SK111896A3 - Production of fibrinogen in transgenic animals - Google Patents
Production of fibrinogen in transgenic animals Download PDFInfo
- Publication number
- SK111896A3 SK111896A3 SK1118-96A SK111896A SK111896A3 SK 111896 A3 SK111896 A3 SK 111896A3 SK 111896 A SK111896 A SK 111896A SK 111896 A3 SK111896 A3 SK 111896A3
- Authority
- SK
- Slovakia
- Prior art keywords
- fibrinogen
- dna
- mammal
- ser
- gly
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4717—Plasma globulins, lactoglobulin
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4732—Casein
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/75—Fibrinogen
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/89—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microinjection
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2207/00—Modified animals
- A01K2207/15—Humanized animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/103—Ovine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/01—Animal expressing industrially exogenous proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Toxicology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Veterinary Medicine (AREA)
- Environmental Sciences (AREA)
- Biodiversity & Conservation Biology (AREA)
- Animal Husbandry (AREA)
- Animal Behavior & Ethology (AREA)
- Hematology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/206,176 US5639940A (en) | 1994-03-03 | 1994-03-03 | Production of fibrinogen in transgenic animals |
| PCT/US1995/002648 WO1995023868A1 (fr) | 1994-03-03 | 1995-03-01 | Production de fibrinogene chez des animaux transgeniques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK111896A3 true SK111896A3 (en) | 1997-07-09 |
Family
ID=22765288
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1118-96A SK111896A3 (en) | 1994-03-03 | 1995-03-01 | Production of fibrinogen in transgenic animals |
Country Status (20)
| Country | Link |
|---|---|
| US (2) | US5639940A (fr) |
| EP (1) | EP0748386B9 (fr) |
| JP (1) | JPH09509839A (fr) |
| CN (1) | CN1079433C (fr) |
| AT (1) | ATE298801T1 (fr) |
| AU (1) | AU685250B2 (fr) |
| BR (1) | BR9506944A (fr) |
| CA (1) | CA2184004C (fr) |
| CZ (1) | CZ296382B6 (fr) |
| DE (1) | DE69534295T4 (fr) |
| DK (1) | DK0748386T4 (fr) |
| ES (1) | ES2245453T5 (fr) |
| FI (1) | FI963419L (fr) |
| HU (1) | HU224550B1 (fr) |
| NO (1) | NO329072B1 (fr) |
| NZ (1) | NZ282601A (fr) |
| PL (1) | PL186074B1 (fr) |
| PT (1) | PT748386E (fr) |
| SK (1) | SK111896A3 (fr) |
| WO (1) | WO1995023868A1 (fr) |
Families Citing this family (84)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1995029686A1 (fr) * | 1994-05-02 | 1995-11-09 | E.R. Squibb & Sons, Inc. | Chaines de fibrine de recombinaison, fibrine et homologues de fibrine |
| US5968809A (en) | 1997-04-11 | 1999-10-19 | Abbot Laboratories | Methods and compositions for synthesis of long chain poly-unsaturated fatty acids |
| GB9715064D0 (en) * | 1997-07-17 | 1997-09-24 | Ppl Therapeutics Scotland Ltd | Protein expression |
| WO1999044625A1 (fr) | 1998-03-03 | 1999-09-10 | John Hopkins University | Inhibiteur d'enzymes de complement, derive du virus de la variole (spice), proteines liees au spice et methode d'inhibition de l'activation du complement |
| US7122620B1 (en) | 1998-05-27 | 2006-10-17 | Medical Research Services And Development Ltd. | Haptotactic peptides |
| EP1082126B1 (fr) * | 1998-05-27 | 2008-02-13 | Hadasit Medical Research Services & Development Co. Ltd. | Nouveaux peptides |
| AU6104799A (en) * | 1998-09-24 | 2000-04-10 | Ppl Therapeutics (Scotland) Limited | Purification of fibrinogen from fluids by precipitation and hydrophoic chromatography |
| GB9825374D0 (en) * | 1998-11-19 | 1999-01-13 | Ppl Therapeutics Scotland Ltd | Method |
| NZ511299A (en) | 1998-11-19 | 2003-02-28 | Ppl Therapeutics Scotland Ltd | Stabilisation of milk from transgenic animals through expression of a serine proteinase inhibitor and optionally fibrinogen in the mammary gland |
| US7208576B2 (en) * | 1999-01-06 | 2007-04-24 | Merrimack Pharmaceuticals, Inc. | Non-glycosylated human alpha-fetoprotein, methods of production, and uses thereof |
| EP1148779B1 (fr) | 1999-01-06 | 2007-12-12 | Merrimack Pharmaceuticals, Inc. | Expression d'alpha-foetoproteines humaines secretees chez des animaux transgeniques |
| US6183803B1 (en) | 1999-06-11 | 2001-02-06 | Biosante Pharmaceuticals, Inc. | Method for processing milk |
| EP1220606A4 (fr) * | 1999-10-14 | 2004-04-14 | Gtc Biotherapeutics Inc | Methodes de production d'une molecule cible chez un animal transgenique et de purification de la molecule cible |
| US7074983B2 (en) | 1999-11-19 | 2006-07-11 | Kirin Beer Kabushiki Kaisha | Transgenic bovine comprising human immunoglobulin loci and producing human immunoglobulin |
| US7414170B2 (en) | 1999-11-19 | 2008-08-19 | Kirin Beer Kabushiki Kaisha | Transgenic bovines capable of human antibody production |
| EP1287013A2 (fr) * | 1999-12-27 | 2003-03-05 | Curagen Corporation | Acides nucleiques contenant des polymorphismes mononucleotidiques et procedes d'utilisation de ces acides |
| CA2408745A1 (fr) * | 2000-05-13 | 2001-11-22 | Bioacta Ltd | Polypeptides anti-angiogeniques |
| AU2001284235A1 (en) * | 2000-09-01 | 2002-03-13 | Bioacta Ltd | Anti-angiogenic peptides |
| EP2351855A1 (fr) | 2000-09-26 | 2011-08-03 | Duke University | Aptamères d'ARN et leurs procédés d'identification |
| MXPA03004313A (es) * | 2000-11-17 | 2007-02-27 | Hematech Llc | Expresion de inmunoglobulinas xenogenas (humanas) en ungulados transgenicos, clonados. |
| US20020073441A1 (en) | 2000-12-13 | 2002-06-13 | Ross Brian D. | Compositions and methods for detecting proteolytic activity |
| PT1497418E (pt) | 2002-04-19 | 2013-01-25 | Dsm Ip Assets Bv | Fosfolípases, ácidos nucleicos que as codificam e métodos para as preparar e utilizar |
| US7226771B2 (en) | 2002-04-19 | 2007-06-05 | Diversa Corporation | Phospholipases, nucleic acids encoding them and methods for making and using them |
| DE10261126A1 (de) * | 2002-08-13 | 2004-03-04 | Aventis Behring Gmbh | Lagerungsstabile, flüssige Fibrinogen-Formulierung |
| IL152609A0 (en) * | 2002-11-03 | 2003-06-24 | Hapto Biotech Inc | Liposomal compositions comprising haptotactic peptides and uses thereof |
| JP2006505291A (ja) | 2002-11-08 | 2006-02-16 | ヘマテック,エルエルシー | プリオンタンパク質活性が低減されたトランスジェニック有蹄動物及びその用途 |
| US7517951B2 (en) * | 2002-12-24 | 2009-04-14 | Nitto Boseki Co., Ltd. | Marker proteins for diagnosing liver disease and method of diagnosing liver disease using the same |
| EP3508578A1 (fr) | 2003-03-06 | 2019-07-10 | BASF Enzymes, LLC | Amylases, acides nucléiques les codant et leurs procédés de fabrication et d'utilisation |
| EP2853593B1 (fr) | 2003-03-07 | 2017-10-04 | DSM IP Assets B.V. | Hydrolases, acides nucléiques les codant et leurs procédés de fabrication et d'utilisation |
| DK2341136T3 (en) | 2003-04-04 | 2016-09-12 | Basf Enzymes Llc | Pectate lyases, nucleic acids encoding them, and methods of making and using them |
| US7514593B2 (en) * | 2003-05-30 | 2009-04-07 | The University Of North Carolina At Chapel Hill | Animal model for chronic obstructive pulmonary disease and cystic fibrosis |
| BRPI0412279A (pt) | 2003-07-02 | 2006-09-19 | Diversa Corp | glucanases, ácidos nucléicos codificando as mesmas e métodos para preparar e aplicar os mesmos |
| CA2535526C (fr) | 2003-08-11 | 2015-09-29 | Diversa Corporation | Laccases, acides nucleiques codant pour ces enzymes et procedes permettant de les produire et de les utiliser |
| US7550263B2 (en) * | 2003-09-05 | 2009-06-23 | Gtc Biotherapeutics, Inc. | Method for the production of fusion proteins in transgenic mammal milk |
| US20050186608A1 (en) * | 2004-02-19 | 2005-08-25 | Olsen Byron V. | Method for the production of transgenic proteins useful in the treatment of obesity and diabetes |
| DE102004009400A1 (de) | 2004-02-24 | 2005-09-08 | Zlb Behring Gmbh | Fibrinogen Reinigung |
| CA2563064A1 (fr) | 2004-04-22 | 2005-11-10 | Kirin Beer Kabushiki Kaisha | Animaux transgeniques et leurs utilisations |
| ES2461857T3 (es) | 2004-06-16 | 2014-05-21 | Dsm Ip Assets B.V. | Composiciones y métodos para la decoloración enzimática de clorofila |
| EP2886658A1 (fr) | 2005-03-10 | 2015-06-24 | BASF Enzymes LLC | Enzymes de lyase, acides nucléiques les codant et leurs procédés de fabrication et d'utilisation |
| CA2842402C (fr) * | 2005-03-10 | 2016-02-23 | Gen-Probe Incorporated | Systemes et procedes permettant d'effectuer des dosages afin de detecter ou de quantifier des analytes dans des echantillons |
| NZ594810A (en) | 2005-03-15 | 2012-12-21 | Verenium Corp | Cellulases, nucleic acids encoding them and methods for making and using them |
| EP2216403A3 (fr) | 2006-02-02 | 2010-11-24 | Verenium Corporation | Estérases et acides nucléiques associés et procédés |
| NZ595501A (en) | 2006-02-10 | 2013-05-31 | Verenium Corp | Cellulolytic enzymes, nucleic acids encoding them and methods for making and using them |
| TR201809912T4 (tr) | 2006-02-14 | 2018-07-23 | Bp Corp North America Inc | Ksilanazlar, bunları kodlayan nükleik asitler ve bunları yapmak ve kullanmak için yöntemler. |
| EP1996186A4 (fr) | 2006-03-06 | 2009-07-22 | Humagene Inc | Procede de preparation de la thrombine recombinante humaine et du fibrinogene |
| EA029538B1 (ru) | 2006-03-07 | 2018-04-30 | Басф Энзаймс Ллк | Полипептид, обладающий активностью альдолазы, полинуклеотид, кодирующий этот полипептид, и способы получения и применения полинуклеотида и полипептида |
| EP2112227B1 (fr) | 2006-03-07 | 2013-05-15 | Cargill, Incorporated | Aldolases, acides nucléiques les codant et procédés de fabrication et d'utilisation de celles-ci |
| US8124831B2 (en) * | 2006-07-06 | 2012-02-28 | Duke University | Transgenic mice carrying functional single nucleotide polymorphisms in brain-specific tryptophan hydroxylase |
| DK2069389T3 (en) | 2006-08-04 | 2015-01-12 | Bp Corp North America Inc | Glucanases, nucleic acids encoding them, and processes for their preparation and use |
| CA2663001A1 (fr) | 2006-09-21 | 2008-03-27 | Verenium Corporation | Phospholipases, acides nucleiques codant pour elles et leurs methodes d'obtention et d'utilisation |
| HUE029140T2 (hu) | 2006-09-21 | 2017-02-28 | Basf Enzymes Llc | Fitázok, ezeket kódoló nukleinsavak, valamint eljárások az elõállításukra és alkalmazásuk |
| BRPI0719449A2 (pt) | 2006-12-21 | 2017-06-20 | Syngenta Participations Ag | molécula de ácido nucléico isolada, sintética ou recombinante, polipeptídeo isolado, planta ou parte de planta, eículo de clonagem que compreende um ácido nucléico, cassete de expressão que compreende uma molécula de ácido nucléico e método para hidrolisar um polissacarídeo, oligossacarídeo ou amido |
| HUE030719T2 (en) | 2007-04-09 | 2017-05-29 | Univ Florida | Raav vector compositions having tyrosine-modified capsid proteins and methods for use |
| CN110577945A (zh) | 2007-10-03 | 2019-12-17 | 维莱尼姆公司 | 木聚糖酶、编码它们的核酸以及其制备和应用方法 |
| EP2217721A4 (fr) * | 2007-10-29 | 2013-01-09 | Univ California | Thérapie génique pour l'ostéoarthrite |
| EP2238242B9 (fr) | 2008-01-03 | 2015-06-10 | BASF Enzymes LLC | Transférases et oxydoréductases, acides nucléiques codant pour celles-ci, et leurs procédés de fabrication et d'utilisation |
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| US20100304873A1 (en) * | 2009-05-28 | 2010-12-02 | Lipa Markowitz | Bowling Ball and Football Game Controller |
| UA109884C2 (uk) | 2009-10-16 | 2015-10-26 | Поліпептид, що має активність ферменту фосфатидилінозитол-специфічної фосфоліпази с, нуклеїнова кислота, що його кодує, та спосіб його виробництва і застосування | |
| UA111708C2 (uk) | 2009-10-16 | 2016-06-10 | Бандж Ойлз, Інк. | Спосіб рафінування олії |
| ES2524886T3 (es) | 2010-01-08 | 2014-12-15 | Profibrix Bv | Preparados de fibrinógeno enriquecidos en fibrinógeno con una cadena alfa extendida |
| US9546381B2 (en) | 2010-03-17 | 2017-01-17 | Pharming Intellectual Property Bv | Use of anticoagulants in the production of recombinant proteins in the milk of transgenic animals |
| KR20200047642A (ko) | 2010-04-23 | 2020-05-07 | 유니버시티 오브 플로리다 리서치 파운데이션, 인크. | 레베르 선천성 흑내장-1(lca1)의 치료를 위한 재조합 아데노-관련된 바이러스-구아닐레이트 사이클라제 조성물 및 방법 |
| BR112015019348A2 (pt) | 2013-02-13 | 2017-08-22 | Lab Francais Du Fractionnement | Métodos para produção de proteína com glicosilação modificada e com sialilação aumentada, para aumentar a atividade de sialil transferase na glândula mamária e para produzir sialil transferase, proteína com glicosilação modificada ou proteína com sialilação aumentada, composição, sialil transferase, mamífero transgênico, e, célula epitelial mamária |
| AU2014217561B2 (en) | 2013-02-13 | 2018-11-15 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Highly galactosylated anti-TNF-alpha antibodies and uses thereof |
| CA2933612A1 (fr) * | 2013-12-24 | 2015-07-02 | Lfb Usa, Inc. | Production transgenique d'heparine |
| CN103995077B (zh) * | 2014-05-21 | 2016-01-27 | 中国计量科学研究院 | 一种测定奶粉中β-乳球蛋白含量的方法 |
| FR3032621A1 (fr) | 2015-02-13 | 2016-08-19 | Lab Francais Du Fractionnement | Colle biologique et son utilisation comme medicament |
| JP6840086B2 (ja) * | 2015-03-20 | 2021-03-10 | ユニベルシテ・パリ・デカルトUniversite Paris Descartes | 薬物として、特に皮膚炎症性疾患において使用するためのフィブリノゲン由来の単離されたペプチドおよびそれらのフラグメント |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| KR101841587B1 (ko) | 2016-01-12 | 2018-05-14 | 주식회사 녹십자홀딩스 | 피브리노겐의 정제방법 |
| EP4293116A3 (fr) | 2016-07-06 | 2024-01-24 | Laboratoire Français du Fractionnement et des Biotechnologies | Fibrinogène liquide stable |
| EP3618853B1 (fr) * | 2018-04-24 | 2020-09-09 | Fibriant B.V. | Variants de gamma prime de fibrinogène pour l'utilisation dans le traitement d'une infection |
| US11266129B2 (en) | 2019-11-05 | 2022-03-08 | Versiti Blood Research Institute Foundation, Inc. | Murine model of fetal/neonatal alloimmune thrombocytopenia |
| CN120168665A (zh) | 2019-11-05 | 2025-06-20 | 弗尔斯蒂血液研究所基金会股份有限公司 | 胎儿/新生儿同种免疫性血小板减少症的鼠模型 |
| WO2024261097A1 (fr) | 2023-06-20 | 2024-12-26 | Institut National de la Santé et de la Recherche Médicale | Nouveau modèle animal non humain pertinent de maladie hépatique stéatosique associée à un dysfonctionnement métabolique (masld) et développement d'athérosclérose |
| CN121186363B (zh) * | 2025-11-25 | 2026-04-10 | 长兴固容生物科技有限公司 | 一种用于泛癌筛查、诊断的标志物组及其用途 |
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| AT359653B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| AT359652B (de) | 1979-02-15 | 1980-11-25 | Immuno Ag | Verfahren zur herstellung eines gewebekleb- stoffes |
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| US4442655A (en) | 1981-06-25 | 1984-04-17 | Serapharm Michael Stroetmann | Fibrinogen-containing dry preparation, manufacture and use thereof |
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| US4627879A (en) | 1984-09-07 | 1986-12-09 | The Trustees Of Columbia University In The City Of New York | Fibrin adhesive prepared as a concentrate from single donor fresh frozen plasma |
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-
1994
- 1994-03-03 US US08/206,176 patent/US5639940A/en not_active Ceased
-
1995
- 1995-03-01 CZ CZ0257596A patent/CZ296382B6/cs not_active IP Right Cessation
- 1995-03-01 WO PCT/US1995/002648 patent/WO1995023868A1/fr not_active Ceased
- 1995-03-01 CN CN95191945A patent/CN1079433C/zh not_active Expired - Lifetime
- 1995-03-01 EP EP95912701A patent/EP0748386B9/fr not_active Expired - Lifetime
- 1995-03-01 CA CA002184004A patent/CA2184004C/fr not_active Expired - Lifetime
- 1995-03-01 JP JP7523049A patent/JPH09509839A/ja not_active Ceased
- 1995-03-01 AU AU19770/95A patent/AU685250B2/en not_active Expired
- 1995-03-01 PL PL95316115A patent/PL186074B1/pl not_active IP Right Cessation
- 1995-03-01 ES ES95912701T patent/ES2245453T5/es not_active Expired - Lifetime
- 1995-03-01 DK DK95912701.0T patent/DK0748386T4/da active
- 1995-03-01 NZ NZ282601A patent/NZ282601A/en not_active IP Right Cessation
- 1995-03-01 DE DE1995634295 patent/DE69534295T4/de not_active Expired - Lifetime
- 1995-03-01 AT AT95912701T patent/ATE298801T1/de active
- 1995-03-01 HU HU9602404A patent/HU224550B1/hu not_active IP Right Cessation
- 1995-03-01 BR BR9506944A patent/BR9506944A/pt not_active Application Discontinuation
- 1995-03-01 SK SK1118-96A patent/SK111896A3/sk unknown
- 1995-03-01 FI FI963419A patent/FI963419L/fi not_active Application Discontinuation
- 1995-03-01 PT PT95912701T patent/PT748386E/pt unknown
-
1996
- 1996-09-02 NO NO19963651A patent/NO329072B1/no not_active IP Right Cessation
-
1999
- 1999-01-15 US US09/232,488 patent/USRE42704E1/en not_active Expired - Lifetime
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