SK17142002A3 - Soľ tiazolidindiónu na liečenie diabetes mellitus - Google Patents

Soľ tiazolidindiónu na liečenie diabetes mellitus Download PDF

Info

Publication number: SK17142002A3
Authority: SK; Slovakia
Prior art keywords: hydrobromide; solvate; pyridyl; ethoxy; methyl
Prior art date: 2000-06-08

Application number

SK1714-2002A

Other languages

English (en)

Slovak (sk)

Inventor

Andrew Simon Craig

Tim Chien Ting Ho

Original Assignee

Smithkline Beecham P. L. C.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-06-08

Filing date

2001-06-08

Publication date

2003-10-07

2001-06-08 Application filed by Smithkline Beecham P. L. C. filed Critical Smithkline Beecham P. L. C.

2003-10-07 Publication of SK17142002A3 publication Critical patent/SK17142002A3/sk

Links

206010012601 diabetes mellitus Diseases 0.000 title claims description 17
238000011282 treatment Methods 0.000 title claims description 9
150000001467 thiazolidinediones Chemical class 0.000 title description 2
239000012453 solvate Substances 0.000 claims abstract description 32
150000001875 compounds Chemical class 0.000 claims abstract description 31
239000003814 drug Substances 0.000 claims abstract description 11
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
238000004519 manufacturing process Methods 0.000 claims abstract description 5
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 claims description 56
238000000034 method Methods 0.000 claims description 12
MSOPDKKENJARPF-UHFFFAOYSA-N 5-[[4-[2-[methyl(pyridin-2-yl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydrobromide Chemical compound Br.C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O MSOPDKKENJARPF-UHFFFAOYSA-N 0.000 claims description 10
238000002844 melting Methods 0.000 claims description 10
230000008018 melting Effects 0.000 claims description 10
150000003839 salts Chemical class 0.000 claims description 9
YASAKCUCGLMORW-UHFFFAOYSA-N Rosiglitazone Chemical compound C=1C=CC=NC=1N(C)CCOC(C=C1)=CC=C1CC1SC(=O)NC1=O YASAKCUCGLMORW-UHFFFAOYSA-N 0.000 claims description 8
229910000042 hydrogen bromide Inorganic materials 0.000 claims description 7
238000011321 prophylaxis Methods 0.000 claims description 7
238000001237 Raman spectrum Methods 0.000 claims description 4
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238000002329 infrared spectrum Methods 0.000 claims description 4
238000000634 powder X-ray diffraction Methods 0.000 claims description 4
238000001460 carbon-13 nuclear magnetic resonance spectrum Methods 0.000 claims description 3
239000007909 solid dosage form Substances 0.000 claims description 2
-1 compound 5-[4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl]thiazolidine-2,4-dione hydrobromide Chemical class 0.000 abstract description 7
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FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
208000007342 Diabetic Nephropathies Diseases 0.000 description 1
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238000005079 FT-Raman Methods 0.000 description 1
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206010060378 Hyperinsulinaemia Diseases 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
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206010029164 Nephrotic syndrome Diseases 0.000 description 1
206010036049 Polycystic ovaries Diseases 0.000 description 1
OFOBLEOULBTSOW-UHFFFAOYSA-N Propanedioic acid Natural products OC(=O)CC(O)=O OFOBLEOULBTSOW-UHFFFAOYSA-N 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
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150000007513 acids Chemical class 0.000 description 1
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239000002671 adjuvant Substances 0.000 description 1
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CEGOLXSVJUTHNZ-UHFFFAOYSA-K aluminium tristearate Chemical compound [Al+3].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CEGOLXSVJUTHNZ-UHFFFAOYSA-K 0.000 description 1
229940063655 aluminum stearate Drugs 0.000 description 1
150000001412 amines Chemical class 0.000 description 1
SWLVFNYSXGMGBS-UHFFFAOYSA-N ammonium bromide Chemical compound [NH4+].[Br-] SWLVFNYSXGMGBS-UHFFFAOYSA-N 0.000 description 1
239000007864 aqueous solution Substances 0.000 description 1
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238000013461 design Methods 0.000 description 1
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208000033679 diabetic kidney disease Diseases 0.000 description 1
HPNMFZURTQLUMO-UHFFFAOYSA-N diethylamine Chemical compound CCNCC HPNMFZURTQLUMO-UHFFFAOYSA-N 0.000 description 1
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208000028208 end stage renal disease Diseases 0.000 description 1
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BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
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239000003589 local anesthetic agent Substances 0.000 description 1
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239000007937 lozenge Substances 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
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QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 1
239000012047 saturated solution Substances 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
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239000008109 sodium starch glycolate Substances 0.000 description 1
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Diabetes (AREA)
General Chemical & Material Sciences (AREA)
Emergency Medicine (AREA)
Hematology (AREA)
Obesity (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Endocrinology (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Thiazole And Isothizaole Compounds (AREA)

SK1714-2002A 2000-06-08 2001-06-08 Soľ tiazolidindiónu na liečenie diabetes mellitus SK17142002A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GBGB0014006.1A GB0014006D0 (en)	2000-06-08	2000-06-08	Novel pharmaceutical
PCT/GB2001/002567 WO2001094344A1 (en)	2000-06-08	2001-06-08	Thiazolidinedione salt for treatment of diabetes mellitus

Publications (1)

Publication Number	Publication Date
SK17142002A3 true SK17142002A3 (sk)	2003-10-07

Family

ID=9893257

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1714-2002A SK17142002A3 (sk)	2000-06-08	2001-06-08	Soľ tiazolidindiónu na liečenie diabetes mellitus

Country Status (23)

Country	Link
EP (1)	EP1296980A1 (cs)
JP (1)	JP2003535862A (cs)
KR (1)	KR20030007918A (cs)
CN (1)	CN1443186A (cs)
AP (1)	AP2002002673A0 (cs)
AU (1)	AU2001264078A1 (cs)
BG (1)	BG107357A (cs)
BR (1)	BR0111536A (cs)
CA (1)	CA2411065A1 (cs)
CZ (1)	CZ20023966A3 (cs)
DZ (1)	DZ3382A1 (cs)
EA (1)	EA200300005A1 (cs)
GB (1)	GB0014006D0 (cs)
HU (1)	HUP0301137A3 (cs)
IL (1)	IL153279A0 (cs)
MA (1)	MA25753A1 (cs)
MX (1)	MXPA02012100A (cs)
NO (1)	NO20025883L (cs)
OA (1)	OA12284A (cs)
PL (1)	PL360592A1 (cs)
SK (1)	SK17142002A3 (cs)
WO (1)	WO2001094344A1 (cs)
ZA (1)	ZA200209954B (cs)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
USRE39384E1 (en)	1993-09-01	2006-11-07	Smithkline Beecham P.L.C.	Substituted thiazolidinedione derivatives
DE102005034406A1 (de) *	2005-07-22	2007-02-01	Ratiopharm Gmbh	Neue Salze von Rosiglitazon
EP2016076A2 (en) *	2007-01-22	2009-01-21	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of rosiglitazone hydrobromide and processes for preparation thereof
EP1956018A1 (de) *	2007-02-06	2008-08-13	Boehringer Ingelheim Pharma GmbH & Co. KG	Verfahren zur Herstellung eines Benzimidazolderivats
WO2010021745A2 (en) *	2008-08-21	2010-02-25	Teva Pharmaceutical Industries Ltd.	Polymorphic forms of rosiglitazone hydrobromide and processes for their preparation

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
GB9218830D0 (en) *	1992-09-05	1992-10-21	Smithkline Beecham Plc	Novel compounds

2000
- 2000-06-08 GB GBGB0014006.1A patent/GB0014006D0/en not_active Ceased
2001
- 2001-06-08 WO PCT/GB2001/002567 patent/WO2001094344A1/en not_active Ceased
- 2001-06-08 BR BR0111536-7A patent/BR0111536A/pt not_active IP Right Cessation
- 2001-06-08 AU AU2001264078A patent/AU2001264078A1/en not_active Abandoned
- 2001-06-08 AP APAP/P/2002/002673A patent/AP2002002673A0/en unknown
- 2001-06-08 MX MXPA02012100A patent/MXPA02012100A/es unknown
- 2001-06-08 CZ CZ20023966A patent/CZ20023966A3/cs unknown
- 2001-06-08 EP EP01938400A patent/EP1296980A1/en not_active Withdrawn
- 2001-06-08 JP JP2002501893A patent/JP2003535862A/ja active Pending
- 2001-06-08 CA CA002411065A patent/CA2411065A1/en not_active Abandoned
- 2001-06-08 CN CN01813190A patent/CN1443186A/zh active Pending
- 2001-06-08 DZ DZ013382A patent/DZ3382A1/xx active
- 2001-06-08 HU HU0301137A patent/HUP0301137A3/hu unknown
- 2001-06-08 EA EA200300005A patent/EA200300005A1/ru unknown
- 2001-06-08 OA OA1200200370A patent/OA12284A/en unknown
- 2001-06-08 IL IL15327901A patent/IL153279A0/xx unknown
- 2001-06-08 KR KR1020027016721A patent/KR20030007918A/ko not_active Withdrawn
- 2001-06-08 PL PL36059201A patent/PL360592A1/xx not_active Application Discontinuation
- 2001-06-08 SK SK1714-2002A patent/SK17142002A3/sk not_active Application Discontinuation
2002
- 2002-12-04 MA MA26933A patent/MA25753A1/fr unknown
- 2002-12-05 BG BG107357A patent/BG107357A/bg unknown
- 2002-12-06 NO NO20025883A patent/NO20025883L/no not_active Application Discontinuation
- 2002-12-09 ZA ZA200209954A patent/ZA200209954B/en unknown

Also Published As

Publication number	Publication date
BG107357A (bg)	2003-08-29
PL360592A1 (en)	2004-09-20
CA2411065A1 (en)	2001-12-13
CN1443186A (zh)	2003-09-17
AU2001264078A1 (en)	2001-12-17
CZ20023966A3 (cs)	2003-04-16
BR0111536A (pt)	2003-07-01
JP2003535862A (ja)	2003-12-02
GB0014006D0 (en)	2000-08-02
NO20025883D0 (no)	2002-12-06
EA200300005A1 (ru)	2003-04-24
DZ3382A1 (fr)	2001-12-13
MXPA02012100A (es)	2003-04-25
AP2002002673A0 (en)	2002-12-31
KR20030007918A (ko)	2003-01-23
MA25753A1 (fr)	2003-04-01
ZA200209954B (en)	2003-10-10
IL153279A0 (en)	2003-07-06
EP1296980A1 (en)	2003-04-02
WO2001094344A1 (en)	2001-12-13
HUP0301137A2 (hu)	2003-08-28
NO20025883L (no)	2003-02-03
HUP0301137A3 (en)	2005-04-28
OA12284A (en)	2003-11-10

Legal Events

Date	Code	Title	Description
2010-05-07	FC9A	Refused patent application

Publication	Publication Date	Title
US6815457B1 (en)	2004-11-09	Thiazolidinedione derivative and its use as antidiabetic
CA2314107A1 (en)	1999-06-24	5-[4-[2- (n-methyl-n- (2-pyridyl)amino) ethoxy]benzyl] thiazolidine-2, 4-dione, maleic acid salt, hydrate as pharmaceutical
SK17142002A3 (sk)	2003-10-07	Soľ tiazolidindiónu na liečenie diabetes mellitus
EP1305312B1 (en)	2008-04-23	Tartrate salts of thiazolidinedione derivative
CZ300653B6 (cs)	2009-07-08	Dihydrát 5-{4-[2-(N-methyl-N-(2-pyridyl)amino)ethoxy]benzyl}thiazolidin-2,4-dion-hydrochloridu, zpusob jeho prípravy a použití a farmaceutický prostredek s jeho obsahem
EP1305311B1 (en)	2008-01-16	Tartrate salt of thiazolidinedione derivative
SK17152002A3 (sk)	2003-05-02	Hydrojodid 5-[4-[2-(N-metyl-N-(2-pyridyl)amíno)etoxy]- benzyl]tiazolidín-2,4-diónu ako liečivo
US20030162815A1 (en)	2003-08-28	Thiazolidinedione salt for treatment of diabetes mellitus
EP1305310B1 (en)	2008-02-20	Tartrate salts of thiazolidinedione derivative
SK1452003A3 (en)	2004-05-04	Tartrate salts of thiazolidinedione derivative
EP1325000B1 (en)	2007-07-25	A thiazolidinedione derivative and its use as antidiabetic
US20040102485A1 (en)	2004-05-27	Tartrate salt of thiazolidinedione derivative
WO2003050111A1 (en)	2003-06-19	Toluenesulfonate salts of a thiazolidinedione derivative
HK1105818A (en)	2008-02-22	A thiazolidinedione derivative and its use as antidiabetic