SK113894A3 - N-t-butyl-androst-3,5-diene-17-beta-carboxamide-3-carboxylic acid polymorph a - Google Patents

N-t-butyl-androst-3,5-diene-17-beta-carboxamide-3-carboxylic acid polymorph a Download PDF

Info

Publication number: SK113894A3
Authority: SK; Slovakia
Prior art keywords: butyl; diene; carboxylic acid; androst; carboxamide
Prior art date: 1992-03-24

Application number

SK1138-94A

Other languages

English (en)

Slovak (sk)

Inventor

Neil H Baine

Neville L Holder

Donald N Klein

Robert L Webb

Gary E Zuber

Original Assignee

Smithkline Beecham Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-03-24

Filing date

1993-03-24

Publication date

1995-04-12

1993-03-24 Application filed by Smithkline Beecham Corp filed Critical Smithkline Beecham Corp

1995-04-12 Publication of SK113894A3 publication Critical patent/SK113894A3/sk

Links

238000000034 method Methods 0.000 claims abstract description 8
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 claims description 39
150000001875 compounds Chemical class 0.000 claims description 16
239000002904 solvent Substances 0.000 claims description 9
239000000725 suspension Substances 0.000 claims description 7
238000002329 infrared spectrum Methods 0.000 claims description 5
BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 claims description 4
238000002441 X-ray diffraction Methods 0.000 claims description 3
238000002955 isolation Methods 0.000 claims description 3
238000002360 preparation method Methods 0.000 claims description 3
239000000126 substance Substances 0.000 claims description 3
238000004519 manufacturing process Methods 0.000 claims description 2
239000000203 mixture Substances 0.000 claims description 2
229920000642 polymer Polymers 0.000 claims 1
239000002253 acid Substances 0.000 description 4
238000002835 absorbance Methods 0.000 description 3
238000002425 crystallisation Methods 0.000 description 3
230000008025 crystallization Effects 0.000 description 3
239000003960 organic solvent Substances 0.000 description 3
QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical group CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 2
239000013078 crystal Substances 0.000 description 2
238000001556 precipitation Methods 0.000 description 2
230000003595 spectral effect Effects 0.000 description 2
238000001228 spectrum Methods 0.000 description 2
238000001665 trituration Methods 0.000 description 2
238000001157 Fourier transform infrared spectrum Methods 0.000 description 1
206010020880 Hypertrophy Diseases 0.000 description 1
241001181114 Neta Species 0.000 description 1
ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
238000004458 analytical method Methods 0.000 description 1
PLZFHNWCKKPCMI-UHFFFAOYSA-N cadmium copper Chemical compound [Cu].[Cd] PLZFHNWCKKPCMI-UHFFFAOYSA-N 0.000 description 1
150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
238000002050 diffraction method Methods 0.000 description 1
238000001914 filtration Methods 0.000 description 1
JMMWKPVZQRWMSS-UHFFFAOYSA-N isopropanol acetate Natural products CC(C)OC(C)=O JMMWKPVZQRWMSS-UHFFFAOYSA-N 0.000 description 1
229940011051 isopropyl acetate Drugs 0.000 description 1
GWYFCOCPABKNJV-UHFFFAOYSA-N isovaleric acid Chemical compound CC(C)CC(O)=O GWYFCOCPABKNJV-UHFFFAOYSA-N 0.000 description 1
230000014759 maintenance of location Effects 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
239000004570 mortar (masonry) Substances 0.000 description 1
230000000704 physical effect Effects 0.000 description 1
238000000634 powder X-ray diffraction Methods 0.000 description 1
210000002307 prostate Anatomy 0.000 description 1
239000002002 slurry Substances 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000008247 solid mixture Substances 0.000 description 1
239000007858 starting material Substances 0.000 description 1
238000003756 stirring Methods 0.000 description 1
238000003860 storage Methods 0.000 description 1
230000001629 suppression Effects 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07J—STEROIDS
- C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
- C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
- C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
General Health & Medical Sciences (AREA)
Steroid Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

SK1138-94A 1992-03-24 1993-03-24 N-t-butyl-androst-3,5-diene-17-beta-carboxamide-3-carboxylic acid polymorph a SK113894A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929206413A GB9206413D0 (en)	1992-03-24	1992-03-24	N-t-butyl-androst-3,5-diene-17b-carboxamide-3-carboxylic acid polymorph a
PCT/US1993/002974 WO1993019081A1 (fr)	1992-03-24	1993-03-24	POLYMORPHE A D'ACIDE N-T-BUTYL-ANDROST-3,5-DIENE-17β-CARBOXAMIDE-3-CARBOXYLIQUE

Publications (1)

Publication Number	Publication Date
SK113894A3 true SK113894A3 (en)	1995-04-12

Family

ID=10712749

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1138-94A SK113894A3 (en)	1992-03-24	1993-03-24	N-t-butyl-androst-3,5-diene-17-beta-carboxamide-3-carboxylic acid polymorph a

Country Status (29)

Country	Link
EP (1)	EP0633892B1 (fr)
JP (1)	JP2736169B2 (fr)
CN (1)	CN1078723A (fr)
AP (1)	AP403A (fr)
AT (1)	ATE180490T1 (fr)
AU (1)	AU669522B2 (fr)
BG (1)	BG99062A (fr)
BR (1)	BR9306139A (fr)
CA (1)	CA2132535A1 (fr)
CZ (1)	CZ286266B6 (fr)
DE (1)	DE69325094T2 (fr)
DK (1)	DK0633892T3 (fr)
ES (1)	ES2134260T3 (fr)
FI (1)	FI114709B (fr)
GB (1)	GB9206413D0 (fr)
GR (1)	GR3030779T3 (fr)
HU (1)	HUT68120A (fr)
IL (1)	IL105102A (fr)
MA (1)	MA22841A1 (fr)
MX (1)	MX9301656A (fr)
NO (1)	NO943547L (fr)
NZ (1)	NZ252008A (fr)
OA (1)	OA10100A (fr)
PL (1)	PL172523B1 (fr)
RU (1)	RU94041839A (fr)
SI (1)	SI9300140A (fr)
SK (1)	SK113894A3 (fr)
WO (1)	WO1993019081A1 (fr)
ZA (1)	ZA932014B (fr)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4910226A (en) *	1987-04-29	1990-03-20	Smithkline Beckman Corporation	Steroid 5-alpha-reductase inhibitors
IL104602A (en) *	1992-02-07	1997-07-13	Smithkline Beecham Corp	Process for the preparation of 3-carbonylandrostadiene- 17-carboxamides and intermediates for this process

1992
- 1992-03-24 GB GB929206413A patent/GB9206413D0/en active Pending
1993
- 1993-03-18 IL IL10510293A patent/IL105102A/xx not_active IP Right Cessation
- 1993-03-18 AP APAP/P/1993/000497A patent/AP403A/en active
- 1993-03-22 ZA ZA932014A patent/ZA932014B/xx unknown
- 1993-03-23 SI SI19939300140A patent/SI9300140A/sl unknown
- 1993-03-23 MA MA23136A patent/MA22841A1/fr unknown
- 1993-03-24 CN CN 93103518 patent/CN1078723A/zh active Pending
- 1993-03-24 WO PCT/US1993/002974 patent/WO1993019081A1/fr not_active Ceased
- 1993-03-24 HU HU9402740A patent/HUT68120A/hu unknown
- 1993-03-24 MX MX9301656A patent/MX9301656A/es unknown
- 1993-03-24 PL PL93305206A patent/PL172523B1/pl unknown
- 1993-03-24 SK SK1138-94A patent/SK113894A3/sk unknown
- 1993-03-24 ES ES93911567T patent/ES2134260T3/es not_active Expired - Lifetime
- 1993-03-24 EP EP93911567A patent/EP0633892B1/fr not_active Expired - Lifetime
- 1993-03-24 JP JP5516858A patent/JP2736169B2/ja not_active Expired - Fee Related
- 1993-03-24 CA CA002132535A patent/CA2132535A1/fr not_active Abandoned
- 1993-03-24 NZ NZ252008A patent/NZ252008A/en unknown
- 1993-03-24 BR BR9306139A patent/BR9306139A/pt not_active Application Discontinuation
- 1993-03-24 RU RU94041839/04A patent/RU94041839A/ru unknown
- 1993-03-24 CZ CZ19942319A patent/CZ286266B6/cs not_active IP Right Cessation
- 1993-03-24 DK DK93911567T patent/DK0633892T3/da active
- 1993-03-24 AT AT93911567T patent/ATE180490T1/de not_active IP Right Cessation
- 1993-03-24 DE DE69325094T patent/DE69325094T2/de not_active Expired - Fee Related
- 1993-03-24 AU AU40448/93A patent/AU669522B2/en not_active Ceased
1994
- 1994-09-20 OA OA60561A patent/OA10100A/en unknown
- 1994-09-23 FI FI944414A patent/FI114709B/fi active
- 1994-09-23 NO NO943547A patent/NO943547L/no unknown
- 1994-09-26 BG BG99062A patent/BG99062A/xx unknown
1999
- 1999-07-14 GR GR990401866T patent/GR3030779T3/el unknown

Also Published As

Publication number	Publication date
BR9306139A (pt)	1998-06-23
EP0633892B1 (fr)	1999-05-26
JP2736169B2 (ja)	1998-04-02
GR3030779T3 (en)	1999-11-30
HUT68120A (en)	1995-05-29
AU4044893A (en)	1993-10-21
MX9301656A (es)	1994-02-28
ZA932014B (en)	1994-09-22
IL105102A0 (en)	1994-08-26
RU94041839A (ru)	1996-08-10
EP0633892A4 (fr)	1995-05-17
CZ231994A3 (en)	1995-01-18
AU669522B2 (en)	1996-06-13
DE69325094T2 (de)	1999-11-18
CA2132535A1 (fr)	1993-09-30
FI944414L (fi)	1994-09-23
FI114709B (fi)	2004-12-15
NO943547D0 (no)	1994-09-23
SI9300140A (en)	1993-09-30
NZ252008A (en)	1996-06-25
OA10100A (en)	1996-12-18
AP9300497A0 (en)	1993-04-30
ES2134260T3 (es)	1999-10-01
ATE180490T1 (de)	1999-06-15
DE69325094D1 (de)	1999-07-01
BG99062A (en)	1995-08-28
JPH07505370A (ja)	1995-06-15
MA22841A1 (fr)	1993-10-01
CN1078723A (zh)	1993-11-24
PL172523B1 (pl)	1997-10-31
NO943547L (no)	1994-09-23
CZ286266B6 (cs)	2000-03-15
FI944414A0 (fi)	1994-09-23
DK0633892T3 (da)	2000-04-10
WO1993019081A1 (fr)	1993-09-30
EP0633892A1 (fr)	1995-01-18
AP403A (en)	1995-08-24
HU9402740D0 (en)	1994-12-28
GB9206413D0 (en)	1992-05-06
IL105102A (en)	1997-02-18

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