SK13097A3 - Optically active (-)-(3r)-3-methyl-4-{4-£4-(4-pyridyl)piperazin- -1-yl|phenoxy} butyric acid and its derivatives, preparation method thereof and their use - Google Patents

Optically active (-)-(3r)-3-methyl-4-{4-£4-(4-pyridyl)piperazin- -1-yl|phenoxy} butyric acid and its derivatives, preparation method thereof and their use Download PDF

Info

Publication number
SK13097A3
SK13097A3 SK130-97A SK13097A SK13097A3 SK 13097 A3 SK13097 A3 SK 13097A3 SK 13097 A SK13097 A SK 13097A SK 13097 A3 SK13097 A3 SK 13097A3
Authority
SK
Slovakia
Prior art keywords
optically active
ester
pharmaceutically acceptable
active compound
amide
Prior art date
Application number
SK130-97A
Other languages
English (en)
Slovak (sk)
Inventor
Stuart Dennett Mills
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of SK13097A3 publication Critical patent/SK13097A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SK130-97A 1995-06-01 1996-05-28 Optically active (-)-(3r)-3-methyl-4-{4-£4-(4-pyridyl)piperazin- -1-yl|phenoxy} butyric acid and its derivatives, preparation method thereof and their use SK13097A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative
PCT/GB1996/001260 WO1996038416A1 (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor

Publications (1)

Publication Number Publication Date
SK13097A3 true SK13097A3 (en) 1997-08-06

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
SK130-97A SK13097A3 (en) 1995-06-01 1996-05-28 Optically active (-)-(3r)-3-methyl-4-{4-£4-(4-pyridyl)piperazin- -1-yl|phenoxy} butyric acid and its derivatives, preparation method thereof and their use

Country Status (31)

Country Link
EP (1) EP0796247A1 (da)
JP (1) JP2885941B2 (da)
KR (1) KR100245957B1 (da)
AT (1) AT406675B (da)
AU (1) AU710105B2 (da)
BE (1) BE1009520A5 (da)
BR (1) BR9606409A (da)
CA (1) CA2194397A1 (da)
CH (1) CH691808A5 (da)
CZ (1) CZ26997A3 (da)
DE (1) DE19680509T1 (da)
DK (1) DK10697A (da)
ES (1) ES2137886B1 (da)
FI (1) FI970393A0 (da)
GB (1) GB2304340B (da)
GR (1) GR1002702B (da)
HU (1) HUP9700274A3 (da)
IE (1) IE960405A1 (da)
IL (1) IL118477A0 (da)
IT (1) IT1290839B1 (da)
LU (1) LU90008B1 (da)
MC (1) MC2418A1 (da)
MX (1) MX9700379A (da)
NL (1) NL1003243C2 (da)
NO (1) NO307460B1 (da)
NZ (1) NZ308597A (da)
PL (1) PL318440A1 (da)
SE (1) SE510812C2 (da)
SK (1) SK13097A3 (da)
TR (1) TR199700020T1 (da)
WO (1) WO1996038416A1 (da)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
GB9406144D0 (en) * 1993-03-29 1994-05-18 Zeneca Ltd Heterocyclic compounds
WO1994022834A1 (en) * 1993-03-29 1994-10-13 Zeneca Limited Heterocyclic derivatives as platelet aggregation inhibitors

Also Published As

Publication number Publication date
FI970393A7 (fi) 1997-01-30
IT1290839B1 (it) 1998-12-14
BE1009520A5 (fr) 1997-04-01
NO970437L (no) 1997-02-20
FI970393L (fi) 1997-01-30
HU9700274D0 (en) 1997-04-28
AU710105B2 (en) 1999-09-16
ITMI961113A0 (it) 1996-05-31
HUP9700274A3 (en) 2000-02-28
MC2418A1 (fr) 1997-05-23
NO307460B1 (no) 2000-04-10
GR1002702B (el) 1997-05-22
CZ26997A3 (en) 1997-08-13
ATA900596A (de) 1999-12-15
IL118477A0 (en) 1996-09-12
IE960405A1 (en) 1996-12-11
ES2137886A1 (es) 1999-12-16
PL318440A1 (en) 1997-06-09
WO1996038416A1 (en) 1996-12-05
AU5827296A (en) 1996-12-18
JP2885941B2 (ja) 1999-04-26
GB9627127D0 (en) 1997-02-19
CH691808A5 (de) 2001-10-31
NO970437D0 (no) 1997-01-31
AT406675B (de) 2000-07-25
TR199700020T1 (tr) 1997-04-22
SE9700203D0 (sv) 1997-01-24
KR970704689A (ko) 1997-09-06
HUP9700274A2 (hu) 1999-06-28
CA2194397A1 (en) 1996-12-05
GB2304340A (en) 1997-03-19
KR100245957B1 (ko) 2000-04-01
GB2304340B (en) 1998-07-29
MX9700379A (es) 1997-04-30
EP0796247A1 (en) 1997-09-24
FI970393A0 (fi) 1997-01-30
DE19680509T1 (de) 1997-12-04
NL1003243C2 (nl) 1996-12-04
NZ308597A (en) 1998-11-25
DK10697A (da) 1997-04-01
SE510812C2 (sv) 1999-06-28
SE9700203L (sv) 1997-01-24
ITMI961113A1 (it) 1997-12-01
JPH09512836A (ja) 1997-12-22
LU90008B1 (fr) 1997-04-16
BR9606409A (pt) 1997-09-30
ES2137886B1 (es) 2000-08-16

Similar Documents

Publication Publication Date Title
DE69912379T2 (de) Antithrombosemittel
US6333337B1 (en) Potassium channel inhibitors
RU2158733C2 (ru) Производные 2,8-дизамещенного хиназолинона или их соли, фармацевтическая композиция с воздействующей на уровень кгмп и камп активностью на их основе
CZ250995A3 (en) Pyridine derivatives, process of their preparation and intermediates employed in this process as well as pharmaceutical compositions containing thereof
JP2002528495A (ja) ニトロソ化およびニトロシル化された非ステロイド抗炎症性化合物、組成物および使用方法
US4873253A (en) Phenylalanine derivative and proteinase inhibitor
CZ297544B6 (cs) Substituované N-[(aminoiminomethyl)-fenyl]propylamidy nebo N-[(aminomethyl)fenyl]propylamidy
SK1272000A3 (en) Heterocyclic derivatives which inhibit factor xa
SK16512000A3 (sk) Heterocyklické deriváty inhibujúce faktor xa, farmaceutická kompozícia s ich obsahom a ich použitie
JP2013543850A (ja) 新規な化合物、その製造方法および用途
SK6992000A3 (en) Compounds useful as competitive inhibitors of trypsin-like serine proteases, method for the preparation thereof, pharmaceutical compositions containing same and their use
EP1124824B1 (de) Chromenon- und chromanonderivate als integrinhemmer
JPH09502448A (ja) 心臓血管系に活性な２−アミノ−１，２，３，４−テトラヒドロナフタレン誘導体
KR101373911B1 (ko) Ｂｃｌ 단백질과 결합 파트너의 상호작용을 억제하기 위한화합물 및 방법
US5137914A (en) Sulfonylamino substituted bicyclo [2.2.1]heptane hydroxamic acid derivatives useful as pharmaceuticals
AU2009248231A1 (en) Novel N-(2-amino-phenyl)-acrylamides
FR2758329A1 (fr) Derives d'imidazole-4-butane boronique, leur preparation et leur utilisation en therapeutique
AU2004276128A1 (en) Amide-type carboxamide derivatives
JPH0717942A (ja) 化合物
US4963587A (en) Glycine derivative and pharmaceutical preparation thereof
AU710105B2 (en) (-)-(3R0-3-methyl-4-(4-(4-(4-pyridyl)piperazin-1-yl)phenoxy) butyric acid as cellular adhesion inhibitor
US5672712A (en) Thiazoline derivatives
CZ389698A3 (cs) Derivát substituovaného amidinobenzenu a farmaceutický prostředek, který ho obsahuje
JPH0770046A (ja) アロファン酸誘導体
CN1155884A (zh) 作为细胞粘连抑制剂的(-)-(3r)-3-甲基-4-(4-(4-(4-吡啶基)哌嗪-1-基)苯氧基)丁酸