SK12082003A3 - Benzamidínové deriváty - Google Patents

Benzamidínové deriváty Download PDF

Info

Publication number
SK12082003A3
SK12082003A3 SK1208-2003A SK12082003A SK12082003A3 SK 12082003 A3 SK12082003 A3 SK 12082003A3 SK 12082003 A SK12082003 A SK 12082003A SK 12082003 A3 SK12082003 A3 SK 12082003A3
Authority
SK
Slovakia
Prior art keywords
group
etooc
prodrug
pharmacologically acceptable
acceptable salt
Prior art date
Application number
SK1208-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Koichi Fujimoto
Naoki Tanaka
Ikuko Shimada
Fumitoshi Asai
Original Assignee
Sankyo Company Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Company Limited filed Critical Sankyo Company Limited
Publication of SK12082003A3 publication Critical patent/SK12082003A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/422—Oxazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/46—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with hetero atoms directly attached to the ring nitrogen atom
    • C07D207/48—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/40—Oxygen atoms
    • C07D211/44—Oxygen atoms attached in position 4
    • C07D211/46—Oxygen atoms attached in position 4 having a hydrogen atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/92—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with a hetero atom directly attached to the ring nitrogen atom
    • C07D211/96—Sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK1208-2003A 2001-04-05 2002-04-03 Benzamidínové deriváty SK12082003A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2001107615 2001-04-05
PCT/JP2002/003355 WO2002081448A1 (en) 2001-04-05 2002-04-03 Benzamidine derivative

Publications (1)

Publication Number Publication Date
SK12082003A3 true SK12082003A3 (sk) 2004-09-08

Family

ID=18959909

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1208-2003A SK12082003A3 (sk) 2001-04-05 2002-04-03 Benzamidínové deriváty

Country Status (19)

Country Link
US (1) US7030138B2 (cs)
EP (1) EP1375482A4 (cs)
KR (1) KR20030087056A (cs)
CN (1) CN1610666A (cs)
AU (1) AU2002246336B2 (cs)
BR (1) BR0208678A (cs)
CA (1) CA2442904A1 (cs)
CO (1) CO5550436A2 (cs)
CZ (1) CZ20032728A3 (cs)
HU (1) HUP0400384A3 (cs)
IL (1) IL158076A0 (cs)
MX (1) MXPA03009097A (cs)
NO (1) NO20034439L (cs)
NZ (1) NZ528517A (cs)
PL (1) PL363961A1 (cs)
RU (1) RU2256652C1 (cs)
SK (1) SK12082003A3 (cs)
WO (1) WO2002081448A1 (cs)
ZA (1) ZA200307646B (cs)

Families Citing this family (68)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10162114A1 (de) * 2001-12-12 2003-06-26 Schering Ag Neue Amidin-Derivate und deren Verwendung in Arzneimitteln
GB0321781D0 (en) 2003-09-17 2003-10-15 Toppan Printing Company Ltd Electroluminescent device
JP4390113B2 (ja) 2003-11-10 2009-12-24 ケンブリッジ ディスプレイ テクノロジー リミテッド ジベンゾシロールポリマー及びその製造方法
GB0329364D0 (en) 2003-12-19 2004-01-21 Cambridge Display Tech Ltd Optical device
KR100804452B1 (ko) 2004-03-31 2008-02-20 닛뽕소다 가부시키가이샤 환형 아민 화합물 및 유해 생물 방제제
AU2005228289B2 (en) * 2004-03-31 2008-01-10 Nippon Soda Co., Ltd. Cyclic amine compound and pest control agent
GB0422391D0 (en) 2004-10-08 2004-11-10 Cambridge Display Tech Ltd Light emitting device
GB0427266D0 (en) 2004-12-13 2005-01-12 Cambridge Display Tech Ltd Phosphorescent OLED
US9179518B2 (en) 2004-12-24 2015-11-03 Cambridge Display Technology Limited Light emissive device
GB2460358B (en) 2004-12-29 2010-01-13 Cambridge Display Tech Ltd Rigid amines
GB0428445D0 (en) 2004-12-29 2005-02-02 Cambridge Display Tech Ltd Blue-shifted triarylamine polymer
GB0428444D0 (en) 2004-12-29 2005-02-02 Cambridge Display Tech Ltd Conductive polymer compositions in opto-electrical devices
GB2426376B (en) * 2005-05-19 2008-12-03 Cdt Oxford Ltd Light-emitting device
GB0514476D0 (en) 2005-07-14 2005-08-17 Cambridge Display Tech Ltd Conductive polymer compositions in opto-electrical devices
US8338607B2 (en) 2005-10-06 2012-12-25 Nippon Soda Co., Ltd. Cyclic amine compounds and agents for pest control
GB2433509A (en) 2005-12-22 2007-06-27 Cambridge Display Tech Ltd Arylamine polymer
GB0526185D0 (en) 2005-12-22 2006-02-01 Cambridge Display Tech Ltd Electronic device
GB0526393D0 (en) 2005-12-23 2006-02-08 Cdt Oxford Ltd Light emissive device
GB2433833A (en) 2005-12-28 2007-07-04 Cdt Oxford Ltd Micro-cavity OLED layer structure with transparent electrode
WO2007089101A1 (en) * 2006-01-31 2007-08-09 Dong Wha Pharmaceutical Ind.Co., Ltd. Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition comprising the same
GB2434916A (en) * 2006-02-03 2007-08-08 Cdt Oxford Ltd OLED for full colour display
GB2434915A (en) 2006-02-03 2007-08-08 Cdt Oxford Ltd Phosphoescent OLED for full colour display
GB0605120D0 (en) 2006-03-14 2006-04-26 Novartis Ag Organic Compounds
GB2440934B (en) 2006-04-28 2009-12-16 Cdt Oxford Ltd Opto-electrical polymers and devices
TWI442563B (zh) 2006-08-01 2014-06-21 劍橋顯示科技有限公司 製造光電裝置之方法
GB0617167D0 (en) * 2006-08-31 2006-10-11 Cdt Oxford Ltd Compounds for use in opto-electrical devices
GB0617723D0 (en) * 2006-09-08 2006-10-18 Cambridge Display Tech Ltd Conductive polymer compositions in opto-electrical devices
GB0620045D0 (en) 2006-10-10 2006-11-22 Cdt Oxford Ltd Otpo-electrical devices and methods of making the same
GB2442724B (en) * 2006-10-10 2009-10-21 Cdt Oxford Ltd Light emissive device
US20100249402A1 (en) * 2007-07-27 2010-09-30 Dong Wha Pharmaceutical Co. Ltd. Novel benzamidine derivatives, process for the preparation thereof and pharmaceutical composition for preventing or treating osteporosis comprising the same
GB2454890B (en) 2007-11-21 2010-08-25 Limited Cambridge Display Technology Light-emitting device and materials therefor
GB2455747B (en) 2007-12-19 2011-02-09 Cambridge Display Tech Ltd Electronic devices and methods of making the same using solution processing techniques
GB2456788B (en) 2008-01-23 2011-03-09 Cambridge Display Tech Ltd White light emitting material
GB2466730B (en) * 2008-01-23 2011-04-20 Cambridge Display Tech Ltd Phosphorescent compositions and their use in displays
GB2458454B (en) 2008-03-14 2011-03-16 Cambridge Display Tech Ltd Electronic devices and methods of making the same using solution processing techniques
GB2459895B (en) 2008-05-09 2011-04-27 Cambridge Display Technology Limited Organic light emissive device
AU2009253078B2 (en) * 2008-05-30 2014-04-17 Novo Nordisk Health Care Ag Method of controlling a polypeptide modification reaction
GB2461527B (en) * 2008-07-01 2011-08-03 Limited Cambridge Display Technology Organic electronic device
GB2462410B (en) 2008-07-21 2011-04-27 Cambridge Display Tech Ltd Compositions and methods for manufacturing light-emissive devices
GB2462122B (en) 2008-07-25 2013-04-03 Cambridge Display Tech Ltd Electroluminescent materials
GB2462314B (en) 2008-08-01 2011-03-16 Cambridge Display Tech Ltd Organic light-emiting materials and devices
GB0814161D0 (en) 2008-08-01 2008-09-10 Cambridge Display Tech Ltd Blue-light emitting material
GB0814971D0 (en) 2008-08-15 2008-09-24 Cambridge Display Tech Ltd Opto-electrical devices and methods of manufacturing the same
GB2462688B (en) * 2008-08-22 2012-03-07 Cambridge Display Tech Ltd Opto-electrical devices and methods of manufacturing the same
GB2469498B (en) 2009-04-16 2012-03-07 Cambridge Display Tech Ltd Polymer and polymerisation method
GB2469497B (en) 2009-04-16 2012-04-11 Cambridge Display Tech Ltd Polymers comprising fluorene derivative repeat units and their preparation
GB0906554D0 (en) 2009-04-16 2009-05-20 Cambridge Display Tech Ltd Organic electroluminescent device
GB2469500B (en) 2009-04-16 2012-06-06 Cambridge Display Tech Ltd Method of forming a polymer
GB2475247B (en) 2009-11-10 2012-06-13 Cambridge Display Tech Ltd Organic optoelectronic device and method
GB2475246B (en) 2009-11-10 2012-02-29 Cambridge Display Tech Ltd Organic opto-electronic device and method
GB2484253B (en) 2010-05-14 2013-09-11 Cambridge Display Tech Ltd Organic light-emitting composition and device
GB2487342B (en) 2010-05-14 2013-06-19 Cambridge Display Tech Ltd Host polymer comprising conjugated repeat units and non-conjugated repeat units for light-emitting compositions, and organic light-emitting devices
GB2485001A (en) 2010-10-19 2012-05-02 Cambridge Display Tech Ltd OLEDs
GB201122316D0 (en) 2011-12-23 2012-02-01 Cambridge Display Tech Ltd Polymer, polymer composition and organic light-emitting device
GB2494096B (en) 2011-01-31 2013-12-18 Cambridge Display Tech Ltd Polymer
CN103339167B (zh) 2011-01-31 2018-01-12 剑桥显示技术有限公司 聚合物
GB201105582D0 (en) 2011-04-01 2011-05-18 Cambridge Display Tech Ltd Organic light-emitting device and method
GB201107905D0 (en) 2011-05-12 2011-06-22 Cambridge Display Tech Ltd Light-emitting material, composition and device
GB201110564D0 (en) 2011-06-22 2011-08-03 Cambridge Display Tech Ltd Polymer and optoelectronic device
WO2013005028A1 (en) 2011-07-04 2013-01-10 Cambridge Display Technology Limited Organic light emitting device and fabrication method thereof
GB201111742D0 (en) 2011-07-08 2011-08-24 Cambridge Display Tech Ltd Solution
GB201210131D0 (en) 2011-11-02 2012-07-25 Cambridge Display Tech Ltd Light emitting composition and device
GB201118997D0 (en) 2011-11-03 2011-12-14 Cambridge Display Tech Ltd Electronic device and method
GB201200619D0 (en) 2012-01-16 2012-02-29 Cambridge Display Tech Ltd Polymer
GB2515909B (en) 2012-01-31 2020-07-15 Cambridge Display Tech Ltd Composition comprising a fluorescent light-emitting material and triplet-accepting polymer and use thereof
GB2508410A (en) 2012-11-30 2014-06-04 Cambridge Display Tech Ltd Polymer and organic electronic device
GB2514818B (en) 2013-06-05 2015-12-16 Cambridge Display Tech Ltd Polymer and organic electronic device
US12092597B2 (en) * 2021-12-03 2024-09-17 Palo Alto Research Center Incorporated Arylphosphine nanomaterial constructs for moisture-insensitive formaldehyde gas sensing

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2004A (en) * 1841-03-12 Improvement in the manner of constructing and propelling steam-vessels
ZA928276B (en) 1991-10-31 1993-05-06 Daiichi Seiyaku Co Aromatic amidine derivates and salts thereof.
PL184824B1 (pl) 1994-12-02 2002-12-31 Yamanouchi Pharmaceu Pochodne amidynonaftylowe oraz ich sole oraz kompozycja farmaceutyczna zawierająca pochodną amidynonaftylową lub jej sól
TW542822B (en) 1997-01-17 2003-07-21 Ajinomoto Kk Benzamidine derivatives
AU4166400A (en) 1999-02-11 2000-08-29 Cor Therapeutics, Inc. Alkenyl and alkynyl compounds as inhibitors of factor xa
US6350761B1 (en) * 1999-07-30 2002-02-26 Berlex Laboratories, Inc. Benzenamine derivatives as anti-coagulants
MXPA02004218A (es) * 1999-10-28 2002-10-17 Sankyo Co Derivados de benzamidina.

Also Published As

Publication number Publication date
HUP0400384A3 (en) 2008-08-28
CN1610666A (zh) 2005-04-27
ZA200307646B (en) 2004-07-13
NO20034439D0 (no) 2003-10-03
WO2002081448A1 (en) 2002-10-17
US7030138B2 (en) 2006-04-18
BR0208678A (pt) 2004-03-30
PL363961A1 (en) 2004-11-29
CO5550436A2 (es) 2005-08-31
NZ528517A (en) 2004-08-27
RU2003129502A (ru) 2005-04-10
CA2442904A1 (en) 2002-10-17
EP1375482A4 (en) 2005-01-19
RU2256652C1 (ru) 2005-07-20
NO20034439L (no) 2003-12-02
HUP0400384A2 (hu) 2004-09-28
KR20030087056A (ko) 2003-11-12
IL158076A0 (en) 2004-03-28
EP1375482A1 (en) 2004-01-02
CZ20032728A3 (cs) 2004-02-18
MXPA03009097A (es) 2004-02-12
US20040147555A1 (en) 2004-07-29
AU2002246336B2 (en) 2005-05-19

Similar Documents

Publication Publication Date Title
SK12082003A3 (sk) Benzamidínové deriváty
US6140333A (en) N-acyl cyclic amine derivatives
US7652021B2 (en) Compounds useful for DPP-IV enzyme inhibition
US7504432B2 (en) Ester derivatives
AU2001268718B2 (en) Aryl phenylheterocyclyl sulfide derivatives and their use as cell adhesion-inhibiting anti-inflammatory and immune-suppressive agents
US7087597B1 (en) Pyrimidine 5-carboxamide compounds, process for producing the same and use thereof
CA2930142C (en) Tetrahydrobenzimidazole derivatives as modulators of tnf activity
CZ295580B6 (cs) Chinoliny a chinazoliny, způsob a meziprodukty pro jejich výrobu, jejich použití a farmaceutické prostředky na jejich bázi
CA3179059A1 (en) Collagen 1 translation inhibitors and methods of use thereof
US7265145B2 (en) Substituted piperidines and pyrrolidines as calcium sensing receptor modulators and method
KR102585193B1 (ko) 신규한 lrrk2 억제제
CZ292379B6 (cs) Tetrahydrochinolinové deriváty, způsob jejich výroby a farmaceutický prostředek s jejich obsahem
ES2299561T3 (es) Analogo de bencilamina.
US20050004154A1 (en) 1,2,8-Triazaspiro{decan-4-one derivatives useful for the treatment of orl-1receptor mediated disorders
US10376502B2 (en) Alkylated imino sugars exhibiting glucosidase inhibition and their method of use
JP2004143164A (ja) 活性化血液凝固第ｘ因子阻害剤
HK1058038A (en) Benzamidine derivative
Khanna et al. Nucleophilic Opening of N-Carboalkoxy-2, 3-anhydro-1-deoxymannojirimycin. A Useful Method for the Syntheses of 2-, 3-and 2, 3-Disubstituted 1-Deoxynojirimycin Analogs
JP2002363159A (ja) ベンズアミジン誘導体
JP3154884B2 (ja) 脂環式アミン誘導体
JP7061663B2 (ja) 新規な１ｈ－ピラゾロピリジン誘導体およびこれを含む薬学組成物
WO2002036122A1 (en) Preventive or therapeutic medicines for hepatitis and/or hepatopathy
JP3730108B2 (ja) ベンズアミジン誘導体
US20010034357A1 (en) Substituted pyridine compounds useful for controlling chemical synaptic transmission
DE10124867A1 (de) Substituierte Aryl- und Heteroarylderivate, deren Herstellung und deren Verwendung als Arzneimittel

Legal Events

Date Code Title Description
FC9A Refused patent application