SG52655A1 - 1,5 Benzodiazepine derivatives and their use in medicine - Google Patents

1,5 Benzodiazepine derivatives and their use in medicine

Info

Publication number: SG52655A1
Authority: SG; Singapore
Prior art keywords: group; phenyl; 4alkyl; substituted; bridgedcycloalkyl
Prior art date: 1992-01-21

Application number

SG1996007401A

Other languages

English (en)

Inventor

Aldo Feriani

Harry Finch

Giorgio Tarzia

David Gordon Trist

Original Assignee

Glazo Wellcome Spa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-01-21

Filing date

1993-01-15

Publication date

1998-09-28

1992-01-21 Priority claimed from GB929201180A external-priority patent/GB9201180D0/en

1992-10-17 Priority claimed from GB929221847A external-priority patent/GB9221847D0/en

1993-01-15 Application filed by Glazo Wellcome Spa filed Critical Glazo Wellcome Spa

1998-09-28 Publication of SG52655A1 publication Critical patent/SG52655A1/en

Links

ZVAPWJGRRUHKGP-UHFFFAOYSA-N 1h-1,5-benzodiazepine Chemical class N1C=CC=NC2=CC=CC=C12 ZVAPWJGRRUHKGP-UHFFFAOYSA-N 0.000 title 1
239000003814 drug Substances 0.000 title 1
125000004178 (C1-C4) alkyl group Chemical group 0.000 abstract 3
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 3
125000005843 halogen group Chemical group 0.000 abstract 3
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 abstract 2
108010089448 Cholecystokinin B Receptor Proteins 0.000 abstract 2
125000000217 alkyl group Chemical group 0.000 abstract 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 abstract 1
125000004454 (C1-C6) alkoxycarbonyl group Chemical group 0.000 abstract 1
125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 1
102000052874 Gastrin receptors Human genes 0.000 abstract 1
102100036016 Gastrin/cholecystokinin type B receptor Human genes 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
AOXOCDRNSPFDPE-UKEONUMOSA-N chembl413654 Chemical compound C([C@H](C(=O)NCC(=O)N[C@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](C)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H]1N(CCC1)C(=O)CNC(=O)[C@@H](N)CCC(O)=O)C1=CC=C(O)C=C1 AOXOCDRNSPFDPE-UKEONUMOSA-N 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
125000004093 cyano group Chemical group *C#N 0.000 abstract 1
125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
-1 hydroxy, phenyl Chemical group 0.000 abstract 1
125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
- C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
- C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D243/12—1,5-Benzodiazepines; Hydrogenated 1,5-benzodiazepines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

SG1996007401A 1992-01-21 1993-01-15 1,5 Benzodiazepine derivatives and their use in medicine SG52655A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929201180A GB9201180D0 (en)	1992-01-21	1992-01-21	Chemical compounds
GB929221847A GB9221847D0 (en)	1992-10-17	1992-10-17	Chemical compounds

Publications (1)

Publication Number	Publication Date
SG52655A1 true SG52655A1 (en)	1998-09-28

Family

ID=26300183

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996007401A SG52655A1 (en)	1992-01-21	1993-01-15	1,5 Benzodiazepine derivatives and their use in medicine

Country Status (6)

Country	Link
EP (1)	EP0558104B1 (es)
AT (1)	ATE169007T1 (es)
DE (1)	DE69319945T2 (es)
DK (1)	DK0558104T3 (es)
ES (1)	ES2121925T3 (es)
SG (1)	SG52655A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN1073089C (zh) *	1993-12-28	2001-10-17	盐野义制药株式会社	苯并二氮杂噁衍生物、其组合物及其在药物制备中的用途
ES2171196T3 (es) *	1994-10-14	2002-09-01	Glaxosmithkline Spa	Uso de antagonistas del receptor cck-b para el tratamiento de trastornos del sueño.
GB9511220D0 (en) *	1995-06-02	1995-07-26	Glaxo Group Ltd	Solid dispersions
CU20090172A7 (es)	2009-10-09	2011-10-05	Ct De Investigación Y Desarrollo De Medicamentos	Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2641280B1 (fr) *	1988-12-29	1994-01-21	Roussel Uclaf	Nouveaux derives de la 2,4-dioxo 2,3,4,5-tetrahydro 1h-1,5-benzodiazepine, leur procede de preparation et leur application comme medicaments

1993
- 1993-01-15 ES ES93200097T patent/ES2121925T3/es not_active Expired - Lifetime
- 1993-01-15 DE DE69319945T patent/DE69319945T2/de not_active Expired - Fee Related
- 1993-01-15 AT AT93200097T patent/ATE169007T1/de not_active IP Right Cessation
- 1993-01-15 EP EP93200097A patent/EP0558104B1/en not_active Expired - Lifetime
- 1993-01-15 SG SG1996007401A patent/SG52655A1/en unknown
- 1993-01-15 DK DK93200097T patent/DK0558104T3/da active

Also Published As

Publication number	Publication date
ATE169007T1 (de)	1998-08-15
EP0558104A1 (en)	1993-09-01
ES2121925T3 (es)	1998-12-16
DE69319945T2 (de)	1999-03-11
DK0558104T3 (da)	1999-04-26
EP0558104B1 (en)	1998-07-29
DE69319945D1 (de)	1998-09-03

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