SK2792004A3 - Process for the preparation of tofisopam and new intermediates - Google Patents

Process for the preparation of tofisopam and new intermediates Download PDF

Info

Publication number
SK2792004A3
SK2792004A3 SK279-2004A SK2792004A SK2792004A3 SK 2792004 A3 SK2792004 A3 SK 2792004A3 SK 2792004 A SK2792004 A SK 2792004A SK 2792004 A3 SK2792004 A3 SK 2792004A3
Authority
SK
Slovakia
Prior art keywords
compound
dimethoxy
formula
alkali metal
magnesium
Prior art date
Application number
SK279-2004A
Other languages
English (en)
Slovak (sk)
Inventor
Samu Erika Molnarne
Gyula Simig
Pal Vago
Zoltan Greff
Original Assignee
Egyt Gyogyszervegyeszeti Gyar
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU0105326A external-priority patent/HU225411B1/hu
Priority claimed from HU0105327A external-priority patent/HUP0105327A3/hu
Application filed by Egyt Gyogyszervegyeszeti Gyar filed Critical Egyt Gyogyszervegyeszeti Gyar
Publication of SK2792004A3 publication Critical patent/SK2792004A3/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/26—Radicals substituted by doubly bound oxygen or sulfur atoms or by two such atoms singly bound to the same carbon atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C07C45/57—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom
    • C07C45/59—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds with oxygen as the only heteroatom in five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/02—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SK279-2004A 2001-12-13 2002-12-12 Process for the preparation of tofisopam and new intermediates SK2792004A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU0105326A HU225411B1 (en) 2001-12-13 2001-12-13 Process for producing tofisopam
HU0105327A HUP0105327A3 (en) 2001-12-13 2001-12-13 Process for the production of 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-pentane-2-one
PCT/HU2002/000141 WO2003050092A2 (en) 2001-12-13 2002-12-12 Process for the preparation of tofisopam and new intermediates

Publications (1)

Publication Number Publication Date
SK2792004A3 true SK2792004A3 (en) 2004-11-03

Family

ID=89979996

Family Applications (1)

Application Number Title Priority Date Filing Date
SK279-2004A SK2792004A3 (en) 2001-12-13 2002-12-12 Process for the preparation of tofisopam and new intermediates

Country Status (7)

Country Link
EP (1) EP1465879A2 (cs)
AU (1) AU2002348942A1 (cs)
BG (1) BG108801A (cs)
CZ (1) CZ2004792A3 (cs)
PL (1) PL370036A1 (cs)
SK (1) SK2792004A3 (cs)
WO (1) WO2003050092A2 (cs)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HU227044B1 (en) * 2002-12-16 2010-05-28 Egis Gyogyszergyar Nyilvanosan Process for producing 3-[2-(3,4-dimethoxybenzoyl)-4,5-dimethoxyphenyl]-pentan-2-one
FR2996845A1 (fr) * 2012-10-12 2014-04-18 Servier Lab Nouveau procede de synthese du 3-(2-bromo-4,5-dimethoxyphenyl)propanenitrile, et application a la synthese de l'ivabradine et de ses sels d'addition a un acide pharmaceutiquement acceptable

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA712798B (en) * 1970-11-06 1972-02-23 Egyt Gyogyszervegyeszeti Gyar New,pharmaceutically active 2,3-diazabicyclo(5.4.0)undecapentaene derivative and process for preparing same

Also Published As

Publication number Publication date
AU2002348942A1 (en) 2003-06-23
WO2003050092A3 (en) 2003-11-06
CZ2004792A3 (cs) 2004-12-15
EP1465879A2 (en) 2004-10-13
BG108801A (en) 2005-04-30
WO2003050092A2 (en) 2003-06-19
AU2002348942A8 (en) 2003-06-23
PL370036A1 (en) 2005-05-16

Similar Documents

Publication Publication Date Title
EP0553213B1 (en) Process for the synthesis of (4r-cis)-1,1-dimethylethyl-6-cyanomethyl-2,2-dimethyl-1,3-dioxane-4-acetate
RU2443671C2 (ru) Новый способ синтеза (е)-стильбеновых производных, который позволяет получить ресвератрол и писатаннол
BG62554B1 (bg) Метод за получаване на силденафил
El Hallaoui et al. Efficient synthesis of symmetrically substituted pyridines and substituted alkenes through green and heterogeneous catalysis with zinc phosphate
CA2308922C (en) Process for cis-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine
SK2792004A3 (en) Process for the preparation of tofisopam and new intermediates
EP0897924B1 (en) Process for the preparation of tetrahydro-indolizines
Cossy et al. Synthetic studies towards ML-3000 a concise synthesis of this non-steroidal anti-inflammatory drug
JP4437093B2 (ja) ３−［２−（３，４−ジメトキシ−ベンゾイル）−４，５−ジメトキシ−フェニル］−ペンタン−２−オンの製法
EP0309626B1 (en) Process for the preparation of dibenzothiepin derivative
HUP0105327A2 (hu) Eljárás 3-[2-(3,4-dimetoxi-benzoil)-4,5-dimetoxi-fenil]-pentán-2-on elżállítására
US4891433A (en) Process for the preparation of dibenzothiepin derivative
US4501891A (en) Method of forming a solution of papavrine carbanion
EP0379935A1 (en) A process for preparing naphthalene derivatives
EP0578849A1 (en) Process for the preparation of 1,3-dioxane-4,6-dione derivates
HU225411B1 (en) Process for producing tofisopam
CA2555051C (en) Process for cis-1-{2-[4-(6-methoxy-2-phenyl-1,2,3,4-tetrahydronaphthalen-1-yl)phenoxy]ethyl}pyrrolidine
CA1294626C (en) Process for the preparation of dibenzothiepin derivative
JPH10316609A (ja) ２−ヒドロキシ−５−ノルボルネン−２−カルボン酸の製造方法
JP2000256338A (ja) エポキシケトンの製造方法
JPH08253472A (ja) ジベンゾチエピン誘導体の製造方法
HK1005026B (en) Process for the synthesis of (4r-cis)-1, 1-dimethylethyl-6-cyanomethyl-2, 2-dimethyl-1, 3-dioxane-4-acetate
JP2000044568A (ja) 生理作用を有するジベンゾオキセピンおよびジベンゾチエピン誘導体の中間体
JP2000026368A (ja) プロピニル化合物