18 |
Family
ID=25094771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG1996004854A SG48985A1 (en) | 1991-10-07 | 1992-10-06 | Dendrimeric polychelants |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5914095A (de) |
| EP (1) | EP0607222B1 (de) |
| JP (1) | JPH07503031A (de) |
| AT (1) | ATE174800T1 (de) |
| AU (1) | AU671601B2 (de) |
| CA (1) | CA2120763A1 (de) |
| DE (1) | DE69227998T2 (de) |
| SG (1) | SG48985A1 (de) |
| WO (1) | WO1993006868A1 (de) |
Families Citing this family (74)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2072934C (en) * | 1991-07-19 | 2007-08-28 | Karl William Aston | Manganese complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| AU6267794A (en) * | 1993-02-24 | 1994-09-14 | Dade International Inc. | Immobilization of specific binding assay reagents |
| US5898005A (en) * | 1993-02-24 | 1999-04-27 | Dade Behring Inc. | Rapid detection of analytes with receptors immobilized on soluble submicron particles |
| US6121056A (en) * | 1993-02-24 | 2000-09-19 | Dade Behring Inc. | Random detection of antigens with antibodies immobilized on soluble submicron particles |
| GB9404208D0 (en) * | 1994-03-04 | 1994-04-20 | Nycomed Salutar Inc | Chelants |
| GB9407812D0 (en) * | 1994-04-20 | 1994-06-15 | Nycomed Salutar Inc | Compounds |
| DE69534990T2 (de) * | 1994-04-20 | 2006-10-05 | Amersham Health Salutar Inc. | Kontrastmittel |
| DE4425857A1 (de) | 1994-07-07 | 1996-01-11 | Schering Ag | Kaskaden-Polymer-Komplexe, Verfahren zur ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| EP0709100A1 (de) * | 1994-09-30 | 1996-05-01 | Nihon Medi-Physics Co., Ltd. | Kontrastmittel mit mehreren Detektionsgruppen pro Molekül |
| US5558968A (en) * | 1995-01-26 | 1996-09-24 | Hewlett-Packard Company | Dendrimeric toner particles for liquid electrophotography |
| US6770261B2 (en) | 1995-06-02 | 2004-08-03 | Research Corporation Technologies | Magnetic resonance imaging agents for the detection of physiological agents |
| US6713045B1 (en) | 1995-06-02 | 2004-03-30 | Research Corporation Technologies, Inc. | Targeted magnetic resonance imaging agents for the detection of physiological processes |
| US6525041B1 (en) | 1995-06-06 | 2003-02-25 | Pharmacia Corporation | Manganese or iron complexes of nitrogen-containing macrocyclic ligands effective as catalysts for dismutating superoxide |
| US5801228A (en) * | 1995-06-07 | 1998-09-01 | Nycomed Imaging As | Polymeric contrast agents for medical imaging |
| US6083708A (en) * | 1995-08-11 | 2000-07-04 | Dade Behring Inc. | Polypeptide: dendrimer complexes |
| AU6896796A (en) | 1995-08-17 | 1997-03-12 | Monsanto Company | Methods of diagnostic image analysis using bioconjugates of metal complexes of nitrogen-containing macrocyclic ligands |
| US5900228A (en) | 1996-07-31 | 1999-05-04 | California Institute Of Technology | Bifunctional detection agents having a polymer covalently linked to an MRI agent and an optical dye |
| EP1011736A2 (de) * | 1997-01-29 | 2000-06-28 | Nycomed Imaging As | Polymere |
| WO1998056427A1 (en) * | 1997-06-12 | 1998-12-17 | Mitsubishi Chemical Corporation | Novel contrast media |
| DE19728954C1 (de) * | 1997-06-30 | 1999-04-22 | Schering Ag | Saccharid-Konjugate, diese enthaltende pharmazeutische Mittel, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US7632651B2 (en) | 1997-09-15 | 2009-12-15 | Mds Analytical Technologies (Us) Inc. | Molecular modification assays |
| US6713046B1 (en) | 1997-10-27 | 2004-03-30 | Research Corporation Technologies | Magnetic resonance imaging agents for the delivery of therapeutic agents |
| AU752812B2 (en) * | 1997-11-17 | 2002-10-03 | Research Corporation Technologies, Inc. | Magnetic resonance imaging agents for the detection of physiological agents |
| US5938934A (en) * | 1998-01-13 | 1999-08-17 | Dow Corning Corporation | Dendrimer-based nanoscopic sponges and metal composites |
| AUPP584398A0 (en) * | 1998-09-14 | 1998-10-08 | Starpharma Limited | Inhibition of toxic materials or substances |
| CN1382062A (zh) * | 1999-07-29 | 2002-11-27 | 埃匹克斯医学股份有限公司 | 通过多位点结合的寻靶多体造影剂 |
| US6565828B2 (en) * | 2000-04-07 | 2003-05-20 | Bristol-Myers Squibb Company | Macrocyclic chelants for metallopharmaceuticals |
| US6673333B1 (en) | 2000-05-04 | 2004-01-06 | Research Corporation Technologies, Inc. | Functional MRI agents for cancer imaging |
| US20040146463A1 (en) * | 2000-05-04 | 2004-07-29 | Meade Thomas J. | Functional MRI agents for cancer imaging |
| AU2001276956A1 (en) | 2000-07-17 | 2002-01-30 | California Institute Of Technology | Macrocyclic mri contrast agents |
| WO2002028441A2 (en) | 2000-10-04 | 2002-04-11 | California Institute Of Technology | Magnetic resonance imaging agents for in vivo labeling and detection of amyloid deposits |
| EP1390079A2 (de) | 2000-11-20 | 2004-02-25 | Board of Regents University of Texas System | Paramagnetischen metallion-basierte makrozyklische kontrastmitteln |
| US6517814B2 (en) | 2001-01-09 | 2003-02-11 | Bristol-Myers Squibb Pharma Company | Macrocyclic chelants useful for metallopharmaceuticals |
| CZ20032564A3 (cs) | 2001-02-23 | 2004-09-15 | Bristol-Myers Squibb Pharma Company | Značené antagonisty receptoru makrofágového lapače pro zobrazování atherosklerosy a citlivých plaků |
| US20030004236A1 (en) * | 2001-04-20 | 2003-01-02 | Meade Thomas J. | Magnetic resonance imaging agents for detection and delivery of therapeutic agents and detection of physiological substances |
| US20020197648A1 (en) * | 2001-05-02 | 2002-12-26 | Silva Robin M. | High throughput screening methods using magnetic resonance imaging agents |
| WO2003001218A2 (en) * | 2001-06-25 | 2003-01-03 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Macromolecular imaging agents for liver imaging |
| TWI221406B (en) * | 2001-07-30 | 2004-10-01 | Epix Medical Inc | Systems and methods for targeted magnetic resonance imaging of the vascular system |
| US6852842B2 (en) * | 2002-08-26 | 2005-02-08 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Methods for functional kidney imaging using small dendrimer contrast agents |
| EP1551292B1 (de) | 2002-09-24 | 2016-04-27 | GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES | Bildgebungsmethode für die konvektionsverstärkte abgabe von therapeutischen mitteln |
| US20040258614A1 (en) * | 2003-06-20 | 2004-12-23 | University Of Maryland, Baltimore | Microparticles for microarterial imaging and radiotherapy |
| AR047692A1 (es) * | 2003-07-10 | 2006-02-08 | Epix Medical Inc | Imagenes de blancos estacionarios |
| US20050171424A1 (en) * | 2004-01-13 | 2005-08-04 | The Gov. Of The Usa As Rep. By The Secretary Of The Dept. Of Health And Human Services | Methods for imaging the lymphatic system using dendrimer-based contrast agents |
| CA2581639C (en) | 2004-09-30 | 2016-07-26 | Molecular Devices Corporation | Luminescent lanthanide complexes |
| US20060204443A1 (en) * | 2005-03-11 | 2006-09-14 | The Government Of The Usa As Represented By The Secretary Of The Dept. Of Health & Human Services | Methods for tumor treatment using dendrimer conjugates |
| DE602006008604D1 (de) * | 2005-04-26 | 2009-10-01 | Koninkl Philips Electronics Nv | Kontrastmittel für die magnetresonanzbildgebung mit cest-aktivem paramagnetischem komplex |
| EP2960263B1 (de) * | 2006-05-27 | 2017-07-12 | Fluidigm Canada Inc. | Polymerrückgratelementetiketten |
| JP5269791B2 (ja) * | 2006-08-30 | 2013-08-21 | ジーイー・ヘルスケア・アクスイェ・セルスカプ | 動的核分極（ｄｎｐ）方法並びに該方法で使用するための化合物及び組成物 |
| DE102007002726A1 (de) * | 2007-01-18 | 2008-07-31 | Bayer Schering Pharma Aktiengesellschaft | Neue Kaskaden-Polymer-Komplexe, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Mittel |
| US8658148B2 (en) | 2007-06-22 | 2014-02-25 | Genzyme Corporation | Chemically modified dendrimers |
| DE102008045937B4 (de) * | 2008-04-11 | 2017-01-26 | Johannes-Gutenberg-Universität Mainz | Radiopharmakon aus einem Metallion und einem Markierungsvorläufer und Verwendung des Radiopharmakons |
| EP2147684A1 (de) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Selektiv gegen Metallproteasen wirkende Diagnosemittel |
| US8524457B2 (en) | 2009-09-22 | 2013-09-03 | William Patterson | Method for the selection of specific affinity binders by homogeneous noncompetitive assay |
| US9125942B2 (en) | 2010-01-19 | 2015-09-08 | Northwestern University | Paramagnetic metal-nanodiamond conjugates |
| ITMI20101054A1 (it) * | 2010-06-11 | 2011-12-12 | Carlo Ghisalberti | Composizioni e sistemi di sequestro ed immunodisattivazione di nichel e cobalto |
| US20120271100A1 (en) | 2011-04-14 | 2012-10-25 | Northwestern University | Compositions and methods for the detection of zinc |
| US9702824B2 (en) | 2012-03-09 | 2017-07-11 | Promega Corporation | pH sensors |
| US20140134665A1 (en) | 2012-11-15 | 2014-05-15 | Northwestern University | Compositions and methods for the detection of zinc |
| JP6484178B2 (ja) | 2012-12-12 | 2019-03-13 | プロメガ コーポレイションＰｒｏｍｅｇａ Ｃｏｒｐｏｒａｔｉｏｎ | 生物活性剤の細胞標的の捕捉のための組成物および方法 |
| US10168323B2 (en) | 2013-03-15 | 2019-01-01 | Promega Corporation | Compositions and methods for capture of cellular targets of bioactive agents |
| ES2929362T3 (es) | 2013-03-15 | 2022-11-28 | Promega Corp | Activación de la bioluminiscencia mediante complementación estructural |
| CN106062565B (zh) | 2014-02-27 | 2018-06-08 | 宝洁公司 | 用于评估生物可利用的锌的方法 |
| WO2015175864A1 (en) | 2014-05-15 | 2015-11-19 | Cleveland Heartlab, Inc. | Compositions and methods for purification and detection of hdl and apoa1 |
| EP3660166A1 (de) | 2014-07-02 | 2020-06-03 | Promega Corporation | Umkehrbare metalionchelatoren für kontrole von enzymatischen reaktionen |
| US9969991B2 (en) | 2014-09-12 | 2018-05-15 | Promega Corporation | Internal protein tags |
| US10406249B2 (en) | 2015-06-26 | 2019-09-10 | Northwestern University | Gd(III)-dithiolane gold nanoparticle conjugates |
| EP3551213A4 (de) | 2016-12-07 | 2020-11-04 | The University of Chicago | Zusammensetzungen und verfahren zur hemmung von foxp3 |
| US20180251522A1 (en) | 2017-02-21 | 2018-09-06 | The Regents Of The University Of Michigan | Il-22bp compositions and method for the treatment of disease therewith |
| WO2020191339A1 (en) | 2019-03-20 | 2020-09-24 | Promega Corporation | Photoaffinity probes |
| US11360096B2 (en) | 2019-05-16 | 2022-06-14 | Duke University | Complex BRET technique for measuring biological interactions |
| US12241839B2 (en) | 2019-11-27 | 2025-03-04 | Promega Corporation | Multipartite luciferase peptides and polypeptides |
| GEAP202316335A (en) * | 2021-02-01 | 2023-10-10 | Bayer Ag | Multimeric chelator compounds for use in targeted radiotherapy |
| US20230357266A1 (en) | 2022-05-04 | 2023-11-09 | Promega Corporation | Photoactivatable compounds and uses thereof |
| CN118949667B (zh) * | 2024-10-16 | 2025-01-14 | 明硕环境科技集团股份有限公司 | 一种高效复合脱硫剂及其制备方法 |
Family Cites Families (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4647447A (en) * | 1981-07-24 | 1987-03-03 | Schering Aktiengesellschaft | Diagnostic media |
| US4587329A (en) * | 1984-08-17 | 1986-05-06 | The Dow Chemical Company | Dense star polymers having two dimensional molecular diameter |
| US4639365A (en) * | 1984-10-18 | 1987-01-27 | The Board Of Regents, The University Of Texas System | Gadolinium chelates as NMR contrast agents |
| SE465907B (sv) * | 1984-11-01 | 1991-11-18 | Nyegaard & Co As | Diagnosticeringsmedel innehaallande en paramagnetisk metall |
| US4678667A (en) * | 1985-07-02 | 1987-07-07 | 501 Regents of the University of California | Macrocyclic bifunctional chelating agents |
| WO1987002893A1 (en) * | 1985-11-18 | 1987-05-21 | Board Of Regents, The University Of Texas System | Polychelating agents for image and spectral enhancement (and spectral shift) |
| US4871779A (en) * | 1985-12-23 | 1989-10-03 | The Dow Chemical Company | Ion exchange/chelation resins containing dense star polymers having ion exchange or chelate capabilities |
| US4885363A (en) * | 1987-04-24 | 1989-12-05 | E. R. Squibb & Sons, Inc. | 1-substituted-1,4,7-triscarboxymethyl-1,4,7,10-tetraazacyclododecane and analogs |
| CA1266344A (en) * | 1986-02-14 | 1990-02-27 | Miki Kurami | High molecular compounds having amino groups, and their utilization |
| US5338532A (en) * | 1986-08-18 | 1994-08-16 | The Dow Chemical Company | Starburst conjugates |
| DE3786000T3 (de) * | 1986-08-18 | 1997-08-21 | Dow Chemical Co | Conjugate dichter Sterne. |
| US5057302A (en) * | 1987-02-13 | 1991-10-15 | Abbott Laboratories | Bifunctional chelating agents |
| DE3728525A1 (de) * | 1987-08-24 | 1989-03-16 | Schering Ag | Mehrkernige substituierte komplexbildner, komplexe und komplexsalze, verfahren zu deren herstellung und diese enthaltende pharmazeutische mittel |
| US4857599A (en) * | 1988-02-08 | 1989-08-15 | The Dow Chemical Company | Modified dense star polymers |
| US4923985A (en) * | 1988-05-25 | 1990-05-08 | The United States Of America As Represented By The Department Of Health & Human Services | Process for synthesizing macrocyclic chelates |
| JP2831073B2 (ja) * | 1988-06-24 | 1998-12-02 | ザ ダウ ケミカル カンパニー | 大環状二官能キレート剤、その錯体及びそれらの抗体接合体 |
| US5364613A (en) * | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
| ES2080160T3 (es) * | 1989-05-26 | 1996-02-01 | Akzo Nobel Nv | Agentes quelantes para union de metales a proteinas. |
| DE3938992A1 (de) * | 1989-11-21 | 1991-05-23 | Schering Ag | Kaskadenpolymer-gebundene komplexbildner, deren komplexe und konjugate, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
| DE4115789A1 (de) * | 1991-05-10 | 1992-11-12 | Schering Ag | Makrocyclische polymer-komplexbildner, deren komplexe, verfahren zu ihrer herstellung und diese enthaltende pharmazeutische mittel |
-
1991
- 1991-10-07 US US07/772,349 patent/US5914095A/en not_active Expired - Lifetime
-
1992
- 1992-10-06 CA CA002120763A patent/CA2120763A1/en not_active Abandoned
- 1992-10-06 JP JP5506624A patent/JPH07503031A/ja active Pending
- 1992-10-06 AT AT92920822T patent/ATE174800T1/de not_active IP Right Cessation
- 1992-10-06 DE DE69227998T patent/DE69227998T2/de not_active Expired - Lifetime
- 1992-10-06 WO PCT/EP1992/002308 patent/WO1993006868A1/en not_active Ceased
- 1992-10-06 EP EP92920822A patent/EP0607222B1/de not_active Expired - Lifetime
- 1992-10-06 AU AU26757/92A patent/AU671601B2/en not_active Ceased
- 1992-10-06 SG SG1996004854A patent/SG48985A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ATE174800T1 (de) | 1999-01-15 |
| CA2120763A1 (en) | 1993-04-15 |
| DE69227998D1 (de) | 1999-02-04 |
| AU2675792A (en) | 1993-05-03 |
| HK1002101A1 (en) | 1998-07-31 |
| AU671601B2 (en) | 1996-09-05 |
| JPH07503031A (ja) | 1995-03-30 |
| EP0607222A1 (de) | 1994-07-27 |
| US5914095A (en) | 1999-06-22 |
| WO1993006868A1 (en) | 1993-04-15 |
| DE69227998T2 (de) | 1999-08-19 |
| EP0607222B1 (de) | 1998-12-23 |
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