SK282991B6 - Stabilizovaná farmaceutická kompozícia na báze kyseliny (E)- 3,5-dihydroxy-7-[4'-4''-fluórfenyl-2'-cyklopropylchinolin-3'yl]- 6-hepténovej - Google Patents

Stabilizovaná farmaceutická kompozícia na báze kyseliny (E)- 3,5-dihydroxy-7-[4'-4''-fluórfenyl-2'-cyklopropylchinolin-3'yl]- 6-hepténovej Download PDF

Info

Publication number: SK282991B6
Authority: SK; Slovakia
Prior art keywords: pharmaceutical composition; stabilized pharmaceutical; composition according; composition; tablets
Prior art date: 1995-12-22

Application number

SK1160-97A

Other languages

English (en)

Slovak (sk)

Other versions

SK116097A3 (en

Inventor

Toyojiro Muramatsu

Katsumi Mashita

Yasuo Shinoda

Hironori Sassa

Hiroyuki Kawashima

Yoshio Tanizawa

Hideatsu Takeuchi

Original Assignee

Kowa Company, Ltd.

Nissan Chemical Industries, Ltd.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-22

Filing date

1996-12-20

Publication date

2003-01-09

1996-12-20 Application filed by Kowa Company, Ltd., Nissan Chemical Industries, Ltd. filed Critical Kowa Company, Ltd.

1998-03-04 Publication of SK116097A3 publication Critical patent/SK116097A3/sk

2003-01-09 Publication of SK282991B6 publication Critical patent/SK282991B6/sk

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 29
239000000203 mixture Substances 0.000 claims abstract description 45
150000003839 salts Chemical class 0.000 claims abstract description 14
150000002148 esters Chemical class 0.000 claims abstract description 13
239000007864 aqueous solution Substances 0.000 claims abstract description 10
239000006185 dispersion Substances 0.000 claims abstract description 10
229920002153 Hydroxypropyl cellulose Polymers 0.000 claims description 17
239000001863 hydroxypropyl cellulose Substances 0.000 claims description 17
235000010977 hydroxypropyl cellulose Nutrition 0.000 claims description 17
GUBGYTABKSRVRQ-QKKXKWKRSA-N lactose group Chemical group OC1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@@H](O)[C@H](O2)CO)[C@H](O1)CO GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 9
239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims description 8
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims description 8
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims description 8
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical group OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims description 8
239000008101 lactose Substances 0.000 claims description 8
-1 magnesium aluminate Chemical class 0.000 claims description 8
238000002360 preparation method Methods 0.000 claims description 8
239000011230 binding agent Substances 0.000 claims description 7
159000000007 calcium salts Chemical class 0.000 claims description 7
239000011777 magnesium Substances 0.000 claims description 7
229910052749 magnesium Inorganic materials 0.000 claims description 7
239000007787 solid Substances 0.000 claims description 7
VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical class [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 claims description 6
239000000314 lubricant Substances 0.000 claims description 6
235000014852 L-arginine Nutrition 0.000 claims description 5
229930064664 L-arginine Natural products 0.000 claims description 5
ZPWVASYFFYYZEW-UHFFFAOYSA-L dipotassium hydrogen phosphate Chemical compound [K+].[K+].OP([O-])([O-])=O ZPWVASYFFYYZEW-UHFFFAOYSA-L 0.000 claims description 5
229940069428 antacid Drugs 0.000 claims description 4
239000003159 antacid agent Substances 0.000 claims description 4
239000007884 disintegrant Substances 0.000 claims description 4
239000000126 substance Substances 0.000 claims description 3
239000002253 acid Substances 0.000 claims description 2
150000001875 compounds Chemical class 0.000 claims description 2
125000002059 L-arginyl group Chemical group O=C([*])[C@](N([H])[H])([H])C([H])([H])C([H])([H])C([H])([H])N([H])C(=N[H])N([H])[H] 0.000 claims 1
HZVVJJIYJKGMFL-UHFFFAOYSA-N almasilate Chemical compound O.[Mg+2].[Al+3].[Al+3].O[Si](O)=O.O[Si](O)=O HZVVJJIYJKGMFL-UHFFFAOYSA-N 0.000 claims 1
230000001458 anti-acid effect Effects 0.000 claims 1
JAUGGEIKQIHSMF-UHFFFAOYSA-N dialuminum;dimagnesium;dioxido(oxo)silane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-][Si]([O-])=O.[O-][Si]([O-])=O.[O-][Si]([O-])=O JAUGGEIKQIHSMF-UHFFFAOYSA-N 0.000 claims 1
230000036962 time dependent Effects 0.000 abstract 1
239000003826 tablet Substances 0.000 description 43
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 18
239000000725 suspension Substances 0.000 description 18
230000000052 comparative effect Effects 0.000 description 13
238000006467 substitution reaction Methods 0.000 description 13
238000003860 storage Methods 0.000 description 11
238000012360 testing method Methods 0.000 description 11
235000019359 magnesium stearate Nutrition 0.000 description 9
238000009472 formulation Methods 0.000 description 8
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 6
230000014759 maintenance of location Effects 0.000 description 6
FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 5
239000008187 granular material Substances 0.000 description 5
229940031705 hydroxypropyl methylcellulose 2910 Drugs 0.000 description 5
239000008188 pellet Substances 0.000 description 5
ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 description 4
239000003814 drug Substances 0.000 description 4
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
201000001320 Atherosclerosis Diseases 0.000 description 3
229920002261 Corn starch Polymers 0.000 description 3
229940121710 HMGCoA reductase inhibitor Drugs 0.000 description 3
HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
239000011575 calcium Substances 0.000 description 3
229920002678 cellulose Polymers 0.000 description 3
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239000011248 coating agent Substances 0.000 description 3
238000000576 coating method Methods 0.000 description 3
239000008120 corn starch Substances 0.000 description 3
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239000002471 hydroxymethylglutaryl coenzyme A reductase inhibitor Substances 0.000 description 3
229910000030 sodium bicarbonate Inorganic materials 0.000 description 3
235000017557 sodium bicarbonate Nutrition 0.000 description 3
238000003756 stirring Methods 0.000 description 3
FKHIFSZMMVMEQY-UHFFFAOYSA-N talc Chemical compound [Mg+2].[O-][Si]([O-])=O FKHIFSZMMVMEQY-UHFFFAOYSA-N 0.000 description 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
229920002134 Carboxymethyl cellulose Polymers 0.000 description 2
CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 2
229920002472 Starch Polymers 0.000 description 2
VJHCJDRQFCCTHL-UHFFFAOYSA-N acetic acid 2,3,4,5,6-pentahydroxyhexanal Chemical compound CC(O)=O.OCC(O)C(O)C(O)C(O)C=O VJHCJDRQFCCTHL-UHFFFAOYSA-N 0.000 description 2
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
229910052782 aluminium Inorganic materials 0.000 description 2
WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 description 2
229910000019 calcium carbonate Inorganic materials 0.000 description 2
235000010948 carboxy methyl cellulose Nutrition 0.000 description 2
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239000001913 cellulose Substances 0.000 description 2
239000003086 colorant Substances 0.000 description 2
230000007423 decrease Effects 0.000 description 2
BNIILDVGGAEEIG-UHFFFAOYSA-L disodium hydrogen phosphate Chemical compound [Na+].[Na+].OP([O-])([O-])=O BNIILDVGGAEEIG-UHFFFAOYSA-L 0.000 description 2
201000005577 familial hyperlipidemia Diseases 0.000 description 2
IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
239000000395 magnesium oxide Substances 0.000 description 2
CPLXHLVBOLITMK-UHFFFAOYSA-N magnesium oxide Inorganic materials [Mg]=O CPLXHLVBOLITMK-UHFFFAOYSA-N 0.000 description 2
AXZKOIWUVFPNLO-UHFFFAOYSA-N magnesium;oxygen(2-) Chemical compound [O-2].[Mg+2] AXZKOIWUVFPNLO-UHFFFAOYSA-N 0.000 description 2
239000004014 plasticizer Substances 0.000 description 2
239000000843 powder Substances 0.000 description 2
239000001488 sodium phosphate Substances 0.000 description 2
239000000243 solution Substances 0.000 description 2
235000019698 starch Nutrition 0.000 description 2
239000008107 starch Substances 0.000 description 2
LWIHDJKSTIGBAC-UHFFFAOYSA-K tripotassium phosphate Chemical compound [K+].[K+].[K+].[O-]P([O-])([O-])=O LWIHDJKSTIGBAC-UHFFFAOYSA-K 0.000 description 2
PVQQCAJOMYNDEJ-UHFFFAOYSA-N 3-acetyl-3-(1,2-dihydroxyethyl)pentane-2,4-dione Chemical compound C(C)(=O)C(C(CO)O)(C(C)=O)C(C)=O PVQQCAJOMYNDEJ-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
102000004286 Hydroxymethylglutaryl CoA Reductases Human genes 0.000 description 1
108090000895 Hydroxymethylglutaryl CoA Reductases Proteins 0.000 description 1
208000031226 Hyperlipidaemia Diseases 0.000 description 1
229930195725 Mannitol Natural products 0.000 description 1
102000004316 Oxidoreductases Human genes 0.000 description 1
108090000854 Oxidoreductases Proteins 0.000 description 1
235000021314 Palmitic acid Nutrition 0.000 description 1
239000004372 Polyvinyl alcohol Substances 0.000 description 1
239000004373 Pullulan Substances 0.000 description 1
229920001218 Pullulan Polymers 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
229930006000 Sucrose Natural products 0.000 description 1
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 1
DOOTYTYQINUNNV-UHFFFAOYSA-N Triethyl citrate Chemical compound CCOC(=O)CC(O)(C(=O)OCC)CC(=O)OCC DOOTYTYQINUNNV-UHFFFAOYSA-N 0.000 description 1
YKTSYUJCYHOUJP-UHFFFAOYSA-N [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] Chemical compound [O--].[Al+3].[Al+3].[O-][Si]([O-])([O-])[O-] YKTSYUJCYHOUJP-UHFFFAOYSA-N 0.000 description 1
239000004480 active ingredient Substances 0.000 description 1
239000000654 additive Substances 0.000 description 1
230000000996 additive effect Effects 0.000 description 1
SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 1
229920003144 amino alkyl methacrylate copolymer Polymers 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
229960005070 ascorbic acid Drugs 0.000 description 1
238000003556 assay Methods 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000002775 capsule Substances 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000007796 conventional method Methods 0.000 description 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
GDVKFRBCXAPAQJ-UHFFFAOYSA-A dialuminum;hexamagnesium;carbonate;hexadecahydroxide Chemical compound [OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[OH-].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Mg+2].[Al+3].[Al+3].[O-]C([O-])=O GDVKFRBCXAPAQJ-UHFFFAOYSA-A 0.000 description 1
229910000397 disodium phosphate Inorganic materials 0.000 description 1
235000019800 disodium phosphate Nutrition 0.000 description 1
239000008298 dragée Substances 0.000 description 1
239000007941 film coated tablet Substances 0.000 description 1
239000000796 flavoring agent Substances 0.000 description 1
235000019634 flavors Nutrition 0.000 description 1
239000012530 fluid Substances 0.000 description 1
238000009477 fluid bed granulation Methods 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
238000005469 granulation Methods 0.000 description 1
230000003179 granulation Effects 0.000 description 1
238000004128 high performance liquid chromatography Methods 0.000 description 1
229910052739 hydrogen Inorganic materials 0.000 description 1
239000001257 hydrogen Substances 0.000 description 1
229960001545 hydrotalcite Drugs 0.000 description 1
229910001701 hydrotalcite Inorganic materials 0.000 description 1
125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
238000010348 incorporation Methods 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000003112 inhibitor Substances 0.000 description 1
230000002401 inhibitory effect Effects 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
229960003511 macrogol Drugs 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
HCWCAKKEBCNQJP-UHFFFAOYSA-N magnesium orthosilicate Chemical compound [Mg+2].[Mg+2].[O-][Si]([O-])([O-])[O-] HCWCAKKEBCNQJP-UHFFFAOYSA-N 0.000 description 1
239000000391 magnesium silicate Substances 0.000 description 1
229910052919 magnesium silicate Inorganic materials 0.000 description 1
235000019792 magnesium silicate Nutrition 0.000 description 1
239000000594 mannitol Substances 0.000 description 1
235000010355 mannitol Nutrition 0.000 description 1
238000004519 manufacturing process Methods 0.000 description 1
238000000034 method Methods 0.000 description 1
238000012986 modification Methods 0.000 description 1
230000004048 modification Effects 0.000 description 1
229910000402 monopotassium phosphate Inorganic materials 0.000 description 1
235000019796 monopotassium phosphate Nutrition 0.000 description 1
WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
125000000962 organic group Chemical group 0.000 description 1
239000000546 pharmaceutical excipient Substances 0.000 description 1
PJNZPQUBCPKICU-UHFFFAOYSA-N phosphoric acid;potassium Chemical compound [K].OP(O)(O)=O PJNZPQUBCPKICU-UHFFFAOYSA-N 0.000 description 1
229940096701 plain lipid modifying drug hmg coa reductase inhibitors Drugs 0.000 description 1
229920002451 polyvinyl alcohol Polymers 0.000 description 1
235000019422 polyvinyl alcohol Nutrition 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
229910000160 potassium phosphate Inorganic materials 0.000 description 1
235000011009 potassium phosphates Nutrition 0.000 description 1
229940088417 precipitated calcium carbonate Drugs 0.000 description 1
230000002035 prolonged effect Effects 0.000 description 1
235000019423 pullulan Nutrition 0.000 description 1
238000007127 saponification reaction Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
235000010378 sodium ascorbate Nutrition 0.000 description 1
229960005055 sodium ascorbate Drugs 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
229910000029 sodium carbonate Inorganic materials 0.000 description 1
229910000162 sodium phosphate Inorganic materials 0.000 description 1
235000011008 sodium phosphates Nutrition 0.000 description 1
159000000000 sodium salts Chemical class 0.000 description 1
PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
239000000600 sorbitol Substances 0.000 description 1
235000010356 sorbitol Nutrition 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000007940 sugar coated tablet Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
235000012222 talc Nutrition 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
239000001069 triethyl citrate Substances 0.000 description 1
VMYFZRTXGLUXMZ-UHFFFAOYSA-N triethyl citrate Natural products CCOC(=O)C(O)(C(=O)OCC)C(=O)OCC VMYFZRTXGLUXMZ-UHFFFAOYSA-N 0.000 description 1
235000013769 triethyl citrate Nutrition 0.000 description 1
RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
239000002023 wood Substances 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Cardiology (AREA)
Obesity (AREA)
Vascular Medicine (AREA)
Urology & Nephrology (AREA)
Inorganic Chemistry (AREA)
Diabetes (AREA)
Hematology (AREA)
Heart & Thoracic Surgery (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Plant Substances (AREA)
Enzymes And Modification Thereof (AREA)
Plural Heterocyclic Compounds (AREA)

SK1160-97A 1995-12-22 1996-12-20 Stabilizovaná farmaceutická kompozícia na báze kyseliny (E)- 3,5-dihydroxy-7-[4'-4''-fluórfenyl-2'-cyklopropylchinolin-3'yl]- 6-hepténovej SK282991B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
JP35465495		1995-12-22
PCT/JP1996/003722 WO1997023200A1 (en)	1995-12-22	1996-12-20	Pharmaceutical composition stabilized with a basic agent

Publications (2)

Publication Number	Publication Date
SK116097A3 SK116097A3 (en)	1998-03-04
SK282991B6 true SK282991B6 (sk)	2003-01-09

Family

ID=18439011

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK1160-97A SK282991B6 (sk)	1995-12-22	1996-12-20	Stabilizovaná farmaceutická kompozícia na báze kyseliny (E)- 3,5-dihydroxy-7-[4'-4''-fluórfenyl-2'-cyklopropylchinolin-3'yl]- 6-hepténovej

Country Status (26)

Country	Link
EP (1)	EP0814782B1 (de)
JP (1)	JP3276962B2 (de)
KR (1)	KR100348842B1 (de)
CN (1)	CN1137684C (de)
AT (1)	ATE228354T1 (de)
AU (1)	AU725622B2 (de)
CA (1)	CA2213608C (de)
CZ (1)	CZ288545B6 (de)
DE (2)	DE69625046T2 (de)
DK (1)	DK0814782T3 (de)
ES (1)	ES2183023T3 (de)
FR (1)	FR11C0007I2 (de)
HU (1)	HU227798B1 (de)
IL (1)	IL121565A (de)
MX (1)	MX9706389A (de)
NO (2)	NO316724B1 (de)
NZ (1)	NZ324446A (de)
PL (1)	PL186907B1 (de)
PT (1)	PT814782E (de)
RU (1)	RU2142790C1 (de)
SI (1)	SI0814782T1 (de)
SK (1)	SK282991B6 (de)
TW (1)	TW436294B (de)
UA (1)	UA29513C2 (de)
WO (1)	WO1997023200A1 (de)
ZA (1)	ZA9610792B (de)

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UA87854C2 (en)	2004-06-07	2009-08-25	Мерк Энд Ко., Инк.	N-(2-benzyl)-2-phenylbutanamides as androgen receptor modulators
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1996
- 1996-12-20 DK DK96942588T patent/DK0814782T3/da active
- 1996-12-20 WO PCT/JP1996/003722 patent/WO1997023200A1/en not_active Ceased
- 1996-12-20 IL IL12156596A patent/IL121565A/en not_active IP Right Cessation
- 1996-12-20 CA CA002213608A patent/CA2213608C/en not_active Expired - Lifetime
- 1996-12-20 JP JP52350097A patent/JP3276962B2/ja not_active Expired - Lifetime
- 1996-12-20 DE DE69625046T patent/DE69625046T2/de not_active Expired - Lifetime
- 1996-12-20 AT AT96942588T patent/ATE228354T1/de active
- 1996-12-20 CZ CZ19972681A patent/CZ288545B6/cs not_active IP Right Cessation
- 1996-12-20 HU HU9903536A patent/HU227798B1/hu unknown
- 1996-12-20 EP EP96942588A patent/EP0814782B1/de not_active Expired - Lifetime
- 1996-12-20 ES ES96942588T patent/ES2183023T3/es not_active Expired - Lifetime
- 1996-12-20 PT PT96942588T patent/PT814782E/pt unknown
- 1996-12-20 UA UA97084351A patent/UA29513C2/uk unknown
- 1996-12-20 PL PL96321868A patent/PL186907B1/pl unknown
- 1996-12-20 KR KR1019970705768A patent/KR100348842B1/ko not_active Expired - Lifetime
- 1996-12-20 AU AU11715/97A patent/AU725622B2/en not_active Expired
- 1996-12-20 SK SK1160-97A patent/SK282991B6/sk not_active IP Right Cessation
- 1996-12-20 CN CNB961920653A patent/CN1137684C/zh not_active Expired - Lifetime
- 1996-12-20 RU RU97114095A patent/RU2142790C1/ru active
- 1996-12-20 NZ NZ324446A patent/NZ324446A/xx not_active IP Right Cessation
- 1996-12-20 DE DE201112000014 patent/DE122011000014I1/de active Pending
- 1996-12-20 ZA ZA9610792A patent/ZA9610792B/xx unknown
- 1996-12-20 SI SI9630566T patent/SI0814782T1/xx unknown
- 1996-12-21 TW TW085115860A patent/TW436294B/zh not_active IP Right Cessation
1997
- 1997-08-19 NO NO19973814A patent/NO316724B1/no not_active IP Right Cessation
- 1997-08-21 MX MX9706389A patent/MX9706389A/es unknown
2011
- 2011-03-17 FR FR11C0007C patent/FR11C0007I2/fr active Active
- 2011-05-04 NO NO2011006C patent/NO2011006I2/no unknown

Also Published As

Publication number	Publication date
HUP9903536A2 (hu)	2000-03-28
EP0814782A1 (de)	1998-01-07
PT814782E (pt)	2003-04-30
CA2213608A1 (en)	1997-07-03
HUP9903536A3 (en)	2001-06-28
UA29513C2 (uk)	2000-11-15
IL121565A (en)	2002-02-10
NZ324446A (en)	1999-08-30
FR11C0007I1 (de)	2011-04-22
AU725622B2 (en)	2000-10-19
CN1189098A (zh)	1998-07-29
NO316724B1 (no)	2004-04-19
FR11C0007I2 (fr)	2012-03-16
NO2011006I2 (no)	2012-10-01
KR100348842B1 (ko)	2002-12-31
JPH11503763A (ja)	1999-03-30
CZ268197A3 (cs)	1998-05-13
ES2183023T3 (es)	2003-03-16
SK116097A3 (en)	1998-03-04
DE122011000014I1 (de)	2011-11-03
WO1997023200A1 (en)	1997-07-03
DK0814782T3 (da)	2002-12-16
DE69625046T2 (de)	2003-04-10
NO973814D0 (no)	1997-08-19
NO2011006I1 (no)	2011-06-06
AU1171597A (en)	1997-07-17
SI0814782T1 (en)	2003-04-30
EP0814782B1 (de)	2002-11-27
CA2213608C (en)	2003-07-08
IL121565A0 (en)	1998-02-08
CZ288545B6 (cs)	2001-07-11
RU2142790C1 (ru)	1999-12-20
HU227798B1 (en)	2012-03-28
MX9706389A (es)	1998-08-30
NO973814L (no)	1997-10-13
ZA9610792B (en)	1997-07-09
ATE228354T1 (de)	2002-12-15
KR19980702370A (ko)	1998-07-15
CN1137684C (zh)	2004-02-11
JP3276962B2 (ja)	2002-04-22
PL321868A1 (en)	1997-12-22
DE69625046D1 (de)	2003-01-09
PL186907B1 (pl)	2004-03-31
TW436294B (en)	2001-05-28

Legal Events

Date	Code	Title	Description
2017-02-02	MK4A	Patent expired	Expiry date: 20161220

Publication	Publication Date	Title
EP0814782B1 (de)	2002-11-27	Pharmazeutische zusammensetzung stabilisiert mit einem basischen medium
AU2000249434B2 (en)	2006-02-02	Stabilized pharmaceutically effective composition and pharmaceutical formulation comprising the same
SK283936B6 (sk)	2004-05-04	Farmaceutický prípravok na ústne podávanie, tabletový prípravok na ústne podávanie, spôsob výroby a použitie tohto prípravku
PL217835B1 (pl)	2014-08-29	Preparat farmaceutyczny zawierający sól wapniową atorwastatyny, sposób wytwarzania tego preparatu i jego zastosowanie do leczenia hipercholesterolemii i hiperlipidemii
ZA200406970B (en)	2005-06-20	Formulations of atorvastatin stabilized with alkali metal additions.
PT1274401E (pt)	2011-12-02	Composições farmacêuticas estáveis contendo ácidos 7-substituídos-3,5-di-hidroxi-heptanóicos ou ácidos 7-substituídos-3,5-di-hidroxi-heptenóicos
CA2692862C (en)	2013-11-12	Stable compositions
US5322698A (en)	1994-06-21	Process for the preparation of a tablet or dragee composition containing a heat-, light- and moisture-sensitive active ingredient having monoclinic crystal structure
US6465477B1 (en)	2002-10-15	Stable pharmaceutical composition
EP2698159A1 (de)	2014-02-19	Pitavastatinhaltiges präparat und herstellungsverfahren dafür
RU2199318C2 (ru)	2003-02-27	Стабилизированные в отношении рацемизации фармацевтические лекарственные формы силанзетрона
EP0159777A1 (de)	1985-10-30	Stabilisiertes 4-Carbamoyl-imidazolium-5-olat
US5091191A (en)	1992-02-25	Pharmaceutical composition with improved dissolution property
JP2006008667A (ja)	2006-01-12	ビタミンｃ類を含む安定化された固形製剤
US20190070167A1 (en)	2019-03-07	Pitavastatin containing preparation and method for producing same
WO2009091346A2 (en)	2009-07-23	Stable pharmaceutical formulation and preparation methods
JP2004010501A (ja)	2004-01-15	固形製剤及びその製造方法
EP1259227A1 (de)	2002-11-27	Verfahren zur herstellung von pharmazeutischen darreichungsformen
JP2003095939A (ja)	2003-04-03	安定なプラバスタチンナトリウム錠
EP1825848A2 (de)	2007-08-29	Stabile pharmazeutische Zusammensetzungen umfassend einen HMG-CoA-Reduktase Inhibitor
HK1034673A (en)	2001-11-02	Pharmaceutical compositions