SG50864A1 - Stabilized albumin-free recombination factor viii preparation having a low sugar content - Google Patents

Stabilized albumin-free recombination factor viii preparation having a low sugar content

Info

Publication number
SG50864A1
SG50864A1 SG1997002388A SG1997002388A SG50864A1 SG 50864 A1 SG50864 A1 SG 50864A1 SG 1997002388 A SG1997002388 A SG 1997002388A SG 1997002388 A SG1997002388 A SG 1997002388A SG 50864 A1 SG50864 A1 SG 50864A1
Authority
SG
Singapore
Prior art keywords
factor viii
sugar content
low sugar
viii preparation
recombination factor
Prior art date
Application number
SG1997002388A
Other languages
English (en)
Inventor
Rajiv Nayar
Original Assignee
Bayer Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer Ag filed Critical Bayer Ag
Publication of SG50864A1 publication Critical patent/SG50864A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/37—Factors VIII
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
SG1997002388A 1996-07-12 1997-07-07 Stabilized albumin-free recombination factor viii preparation having a low sugar content SG50864A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/678,492 US5763401A (en) 1996-07-12 1996-07-12 Stabilized albumin-free recombinant factor VIII preparation having a low sugar content

Publications (1)

Publication Number Publication Date
SG50864A1 true SG50864A1 (en) 1998-07-20

Family

ID=24723010

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1997002388A SG50864A1 (en) 1996-07-12 1997-07-07 Stabilized albumin-free recombination factor viii preparation having a low sugar content

Country Status (30)

Country Link
US (2) US5763401A (cs)
EP (1) EP0818204B1 (cs)
JP (1) JP4077055B2 (cs)
KR (1) KR100491281B1 (cs)
CN (1) CN1130224C (cs)
AR (1) AR007845A1 (cs)
AT (1) ATE191146T1 (cs)
AU (1) AU718901B2 (cs)
BR (1) BR9704407B1 (cs)
CA (1) CA2210038C (cs)
CO (1) CO4700302A1 (cs)
CZ (1) CZ292183B6 (cs)
DE (1) DE69701548T2 (cs)
DK (1) DK0818204T3 (cs)
ES (1) ES2144293T3 (cs)
GR (1) GR3033669T3 (cs)
HU (1) HU221415B1 (cs)
ID (1) ID19074A (cs)
IL (1) IL121273A (cs)
MY (1) MY125544A (cs)
NZ (1) NZ328297A (cs)
PL (1) PL186950B1 (cs)
PT (1) PT818204E (cs)
RU (1) RU2201252C2 (cs)
SG (1) SG50864A1 (cs)
SK (1) SK282207B6 (cs)
TR (1) TR199700628A2 (cs)
TW (1) TW381027B (cs)
UA (1) UA43882C2 (cs)
ZA (1) ZA976167B (cs)

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US5763401A (en) * 1996-07-12 1998-06-09 Bayer Corporation Stabilized albumin-free recombinant factor VIII preparation having a low sugar content
EP2921180B1 (en) * 1999-02-22 2019-08-14 University of Connecticut Albumin-free factor VIII formulations
US7601691B2 (en) * 1999-05-17 2009-10-13 Conjuchem Biotechnologies Inc. Anti-obesity agents
US6887470B1 (en) 1999-09-10 2005-05-03 Conjuchem, Inc. Protection of endogenous therapeutic peptides from peptidase activity through conjugation to blood components
US20040266673A1 (en) * 2002-07-31 2004-12-30 Peter Bakis Long lasting natriuretic peptide derivatives
KR20020072563A (ko) * 1999-12-30 2002-09-16 인터뮨, 인크. γ―ＩＦＮ 액체―소적 에어로졸 및 방법
US6689353B1 (en) 2000-06-28 2004-02-10 Bayer Pharmaceuticals Corporation Stabilized interleukin 2
AU2002351756A1 (en) * 2001-12-21 2003-07-15 Novo Nordisk Health Care Ag Liquid composition of factor vii polypeptides
DE10211227A1 (de) * 2002-03-13 2003-10-02 Aventis Behring Gmbh Verfahren zur Rekonstitution von Iyophilisierten Proteinen
GB0207092D0 (en) * 2002-03-26 2002-05-08 Sod Conseils Rech Applic Stable pharmaceutical composition containing factor VIII
PT1517698E (pt) * 2002-06-21 2014-11-19 Novo Nordisk Healthcare Ag Composições sólidas estabilizadas de polipéptidos do fator viia
EP1562626B1 (en) * 2002-10-29 2007-11-28 ALZA Corporation Stabilized, solid-state polypeptide particles
AU2003293543A1 (en) * 2002-12-13 2004-07-09 Abgenix, Inc. System and method for stabilizing antibodies with histidine
GB0304636D0 (en) * 2003-02-28 2003-04-02 Britannia Pharmaceuticals Ltd Pharmaceutical composition for nasal delivery
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MXPA06001283A (es) 2003-08-05 2006-04-11 Novo Nordisk As Derivados de insulina novedosos.
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RU2373953C2 (ru) * 2003-12-19 2009-11-27 Ново Нордиск Хелс Кеа Аг Стабилизированная композиция, содержащая полипептид фактора vii
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DK2100904T3 (da) 2004-04-23 2010-11-08 Conjuchem Biotechnologies Inc Fast fase til anvendelse i en fremgangsmåde til rensning af albuminkonjugater
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KR100624013B1 (ko) * 2004-06-25 2006-09-19 주식회사 녹십자홀딩스 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제
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CN102614134B (zh) 2005-03-25 2016-09-07 瑞泽恩制药公司 Vegf拮抗剂制剂
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JP4808785B2 (ja) 2005-12-28 2011-11-02 ノボ・ノルデイスク・エー／エス インスリン組成物および組成物の製造方法
US7608261B2 (en) 2006-06-16 2009-10-27 Regeneron Pharmacuticals, Inc. VEGF antagonist formulations suitable for intravitreal administration
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RU2469739C2 (ru) * 2007-04-26 2012-12-20 БАЙЕР ХЕЛСКЕА ЛЛСи Стабилизация жидких растворов рекомбинантного белка для хранения в замороженном состоянии
JP2010530846A (ja) * 2007-06-01 2010-09-16 アコロジックス インコーポレイティッド 高温で安定なペプチド製剤
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US20110178019A1 (en) * 2008-09-03 2011-07-21 Brita Rippner New protecting compositions for recombinantly produced factor viii
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CN103282569B (zh) * 2010-12-28 2015-11-25 纳幕尔杜邦公司 由氟化聚酯共混物纱线制得的织物
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JP2017509658A (ja) * 2014-04-01 2017-04-06 アドヴァンテック・バイオサイエンス・ファルマスーティカ・リミターダ カルシウム添加剤を使用しない第ｖｉｉｉ因子の安定化
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KR102486321B1 (ko) 2014-07-18 2023-01-09 사노피 암을 앓고 있는 것으로 의심되는 환자를 아플리베르셉트로 치료한 결과를 예측하는 방법
US10238718B2 (en) 2014-08-04 2019-03-26 Csl Limited Factor VIII formulation
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CN106139127B (zh) * 2016-08-05 2020-04-07 无锡药明生物技术股份有限公司 重组凝血因子ⅷ冻干制剂
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Also Published As

Publication number Publication date
DK0818204T3 (da) 2000-07-17
ID19074A (id) 1998-06-11
ZA976167B (en) 1998-02-02
CN1181974A (zh) 1998-05-20
EP0818204A3 (en) 1998-02-04
CZ219497A3 (cs) 1998-01-14
AU718901B2 (en) 2000-04-20
AR007845A1 (es) 1999-11-24
CO4700302A1 (es) 1998-12-29
CA2210038C (en) 2007-03-13
CN1130224C (zh) 2003-12-10
BR9704407A (pt) 2000-06-06
MY125544A (en) 2006-08-30
SK282207B6 (sk) 2001-12-03
PL186950B1 (pl) 2004-04-30
PL321058A1 (en) 1998-01-19
JPH1067679A (ja) 1998-03-10
IL121273A (en) 2000-09-28
JP4077055B2 (ja) 2008-04-16
US5874408A (en) 1999-02-23
ES2144293T3 (es) 2000-06-01
US5763401A (en) 1998-06-09
HU221415B1 (en) 2002-09-28
AU2860497A (en) 1998-01-22
EP0818204A2 (en) 1998-01-14
KR100491281B1 (ko) 2005-08-05
SK92197A3 (en) 1998-02-04
RU2201252C2 (ru) 2003-03-27
HUP9701191A2 (hu) 1999-06-28
MX9705209A (es) 1998-05-31
TW381027B (en) 2000-02-01
CA2210038A1 (en) 1998-01-12
TR199700628A2 (xx) 1998-01-21
BR9704407B1 (pt) 2010-03-09
CZ292183B6 (cs) 2003-08-13
DE69701548D1 (de) 2000-05-04
HU9701191D0 (en) 1997-08-28
KR980008241A (ko) 1998-04-30
DE69701548T2 (de) 2000-07-27
PT818204E (pt) 2000-08-31
ATE191146T1 (de) 2000-04-15
IL121273A0 (en) 1998-01-04
UA43882C2 (uk) 2002-01-15
NZ328297A (en) 1999-09-29
HUP9701191A3 (en) 2000-08-28
EP0818204B1 (en) 2000-03-29
GR3033669T3 (en) 2000-10-31

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