SG52784A1 - New process for the production of cephalosporines and novel intermediates in this process - Google Patents

New process for the production of cephalosporines and novel intermediates in this process

Info

Publication number: SG52784A1
Authority: SG; Singapore
Prior art keywords: production; cephalosporines; hydrogen; new; novel intermediates
Prior art date: 1991-08-21

Application number

SG1996009489A

Other languages

English (en)

Inventor

Johannes Ludescher

Hubert Sturm

Josef Wieser

Original Assignee

Biochemie Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1991-08-21

Filing date

1992-08-12

Publication date

1998-09-28

1992-08-12 Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh

1998-09-28 Publication of SG52784A1 publication Critical patent/SG52784A1/en

Links

125000001271 cephalosporin group Chemical group 0.000 title 1
239000000543 intermediate Substances 0.000 title 1
229910052739 hydrogen Inorganic materials 0.000 abstract 3
239000001257 hydrogen Substances 0.000 abstract 3
125000001181 organosilyl group Chemical group [SiH3]* 0.000 abstract 2
ZYLDQHILNOZKIF-IOJJLOCKSA-N (6R)-7-amino-8-oxo-3-prop-1-enyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Chemical class CC=CC1=C(N2[C@H](SC1)C(N)C2=O)C(O)=O ZYLDQHILNOZKIF-IOJJLOCKSA-N 0.000 abstract 1
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
239000002253 acid Substances 0.000 abstract 1
150000001875 compounds Chemical class 0.000 abstract 1
150000002431 hydrogen Chemical group 0.000 abstract 1
125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 1
239000012038 nucleophile Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D501/00—Heterocyclic compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
- C07D501/14—Compounds having a nitrogen atom directly attached in position 7
- C07D501/16—Compounds having a nitrogen atom directly attached in position 7 with a double bond between positions 2 and 3
- C07D501/20—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids
- C07D501/24—7-Acylaminocephalosporanic or substituted 7-acylaminocephalosporanic acids in which the acyl radicals are derived from carboxylic acids with hydrocarbon radicals, substituted by hetero atoms or hetero rings, attached in position 3
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
- C07F7/02—Silicon compounds
- C07F7/08—Compounds having one or more C—Si linkages
- C07F7/10—Compounds having one or more C—Si linkages containing nitrogen having a Si-N linkage
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Cephalosporin Compounds (AREA)

SG1996009489A 1991-08-21 1992-08-12 New process for the production of cephalosporines and novel intermediates in this process SG52784A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
AT0163691A AT396108B (de)	1991-08-21	1991-08-21	Neues verfahren und neue zwischenprodukte zur herstellung von 7-aminocephalosporansaeurederivaten

Publications (1)

Publication Number	Publication Date
SG52784A1 true SG52784A1 (en)	1998-09-28

Family

ID=3517697

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG1996009489A SG52784A1 (en)	1991-08-21	1992-08-12	New process for the production of cephalosporines and novel intermediates in this process

Country Status (9)

Country	Link
US (3)	US5686604A (fr)
EP (1)	EP0528343B1 (fr)
JP (1)	JP2561780B2 (fr)
KR (2)	KR930004312A (fr)
AT (2)	AT396108B (fr)
DE (1)	DE69232776T2 (fr)
ES (1)	ES2183804T3 (fr)
PT (1)	PT528343E (fr)
SG (1)	SG52784A1 (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR0164458B1 (ko) *	1995-04-04	1999-01-15	김은영	암모니오세팔로스포린 계열 항생제 및 그의 제조방법
AT403161B (de) *	1995-07-19	1997-11-25	Biochemie Gmbh	Verfahren zur herstellung von cephemverbindungen
US5872249A (en) *	1995-09-01	1999-02-16	Korea Institute Of Science And Technology	3-ammoniopropenyl cephalosporin compounds as antibacterial agents and process for preparing the same
US6011136A (en) *	1995-11-21	2000-01-04	Novartis Ag	Cyclopeptolides
KR100414336B1 (ko) *	1998-06-22	2004-01-07	바실리어 파마슈티카 아게	프로페닐 세팔로스포린 유도체

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DK154939C (da) *	1974-12-19	1989-06-12	Takeda Chemical Industries Ltd	Analogifremgangsmaade til fremstilling af thiazolylacetamido-cephemforbindelser eller farmaceutisk acceptable salte eller estere deraf
US4049806A (en) *	1975-08-15	1977-09-20	Syntex (U.S.A.) Inc.	Cephalosporin type antibacterials
US4112087A (en) *	1976-11-04	1978-09-05	Syntex (U.S.A.) Inc.	Cephalosporin type antibacterials having a substituted propenyl group in the 3-position
DE2659288A1 (de) *	1976-12-29	1978-07-06	Schering Ag	Mittel mit bakterizider und fungizider wirkung
NL162387C (nl) *	1977-09-06	1980-05-16	Gist Brocades Nv	Werkwijze voor het bereiden van 6-(d-alpha-amino-p- -hydroxyfenylacetamido)penicillanzuur.
US4640798A (en) *	1982-05-26	1987-02-03	Lilly Industries Ltd.	Intermediates for the preparation of penicillin and cephalosporin compounds
ZM884A1 (en) *	1983-01-28	1984-10-22	Bristol Myers Co	Substituted vinyl cephalosporins
US4486586A (en) *	1983-02-10	1984-12-04	Bristol-Myers Company	Cephalosporin derivatives
CA1276929C (fr) *	1984-04-09	1990-11-27	Masahisa Oka	Agents antibacteriens de cephalosporine
ATE177104T1 (de) *	1984-11-23	1999-03-15	Biochemie Gmbh	Cephalosporinderivative
AT382873B (de) *	1984-11-23	1987-04-27	Biochemie Gmbh	Verfahren zur herstellung von cephalosporinderivaten
US4703118A (en) *	1985-04-08	1987-10-27	Eli Lilly And Company	Synthesis of 3-iodomethyl cephalosporins
ATE114657T1 (de) *	1985-12-26	1994-12-15	Eisai Co Ltd	Cephalosporin-verbindungen.
IL84128A (en) *	1986-10-13	1992-12-01	Eisai Co Ltd	3-propenylcephem derivatives, their preparation and pharmaceutical compositions containing them
FR2622585B1 (fr) *	1987-11-03	1991-04-19	Roussel Uclaf	Nouvelles cephalosporines comportant en position 3 un radical vinyle substitue, leur procede de preparation, leur application comme medicaments, les compositions les renfermant et les nouveaux intermediaires obtenus
CA1339738C (fr) *	1988-03-16	1998-03-17	Takashi Kamiya	Methode de preparation de derives de cephemes; produits intermediaires utiles a cette fin

1991
- 1991-08-21 AT AT0163691A patent/AT396108B/de not_active IP Right Cessation
1992
- 1992-08-12 EP EP92113715A patent/EP0528343B1/fr not_active Expired - Lifetime
- 1992-08-12 DE DE69232776T patent/DE69232776T2/de not_active Expired - Fee Related
- 1992-08-12 SG SG1996009489A patent/SG52784A1/en unknown
- 1992-08-12 PT PT92113715T patent/PT528343E/pt unknown
- 1992-08-12 ES ES92113715T patent/ES2183804T3/es not_active Expired - Lifetime
- 1992-08-12 AT AT92113715T patent/ATE224393T1/de not_active IP Right Cessation
- 1992-08-19 KR KR1019920014890A patent/KR930004312A/ko not_active Ceased
- 1992-08-20 JP JP4221330A patent/JP2561780B2/ja not_active Expired - Fee Related
1995
- 1995-05-05 US US08/437,083 patent/US5686604A/en not_active Expired - Fee Related
- 1995-05-05 US US08/437,084 patent/US5644052A/en not_active Expired - Lifetime
1997
- 1997-10-08 US US08/947,215 patent/US6169180B1/en not_active Expired - Fee Related
1999
- 1999-11-27 KR KR1019990053237A patent/KR100286422B1/ko not_active Expired - Fee Related

Also Published As

Publication number	Publication date
JP2561780B2 (ja)	1996-12-11
JPH05194533A (ja)	1993-08-03
ES2183804T3 (es)	2003-04-01
ATA163691A (de)	1992-10-15
KR100286422B1 (ko)	2001-03-15
AT396108B (de)	1993-06-25
EP0528343B1 (fr)	2002-09-18
ATE224393T1 (de)	2002-10-15
US6169180B1 (en)	2001-01-02
EP0528343A2 (fr)	1993-02-24
US5686604A (en)	1997-11-11
US5644052A (en)	1997-07-01
DE69232776T2 (de)	2003-04-30
KR930004312A (ko)	1993-03-22
DE69232776D1 (de)	2002-10-24
PT528343E (pt)	2002-12-31
EP0528343A3 (en)	1993-03-10

Publication	Publication Date	Title
AU3621689A (en)	1989-09-28	Carbamate compounds, compositions, and method of making the same
AU2381695A (en)	1995-11-29	Intermediates in pharmaceutical camptothecin preparation
NZ212750A (en)	1989-04-26	3-acylamino-2-azetidinone derivatives useful as intermediates in the preparation of antibacterial agents
HU9401943D0 (en)	1994-09-28	Process for producing amide and urea derivatives and compositions containing them
AU4946185A (en)	1986-05-22	Quinolonecarboxylic acid derivatives
ES2010246A6 (es)	1989-11-01	Un compuesto.
EP0503453A3 (en)	1992-12-09	New process for the production of cephalosporines and novel intermediates in this process
DE3068029D1 (en)	1984-07-05	Intermediates for the preparation of thienamycin and process for preparing intermediates
AU669212B2 (en)	1996-05-30	Process for the purification of crude clavulanic acid
ES8706144A1 (es)	1987-06-01	Un procedimiento para preparar derivados de 1,8-naftiridina
EP0528343A3 (en)	1993-03-10	New process for the production of cephalosporines and novel intermediates in this process
AU3354095A (en)	1996-03-27	Process for producing alkoxyiminoacetamide derivative
ES8600311A1 (es)	1985-10-01	Un procedimiento para la preparacion de derivados vinilacetamido oxacefalosporina
AU8606291A (en)	1992-04-30	8-azabicyclo(3.2.1)octylalkylthiazolidinones, a process for their preparation and their use as medicaments
AU2014188A (en)	1989-02-02	Naphthothiazepine derivatives and preparation thereof
AU572147B2 (en)	1988-05-05	Dibenzopyran derivatives
GR81771B (fr)	1984-12-12
AU7254187A (en)	1987-11-19	Preparation of cephalosporin derivatives
GR3002688T3 (en)	1993-01-25	Thiadiazolylacetamide derivatives, process for the preparation thereof and their use
GB8600879D0 (en)	1986-02-19	Pregnane derivatives