SK282052B6 - Derivát benzoylguanidínu obsahujúceho fluór, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje - Google Patents

Derivát benzoylguanidínu obsahujúceho fluór, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje Download PDF

Info

Publication number: SK282052B6
Authority: SK; Slovakia
Prior art keywords: formula; benzoylguanidine; general formula; compounds; methyl
Prior art date: 1995-05-16

Application number

SK590-96A

Other languages

English (en)

Slovak (sk)

Other versions

SK59096A3 (en

Inventor

Dieter Dorsch

Manfred Baumgarth

Rolf Gericke

Klaus-Otto Minck

Norbert Beier

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-05-16

Filing date

1996-05-09

Publication date

2001-10-08

1996-05-09 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

1996-12-04 Publication of SK59096A3 publication Critical patent/SK59096A3/sk

2001-10-08 Publication of SK282052B6 publication Critical patent/SK282052B6/sk

Links

238000002360 preparation method Methods 0.000 title claims description 9
AJDQRQQNNLZLPM-UHFFFAOYSA-N n-(diaminomethylidene)benzamide Chemical class NC(N)=NC(=O)C1=CC=CC=C1 AJDQRQQNNLZLPM-UHFFFAOYSA-N 0.000 title claims description 7
229910052731 fluorine Inorganic materials 0.000 title description 4
239000011737 fluorine Substances 0.000 title description 4
PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 title 1
239000000825 pharmaceutical preparation Substances 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 48
ZRALSGWEFCBTJO-UHFFFAOYSA-N Guanidine Chemical compound NC(N)=N ZRALSGWEFCBTJO-UHFFFAOYSA-N 0.000 claims abstract description 24
150000003839 salts Chemical class 0.000 claims abstract description 19
238000011282 treatment Methods 0.000 claims abstract description 14
CHJJGSNFBQVOTG-UHFFFAOYSA-N N-methyl-guanidine Natural products CNC(N)=N CHJJGSNFBQVOTG-UHFFFAOYSA-N 0.000 claims abstract description 12
SWSQBOPZIKWTGO-UHFFFAOYSA-N dimethylaminoamidine Natural products CN(C)C(N)=N SWSQBOPZIKWTGO-UHFFFAOYSA-N 0.000 claims abstract description 12
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239000012442 inert solvent Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
230000000302 ischemic effect Effects 0.000 description 1
230000007654 ischemic lesion Effects 0.000 description 1
238000002955 isolation Methods 0.000 description 1
150000002576 ketones Chemical class 0.000 description 1
210000003734 kidney Anatomy 0.000 description 1
235000019388 lanolin Nutrition 0.000 description 1
229940039717 lanolin Drugs 0.000 description 1
210000000265 leukocyte Anatomy 0.000 description 1
210000004185 liver Anatomy 0.000 description 1
239000006210 lotion Substances 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
210000004072 lung Anatomy 0.000 description 1
229940057948 magnesium stearate Drugs 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
239000012528 membrane Substances 0.000 description 1
UKIMWXUUSVBJJS-UHFFFAOYSA-N methyl 2-methyl-5-methylsulfonyl-4-(trifluoromethyl)benzoate Chemical compound COC(=O)C1=CC(S(C)(=O)=O)=C(C(F)(F)F)C=C1C UKIMWXUUSVBJJS-UHFFFAOYSA-N 0.000 description 1
LQODVVRNKLSHHZ-UHFFFAOYSA-N methyl 3-methylsulfonyl-4-(trifluoromethyl)benzoate Chemical compound COC(=O)C1=CC=C(C(F)(F)F)C(S(C)(=O)=O)=C1 LQODVVRNKLSHHZ-UHFFFAOYSA-N 0.000 description 1
QGAGCQPVCPGBJM-UHFFFAOYSA-N methyl 4-bromo-3-methylsulfonylbenzoate Chemical compound COC(=O)C1=CC=C(Br)C(S(C)(=O)=O)=C1 QGAGCQPVCPGBJM-UHFFFAOYSA-N 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 1
LNOPIUAQISRISI-UHFFFAOYSA-N n'-hydroxy-2-propan-2-ylsulfonylethanimidamide Chemical compound CC(C)S(=O)(=O)CC(N)=NO LNOPIUAQISRISI-UHFFFAOYSA-N 0.000 description 1
PJNVHCLQAAYUSK-UHFFFAOYSA-N n-(diaminomethylidene)-2-methyl-4-phenoxy-5-(trifluoromethyl)benzamide Chemical compound C1=C(C(=O)N=C(N)N)C(C)=CC(OC=2C=CC=CC=2)=C1C(F)(F)F PJNVHCLQAAYUSK-UHFFFAOYSA-N 0.000 description 1
TWANYRKMWKQXDZ-UHFFFAOYSA-N n-(diaminomethylidene)-2-methyl-5-methylsulfonyl-4-(trifluoromethoxy)benzamide;2-methyl-5-methylsulfonyl-4-(trifluoromethoxy)benzoic acid Chemical compound CC1=CC(OC(F)(F)F)=C(S(C)(=O)=O)C=C1C(O)=O.CC1=CC(OC(F)(F)F)=C(S(C)(=O)=O)C=C1C(=O)N=C(N)N TWANYRKMWKQXDZ-UHFFFAOYSA-N 0.000 description 1
URBDIHSNGQFELA-UHFFFAOYSA-N n-(diaminomethylidene)-3-methylsulfonyl-4-(trifluoromethyl)benzamide Chemical compound CS(=O)(=O)C1=CC(C(=O)N=C(N)N)=CC=C1C(F)(F)F URBDIHSNGQFELA-UHFFFAOYSA-N 0.000 description 1
150000002825 nitriles Chemical class 0.000 description 1
150000002828 nitro derivatives Chemical class 0.000 description 1
LYGJENNIWJXYER-UHFFFAOYSA-N nitromethane Chemical compound C[N+]([O-])=O LYGJENNIWJXYER-UHFFFAOYSA-N 0.000 description 1
238000007339 nucleophilic aromatic substitution reaction Methods 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
239000012074 organic phase Substances 0.000 description 1
238000006053 organic reaction Methods 0.000 description 1
230000003204 osmotic effect Effects 0.000 description 1
238000007911 parenteral administration Methods 0.000 description 1
239000006072 paste Substances 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
150000003016 phosphoric acids Chemical class 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
229940116317 potato starch Drugs 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
208000037920 primary disease Diseases 0.000 description 1
235000013772 propylene glycol Nutrition 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
238000000746 purification Methods 0.000 description 1
230000001603 reducing effect Effects 0.000 description 1
230000033764 rhythmic process Effects 0.000 description 1
230000000894 saliuretic effect Effects 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
208000037921 secondary disease Diseases 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
239000007921 spray Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
238000003756 stirring Methods 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
229960004793 sucrose Drugs 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
238000011477 surgical intervention Methods 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
229940124597 therapeutic agent Drugs 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
230000002792 vascular Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/04—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton
- C07C279/14—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to acyclic carbon atoms of a carbon skeleton being further substituted by carboxyl groups
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/20—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups containing any of the groups, X being a hetero atom, Y being any atom, e.g. acylguanidines
- C07C279/22—Y being a hydrogen or a carbon atom, e.g. benzoylguanidines

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Engineering & Computer Science (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Diabetes (AREA)
Hematology (AREA)
Vascular Medicine (AREA)
Emergency Medicine (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Obesity (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Phenolic Resins Or Amino Resins (AREA)
Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

SK590-96A 1995-05-16 1996-05-09 Derivát benzoylguanidínu obsahujúceho fluór, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje SK282052B6 (sk)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE19517848A DE19517848A1 (de)	1995-05-16	1995-05-16	Fluorhaltige Benzoylguanidine

Publications (2)

Publication Number	Publication Date
SK59096A3 SK59096A3 (en)	1996-12-04
SK282052B6 true SK282052B6 (sk)	2001-10-08

Family

ID=7761987

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK590-96A SK282052B6 (sk)	1995-05-16	1996-05-09	Derivát benzoylguanidínu obsahujúceho fluór, spôsob jeho prípravy, jeho použitie a farmaceutický prostriedok, ktorý ho obsahuje

Country Status (23)

Country	Link
US (1)	US5747539A (fr)
EP (1)	EP0743301B1 (fr)
JP (1)	JPH08311011A (fr)
KR (1)	KR960041154A (fr)
CN (1)	CN1064955C (fr)
AT (1)	ATE204856T1 (fr)
AU (1)	AU713743B2 (fr)
CA (1)	CA2176553A1 (fr)
CZ (1)	CZ287750B6 (fr)
DE (2)	DE19517848A1 (fr)
DK (1)	DK0743301T3 (fr)
ES (1)	ES2161936T3 (fr)
GR (1)	GR3037033T3 (fr)
HU (1)	HU223046B1 (fr)
NO (1)	NO306157B1 (fr)
PL (1)	PL184192B1 (fr)
PT (1)	PT743301E (fr)
RU (1)	RU2159230C2 (fr)
SI (1)	SI0743301T1 (fr)
SK (1)	SK282052B6 (fr)
TW (1)	TW363052B (fr)
UA (1)	UA44260C2 (fr)
ZA (1)	ZA963870B (fr)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE4328352A1 (de) *	1993-08-24	1995-03-02	Hoechst Ag	Substituierte N,N'-Di-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19606509A1 (de) *	1996-02-22	1997-08-28	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19608161A1 (de)	1996-03-04	1997-09-11	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
US5747639A (en) *	1996-03-06	1998-05-05	Amgen Boulder Inc.	Use of hydrophobic interaction chromatography to purify polyethylene glycols
DE19713427A1 (de) *	1997-04-01	1998-10-08	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
CN1328452A (zh) *	1998-11-26	2001-12-26	默克专利股份公司	苯甲酰基胍类治疗非胰岛素依赖性糖尿病的用途
US7375138B2 (en)	2002-05-18	2008-05-20	Sanofi-Aventis Deutschland Gmbh	Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them
DE10222192A1 (de) *	2002-05-18	2003-11-27	Aventis Pharma Gmbh	Pentafluorsulfuranyl-benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE10226462A1 (de) *	2002-06-13	2003-12-24	Aventis Pharma Gmbh	Fluorierte Cycloalkyl-derivatisierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament, sowie sie enthaltendes Medikament
US20050124666A1 (en) *	2003-11-13	2005-06-09	Aventis Pharma Deutschland Gmbh	Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same
OA13285A (en) *	2003-11-13	2007-01-31	Sanofi Aventis Deutschland	Pentafluorosulfanyl benzoylguanidines, method for their production, their use as medicaments or diagnostic agents and medicament containing the same.
DE10353204A1 (de) *	2003-11-13	2005-06-16	Aventis Pharma Deutschland Gmbh	Verfahren zur Herstellung von 4-Pentafluorsulfanyl-benzoylguanidinen

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3929582A1 (de) *	1989-09-06	1991-03-07	Hoechst Ag	Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament
EP0556674B1 (fr) *	1992-02-15	1996-06-19	Hoechst Aktiengesellschaft	Benzoylguanidines 3,5-substitués avec une activité antiarrhythmique et une activité inhibitrice de la prolifération des cellules
CZ284456B6 (cs) *	1992-02-15	1998-12-16	Hoechst Aktiengesellschaft	Aminosubstituované benzoylguanidiny, způsob jejich přípravy, jejich použití jako léčiv a léčivo, které je obsahuje
DK0556673T3 (da) *	1992-02-15	1998-04-14	Hoechst Ag	o-Substituerede benzoylguanidiner til behandling og profylakse af hjerterytmeforstyrrelser og iskæmisk inducerede skader samt til inhiberering af celleproliferation
DK0589336T3 (da) *	1992-09-22	1997-06-16	Hoechst Ag	Benzylguanidiner, fremgangsmåde til deres fremstilling samt deres anvendelse som antiarytmetika
TW250477B (fr) *	1992-12-15	1995-07-01	Hoechst Ag
TW250479B (fr) *	1992-12-15	1995-07-01	Hoechst Ag
ATE157351T1 (de) *	1993-02-20	1997-09-15	Hoechst Ag	Substituierte benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament, als inhibitoren des zellulären na+/h+-austauschs oder als diagnostikum sowie sie enthaltendes medikament
DE4318756A1 (de) *	1993-06-05	1994-12-08	Hoechst Ag	Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4328869A1 (de) *	1993-08-27	1995-03-02	Hoechst Ag	Ortho-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4417004A1 (de) *	1994-05-13	1995-11-16	Hoechst Ag	Perfluoralkyl-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE4430916A1 (de) *	1994-08-31	1996-03-07	Merck Patent Gmbh	Alkyl-benzoylguanidin-Derivate

1995
- 1995-05-16 DE DE19517848A patent/DE19517848A1/de not_active Withdrawn
1996
- 1996-03-25 TW TW085103561A patent/TW363052B/zh active
- 1996-05-02 AT AT96106881T patent/ATE204856T1/de not_active IP Right Cessation
- 1996-05-02 DK DK96106881T patent/DK0743301T3/da active
- 1996-05-02 ES ES96106881T patent/ES2161936T3/es not_active Expired - Lifetime
- 1996-05-02 DE DE59607559T patent/DE59607559D1/de not_active Expired - Fee Related
- 1996-05-02 PT PT96106881T patent/PT743301E/pt unknown
- 1996-05-02 EP EP96106881A patent/EP0743301B1/fr not_active Expired - Lifetime
- 1996-05-02 SI SI9630361T patent/SI0743301T1/xx unknown
- 1996-05-09 SK SK590-96A patent/SK282052B6/sk unknown
- 1996-05-13 CN CN961058854A patent/CN1064955C/zh not_active Expired - Fee Related
- 1996-05-13 UA UA96051860A patent/UA44260C2/uk unknown
- 1996-05-13 AU AU52252/96A patent/AU713743B2/en not_active Ceased
- 1996-05-14 CA CA002176553A patent/CA2176553A1/fr not_active Abandoned
- 1996-05-15 ZA ZA963870A patent/ZA963870B/xx unknown
- 1996-05-15 US US08/647,789 patent/US5747539A/en not_active Expired - Fee Related
- 1996-05-15 RU RU96109204/04A patent/RU2159230C2/ru not_active IP Right Cessation
- 1996-05-15 KR KR1019960016096A patent/KR960041154A/ko not_active Abandoned
- 1996-05-15 CZ CZ19961408A patent/CZ287750B6/cs not_active IP Right Cessation
- 1996-05-15 NO NO961997A patent/NO306157B1/no not_active IP Right Cessation
- 1996-05-15 HU HU9601305A patent/HU223046B1/hu not_active IP Right Cessation
- 1996-05-15 PL PL96314259A patent/PL184192B1/pl unknown
- 1996-05-16 JP JP8144881A patent/JPH08311011A/ja active Pending
2001
- 2001-10-30 GR GR20010401903T patent/GR3037033T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
HU223046B1 (hu)	2004-03-01
RU2159230C2 (ru)	2000-11-20
AU5225296A (en)	1996-11-28
HUP9601305A2 (en)	1997-05-28
HU9601305D0 (en)	1996-07-29
TW363052B (en)	1999-07-01
GR3037033T3 (en)	2002-01-31
US5747539A (en)	1998-05-05
EP0743301A2 (fr)	1996-11-20
SI0743301T1 (en)	2002-02-28
PL314259A1 (en)	1996-11-25
JPH08311011A (ja)	1996-11-26
DK0743301T3 (da)	2001-11-26
NO961997D0 (no)	1996-05-15
CN1143632A (zh)	1997-02-26
EP0743301B1 (fr)	2001-08-29
NO306157B1 (no)	1999-09-27
NO961997L (no)	1996-11-18
ATE204856T1 (de)	2001-09-15
HUP9601305A3 (en)	1997-11-28
EP0743301A3 (fr)	1997-06-11
ES2161936T3 (es)	2001-12-16
PT743301E (pt)	2002-01-30
DE59607559D1 (de)	2001-10-04
CA2176553A1 (fr)	1996-11-17
AU713743B2 (en)	1999-12-09
ZA963870B (en)	1996-11-21
SK59096A3 (en)	1996-12-04
PL184192B1 (pl)	2002-09-30
KR960041154A (ko)	1996-12-19
CZ287750B6 (en)	2001-01-17
UA44260C2 (uk)	2002-02-15
CN1064955C (zh)	2001-04-25
CZ140896A3 (en)	1997-02-12
DE19517848A1 (de)	1996-11-21

Publication	Publication Date	Title
EP0640593B1 (fr)	1997-12-29	Benzoylguanidines substituées, procédé pour leur préparation, leur utilisation comme médicament ou en diagnostic et médicaments les contenant
SK281766B6 (sk)	2001-07-10	Substituované sulfónimidamidy, spôsob ich prípravy, ich použitie ako liečiva alebo diagnostika, ako i liečivo, ktoré ich obsahuje
US5849796A (en)	1998-12-15	Ortho-substituted benzoil acid derivatives
EP0602522B1 (fr)	1996-05-29	Benzoylguanidines substituées, leur procédé de préparation, leur utilisation comme agents antiarrhythmiques
CZ287750B6 (en)	2001-01-17	Fluorine-containing benzoylguanidine derivative, process of its preparation and pharmaceutical preparation in which it is comprised
PL184320B1 (pl)	2002-10-31	Nowe związki, pochodne 4-sulfonylo-lub 4-sulfinylobenzoiloguanidyny, sposób ich wytwarzania oraz preparat farmaceutyczny
SK13196A3 (en)	1996-09-04	Alkalicly substituted benzoylguanidines, manufacturing process thereof, their use as drug or diagnostic agent and drugs containing these compositions
SK96596A3 (en)	1997-03-05	Substituted guanidines of cinnamic acid, manufacturing process thereof, their use as drug or diagnosticum as a drug containing them
SK62996A3 (en)	1996-12-04	Substituted benzyloxycarbonyl guanidines, method of their producing, their use and drugs containing them
UA44237C2 (uk)	2002-02-15	Арилбензоїлгуанідини, спосіб їх отримання, фармацевтична композиція
CZ288015B6 (cs)	2001-04-11	Derivát alkylbenzoylguanidinu, způsob jeho přípravy a farmaceutický prostředek, který ho obsahuje
SK281198B6 (sk)	2001-01-18	Derivát 4-aminobenzoylguanidínu, spôsob jeho prípravy a farmaceutický prostriedok, ktorý ho obsahuje
US5756535A (en)	1998-05-26	Substituted thiophenylalkenylcarboxylic acid guanidines, processes for their preparation, their use as a medicament or diagnositc, and a medicament containing them
SK283040B6 (sk)	2003-02-04	Heterocyklyloxybenzoylguanidíny, spôsob ich výroby, ich použitie a farmaceutické prostriedky na ich báze
HU224011B1 (hu)	2005-04-28	Alkil-5-metil-szulfonil-benzoil-guanidin-származékok, eljárás előállításukra az ezeket tartalmazó gyógyászati készítmények és alkalmazásuk
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