SK1562003A3 - Process for preparing discodermolide and analogues thereof - Google Patents

Process for preparing discodermolide and analogues thereof Download PDF

Info

Publication number
SK1562003A3
SK1562003A3 SK156-2003A SK1562003A SK1562003A3 SK 1562003 A3 SK1562003 A3 SK 1562003A3 SK 1562003 A SK1562003 A SK 1562003A SK 1562003 A3 SK1562003 A3 SK 1562003A3
Authority
SK
Slovakia
Prior art keywords
alkyl
group
carbon atoms
formula
compound
Prior art date
Application number
SK156-2003A
Other languages
English (en)
Slovak (sk)
Inventor
Frederick Ray Kinder
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of SK1562003A3 publication Critical patent/SK1562003A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/12—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
    • C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00—Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/02—Silicon compounds
    • C07F7/08—Compounds having one or more C—Si linkages
    • C07F7/18—Compounds having one or more C—Si linkages as well as one or more C—O—Si linkages
    • C07F7/1804—Compounds having Si-O-C linkages
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Steroid Compounds (AREA)
  • Pyrane Compounds (AREA)
SK156-2003A 2000-08-07 2001-08-06 Process for preparing discodermolide and analogues thereof SK1562003A3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US63375300A 2000-08-07 2000-08-07
PCT/EP2001/009068 WO2002012220A2 (en) 2000-08-07 2001-08-06 Process for preparing discodermolide and analogues thereof

Publications (1)

Publication Number Publication Date
SK1562003A3 true SK1562003A3 (en) 2003-08-05

Family

ID=24540984

Family Applications (1)

Application Number Title Priority Date Filing Date
SK156-2003A SK1562003A3 (en) 2000-08-07 2001-08-06 Process for preparing discodermolide and analogues thereof

Country Status (29)

Country Link
EP (1) EP1309583B1 (es)
JP (1) JP2004505963A (es)
KR (1) KR100796396B1 (es)
CN (1) CN1293067C (es)
AR (1) AR032761A1 (es)
AT (1) ATE330948T1 (es)
AU (2) AU2001293726B2 (es)
BR (1) BR0112876A (es)
CA (1) CA2416769C (es)
CY (1) CY1105338T1 (es)
CZ (1) CZ300855B6 (es)
DE (1) DE60120991T2 (es)
DK (1) DK1309583T3 (es)
EC (1) ECSP034459A (es)
ES (1) ES2266266T3 (es)
HU (1) HUP0300742A3 (es)
IL (2) IL154109A0 (es)
MX (1) MXPA03001192A (es)
MY (1) MY127609A (es)
NO (1) NO328365B1 (es)
NZ (1) NZ523999A (es)
PE (1) PE20020263A1 (es)
PL (1) PL358839A1 (es)
PT (1) PT1309583E (es)
RU (1) RU2283309C2 (es)
SK (1) SK1562003A3 (es)
TW (1) TWI251591B (es)
WO (1) WO2002012220A2 (es)
ZA (1) ZA200300590B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004009574A1 (en) * 2002-07-22 2004-01-29 Novartis Ag Synthesis of discodermolide
AU2003263090A1 (en) 2002-09-06 2004-03-29 University Of Pittsburgh Analogs of discodermolide and dictyostatin-1, intermediates therefor and methods of synthesis thereof
US7321046B2 (en) 2002-09-06 2008-01-22 University Of Pittsburgh Analogs of dictyostatin, intermediates therefor and methods of synthesis thereof
US7214708B2 (en) 2004-11-18 2007-05-08 Kosan Biosciences Incorporated Synthetic discodermolide analogs

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4939168A (en) * 1989-08-11 1990-07-03 Harbor Branch Oceanographics Institution, Inc. Discodermolide compounds, compositions containing same and methods of preparation and use
IL108432A (en) * 1993-01-29 1997-09-30 Sankyo Co DERIVATIVES OF 3, 5-DIHYDROXY-7- £1, 2, 6, 7, 8, 8a-HEXAHYDRO-2- METHYL-8- (SUBSTITUTED ALKANOYLOXY)-1-NAPHTHYL| HEPTANOIC ACID AND THEIR LACTONES, THEIR PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
GB9315802D0 (en) * 1993-07-30 1993-09-15 Roussel Lab Ltd Chemical compounds
US6096904A (en) * 1996-12-03 2000-08-01 The Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives
US5789605A (en) * 1996-12-03 1998-08-04 Trustees Of The University Of Pennsylvania Synthetic techniques and intermediates for polyhydroxy, dienyl lactones and mimics thereof
AU7267298A (en) * 1997-04-30 1998-11-24 Regents Of The University Of California, The Synthesis of discodermolide and analogs
GB0101599D0 (en) * 2001-01-22 2001-03-07 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
CY1105338T1 (el) 2010-03-03
PT1309583E (pt) 2006-10-31
PL358839A1 (en) 2004-08-23
IL154109A0 (en) 2003-07-31
DK1309583T3 (da) 2006-10-16
ATE330948T1 (de) 2006-07-15
WO2002012220A2 (en) 2002-02-14
ECSP034459A (es) 2003-03-10
NO20030587L (no) 2003-02-06
ES2266266T3 (es) 2007-03-01
ZA200300590B (en) 2004-04-01
NO20030587D0 (no) 2003-02-06
CA2416769A1 (en) 2002-02-14
KR20030040385A (ko) 2003-05-22
CZ300855B6 (cs) 2009-08-26
KR100796396B1 (ko) 2008-01-21
HK1055962A1 (en) 2004-01-30
JP2004505963A (ja) 2004-02-26
CZ2003330A3 (cs) 2003-05-14
IL154109A (en) 2008-11-03
MY127609A (en) 2006-12-29
CN1293067C (zh) 2007-01-03
DE60120991D1 (de) 2006-08-03
HUP0300742A3 (en) 2005-11-28
AU2001293726B2 (en) 2005-04-14
WO2002012220A3 (en) 2002-06-13
DE60120991T2 (de) 2007-06-21
HUP0300742A2 (hu) 2003-09-29
RU2283309C2 (ru) 2006-09-10
NO328365B1 (no) 2010-02-01
AR032761A1 (es) 2003-11-26
MXPA03001192A (es) 2003-06-30
NZ523999A (en) 2004-08-27
TWI251591B (en) 2006-03-21
PE20020263A1 (es) 2002-05-14
CN1446208A (zh) 2003-10-01
AU9372601A (en) 2002-02-18
CA2416769C (en) 2009-02-17
BR0112876A (pt) 2003-07-01
EP1309583B1 (en) 2006-06-21
EP1309583A2 (en) 2003-05-14

Similar Documents

Publication Publication Date Title
HU207288B (en) Process for enenthioselective producing phenyl-isoserine derivatives
US6001994A (en) Process for making gemcitabine hydrochloride
EP1309583B1 (en) Process for preparing discodermolide and analogues thereof
US5756775A (en) Process to make α,α-difluoro-β-hydroxyl thiol esters
US6506910B1 (en) Process for preparing discodermolide and analogues thereof
CA2435371A1 (en) Process for preparing intermediates for the manufacture of discodermolide and discodermolide analogues
AU2001293726A1 (en) Process for preparing discodermolide and analogues thereof
US4940797A (en) Process for synthesis of FK-506 C10-C18 intermediates
CN100582073C (zh) 制备5-羟基-3-氧-己酸衍生物的新方法
HK1055962B (en) Process for preparing discodermolide and analogues thereof
JP2000501738A (ja) α，α―ジフルオロ―β―ヒドロキシチオールエステル及びその合成
US5155228A (en) FK-506 C10-C18 process intermediates
JPH04230360A (ja) 複素環誘導体
WO2003080567A2 (en) Intermediates for the synthesis of discodermolide and related analogues and methods for their preparation
JPH06247957A (ja) オクタヒドロナフトフラン化合物
WO2004009574A1 (en) Synthesis of discodermolide
JPWO2004048360A1 (ja) マクロスフェライド類の合成方法
EP0398474A2 (en) Oxazole derivatives and intermediates for their preparation
JPH07179437A (ja) ４，６−ジアルコキシ−２−ヒドロキシメチルピリミジン誘導体の製造法
JPH06793B2 (ja) Ｅ―２―メチル―α，β―不飽和アルデヒドの合成方法
JPH061761A (ja) γ，δ−不飽和−β−アミノ酸誘導体及びその製造方法
KR20040019540A (ko) 심바스타틴의 신규 제조방법 및 그에 사용되는 합성 중간체

Legal Events

Date Code Title Description
FB9A Suspension of patent application procedure