SK283370B6 - Bioadhezívna farmaceutická kompozícia a spôsob jej prípravy - Google Patents

Bioadhezívna farmaceutická kompozícia a spôsob jej prípravy Download PDF

Info

Publication number: SK283370B6
Authority: SK; Slovakia
Prior art keywords: composition; weight; tablet; composition according; tablets
Prior art date: 1995-12-27

Application number

SK887-98A

Other languages

English (en)

Slovak (sk)

Other versions

SK88798A3 (en

Inventor

Paul Marie Victor Gilis

Original Assignee

Janssen Pharmaceutica N. V.

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1995-12-27

Filing date

1996-12-20

Publication date

2003-06-03

1996-12-20 Application filed by Janssen Pharmaceutica N. V. filed Critical Janssen Pharmaceutica N. V.

1998-11-04 Publication of SK88798A3 publication Critical patent/SK88798A3/sk

2003-06-03 Publication of SK283370B6 publication Critical patent/SK283370B6/sk

Links

239000000227 bioadhesive Substances 0.000 title claims abstract description 16
238000000034 method Methods 0.000 title claims abstract description 11
239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 5
238000002360 preparation method Methods 0.000 title claims description 3
239000000203 mixture Substances 0.000 claims abstract description 50
239000000314 lubricant Substances 0.000 claims abstract description 19
229920000642 polymer Polymers 0.000 claims abstract description 14
239000011159 matrix material Substances 0.000 claims abstract description 11
239000004480 active ingredient Substances 0.000 claims abstract description 8
229920000881 Modified starch Polymers 0.000 claims abstract description 7
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims abstract description 5
239000003513 alkali Substances 0.000 claims abstract 2
239000003826 tablet Substances 0.000 claims description 48
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 17
MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 claims description 15
229940045902 sodium stearyl fumarate Drugs 0.000 claims description 15
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MCCACAIVAXEFAL-UHFFFAOYSA-N 1-[2-(2,4-dichlorophenyl)-2-[(2,4-dichlorophenyl)methoxy]ethyl]imidazole;nitric acid Chemical compound O[N+]([O-])=O.ClC1=CC(Cl)=CC=C1COC(C=1C(=CC(Cl)=CC=1)Cl)CN1C=NC=C1 MCCACAIVAXEFAL-UHFFFAOYSA-N 0.000 claims description 11
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YREYEVIYCVEVJK-UHFFFAOYSA-N rabeprazole Chemical compound COCCCOC1=CC=NC(CS(=O)C=2NC3=CC=CC=C3N=2)=C1C YREYEVIYCVEVJK-UHFFFAOYSA-N 0.000 description 1
229960003401 ramipril Drugs 0.000 description 1
HDACQVRGBOVJII-JBDAPHQKSA-N ramipril Chemical compound C([C@@H](C(=O)OCC)N[C@@H](C)C(=O)N1[C@@H](C[C@@H]2CCC[C@@H]21)C(O)=O)CC1=CC=CC=C1 HDACQVRGBOVJII-JBDAPHQKSA-N 0.000 description 1
229960000620 ranitidine Drugs 0.000 description 1
VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
BJOIZNZVOZKDIG-MDEJGZGSSA-N reserpine Chemical compound O([C@H]1[C@@H]([C@H]([C@H]2C[C@@H]3C4=C([C]5C=CC(OC)=CC5=N4)CCN3C[C@H]2C1)C(=O)OC)OC)C(=O)C1=CC(OC)=C(OC)C(OC)=C1 BJOIZNZVOZKDIG-MDEJGZGSSA-N 0.000 description 1
229960003147 reserpine Drugs 0.000 description 1
229960004181 riluzole Drugs 0.000 description 1
229960000311 ritonavir Drugs 0.000 description 1
NCDNCNXCDXHOMX-XGKFQTDJSA-N ritonavir Chemical compound N([C@@H](C(C)C)C(=O)N[C@H](C[C@H](O)[C@H](CC=1C=CC=CC=1)NC(=O)OCC=1SC=NC=1)CC=1C=CC=CC=1)C(=O)N(C)CC1=CSC(C(C)C)=N1 NCDNCNXCDXHOMX-XGKFQTDJSA-N 0.000 description 1
GWHQHAUAXRMMOT-MBANBULQSA-N rivastigmine tartrate Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O.CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 GWHQHAUAXRMMOT-MBANBULQSA-N 0.000 description 1
MDMGHDFNKNZPAU-UHFFFAOYSA-N roserpine Natural products C1C2CN3CCC(C4=CC=C(OC)C=C4N4)=C4C3CC2C(OC(C)=O)C(OC)C1OC(=O)C1=CC(OC)=C(OC)C(OC)=C1 MDMGHDFNKNZPAU-UHFFFAOYSA-N 0.000 description 1
235000002020 sage Nutrition 0.000 description 1
229960001852 saquinavir Drugs 0.000 description 1
QWAXKHKRTORLEM-UGJKXSETSA-N saquinavir Chemical compound C([C@@H]([C@H](O)CN1C[C@H]2CCCC[C@H]2C[C@H]1C(=O)NC(C)(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)C=1N=C2C=CC=CC2=CC=1)C1=CC=CC=C1 QWAXKHKRTORLEM-UGJKXSETSA-N 0.000 description 1
229960002646 scopolamine Drugs 0.000 description 1
STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 1
229940125723 sedative agent Drugs 0.000 description 1
239000000932 sedative agent Substances 0.000 description 1
IYETZZCWLLUHIJ-UTONKHPSSA-N selegiline hydrochloride Chemical compound [Cl-].C#CC[NH+](C)[C@H](C)CC1=CC=CC=C1 IYETZZCWLLUHIJ-UTONKHPSSA-N 0.000 description 1
235000012239 silicon dioxide Nutrition 0.000 description 1
229960002855 simvastatin Drugs 0.000 description 1
RYMZZMVNJRMUDD-HGQWONQESA-N simvastatin Chemical compound C([C@H]1[C@@H](C)C=CC2=C[C@H](C)C[C@@H]([C@H]12)OC(=O)C(C)(C)CC)C[C@@H]1C[C@@H](O)CC(=O)O1 RYMZZMVNJRMUDD-HGQWONQESA-N 0.000 description 1
230000036556 skin irritation Effects 0.000 description 1
231100000475 skin irritation Toxicity 0.000 description 1
229940083542 sodium Drugs 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
OTEANHMVDHZOPB-SLINCCQESA-N sodium;(2s,5r,6r)-6-[[3-(2-chloro-6-fluorophenyl)-5-methyl-1,2-oxazole-4-carbonyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid Chemical compound [Na+].N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(F)C=CC=C1Cl OTEANHMVDHZOPB-SLINCCQESA-N 0.000 description 1
STFSJTPVIIDAQX-LTRPLHCISA-M sodium;(e)-4-octadecoxy-4-oxobut-2-enoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCCOC(=O)\C=C\C([O-])=O STFSJTPVIIDAQX-LTRPLHCISA-M 0.000 description 1
JGMJQSFLQWGYMQ-UHFFFAOYSA-M sodium;2,6-dichloro-n-phenylaniline;acetate Chemical compound [Na+].CC([O-])=O.ClC1=CC=CC(Cl)=C1NC1=CC=CC=C1 JGMJQSFLQWGYMQ-UHFFFAOYSA-M 0.000 description 1
KQKPFRSPSRPDEB-UHFFFAOYSA-N sumatriptan Chemical compound CNS(=O)(=O)CC1=CC=C2NC=C(CCN(C)C)C2=C1 KQKPFRSPSRPDEB-UHFFFAOYSA-N 0.000 description 1
229960003708 sumatriptan Drugs 0.000 description 1
238000013268 sustained release Methods 0.000 description 1
239000012730 sustained-release form Substances 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
229960001685 tacrine Drugs 0.000 description 1
YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 description 1
230000009967 tasteless effect Effects 0.000 description 1
229960000351 terfenadine Drugs 0.000 description 1
229940116411 terpineol Drugs 0.000 description 1
238000012360 testing method Methods 0.000 description 1
239000001585 thymus vulgaris Substances 0.000 description 1
229950011282 tivirapine Drugs 0.000 description 1
229960002044 tolmetin sodium Drugs 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
229960002117 triamcinolone acetonide Drugs 0.000 description 1
YNDXUCZADRHECN-JNQJZLCISA-N triamcinolone acetonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O YNDXUCZADRHECN-JNQJZLCISA-N 0.000 description 1
GPMXUUPHFNMNDH-UHFFFAOYSA-N trifluperidol Chemical compound C1CC(O)(C=2C=C(C=CC=2)C(F)(F)F)CCN1CCCC(=O)C1=CC=C(F)C=C1 GPMXUUPHFNMNDH-UHFFFAOYSA-N 0.000 description 1
229960002341 trifluperidol Drugs 0.000 description 1
229960001722 verapamil Drugs 0.000 description 1
239000000341 volatile oil Substances 0.000 description 1
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
229960005080 warfarin Drugs 0.000 description 1
238000009736 wetting Methods 0.000 description 1
229960000607 ziprasidone Drugs 0.000 description 1
MVWVFYHBGMAFLY-UHFFFAOYSA-N ziprasidone Chemical compound C1=CC=C2C(N3CCN(CC3)CCC3=CC=4CC(=O)NC=4C=C3Cl)=NSC2=C1 MVWVFYHBGMAFLY-UHFFFAOYSA-N 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
General Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Diabetes (AREA)
Nutrition Science (AREA)
Molecular Biology (AREA)
Biophysics (AREA)
Hematology (AREA)
Physiology (AREA)
Endocrinology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Obesity (AREA)
Heart & Thoracic Surgery (AREA)
Cardiology (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK887-98A 1995-12-27 1996-12-20 Bioadhezívna farmaceutická kompozícia a spôsob jej prípravy SK283370B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP95203649		1995-12-27
PCT/EP1996/005884 WO1997024109A1 (en)	1995-12-27	1996-12-20	Bioadhesive solid dosage form

Publications (2)

Publication Number	Publication Date
SK88798A3 SK88798A3 (en)	1998-11-04
SK283370B6 true SK283370B6 (sk)	2003-06-03

Family

ID=8221021

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK887-98A SK283370B6 (sk)	1995-12-27	1996-12-20	Bioadhezívna farmaceutická kompozícia a spôsob jej prípravy

Country Status (26)

Country	Link
US (1)	US6303147B1 (de)
EP (1)	EP0869772B1 (de)
JP (1)	JP4317264B2 (de)
KR (1)	KR100459029B1 (de)
CN (1)	CN1146401C (de)
AT (1)	ATE206304T1 (de)
AU (1)	AU713849B2 (de)
BR (1)	BR9612291A (de)
CA (1)	CA2232152C (de)
CY (1)	CY2269B1 (de)
CZ (1)	CZ298690B6 (de)
DE (1)	DE69615704T2 (de)
DK (1)	DK0869772T3 (de)
EA (1)	EA000818B1 (de)
ES (1)	ES2164940T3 (de)
HU (1)	HU228350B1 (de)
IL (1)	IL123636A (de)
NO (1)	NO320015B1 (de)
NZ (1)	NZ325844A (de)
PL (1)	PL186278B1 (de)
PT (1)	PT869772E (de)
SI (1)	SI0869772T1 (de)
SK (1)	SK283370B6 (de)
TR (1)	TR199800894T2 (de)
WO (1)	WO1997024109A1 (de)
ZA (1)	ZA9610886B (de)

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US7198795B2 (en)	2000-09-21	2007-04-03	Elan Pharma International Ltd.	In vitro methods for evaluating the in vivo effectiveness of dosage forms of microparticulate of nanoparticulate active agent compositions
US8980334B2 (en) *	2001-02-28	2015-03-17	Axiomedic Ltd.	Double-layered absorbable solid compositions for the topical treatment of oral mucosal disorders
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GB0417401D0 (en)	2004-08-05	2004-09-08	Controlled Therapeutics Sct	Stabilised prostaglandin composition
EA201001086A1 (ru)	2004-08-13	2011-10-31	Бёрингер Ингельхайм Интернациональ Гмбх	Композиция пеллеты пролонгированного высвобождения, содержащая прамипексол или его фармацевтически приемлемую соль, способ ее изготовления и ее применение
US20070048369A1 (en) *	2005-08-26	2007-03-01	National Starch And Chemical Investment Holding Corporation	Mucosal delivery tablet
GB0518129D0 (en) *	2005-09-06	2005-10-12	Arrow Int Ltd	Ramipril formulation
US20070098782A1 (en) *	2005-10-28	2007-05-03	Selamine Limited	Ramipril Formulation
GB2431579A (en) *	2005-10-28	2007-05-02	Arrow Int Ltd	Ramipril formulations
US8349120B2 (en) *	2006-03-07	2013-01-08	Ora Health Corporation	Multi-layer patch made on a sheet and enclosed in a blister
EP1837020A1 (de)	2006-03-24	2007-09-26	Bioalliance Pharma	Bioadhäsive Schleimhautträger zur langsamen Verabreichung von aktiven Substanzen
US20070248655A1 (en) *	2006-04-21	2007-10-25	Haley Jeffrey T	Lenticular shaped protective mouth sore discs
KR101474871B1 (ko) *	2006-05-23	2014-12-19	오라헬쓰 코포레이션	아카시아 껌 접착제를 갖는 2층 구강 접착 정제
US20070293587A1 (en) *	2006-05-23	2007-12-20	Haley Jeffrey T	Combating sinus, throat, and blood infections with xylitol delivered in the mouth
GB0613333D0 (en)	2006-07-05	2006-08-16	Controlled Therapeutics Sct	Hydrophilic polyurethane compositions
GB0613638D0 (en)	2006-07-08	2006-08-16	Controlled Therapeutics Sct	Polyurethane elastomers
WO2008007098A2 (en) *	2006-07-12	2008-01-17	Controlled Therapeutics (Scotland) Ltd.	Drug delivery polymer with hydrochloride salt of clindamycin
GB0620685D0 (en)	2006-10-18	2006-11-29	Controlled Therapeutics Sct	Bioresorbable polymers
GB0624087D0 (en) *	2006-12-01	2007-01-10	Selamine Ltd	Ramipril combination salt
US8974825B2 (en) *	2007-07-06	2015-03-10	Lupin Limited	Pharmaceutical compositions for gastrointestinal drug delivery
EP3620153A1 (de)	2007-07-06	2020-03-11	Lupin Limited	Pharmazeutische zusammensetzungen zur wirkstoffverabreichung im magen-darm-trakt
US20120027855A1 (en)	2007-07-06	2012-02-02	Lupin Limited	Pharmaceutical compositions for gastrointestinal drug delivery
EP2163240A1 (de) *	2008-09-12	2010-03-17	Universita' Degli Studi Di Genova	Verfahren zur Herstellung von bioadhesiven Kompaktmatrizen
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1996
- 1996-12-20 AT AT96944692T patent/ATE206304T1/de active
- 1996-12-20 WO PCT/EP1996/005884 patent/WO1997024109A1/en not_active Ceased
- 1996-12-20 JP JP52403297A patent/JP4317264B2/ja not_active Expired - Lifetime
- 1996-12-20 SI SI9630387T patent/SI0869772T1/xx unknown
- 1996-12-20 EA EA199800350A patent/EA000818B1/ru not_active IP Right Cessation
- 1996-12-20 US US09/091,685 patent/US6303147B1/en not_active Expired - Lifetime
- 1996-12-20 NZ NZ325844A patent/NZ325844A/xx not_active IP Right Cessation
- 1996-12-20 DK DK96944692T patent/DK0869772T3/da active
- 1996-12-20 ES ES96944692T patent/ES2164940T3/es not_active Expired - Lifetime
- 1996-12-20 SK SK887-98A patent/SK283370B6/sk not_active IP Right Cessation
- 1996-12-20 EP EP96944692A patent/EP0869772B1/de not_active Expired - Lifetime
- 1996-12-20 HU HU9802913A patent/HU228350B1/hu unknown
- 1996-12-20 KR KR1019980703055A patent/KR100459029B1/ko not_active Expired - Lifetime
- 1996-12-20 CN CNB961978783A patent/CN1146401C/zh not_active Expired - Lifetime
- 1996-12-20 PT PT96944692T patent/PT869772E/pt unknown
- 1996-12-20 IL IL12363696A patent/IL123636A/en not_active IP Right Cessation
- 1996-12-20 PL PL96326196A patent/PL186278B1/pl unknown
- 1996-12-20 TR TR1998/00894T patent/TR199800894T2/xx unknown
- 1996-12-20 CA CA002232152A patent/CA2232152C/en not_active Expired - Lifetime
- 1996-12-20 AU AU13085/97A patent/AU713849B2/en not_active Expired
- 1996-12-20 CZ CZ0199298A patent/CZ298690B6/cs not_active IP Right Cessation
- 1996-12-20 BR BR9612291A patent/BR9612291A/pt not_active IP Right Cessation
- 1996-12-20 DE DE69615704T patent/DE69615704T2/de not_active Expired - Lifetime
- 1996-12-23 ZA ZA9610886A patent/ZA9610886B/xx unknown
1998
- 1998-03-09 NO NO19981027A patent/NO320015B1/no not_active IP Right Cessation
2002
- 2002-04-25 CY CY0200020A patent/CY2269B1/xx unknown

Also Published As

Publication number	Publication date
CZ298690B6 (cs)	2007-12-27
AU713849B2 (en)	1999-12-09
TR199800894T2 (xx)	1998-08-21
ATE206304T1 (de)	2001-10-15
NO981027L (no)	1998-06-15
CY2269B1 (en)	2003-07-04
DE69615704D1 (de)	2001-11-08
ES2164940T3 (es)	2002-03-01
US6303147B1 (en)	2001-10-16
KR19990067112A (ko)	1999-08-16
JP4317264B2 (ja)	2009-08-19
AU1308597A (en)	1997-07-28
ZA9610886B (en)	1998-06-23
DK0869772T3 (da)	2002-01-21
EP0869772A1 (de)	1998-10-14
SK88798A3 (en)	1998-11-04
JP2000502691A (ja)	2000-03-07
BR9612291A (pt)	1999-07-13
WO1997024109A1 (en)	1997-07-10
EA000818B1 (ru)	2000-04-24
CZ199298A3 (cs)	1998-09-16
NO981027D0 (no)	1998-03-09
PL326196A1 (en)	1998-08-31
HUP9802913A3 (en)	2000-06-28
IL123636A (en)	2001-04-30
EA199800350A1 (ru)	1998-10-29
IL123636A0 (en)	1998-10-30
KR100459029B1 (ko)	2006-03-27
NO320015B1 (no)	2005-10-10
CN1146401C (zh)	2004-04-21
PT869772E (pt)	2002-03-28
EP0869772B1 (de)	2001-10-04
HU228350B1 (hu)	2013-03-28
HUP9802913A2 (hu)	1999-06-28
DE69615704T2 (de)	2002-07-11
PL186278B1 (pl)	2003-12-31
CA2232152A1 (en)	1997-07-10
CA2232152C (en)	2007-02-06
SI0869772T1 (en)	2002-04-30
CN1200667A (zh)	1998-12-02
HK1015680A1 (en)	1999-10-22
NZ325844A (en)	1999-06-29

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2017-01-03

PC4A

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Owner name: JANSSEN SCIENCES IRELAND UC, EASTGATE, LITTLE , IE

Free format text: FORMER OWNER: JANSSEN R&D IRELAND, EASTGATE, LITTLE ISLAND, CO CORK, IE

Effective date: 20161206

2017-01-03

TC4A

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Owner name: JANSSEN R&D IRELAND, EASTGATE, LITTLE ISLAND, , IE