SK2132000A3 - Cyclopeptide derivatives as adhesion inhibitors - Google Patents

Cyclopeptide derivatives as adhesion inhibitors Download PDF

Info

Publication number: SK2132000A3
Authority: SK; Slovakia
Prior art keywords: formula; compound; compounds; group; acid
Prior art date: 1997-08-23

Application number

SK213-2000A

Other languages

English (en)

Slovak (sk)

Inventor

Gunter Holzemann

Simon Goodman

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-08-23

Filing date

1998-08-14

Publication date

2000-09-12

1998-08-14 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2000-09-12 Publication of SK2132000A3 publication Critical patent/SK2132000A3/sk

Links

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229940002612 prodrug Drugs 0.000 description 1
239000000047 product Substances 0.000 description 1
230000005522 programmed cell death Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
230000002285 radioactive effect Effects 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000000926 separation method Methods 0.000 description 1
238000010898 silica gel chromatography Methods 0.000 description 1
229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000007790 solid phase Substances 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
125000003107 substituted aryl group Chemical group 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
235000000346 sugar Nutrition 0.000 description 1
150000008163 sugars Chemical class 0.000 description 1
239000000725 suspension Substances 0.000 description 1
230000002459 sustained effect Effects 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
125000004213 tert-butoxy group Chemical group [H]C([H])([H])C(O*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
WROMPOXWARCANT-UHFFFAOYSA-N tfa trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F.OC(=O)C(F)(F)F WROMPOXWARCANT-UHFFFAOYSA-N 0.000 description 1
HNKJADCVZUBCPG-UHFFFAOYSA-N thioanisole Chemical compound CSC1=CC=CC=C1 HNKJADCVZUBCPG-UHFFFAOYSA-N 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
125000003774 valeryl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
210000005167 vascular cell Anatomy 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
230000029663 wound healing Effects 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
- C07K5/0202—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmacology & Pharmacy (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Rheumatology (AREA)
Heart & Thoracic Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biophysics (AREA)
Biochemistry (AREA)
Orthopedic Medicine & Surgery (AREA)
Hospice & Palliative Care (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Crystallography & Structural Chemistry (AREA)
Communicable Diseases (AREA)
Hematology (AREA)
Diabetes (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Peptides Or Proteins (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

SK213-2000A 1997-08-23 1998-08-14 Cyclopeptide derivatives as adhesion inhibitors SK2132000A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE19736772A DE19736772A1 (de)	1997-08-23	1997-08-23	Cyclopeptidderivate
PCT/EP1998/005161 WO1999010371A2 (de)	1997-08-23	1998-08-14	Cyclopeptidderivate als adhäsionsinhibitoren

Publications (1)

Publication Number	Publication Date
SK2132000A3 true SK2132000A3 (en)	2000-09-12

Family

ID=7839977

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK213-2000A SK2132000A3 (en)	1997-08-23	1998-08-14	Cyclopeptide derivatives as adhesion inhibitors

Country Status (18)

Country	Link
EP (1)	EP1007545A2 (de)
JP (1)	JP2001514186A (de)
KR (1)	KR20010022828A (de)
CN (1)	CN1267306A (de)
AR (1)	AR013650A1 (de)
AU (1)	AU734829B2 (de)
BR (1)	BR9811992A (de)
CA (1)	CA2301182A1 (de)
DE (1)	DE19736772A1 (de)
HU (1)	HUP0003500A3 (de)
ID (1)	ID23952A (de)
NO (1)	NO20000860L (de)
PL (1)	PL341090A1 (de)
RU (1)	RU2200166C2 (de)
SK (1)	SK2132000A3 (de)
TW (1)	TW477793B (de)
WO (1)	WO1999010371A2 (de)
ZA (1)	ZA987558B (de)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
UA43823C2 (uk) *	1992-07-06	2002-01-15	Мерк Патент Геселлшафт Міт Бесшренктер Хафтунг	ФАРМАЦЕВТИЧНА КОМПОЗИЦІЯ ДЛЯ ІНГІБУВАННЯ ІНТЕГРИН <font face="Symbol">a</font><sub>V</sub><font face="Symbol">b</font><sub>3</sub>-ОПОСЕРЕДКОВАНОЇ КЛІТИННОЇ АДГЕЗІЇ КЛІТИН ССАВЦІВ, СПОСІБ ЛІКУВАННЯ ТА ПРОФІЛАКТИКИ ЗАХВОРЮВАННЯ, АСОЦІЙОВАНОГО З ПОРУШЕННЯМ АДГЕЗІЇ КЛІТИН, СПОСІБ БЛОКУВАННЯ ЗВ'ЯЗУВАННЯ ФІБРИНОГЕНОМ ІНТЕГРИНУ, КОМПОЗИЦІЯ ДЛЯ ЗАГОЄННЯ РАН
US5879657A (en) *	1993-03-30	1999-03-09	The Dupont Merck Pharmaceutical Company	Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
DE4310643A1 (de) *	1993-04-01	1994-10-06	Merck Patent Gmbh	Cyclische Adhäsionsinhibitoren
DE4415310A1 (de) *	1994-04-30	1995-11-02	Merck Patent Gmbh	Cyclopeptide
JPH07316193A (ja) *	1994-05-24	1995-12-05	Asahi Glass Co Ltd	ペプチド誘導体およびその用途

1997
- 1997-08-23 DE DE19736772A patent/DE19736772A1/de not_active Withdrawn
1998
- 1998-08-14 CN CN98808380A patent/CN1267306A/zh active Pending
- 1998-08-14 PL PL98341090A patent/PL341090A1/xx unknown
- 1998-08-14 AU AU95319/98A patent/AU734829B2/en not_active Ceased
- 1998-08-14 HU HU0003500A patent/HUP0003500A3/hu unknown
- 1998-08-14 BR BR9811992-3A patent/BR9811992A/pt not_active IP Right Cessation
- 1998-08-14 CA CA002301182A patent/CA2301182A1/en not_active Abandoned
- 1998-08-14 ID IDW20000532A patent/ID23952A/id unknown
- 1998-08-14 SK SK213-2000A patent/SK2132000A3/sk unknown
- 1998-08-14 KR KR1020007001430A patent/KR20010022828A/ko not_active Withdrawn
- 1998-08-14 JP JP2000507697A patent/JP2001514186A/ja active Pending
- 1998-08-14 RU RU2000107122/04A patent/RU2200166C2/ru not_active IP Right Cessation
- 1998-08-14 EP EP98948833A patent/EP1007545A2/de not_active Withdrawn
- 1998-08-14 WO PCT/EP1998/005161 patent/WO1999010371A2/de not_active Ceased
- 1998-08-19 TW TW087113657A patent/TW477793B/zh not_active IP Right Cessation
- 1998-08-20 ZA ZA987558A patent/ZA987558B/xx unknown
- 1998-08-21 AR ARP980104136A patent/AR013650A1/es not_active Application Discontinuation
2000
- 2000-02-22 NO NO20000860A patent/NO20000860L/no unknown

Also Published As

Publication number	Publication date
CA2301182A1 (en)	1999-03-04
ZA987558B (en)	1999-02-23
EP1007545A2 (de)	2000-06-14
PL341090A1 (en)	2001-03-26
NO20000860D0 (no)	2000-02-22
WO1999010371A2 (de)	1999-03-04
HUP0003500A3 (en)	2001-12-28
HUP0003500A2 (hu)	2001-02-28
TW477793B (en)	2002-03-01
AU9531998A (en)	1999-03-16
WO1999010371A3 (de)	1999-05-27
NO20000860L (no)	2000-02-22
BR9811992A (pt)	2000-09-05
JP2001514186A (ja)	2001-09-11
DE19736772A1 (de)	1999-02-25
AR013650A1 (es)	2001-01-10
AU734829B2 (en)	2001-06-21
CN1267306A (zh)	2000-09-20
RU2200166C2 (ru)	2003-03-10
KR20010022828A (ko)	2001-03-26
ID23952A (id)	2000-06-08

Publication	Publication Date	Title
US6326403B1 (en)	2001-12-04	Diacylhydrazine derivatives as integrin inhibitors
RU2157379C2 (ru)	2000-10-10	Циклопептиды, способ их получения, содержащая их фармацевтическая композиция, способ ее получения
SK176898A3 (en)	1999-05-07	Phenylalamine derivatives as integrin inhibitors
CZ286705B6 (en)	2000-06-14	Cyclopeptide, process of its preparation, its use and pharmaceutical preparation containing thereof
US6566491B2 (en)	2003-05-20	Cyclopeptide derivatives
US6534478B1 (en)	2003-03-18	Cyclic azapeptides with angiogenic effect
AU722817B2 (en)	2000-08-10	Cyclopeptide derivatives
SK280597B6 (sk)	2000-04-10	Cyklopeptidy, spôsob ich výroby, farmaceutický pro
AU734829B2 (en)	2001-06-21	Cyclopeptide derivatives
CZ2000636A3 (cs)	2000-06-14	Derivát cyklického peptidu jakožto inhibitor adheze
HUP0200643A2 (hu)	2002-07-29	Dibenzoazulénszármazékok, a vegyületeket tartalmazó gyógyszerkészítmények, eljárás előállításukra, valamint a vegyületek alkalmazása gyógyszerkészítmények előállítására
CZ465899A3 (cs)	2000-05-17	Derivát cyklického azapeptidu s angiogenním působením
CZ2001141A3 (cs)	2001-06-13	Derivát diacylhydrazinu jakožto integrinový inhibitor, způsob jeho přípravy, jeho použití a farmaceutický prostředek, který ho obsahuje
MXPA00001728A (en)	2001-05-17	Cyclopeptide derivatives as adhesion inhibitors
MXPA01000437A (en)	2001-12-13	Diacylhydrazine derivatives as integrin inhibitors
HK1029352A (en)	2001-03-30	Cyclopeptide derivatives as adhesion inhibitors