CA2194397A1 - (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor - Google Patents

(-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor

Info

Publication number
CA2194397A1
CA2194397A1 CA002194397A CA2194397A CA2194397A1 CA 2194397 A1 CA2194397 A1 CA 2194397A1 CA 002194397 A CA002194397 A CA 002194397A CA 2194397 A CA2194397 A CA 2194397A CA 2194397 A1 CA2194397 A1 CA 2194397A1
Authority
CA
Canada
Prior art keywords
optically active
pharmaceutically
ester
active compound
amide
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA002194397A
Other languages
English (en)
French (fr)
Inventor
Stuart Dennett Mills
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/457,538 external-priority patent/US5652242A/en
Priority claimed from GBGB9518188.9A external-priority patent/GB9518188D0/en
Application filed by Individual filed Critical Individual
Publication of CA2194397A1 publication Critical patent/CA2194397A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
CA002194397A 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor Abandoned CA2194397A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/457538 1995-06-01
US08/457,538 US5652242A (en) 1993-03-29 1995-06-01 Heterocyclic derivatives
GB9518188.9 1995-09-07
GBGB9518188.9A GB9518188D0 (en) 1995-09-07 1995-09-07 Optically active derivative

Publications (1)

Publication Number Publication Date
CA2194397A1 true CA2194397A1 (en) 1996-12-05

Family

ID=26307696

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002194397A Abandoned CA2194397A1 (en) 1995-06-01 1996-05-28 (-)-(3r)-3-methyl-4-{4-[4-(4-pyridyl)piperazin-1-yl]phenoxy} butyric acid as cellular adhesion inhibitor

Country Status (31)

Country Link
EP (1) EP0796247A1 (da)
JP (1) JP2885941B2 (da)
KR (1) KR100245957B1 (da)
AT (1) AT406675B (da)
AU (1) AU710105B2 (da)
BE (1) BE1009520A5 (da)
BR (1) BR9606409A (da)
CA (1) CA2194397A1 (da)
CH (1) CH691808A5 (da)
CZ (1) CZ26997A3 (da)
DE (1) DE19680509T1 (da)
DK (1) DK10697A (da)
ES (1) ES2137886B1 (da)
FI (1) FI970393A0 (da)
GB (1) GB2304340B (da)
GR (1) GR1002702B (da)
HU (1) HUP9700274A3 (da)
IE (1) IE960405A1 (da)
IL (1) IL118477A0 (da)
IT (1) IT1290839B1 (da)
LU (1) LU90008B1 (da)
MC (1) MC2418A1 (da)
MX (1) MX9700379A (da)
NL (1) NL1003243C2 (da)
NO (1) NO307460B1 (da)
NZ (1) NZ308597A (da)
PL (1) PL318440A1 (da)
SE (1) SE510812C2 (da)
SK (1) SK13097A3 (da)
TR (1) TR199700020T1 (da)
WO (1) WO1996038416A1 (da)

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0100158A3 (en) * 1982-07-28 1985-03-27 The Upjohn Company (3-pyridinyl)heteroalkarylalkanols, alkanoic acids and esters
GB8609630D0 (en) * 1986-04-19 1986-05-21 Pfizer Ltd Anti-arrhythmia agents
AU692438B2 (en) * 1993-03-29 1998-06-11 Astrazeneca Ab Heterocyclic derivatives as platelet aggregation inhibitors
EP0690847A1 (en) * 1993-03-29 1996-01-10 Zeneca Limited Heterocyclic compounds as platelet aggregation inhibitors

Also Published As

Publication number Publication date
NO970437D0 (no) 1997-01-31
HUP9700274A2 (hu) 1999-06-28
JP2885941B2 (ja) 1999-04-26
FI970393L (fi) 1997-01-30
SE9700203L (sv) 1997-01-24
IL118477A0 (en) 1996-09-12
ITMI961113A0 (it) 1996-05-31
NL1003243C2 (nl) 1996-12-04
NZ308597A (en) 1998-11-25
JPH09512836A (ja) 1997-12-22
AT406675B (de) 2000-07-25
EP0796247A1 (en) 1997-09-24
CH691808A5 (de) 2001-10-31
TR199700020T1 (tr) 1997-04-22
MC2418A1 (fr) 1997-05-23
GB2304340A (en) 1997-03-19
GB9627127D0 (en) 1997-02-19
ES2137886B1 (es) 2000-08-16
ES2137886A1 (es) 1999-12-16
HU9700274D0 (en) 1997-04-28
CZ26997A3 (en) 1997-08-13
SE9700203D0 (sv) 1997-01-24
BR9606409A (pt) 1997-09-30
SE510812C2 (sv) 1999-06-28
BE1009520A5 (fr) 1997-04-01
NO307460B1 (no) 2000-04-10
GR1002702B (el) 1997-05-22
MX9700379A (es) 1997-04-30
FI970393A7 (fi) 1997-01-30
IT1290839B1 (it) 1998-12-14
ITMI961113A1 (it) 1997-12-01
AU5827296A (en) 1996-12-18
FI970393A0 (fi) 1997-01-30
LU90008B1 (fr) 1997-04-16
KR100245957B1 (ko) 2000-04-01
IE960405A1 (en) 1996-12-11
ATA900596A (de) 1999-12-15
DK10697A (da) 1997-04-01
GB2304340B (en) 1998-07-29
SK13097A3 (en) 1997-08-06
KR970704689A (ko) 1997-09-06
DE19680509T1 (de) 1997-12-04
NO970437L (no) 1997-02-20
PL318440A1 (en) 1997-06-09
AU710105B2 (en) 1999-09-16
HUP9700274A3 (en) 2000-02-28
WO1996038416A1 (en) 1996-12-05

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Legal Events

Date Code Title Description
FZDE Discontinued