SK13242000A3 - Vyhľadávanie a návrh ligandov röntgenovou kryštalografiou - Google Patents
Vyhľadávanie a návrh ligandov röntgenovou kryštalografiou Download PDFInfo
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- SK13242000A3 SK13242000A3 SK1324-2000A SK13242000A SK13242000A3 SK 13242000 A3 SK13242000 A3 SK 13242000A3 SK 13242000 A SK13242000 A SK 13242000A SK 13242000 A3 SK13242000 A3 SK 13242000A3
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- ligand
- target
- crystal
- biomolecule
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/90—Enzymes; Proenzymes
- G01N2333/914—Hydrolases (3)
- G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
- G01N2333/972—Plasminogen activators
- G01N2333/9723—Urokinase
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2500/00—Screening for compounds of potential therapeutic value
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- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Bioinformatics & Computational Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicinal Chemistry (AREA)
- Food Science & Technology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Analysing Materials By The Use Of Radiation (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3618498A | 1998-03-06 | 1998-03-06 | |
| PCT/US1999/004967 WO1999045379A2 (fr) | 1998-03-06 | 1999-03-05 | Criblage et elaboration de ligands par cristallographie aux rayons x |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SK13242000A3 true SK13242000A3 (sk) | 2001-03-12 |
Family
ID=21887121
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SK1324-2000A SK13242000A3 (sk) | 1998-03-06 | 1999-03-05 | Vyhľadávanie a návrh ligandov röntgenovou kryštalografiou |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6297021B1 (fr) |
| EP (1) | EP1068531B1 (fr) |
| JP (1) | JP2002506206A (fr) |
| KR (1) | KR20010041653A (fr) |
| CN (2) | CN100354627C (fr) |
| AT (1) | ATE375510T1 (fr) |
| AU (3) | AU2887099A (fr) |
| BG (1) | BG104802A (fr) |
| BR (1) | BR9908563A (fr) |
| CA (1) | CA2321968A1 (fr) |
| DE (1) | DE69937292T2 (fr) |
| HU (1) | HUP0101959A3 (fr) |
| IL (1) | IL137758A0 (fr) |
| NO (1) | NO20004433L (fr) |
| PL (1) | PL343264A1 (fr) |
| SK (1) | SK13242000A3 (fr) |
| TR (4) | TR200101127T2 (fr) |
| WO (2) | WO1999045389A2 (fr) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20030049678A1 (en) * | 1999-03-05 | 2003-03-13 | Nienaber Vicki L. | Ligand screening and design by X-ray crystallography |
| US20030022383A1 (en) * | 1999-04-06 | 2003-01-30 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
| US7247490B2 (en) | 1999-04-06 | 2007-07-24 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
| US7214540B2 (en) * | 1999-04-06 | 2007-05-08 | Uab Research Foundation | Method for screening crystallization conditions in solution crystal growth |
| US7244396B2 (en) | 1999-04-06 | 2007-07-17 | Uab Research Foundation | Method for preparation of microarrays for screening of crystal growth conditions |
| US7250305B2 (en) | 2001-07-30 | 2007-07-31 | Uab Research Foundation | Use of dye to distinguish salt and protein crystals under microcrystallization conditions |
| US6630006B2 (en) * | 1999-06-18 | 2003-10-07 | The Regents Of The University Of California | Method for screening microcrystallizations for crystal formation |
| US20040252299A9 (en) | 2000-01-07 | 2004-12-16 | Lemmo Anthony V. | Apparatus and method for high-throughput preparation and spectroscopic classification and characterization of compositions |
| US7108970B2 (en) | 2000-01-07 | 2006-09-19 | Transform Pharmaceuticals, Inc. | Rapid identification of conditions, compounds, or compositions that inhibit, prevent, induce, modify, or reverse transitions of physical state |
| GB0008563D0 (en) | 2000-04-07 | 2000-05-24 | Cambridge Discovery Chemistry | Investigating different physical and/or chemical forms of materials |
| WO2002022154A2 (fr) * | 2000-09-13 | 2002-03-21 | Praecis Pharmaceuticals Incorporated | Compositions pharmaceutiques pour medicaments a liberation prolongee |
| US7806980B2 (en) | 2000-12-23 | 2010-10-05 | Elan Pharmaceuticals, Inc. | Method for crystallizing human beta secretase in complex with an inhibitor |
| US7601528B1 (en) | 2000-12-23 | 2009-10-13 | Elan Pharmaceuticals, Inc. | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in alzheimer's disease |
| US7217556B1 (en) | 2000-12-23 | 2007-05-15 | Pfizer Inc | Crystallization and structure determination of glycosylated human beta secretase, an enzyme implicated in Alzheimer's disease |
| US7670429B2 (en) | 2001-04-05 | 2010-03-02 | The California Institute Of Technology | High throughput screening of crystallization of materials |
| WO2002083938A2 (fr) * | 2001-04-11 | 2002-10-24 | Emerald Biostructures, Inc. | Procedes de criblage pour l'identification de ligands |
| US7384773B1 (en) * | 2001-05-10 | 2008-06-10 | Pfizer Inc | Crystal of HIV protease-cleaved human beta secretase and method for crystallization thereof |
| US7524668B1 (en) * | 2001-05-10 | 2009-04-28 | Elan Pharmaceuticals, Inc. | Crystal of human beta secretase having monoclinic space group symmetry C2 and methods for crystallization thereof |
| US7130747B1 (en) * | 2001-05-31 | 2006-10-31 | Los Alamos National Security, Llc | High throughput screening of ligand binding to macromolecules using high resolution powder diffraction |
| IL151012A0 (en) * | 2001-08-03 | 2003-02-12 | Ribosomes Structure And Protei | Ribosomes structure and protein synthesis inhibitors |
| AU2002333508A1 (en) * | 2001-08-22 | 2003-03-10 | Novartis Ag | Method to identify modulators for human 3alpha-hydroxysteroid dehydrogenase |
| US20030211538A1 (en) * | 2001-12-03 | 2003-11-13 | Ming Luo | CAP-Gly domain structure and uses thereof |
| US20040171062A1 (en) * | 2002-02-28 | 2004-09-02 | Plexxikon, Inc. | Methods for the design of molecular scaffolds and ligands |
| US7469036B2 (en) * | 2002-04-19 | 2008-12-23 | Los Alamos National Security, Llc | Analysis of macromolecules, ligands and macromolecule-ligand complexes |
| US7442537B1 (en) | 2002-05-10 | 2008-10-28 | Elan Pharmaceuticals, Inc. | Crystals of unliganded beta secretase and/or beta secretase-like proteins and the use thereof |
| US6989392B2 (en) * | 2002-06-18 | 2006-01-24 | Abbott Laboratories | 2-Aminoquinolines as melanin concentrating hormone receptor antagonists |
| US8019550B2 (en) * | 2002-07-24 | 2011-09-13 | Keddem Bioscience Ltd. | Drug discovery method |
| AU2003272548A1 (en) * | 2002-09-16 | 2004-04-30 | Plexxikon, Inc. | Crystal structure of pim-1 kinase |
| WO2006078228A1 (fr) * | 2002-09-16 | 2006-07-27 | Plexxikon, Inc. | Procedes de conception d'echafaudages moleculaires et de ligands |
| JP2006516095A (ja) * | 2002-11-14 | 2006-06-22 | ザ スクリップス リサーチ インスティテュート | 脂肪酸アミドヒドロラーゼ(faah)の結晶形 |
| ATE354096T1 (de) * | 2002-12-23 | 2007-03-15 | Astex Therapeutics Ltd | Synthese und screening von liganden mit hilfe von röntgenkristallographie |
| JP2007524374A (ja) * | 2003-02-28 | 2007-08-30 | プレキシコン,インコーポレーテッド | Pyk2結晶構造および使用 |
| WO2004092727A2 (fr) * | 2003-04-11 | 2004-10-28 | Structural Genomix, Inc. | Bibliotheques de composes et procedes de decouverte de medicaments |
| US20050079548A1 (en) * | 2003-07-07 | 2005-04-14 | Plexxikon, Inc. | Ligand development using PDE4B crystal structures |
| WO2005017533A1 (fr) * | 2003-08-06 | 2005-02-24 | Proteros Biostructures Gmbh | Procede d'identification de fragments moleculaires a faible pouvoir de liaison, aux proprietes de ligands, lesdits fragments moleculaires etant appliques sur un cristal, sous forme de microgouttes d'une solution appropriee |
| DE10336110B4 (de) * | 2003-08-06 | 2008-01-03 | Proteros Biostructures Gmbh | Vorrichtung und Verfahren zum Behandeln eines Proteinkristalls |
| WO2005028624A2 (fr) * | 2003-09-15 | 2005-03-31 | Plexxikon, Inc. | Echafaudages moleculaires pour le developpement de ligands des proteines kinases |
| DE10343522B4 (de) * | 2003-09-19 | 2008-09-18 | Proteros Biostructures Gmbh | Verfahren und Speichermedium zur Steuerung der Behandlung eines Kristalls mit einer Flüssigkeit |
| EP1899370A4 (fr) * | 2005-05-12 | 2009-11-11 | Cytopia Res Pty Ltd | Structure cristalline et son utilisation |
| US20090317850A1 (en) * | 2008-06-20 | 2009-12-24 | Tomoko Sunami | Crystal Structure of Human 70KD Ribosomal Protein S6 Kinase 1 Kinase Domain |
| CN101339167B (zh) * | 2008-08-27 | 2011-12-14 | 中国药科大学 | 基于靶蛋白亲和选择的活性成分高通量筛选方法 |
| DE102008049675A1 (de) | 2008-09-30 | 2010-04-01 | Markus Dr. Heinrich | Verfahren zur Herstellung von 3-Aminobiphenylen |
| WO2010100847A1 (fr) * | 2009-03-03 | 2010-09-10 | 独立行政法人国立高等専門学校機構 | Dispositif pour la cristallisation d'un biopolymère, cellule de solution pour la cristallisation d'un biopolymère, procédé pour le contrôle de l'alignement d'un biopolymère, procédé pour la cristallisation d'un biopolymère et cristal de biopolymère |
| CN102101886A (zh) | 2009-12-18 | 2011-06-22 | 四川辉阳生命工程股份有限公司 | 构象改变的重组干扰素晶体、其三维结构及应用 |
| JP5598238B2 (ja) * | 2010-10-08 | 2014-10-01 | 株式会社リコー | 画像形成装置 |
| CN106033064B (zh) * | 2015-03-10 | 2019-05-07 | 上海上药信谊药厂有限公司 | 胆维丁测定方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5112755A (en) | 1982-04-15 | 1992-05-12 | Genentech, Inc. | Preparation of functional human urokinase proteins |
-
1999
- 1999-03-01 WO PCT/US1999/004518 patent/WO1999045389A2/fr not_active Ceased
- 1999-03-01 AU AU28870/99A patent/AU2887099A/en not_active Withdrawn
- 1999-03-05 CN CNB998058866A patent/CN100354627C/zh not_active Expired - Fee Related
- 1999-03-05 TR TR2001/01127T patent/TR200101127T2/xx unknown
- 1999-03-05 HU HU0101959A patent/HUP0101959A3/hu unknown
- 1999-03-05 TR TR2000/02572T patent/TR200002572T2/xx unknown
- 1999-03-05 DE DE69937292T patent/DE69937292T2/de not_active Expired - Fee Related
- 1999-03-05 TR TR2001/01129T patent/TR200101129T2/xx unknown
- 1999-03-05 SK SK1324-2000A patent/SK13242000A3/sk unknown
- 1999-03-05 JP JP2000534866A patent/JP2002506206A/ja active Pending
- 1999-03-05 BR BR9908563-1A patent/BR9908563A/pt not_active IP Right Cessation
- 1999-03-05 KR KR1020007009855A patent/KR20010041653A/ko not_active Withdrawn
- 1999-03-05 CN CN200710181713.2A patent/CN101221138A/zh active Pending
- 1999-03-05 AU AU29878/99A patent/AU767991B2/en not_active Ceased
- 1999-03-05 PL PL99343264A patent/PL343264A1/xx unknown
- 1999-03-05 AT AT99911174T patent/ATE375510T1/de not_active IP Right Cessation
- 1999-03-05 CA CA002321968A patent/CA2321968A1/fr not_active Abandoned
- 1999-03-05 US US09/263,904 patent/US6297021B1/en not_active Expired - Lifetime
- 1999-03-05 WO PCT/US1999/004967 patent/WO1999045379A2/fr not_active Ceased
- 1999-03-05 IL IL13775899A patent/IL137758A0/xx unknown
- 1999-03-05 EP EP99911174A patent/EP1068531B1/fr not_active Expired - Lifetime
- 1999-03-05 TR TR2001/01200T patent/TR200101200T2/xx unknown
-
2000
- 2000-09-05 NO NO20004433A patent/NO20004433L/no not_active Application Discontinuation
- 2000-09-27 BG BG104802A patent/BG104802A/bg unknown
-
2003
- 2003-10-16 AU AU2003255167A patent/AU2003255167A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| TR200101129T2 (tr) | 2002-06-21 |
| CN100354627C (zh) | 2007-12-12 |
| AU2987899A (en) | 1999-09-20 |
| HUP0101959A3 (en) | 2003-10-28 |
| AU2003255167A1 (en) | 2003-11-13 |
| EP1068531A2 (fr) | 2001-01-17 |
| TR200002572T2 (tr) | 2000-11-21 |
| ATE375510T1 (de) | 2007-10-15 |
| IL137758A0 (en) | 2001-10-31 |
| DE69937292D1 (de) | 2007-11-22 |
| AU2887099A (en) | 1999-09-20 |
| WO1999045389A2 (fr) | 1999-09-10 |
| NO20004433L (no) | 2000-11-06 |
| WO1999045389A3 (fr) | 2000-02-10 |
| US6297021B1 (en) | 2001-10-02 |
| WO1999045379A3 (fr) | 1999-11-25 |
| JP2002506206A (ja) | 2002-02-26 |
| TR200101200T2 (tr) | 2002-02-21 |
| CN101221138A (zh) | 2008-07-16 |
| WO1999045379A2 (fr) | 1999-09-10 |
| NO20004433D0 (no) | 2000-09-05 |
| HUP0101959A2 (hu) | 2001-09-28 |
| TR200101127T2 (tr) | 2002-06-21 |
| EP1068531B1 (fr) | 2007-10-10 |
| BG104802A (bg) | 2001-04-30 |
| CA2321968A1 (fr) | 1999-09-10 |
| KR20010041653A (ko) | 2001-05-25 |
| CN1299467A (zh) | 2001-06-13 |
| DE69937292T2 (de) | 2008-07-03 |
| PL343264A1 (en) | 2001-07-30 |
| AU767991B2 (en) | 2003-11-27 |
| BR9908563A (pt) | 2000-11-21 |
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