SK13242000A3 - Vyhľadávanie a návrh ligandov röntgenovou kryštalografiou - Google Patents

Vyhľadávanie a návrh ligandov röntgenovou kryštalografiou Download PDF

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Publication number
SK13242000A3
SK13242000A3 SK1324-2000A SK13242000A SK13242000A3 SK 13242000 A3 SK13242000 A3 SK 13242000A3 SK 13242000 A SK13242000 A SK 13242000A SK 13242000 A3 SK13242000 A3 SK 13242000A3
Authority
SK
Slovakia
Prior art keywords
ligand
target
crystal
biomolecule
compound
Prior art date
Application number
SK1324-2000A
Other languages
English (en)
Slovak (sk)
Inventor
Vicki L. Nienaber
Jonathan Greer
Celerino Abad-Zapatero
Daniel W. Norbeck
Original Assignee
Abbott Laboratories
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Laboratories filed Critical Abbott Laboratories
Publication of SK13242000A3 publication Critical patent/SK13242000A3/sk

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Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6845Methods of identifying protein-protein interactions in protein mixtures
    • CCHEMISTRY; METALLURGY
    • C30CRYSTAL GROWTH
    • C30BSINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B7/00Single-crystal growth from solutions using solvents which are liquid at normal temperature, e.g. aqueous solutions
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N23/00Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00
    • G01N23/20Investigating or analysing materials by the use of wave or particle radiation, e.g. X-rays or neutrons, not covered by groups G01N3/00 – G01N17/00, G01N21/00 or G01N22/00 by using diffraction of the radiation by the materials, e.g. for investigating crystal structure; by using scattering of the radiation by the materials, e.g. for investigating non-crystalline materials; by using reflection of the radiation by the materials
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6803General methods of protein analysis not limited to specific proteins or families of proteins
    • G01N33/6842Proteomic analysis of subsets of protein mixtures with reduced complexity, e.g. membrane proteins, phosphoproteins, organelle proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2299/00Coordinates from 3D structures of peptides, e.g. proteins or enzymes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90Enzymes; Proenzymes
    • G01N2333/914Hydrolases (3)
    • G01N2333/948Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/972Plasminogen activators
    • G01N2333/9723Urokinase
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • Biotechnology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Materials Engineering (AREA)
  • Metallurgy (AREA)
  • Organic Chemistry (AREA)
  • Analysing Materials By The Use Of Radiation (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SK1324-2000A 1998-03-06 1999-03-05 Vyhľadávanie a návrh ligandov röntgenovou kryštalografiou SK13242000A3 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3618498A 1998-03-06 1998-03-06
PCT/US1999/004967 WO1999045379A2 (en) 1998-03-06 1999-03-05 Ligand screening and design by x-ray crystallography

Publications (1)

Publication Number Publication Date
SK13242000A3 true SK13242000A3 (sk) 2001-03-12

Family

ID=21887121

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1324-2000A SK13242000A3 (sk) 1998-03-06 1999-03-05 Vyhľadávanie a návrh ligandov röntgenovou kryštalografiou

Country Status (18)

Country Link
US (1) US6297021B1 (de)
EP (1) EP1068531B1 (de)
JP (1) JP2002506206A (de)
KR (1) KR20010041653A (de)
CN (2) CN100354627C (de)
AT (1) ATE375510T1 (de)
AU (3) AU2887099A (de)
BG (1) BG104802A (de)
BR (1) BR9908563A (de)
CA (1) CA2321968A1 (de)
DE (1) DE69937292T2 (de)
HU (1) HUP0101959A3 (de)
IL (1) IL137758A0 (de)
NO (1) NO20004433L (de)
PL (1) PL343264A1 (de)
SK (1) SK13242000A3 (de)
TR (4) TR200101127T2 (de)
WO (2) WO1999045389A2 (de)

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US20030022383A1 (en) * 1999-04-06 2003-01-30 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7247490B2 (en) 1999-04-06 2007-07-24 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7244396B2 (en) 1999-04-06 2007-07-17 Uab Research Foundation Method for preparation of microarrays for screening of crystal growth conditions
US7250305B2 (en) 2001-07-30 2007-07-31 Uab Research Foundation Use of dye to distinguish salt and protein crystals under microcrystallization conditions
US6630006B2 (en) * 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US20040252299A9 (en) 2000-01-07 2004-12-16 Lemmo Anthony V. Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions
US7108970B2 (en) 2000-01-07 2006-09-19 Transform Pharmaceuticals, Inc. Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state
GB0008563D0 (en) 2000-04-07 2000-05-24 Cambridge Discovery Chemistry Investigating different physical and/or chemical forms of materials
WO2002022154A2 (en) * 2000-09-13 2002-03-21 Praecis Pharmaceuticals Incorporated Pharmaceutical compositions for sustained drug delivery
US7806980B2 (en) 2000-12-23 2010-10-05 Elan Pharmaceuticals, Inc. Method for crystallizing human beta secretase in complex with an inhibitor
US7601528B1 (en) 2000-12-23 2009-10-13 Elan Pharmaceuticals, Inc. Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease
US7217556B1 (en) 2000-12-23 2007-05-15 Pfizer Inc Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease
US7670429B2 (en) 2001-04-05 2010-03-02 The California Institute Of Technology High throughput screening of crystallization of materials
WO2002083938A2 (en) * 2001-04-11 2002-10-24 Emerald Biostructures, Inc. Screening methods for identifying ligands
US7384773B1 (en) * 2001-05-10 2008-06-10 Pfizer Inc Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof
US7524668B1 (en) * 2001-05-10 2009-04-28 Elan Pharmaceuticals, Inc. Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof
US7130747B1 (en) * 2001-05-31 2006-10-31 Los Alamos National Security, Llc High throughput screening of ligand binding to macromolecules using high resolution powder diffraction
IL151012A0 (en) * 2001-08-03 2003-02-12 Ribosomes Structure And Protei Ribosomes structure and protein synthesis inhibitors
AU2002333508A1 (en) * 2001-08-22 2003-03-10 Novartis Ag Method to identify modulators for human 3alpha-hydroxysteroid dehydrogenase
US20030211538A1 (en) * 2001-12-03 2003-11-13 Ming Luo CAP-Gly domain structure and uses thereof
US20040171062A1 (en) * 2002-02-28 2004-09-02 Plexxikon, Inc. Methods for the design of molecular scaffolds and ligands
US7469036B2 (en) * 2002-04-19 2008-12-23 Los Alamos National Security, Llc Analysis of macromolecules, ligands and macromolecule-ligand complexes
US7442537B1 (en) 2002-05-10 2008-10-28 Elan Pharmaceuticals, Inc. Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof
US6989392B2 (en) * 2002-06-18 2006-01-24 Abbott Laboratories 2-Aminoquinolines as melanin concentrating hormone receptor antagonists
US8019550B2 (en) * 2002-07-24 2011-09-13 Keddem Bioscience Ltd. Drug discovery method
AU2003272548A1 (en) * 2002-09-16 2004-04-30 Plexxikon, Inc. Crystal structure of pim-1 kinase
WO2006078228A1 (en) * 2002-09-16 2006-07-27 Plexxikon, Inc. Methods for the design of molecular scaffolds and ligands
JP2006516095A (ja) * 2002-11-14 2006-06-22 ザ スクリップス リサーチ インスティテュート 脂肪酸アミドヒドロラーゼ(faah)の結晶形
ATE354096T1 (de) * 2002-12-23 2007-03-15 Astex Therapeutics Ltd Synthese und screening von liganden mit hilfe von röntgenkristallographie
JP2007524374A (ja) * 2003-02-28 2007-08-30 プレキシコン,インコーポレーテッド Pyk2結晶構造および使用
WO2004092727A2 (en) * 2003-04-11 2004-10-28 Structural Genomix, Inc. Compound libraries and methods for drug discovery
US20050079548A1 (en) * 2003-07-07 2005-04-14 Plexxikon, Inc. Ligand development using PDE4B crystal structures
WO2005017533A1 (de) * 2003-08-06 2005-02-24 Proteros Biostructures Gmbh Verfahren zur identifizierung von schwach bindenden molekülfragmenten mit ligandeneigenschaften, wobei die molekülfragmente als mikrotropfen einer entsprechenden lösung auf den kristall aufgebracht werden
DE10336110B4 (de) * 2003-08-06 2008-01-03 Proteros Biostructures Gmbh Vorrichtung und Verfahren zum Behandeln eines Proteinkristalls
WO2005028624A2 (en) * 2003-09-15 2005-03-31 Plexxikon, Inc. Molecular scaffolds for kinase ligand development
DE10343522B4 (de) * 2003-09-19 2008-09-18 Proteros Biostructures Gmbh Verfahren und Speichermedium zur Steuerung der Behandlung eines Kristalls mit einer Flüssigkeit
EP1899370A4 (de) * 2005-05-12 2009-11-11 Cytopia Res Pty Ltd Kristallstruktur und anwendungen davon
US20090317850A1 (en) * 2008-06-20 2009-12-24 Tomoko Sunami Crystal Structure of Human 70KD Ribosomal Protein S6 Kinase 1 Kinase Domain
CN101339167B (zh) * 2008-08-27 2011-12-14 中国药科大学 基于靶蛋白亲和选择的活性成分高通量筛选方法
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Also Published As

Publication number Publication date
TR200101129T2 (tr) 2002-06-21
CN100354627C (zh) 2007-12-12
AU2987899A (en) 1999-09-20
HUP0101959A3 (en) 2003-10-28
AU2003255167A1 (en) 2003-11-13
EP1068531A2 (de) 2001-01-17
TR200002572T2 (tr) 2000-11-21
ATE375510T1 (de) 2007-10-15
IL137758A0 (en) 2001-10-31
DE69937292D1 (de) 2007-11-22
AU2887099A (en) 1999-09-20
WO1999045389A2 (en) 1999-09-10
NO20004433L (no) 2000-11-06
WO1999045389A3 (en) 2000-02-10
US6297021B1 (en) 2001-10-02
WO1999045379A3 (en) 1999-11-25
JP2002506206A (ja) 2002-02-26
TR200101200T2 (tr) 2002-02-21
CN101221138A (zh) 2008-07-16
WO1999045379A2 (en) 1999-09-10
NO20004433D0 (no) 2000-09-05
HUP0101959A2 (hu) 2001-09-28
TR200101127T2 (tr) 2002-06-21
EP1068531B1 (de) 2007-10-10
BG104802A (bg) 2001-04-30
CA2321968A1 (en) 1999-09-10
KR20010041653A (ko) 2001-05-25
CN1299467A (zh) 2001-06-13
DE69937292T2 (de) 2008-07-03
PL343264A1 (en) 2001-07-30
AU767991B2 (en) 2003-11-27
BR9908563A (pt) 2000-11-21

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