SK11399A3 - A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction - Google Patents

A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction Download PDF

Info

Publication number: SK11399A3
Authority: SK; Slovakia
Prior art keywords: glycine; nutritional; medicament; cyclosporin; renal dysfunction
Prior art date: 1996-07-30

Application number

SK113-99A

Other languages

English (en)

Slovak (sk)

Inventor

Heinz Schneider

Original Assignee

Novartis Nutrition Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-07-30

Filing date

1997-07-29

Publication date

1999-09-10

1997-07-29 Application filed by Novartis Nutrition Ag filed Critical Novartis Nutrition Ag

1999-09-10 Publication of SK11399A3 publication Critical patent/SK11399A3/sk

Links

DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 title claims abstract description 187
239000004471 Glycine Substances 0.000 title claims abstract description 94
239000000203 mixture Substances 0.000 title claims abstract description 58
235000016709 nutrition Nutrition 0.000 title claims abstract description 48
239000003814 drug Substances 0.000 title claims abstract description 38
230000008085 renal dysfunction Effects 0.000 title claims abstract description 19
238000011321 prophylaxis Methods 0.000 title claims abstract description 14
238000002560 therapeutic procedure Methods 0.000 title claims abstract description 14
238000009472 formulation Methods 0.000 title abstract description 14
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238000002360 preparation method Methods 0.000 claims abstract description 22
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PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims description 41
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235000013024 sodium fluoride Nutrition 0.000 description 1
PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
239000000243 solution Substances 0.000 description 1
239000003549 soybean oil Substances 0.000 description 1
235000012424 soybean oil Nutrition 0.000 description 1
235000019710 soybean protein Nutrition 0.000 description 1
235000013599 spices Nutrition 0.000 description 1
239000008107 starch Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
238000001356 surgical procedure Methods 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000011975 tartaric acid Substances 0.000 description 1
235000002906 tartaric acid Nutrition 0.000 description 1
235000019157 thiamine Nutrition 0.000 description 1
229960003495 thiamine Drugs 0.000 description 1
239000011721 thiamine Substances 0.000 description 1
KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 1
229940113082 thymine Drugs 0.000 description 1
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 1
230000000472 traumatic effect Effects 0.000 description 1
UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
PLSARIKBYIPYPF-UHFFFAOYSA-H trimagnesium dicitrate Chemical compound [Mg+2].[Mg+2].[Mg+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O PLSARIKBYIPYPF-UHFFFAOYSA-H 0.000 description 1
UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 description 1
229940045145 uridine Drugs 0.000 description 1
108010082372 valspodar Proteins 0.000 description 1
229950010938 valspodar Drugs 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000003981 vehicle Substances 0.000 description 1
235000019155 vitamin A Nutrition 0.000 description 1
239000011719 vitamin A Substances 0.000 description 1
235000019156 vitamin B Nutrition 0.000 description 1
239000011720 vitamin B Substances 0.000 description 1
235000019164 vitamin B2 Nutrition 0.000 description 1
239000011716 vitamin B2 Substances 0.000 description 1
239000011718 vitamin C Substances 0.000 description 1
235000019154 vitamin C Nutrition 0.000 description 1
235000019166 vitamin D Nutrition 0.000 description 1
239000011710 vitamin D Substances 0.000 description 1
150000003710 vitamin D derivatives Chemical class 0.000 description 1
235000005282 vitamin D3 Nutrition 0.000 description 1
239000011647 vitamin D3 Substances 0.000 description 1
QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 description 1
235000019168 vitamin K Nutrition 0.000 description 1
239000011712 vitamin K Substances 0.000 description 1
150000003721 vitamin K derivatives Chemical class 0.000 description 1
229940045997 vitamin a Drugs 0.000 description 1
229940046008 vitamin d Drugs 0.000 description 1
229940021056 vitamin d3 Drugs 0.000 description 1
229940046010 vitamin k Drugs 0.000 description 1
238000005303 weighing Methods 0.000 description 1
239000000230 xanthan gum Substances 0.000 description 1
229920001285 xanthan gum Polymers 0.000 description 1
235000010493 xanthan gum Nutrition 0.000 description 1
229940082509 xanthan gum Drugs 0.000 description 1
239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1
NWONKYPBYAMBJT-UHFFFAOYSA-L zinc sulfate Chemical compound [Zn+2].[O-]S([O-])(=O)=O NWONKYPBYAMBJT-UHFFFAOYSA-L 0.000 description 1
239000011686 zinc sulphate Substances 0.000 description 1
235000009529 zinc sulphate Nutrition 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/17—Amino acids, peptides or proteins
- A23L33/175—Amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A61K38/13—Cyclosporins
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Nutrition Science (AREA)
Organic Chemistry (AREA)
Gastroenterology & Hepatology (AREA)
Immunology (AREA)
Chemical Kinetics & Catalysis (AREA)
Mycology (AREA)
General Chemical & Material Sciences (AREA)
Food Science & Technology (AREA)
Polymers & Plastics (AREA)
Urology & Nephrology (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Coloring Foods And Improving Nutritive Qualities (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK113-99A 1996-07-30 1997-07-29 A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction SK11399A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/690,476 US6096785A (en)	1996-07-30	1996-07-30	Amino acid compositions and use thereof in treating renal dysfunction
PCT/EP1997/004125 WO1998004256A1 (en)	1996-07-30	1997-07-29	Amino acid compositions and use thereof in immunosuppression

Publications (1)

Publication Number	Publication Date
SK11399A3 true SK11399A3 (en)	1999-09-10

Family

ID=24772611

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK113-99A SK11399A3 (en)	1996-07-30	1997-07-29	A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction

Country Status (17)

Country	Link
US (2)	US6096785A (cs)
EP (1)	EP0952827A1 (cs)
JP (1)	JP4199308B2 (cs)
KR (1)	KR20000029698A (cs)
CN (1)	CN1146414C (cs)
AU (1)	AU722442B2 (cs)
CA (1)	CA2260956A1 (cs)
CZ (1)	CZ31299A3 (cs)
ID (1)	ID19428A (cs)
IL (1)	IL127907A0 (cs)
MY (1)	MY124560A (cs)
NO (1)	NO325946B1 (cs)
PL (1)	PL331355A1 (cs)
RU (1)	RU2219925C2 (cs)
SK (1)	SK11399A3 (cs)
WO (1)	WO1998004256A1 (cs)
ZA (1)	ZA976807B (cs)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9701674D0 (en) *	1997-01-28	1997-03-19	Novartis Nutrition Ag	Use of organic compounds
EP0882451B1 (en) *	1997-06-05	2004-05-12	Novartis Nutrition AG	Glycine for prevention or treatment of transplant rejection
US6281244B1 (en) *	1997-06-05	2001-08-28	Novartis Nutrition Ag	Therapeutic use for glycine
US6288116B1 (en) *	1998-05-13	2001-09-11	Novartis Nutrition Ag	Method of administration of a nutritional product to a person having renal failure
US20070032853A1 (en)	2002-03-27	2007-02-08	Hossainy Syed F	40-O-(2-hydroxy)ethyl-rapamycin coated stent
DE60011261T2 (de) *	2000-07-14	2005-08-25	Nutri-Fit Gmbh & Co. Kg	Grüntee-Extrakt zur Behandlung von Cyclosporin oder Ascomycin induzierten Nieren-Funktionsstörungen
CA2439293A1 (en) *	2001-03-05	2002-09-12	Stephen P. Ernest	Enteral formulation
PE20030828A1 (es) *	2002-03-04	2003-11-04	Novartis Ag	Composicion oftalmica que comprende ascomicina
US20050118344A1 (en)	2003-12-01	2005-06-02	Pacetti Stephen D.	Temperature controlled crimping
US20060281642A1 (en) *	2005-05-18	2006-12-14	David Colbourne	Lubricating oil composition and use thereof
JP4256419B2 (ja)	2006-10-05	2009-04-22	ファナック株式会社	旋削加工用のプログラム作成装置
AU2012237345A1 (en) *	2011-03-31	2013-09-19	Nestec S.A.	Nutritional compositions for increasing arginine levels and methods of using same
CN103458890A (zh) *	2011-04-12	2013-12-18	雀巢产品技术援助有限公司	包括支链脂肪酸的营养组合物及其使用方法
JOP20190146A1 (ar)	2016-12-19	2019-06-18	Axcella Health Inc	تركيبات حمض أميني وطرق لمعالجة أمراض الكبد
MX2020001765A (es)	2017-08-14	2020-07-29	Axcella Health Inc	Composiciones de aminoacidos para el tratamiento de enfermedad hepatica.
CN112839643A (zh)	2018-06-20	2021-05-25	胺细拉健康公司	用于治疗肌肉中脂肪浸润的组合物及方法

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3843241A1 (de) *	1988-12-22	1990-06-28	Skrezek Christian	Nephroprotektive infusionsloesung
US5290538A (en) *	1988-12-22	1994-03-01	Skrezek Christian	Nephro protective infusion solutions
CN1074134A (zh) *	1992-01-10	1993-07-14	I·A·考米沙劳娃	药用粒化组合物及其制备方法
US5576287A (en) *	1994-04-29	1996-11-19	Wake Forest University	Method for treating acute renal disease and failure
US5656608B1 (en) *	1995-02-23	2000-09-26	Novartis Nutrition Ltd	Amino acid compositions and methods of treatment using same
HUP9800049A3 (en) *	1995-02-23	1999-01-28	Novartis Nutrition Ag	Amino acid compositions and use thereof in clinical nutrition, and use of the said amino acids for preparing pharmaceutical compns. for the diminution of tnf

1996
- 1996-07-30 US US08/690,476 patent/US6096785A/en not_active Expired - Fee Related
1997
- 1997-07-25 ID IDP972588A patent/ID19428A/id unknown
- 1997-07-29 EP EP97934554A patent/EP0952827A1/en not_active Withdrawn
- 1997-07-29 RU RU99103692/15A patent/RU2219925C2/ru not_active IP Right Cessation
- 1997-07-29 PL PL97331355A patent/PL331355A1/xx unknown
- 1997-07-29 MY MYPI97003455A patent/MY124560A/en unknown
- 1997-07-29 CA CA002260956A patent/CA2260956A1/en not_active Abandoned
- 1997-07-29 CZ CZ99312A patent/CZ31299A3/cs unknown
- 1997-07-29 AU AU37716/97A patent/AU722442B2/en not_active Ceased
- 1997-07-29 US US09/230,873 patent/US6204244B1/en not_active Expired - Fee Related
- 1997-07-29 JP JP50851598A patent/JP4199308B2/ja not_active Expired - Fee Related
- 1997-07-29 CN CNB971969019A patent/CN1146414C/zh not_active Expired - Fee Related
- 1997-07-29 IL IL12790797A patent/IL127907A0/xx not_active IP Right Cessation
- 1997-07-29 KR KR1019997000797A patent/KR20000029698A/ko not_active Ceased
- 1997-07-29 WO PCT/EP1997/004125 patent/WO1998004256A1/en not_active Ceased
- 1997-07-29 SK SK113-99A patent/SK11399A3/sk unknown
- 1997-07-30 ZA ZA976807A patent/ZA976807B/xx unknown
1999
- 1999-01-27 NO NO19990373A patent/NO325946B1/no not_active IP Right Cessation

Also Published As

Publication number	Publication date
PL331355A1 (en)	1999-07-05
JP4199308B2 (ja)	2008-12-17
AU722442B2 (en)	2000-08-03
WO1998004256A1 (en)	1998-02-05
ZA976807B (en)	1999-02-01
KR20000029698A (ko)	2000-05-25
EP0952827A1 (en)	1999-11-03
US6096785A (en)	2000-08-01
CN1146414C (zh)	2004-04-21
ID19428A (id)	1998-07-09
MY124560A (en)	2006-06-30
AU3771697A (en)	1998-02-20
RU2219925C2 (ru)	2003-12-27
NO990373L (no)	1999-01-27
NO990373D0 (no)	1999-01-27
NO325946B1 (no)	2008-08-25
CA2260956A1 (en)	1998-02-05
CN1226827A (zh)	1999-08-25
JP2000515875A (ja)	2000-11-28
IL127907A0 (en)	1999-11-30
US6204244B1 (en)	2001-03-20
CZ31299A3 (cs)	1999-05-12

Publication	Publication Date	Title
US5231085A (en)	1993-07-27	Compositions and methods for the enhancement of host defense mechanisms
DE69607750T2 (de)	2000-08-31	Aminosäurenzusammensetzungen und verwendung derselben klinischen nährung
SK11399A3 (en)	1999-09-10	A medicament or nutritional formulation on glycine base for the prophylaxis and/or therapy of renal dysfunction
EP0367724B1 (en)	1993-02-10	Improvements in or relating to organic compounds
US5612060A (en)	1997-03-18	Enhancement of transplant graft survival through nutritional immunomodulation and immunosuppressive therapy
SK106594A3 (en)	1995-09-13	Nutrituve supplement
US5888553A (en)	1999-03-30	Non-steroidal anabolic composition
EP1542669A1 (en)	2005-06-22	Leucine-enriched nutritional compositions
US6048543A (en)	2000-04-11	Amino acid compositions and use thereof in clinical nutrition
US5268365A (en)	1993-12-07	Nucleotides, nucleosides, and nucleobases in immune function restoration enhancement or maintenance
ES2285700T3 (es)	2007-11-16	Composiciones para mejorar la respuesta inmune.
US6013273A (en)	2000-01-11	Treatment of endotoxic shock
US6864230B2 (en)	2005-03-08	Glutamine rich dietary composition
WO1998004255A1 (en)	1998-02-05	Amino acid composition and use thereof in treating tumor growth and metastasis
RU2740905C2 (ru)	2021-01-21	Питательный продукт для снижения уровней фенилаланина у больных фку
EP0882451B1 (en)	2004-05-12	Glycine for prevention or treatment of transplant rejection
HUP9903208A2 (hu)	2000-02-28	Aminosav tartalmú, immunszuppressziós hatású készítmények és glicin alkalmazása ilyen készítmények előállítására
HK1020877A (en)	2000-05-26	Amino acid compositions and use thereof in immunosuppression
MXPA97006140A (en)	1998-07-03	Compositions of amino acids and the use of them in nutrition clin