SK155997A3 - Use of ribavirin and interferon alpha for the treatment of hepatitis c - Google Patents

Use of ribavirin and interferon alpha for the treatment of hepatitis c Download PDF

Info

Publication number: SK155997A3
Authority: SK; Slovakia
Prior art keywords: ribavirin; interferon alpha; hepatitis; interferon; amount
Prior art date: 1995-05-19

Application number

SK1559-97A

Other languages

English (en)

Slovak (sk)

Inventor

Janice K Albrecht

Paul C Grint

Original Assignee

Schering Corp

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-19

Filing date

1996-05-15

Publication date

1998-10-07

1996-05-15 Application filed by Schering Corp filed Critical Schering Corp

1998-10-07 Publication of SK155997A3 publication Critical patent/SK155997A3/sk

Links

IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical compound N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 title claims abstract description 24
229960000329 ribavirin Drugs 0.000 title claims abstract description 24
HZCAHMRRMINHDJ-DBRKOABJSA-N ribavirin Natural products O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1N=CN=C1 HZCAHMRRMINHDJ-DBRKOABJSA-N 0.000 title claims abstract description 24
108010047761 Interferon-alpha Proteins 0.000 title claims abstract description 22
102000006992 Interferon-alpha Human genes 0.000 title claims abstract description 22
208000006454 hepatitis Diseases 0.000 title description 2
231100000283 hepatitis Toxicity 0.000 title 1
230000001684 chronic effect Effects 0.000 claims description 12
208000037319 Hepatitis infectious Diseases 0.000 claims description 10
208000005252 hepatitis A Diseases 0.000 claims description 10
239000003814 drug Substances 0.000 claims description 3
102100040018 Interferon alpha-2 Human genes 0.000 claims description 2
108010079944 Interferon-alpha2b Proteins 0.000 claims description 2
206010062237 Renal impairment Diseases 0.000 claims 2
208000020832 chronic kidney disease Diseases 0.000 claims 1
230000003442 weekly effect Effects 0.000 claims 1
230000000694 effects Effects 0.000 abstract description 15
208000020403 chronic hepatitis C virus infection Diseases 0.000 abstract description 3
238000000034 method Methods 0.000 abstract description 2
102000014150 Interferons Human genes 0.000 description 12
108010050904 Interferons Proteins 0.000 description 12
238000002560 therapeutic procedure Methods 0.000 description 11
229940079322 interferon Drugs 0.000 description 9
238000009097 single-agent therapy Methods 0.000 description 9
208000024891 symptom Diseases 0.000 description 7
238000002648 combination therapy Methods 0.000 description 6
108010078049 Interferon alpha-2 Proteins 0.000 description 5
239000000203 mixture Substances 0.000 description 5
208000005176 Hepatitis C Diseases 0.000 description 4
238000009472 formulation Methods 0.000 description 3
229940047124 interferons Drugs 0.000 description 3
206010022004 Influenza like illness Diseases 0.000 description 2
230000008030 elimination Effects 0.000 description 2
238000003379 elimination reaction Methods 0.000 description 2
208000015181 infectious disease Diseases 0.000 description 2
230000002458 infectious effect Effects 0.000 description 2
229960003507 interferon alfa-2b Drugs 0.000 description 2
208000019423 liver disease Diseases 0.000 description 2
238000004519 manufacturing process Methods 0.000 description 2
238000007911 parenteral administration Methods 0.000 description 2
MIXCUJKCXRNYFM-UHFFFAOYSA-M sodium;diiodomethanesulfonate;n-propyl-n-[2-(2,4,6-trichlorophenoxy)ethyl]imidazole-1-carboxamide Chemical compound [Na+].[O-]S(=O)(=O)C(I)I.C1=CN=CN1C(=O)N(CCC)CCOC1=C(Cl)C=C(Cl)C=C1Cl MIXCUJKCXRNYFM-UHFFFAOYSA-M 0.000 description 2
206010008909 Chronic Hepatitis Diseases 0.000 description 1
208000006154 Chronic hepatitis C Diseases 0.000 description 1
206010019233 Headaches Diseases 0.000 description 1
206010019837 Hepatocellular injury Diseases 0.000 description 1
102000003996 Interferon-beta Human genes 0.000 description 1
108090000467 Interferon-beta Proteins 0.000 description 1
208000000112 Myalgia Diseases 0.000 description 1
206010037660 Pyrexia Diseases 0.000 description 1
102000007397 Species specific proteins Human genes 0.000 description 1
108020005719 Species specific proteins Proteins 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
208000007502 anemia Diseases 0.000 description 1
239000002775 capsule Substances 0.000 description 1
230000004663 cell proliferation Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
208000019425 cirrhosis of liver Diseases 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
229940079593 drug Drugs 0.000 description 1
230000001747 exhibiting effect Effects 0.000 description 1
231100000869 headache Toxicity 0.000 description 1
208000007475 hemolytic anemia Diseases 0.000 description 1
208000010710 hepatitis C virus infection Diseases 0.000 description 1
206010073071 hepatocellular carcinoma Diseases 0.000 description 1
231100000844 hepatocellular carcinoma Toxicity 0.000 description 1
230000028993 immune response Effects 0.000 description 1
108010055511 interferon alfa-2c Proteins 0.000 description 1
108010006088 interferon alfa-n1 Proteins 0.000 description 1
229960001388 interferon-beta Drugs 0.000 description 1
239000007927 intramuscular injection Substances 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
208000013465 muscle pain Diseases 0.000 description 1
239000007922 nasal spray Substances 0.000 description 1
229940097496 nasal spray Drugs 0.000 description 1
230000002250 progressing effect Effects 0.000 description 1
238000007920 subcutaneous administration Methods 0.000 description 1
239000000829 suppository Substances 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
-1 transdermal Substances 0.000 description 1
230000029812 viral genome replication Effects 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/19—Cytokines; Lymphokines; Interferons
- A61K38/21—Interferons [IFN]
- A61K38/212—IFN-alpha
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Gastroenterology & Hepatology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Immunology (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Zoology (AREA)
Virology (AREA)
Organic Chemistry (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Oncology (AREA)
Molecular Biology (AREA)
Communicable Diseases (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK1559-97A 1995-05-19 1996-05-15 Use of ribavirin and interferon alpha for the treatment of hepatitis c SK155997A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US08/444,584 US6387365B1 (en)	1995-05-19	1995-05-19	Combination therapy for chronic hepatitis C infection
PCT/US1996/006552 WO1996036351A1 (en)	1995-05-19	1996-05-15	Use of ribavirin and interferon alpha for the treatment of hepatitis c

Publications (1)

Publication Number	Publication Date
SK155997A3 true SK155997A3 (en)	1998-10-07

Family

ID=23765515

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1559-97A SK155997A3 (en)	1995-05-19	1996-05-15	Use of ribavirin and interferon alpha for the treatment of hepatitis c

Country Status (15)

Country	Link
US (2)	US6387365B1 (de)
EP (2)	EP0707855A3 (de)
JP (1)	JPH10506640A (de)
KR (1)	KR19990014925A (de)
CN (1)	CN1190895A (de)
AU (1)	AU5919296A (de)
BR (1)	BR9608758A (de)
CA (1)	CA2221314A1 (de)
CZ (1)	CZ365497A3 (de)
HU (1)	HUP9802324A3 (de)
NO (1)	NO975309D0 (de)
NZ (1)	NZ309217A (de)
PL (1)	PL323477A1 (de)
SK (1)	SK155997A3 (de)
WO (1)	WO1996036351A1 (de)

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AU5157998A (en) *	1996-11-01	1998-05-29	Thomas Najarian	Methods and compositions for treatment of hepatitis c infection
US6172046B1 (en) *	1997-09-21	2001-01-09	Schering Corporation	Combination therapy for eradicating detectable HCV-RNA in patients having chronic Hepatitis C infection
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US6472373B1 (en)	1997-09-21	2002-10-29	Schering Corporation	Combination therapy for eradicating detectable HCV-RNA in antiviral treatment naive patients having chronic hepatitis C infection
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RU2001113268A (ru) *	1998-10-16	2003-09-27	Шеринг Корпорейшн (US)	Сочетанная терапия рибавирином и интерфероном α для удаления определяемой рнк вируса гепатита с у пациентов с хроническим гепатитом с
US6277830B1 (en)	1998-10-16	2001-08-21	Schering Corporation	5′-amino acid esters of ribavirin and the use of same to treat hepatitis C with interferon
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US6926898B2 (en) *	2000-04-12	2005-08-09	Human Genome Sciences, Inc.	Albumin fusion proteins
US6924270B2 (en) *	2000-04-20	2005-08-02	Schering Corporation	Ribavirin-interferon alfa combination therapy for eradicating detectable HCV-RNA in patients having chronic hepatitis C infection
EP1325324A4 (de) *	2000-08-02	2004-11-10	Ortho Mcneil Pharm Inc	Verbesserte antivirus- und antitumor-chemotherapie durch verabreichung von erythropoeitin
WO2002015664A2 (en) *	2000-08-23	2002-02-28	The New York Hospital Medical Center Of Queens	Methods of preventing or treating west nile virus and other infections
US20060024270A1 (en) *	2000-08-23	2006-02-02	The New York Hospital Medical Center Of Queens	Compositions and methods for preventing or treating encephalitis with interferon
AU2002213343A1 (en) *	2000-10-18	2002-04-29	Schering Corporation	Ribavirin-pegylated interferon alfa HCV combination therapy
US6720000B2 (en)	2001-03-19	2004-04-13	Three Rivers Pharmaceutical, Llc	Process for producing wet ribavirin pellets
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EP1534299A4 (de) *	2002-07-02	2007-04-11	Corcept Therapeutics Inc	Verfahren zur behandlung von psychose im zusammenhang mit einer therapie mit interferon-alpha
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US7538094B2 (en)	2002-09-19	2009-05-26	Three Rivers Pharmacueticals, Llc	Composition containing ribavirin and use thereof
JP2004143113A (ja) *	2002-10-25	2004-05-20	Shinya Nakajima	インターフェロン製剤及びその投与システム
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JP2006524227A (ja) *	2003-03-28	2006-10-26	ファーマセット，インク．	フラビウイルス科ウイルス感染の治療のための化合物
US7109172B2 (en)	2003-07-18	2006-09-19	Vertex Pharmaceuticals Incorporated	Inhibitors of serine proteases, particularly HCV NS3-NS4A protease
JPWO2006033453A1 (ja) *	2004-09-22	2008-05-15	学校法人順天堂	インターフェロン作用物質の活性増強剤
US7723310B2 (en)	2004-10-18	2010-05-25	Three Rivers Pharmaceuticals, Llc	Large dose ribavirin formulations
EP1850862A2 (de) *	2005-01-19	2007-11-07	Avigenics, Inc.	Verfahren zur krankheitsbehandlung mit glycosyliertem interferon
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CN102727437A (zh)	2006-08-02	2012-10-17	牛津大学院长校长专家委员会	病毒感染的脂质体治疗
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EP2410989A2 (de) *	2009-03-27	2012-02-01	The Chancellor, Masters and Scholars of the University of Oxford	Liposome zur senkung des cholesterinspiegels
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1995
- 1995-05-19 US US08/444,584 patent/US6387365B1/en not_active Expired - Lifetime
- 1995-12-28 EP EP95309499A patent/EP0707855A3/de not_active Ceased
- 1995-12-28 EP EP99123925A patent/EP1005868A1/de not_active Withdrawn
1996
- 1996-05-15 HU HU9802324A patent/HUP9802324A3/hu unknown
- 1996-05-15 BR BR9608758A patent/BR9608758A/pt not_active Application Discontinuation
- 1996-05-15 CZ CZ973654A patent/CZ365497A3/cs unknown
- 1996-05-15 NZ NZ309217A patent/NZ309217A/xx unknown
- 1996-05-15 SK SK1559-97A patent/SK155997A3/sk unknown
- 1996-05-15 CA CA002221314A patent/CA2221314A1/en not_active Abandoned
- 1996-05-15 PL PL96323477A patent/PL323477A1/xx unknown
- 1996-05-15 KR KR1019970708271A patent/KR19990014925A/ko not_active Ceased
- 1996-05-15 CN CN96195591A patent/CN1190895A/zh active Pending
- 1996-05-15 JP JP8534904A patent/JPH10506640A/ja active Pending
- 1996-05-15 AU AU59192/96A patent/AU5919296A/en not_active Abandoned
- 1996-05-15 WO PCT/US1996/006552 patent/WO1996036351A1/en not_active Ceased
1997
- 1997-11-19 NO NO975309A patent/NO975309D0/no not_active Application Discontinuation
2000
- 2000-05-02 US US09/563,649 patent/US6299872B1/en not_active Expired - Lifetime

Also Published As

Publication number	Publication date
US6299872B1 (en)	2001-10-09
WO1996036351A1 (en)	1996-11-21
AU5919296A (en)	1996-11-29
HUP9802324A2 (hu)	1999-05-28
CZ365497A3 (cs)	1998-07-15
NZ309217A (en)	2000-08-25
US6387365B1 (en)	2002-05-14
CA2221314A1 (en)	1996-11-21
BR9608758A (pt)	1999-07-06
EP0707855A2 (de)	1996-04-24
KR19990014925A (ko)	1999-02-25
EP0707855A3 (de)	1996-11-27
CN1190895A (zh)	1998-08-19
NO975309L (no)	1997-11-19
JPH10506640A (ja)	1998-06-30
PL323477A1 (en)	1998-03-30
MX9708885A (es)	1998-03-31
EP1005868A1 (de)	2000-06-07
NO975309D0 (no)	1997-11-19
HUP9802324A3 (en)	2001-04-28

Publication	Publication Date	Title
US6299872B1 (en)	2001-10-09	Combination therapy for chronic hepatitis c infection
US20050112093A1 (en)	2005-05-26	Combination therapy for HCV infection
KR20050055053A (ko)	2005-06-10	만성 Ｃ형 간염을 치료하기 위한 폴리에틸렌글리콜-인터페론-α 및 리바비린의 용도
JP2002515453A5 (de)	2006-06-15
CA2245938A1 (en)	1999-03-21	Combination therapy for eradicating detectable hcv-rna in patients having chronic hepatitis c infection
US20070202078A1 (en)	2007-08-30	Method Of Treating Viral Infections
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