SK283636B6 - Deriváty dekahydroizochinolínkarboxamidu, farmaceutické prípravky, ktoré ich obsahujú a ich použitie - Google Patents

Deriváty dekahydroizochinolínkarboxamidu, farmaceutické prípravky, ktoré ich obsahujú a ich použitie Download PDF

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Publication number
SK283636B6
SK283636B6 SK1222-99A SK122299A SK283636B6 SK 283636 B6 SK283636 B6 SK 283636B6 SK 122299 A SK122299 A SK 122299A SK 283636 B6 SK283636 B6 SK 283636B6
Authority
SK
Slovakia
Prior art keywords
derivative according
alkyl
compound
pharmaceutical composition
group
Prior art date
Application number
SK1222-99A
Other languages
English (en)
Slovak (sk)
Other versions
SK122299A3 (en
Inventor
Kim F. Albizati
Siegfried Reich
Michael D. Varney
Kanyin E. Zhang
Takuo Kobayashi
Original Assignee
Agouron Pharmaceuticals, Inc.
Japan Tobacco, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals, Inc., Japan Tobacco, Inc. filed Critical Agouron Pharmaceuticals, Inc.
Publication of SK122299A3 publication Critical patent/SK122299A3/sk
Publication of SK283636B6 publication Critical patent/SK283636B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
    • C07D217/26—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/472—Non-condensed isoquinolines, e.g. papaverine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/22—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/02—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
SK1222-99A 1997-03-13 1998-03-12 Deriváty dekahydroizochinolínkarboxamidu, farmaceutické prípravky, ktoré ich obsahujú a ich použitie SK283636B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US81595197A 1997-03-13 1997-03-13
PCT/US1998/004735 WO1998040357A2 (fr) 1997-03-13 1998-03-12 Inhibiteurs de la protease du vih

Publications (2)

Publication Number Publication Date
SK122299A3 SK122299A3 (en) 2000-05-16
SK283636B6 true SK283636B6 (sk) 2003-11-04

Family

ID=25219265

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1222-99A SK283636B6 (sk) 1997-03-13 1998-03-12 Deriváty dekahydroizochinolínkarboxamidu, farmaceutické prípravky, ktoré ich obsahujú a ich použitie

Country Status (35)

Country Link
EP (1) EP0970055A2 (fr)
JP (1) JP2001516350A (fr)
KR (1) KR100511089B1 (fr)
CN (1) CN1179948C (fr)
AP (1) AP1358A (fr)
AR (1) AR012556A1 (fr)
AU (1) AU743078B2 (fr)
BG (1) BG63540B1 (fr)
BR (1) BR9808867A (fr)
CA (1) CA2284163A1 (fr)
CO (1) CO4940496A1 (fr)
CZ (1) CZ296647B6 (fr)
EA (1) EA002378B1 (fr)
EE (1) EE04114B1 (fr)
GE (1) GEP20022764B (fr)
HR (1) HRP980112A2 (fr)
HU (1) HUP0001380A3 (fr)
IL (2) IL131870A0 (fr)
IS (1) IS5176A (fr)
MX (1) MXPA99008395A (fr)
MY (1) MY117535A (fr)
NO (1) NO315555B1 (fr)
NZ (1) NZ337706A (fr)
OA (1) OA11196A (fr)
PA (1) PA8448801A1 (fr)
PE (1) PE58799A1 (fr)
PL (1) PL192786B1 (fr)
SA (1) SA98181116B1 (fr)
SK (1) SK283636B6 (fr)
SV (1) SV1998000038A (fr)
TR (1) TR199902508T2 (fr)
TW (1) TW200517112A (fr)
UA (1) UA57772C2 (fr)
WO (1) WO1998040357A2 (fr)
ZA (1) ZA982047B (fr)

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5484926A (en) * 1993-10-07 1996-01-16 Agouron Pharmaceuticals, Inc. HIV protease inhibitors

Also Published As

Publication number Publication date
MXPA99008395A (es) 2003-08-12
BR9808867A (pt) 2000-07-11
CN1253548A (zh) 2000-05-17
CO4940496A1 (es) 2000-07-24
EP0970055A2 (fr) 2000-01-12
SA98181116B1 (ar) 2006-10-04
NO315555B1 (no) 2003-09-22
TW200517112A (en) 2005-06-01
AP1358A (en) 2004-12-03
GEP20022764B (en) 2002-08-26
PL192786B1 (pl) 2006-12-29
AU743078B2 (en) 2002-01-17
CN1179948C (zh) 2004-12-15
EA199900823A1 (ru) 2000-04-24
EE04114B1 (et) 2003-08-15
WO1998040357A2 (fr) 1998-09-17
PL335672A1 (en) 2000-05-08
BG63540B1 (bg) 2002-04-30
CZ319199A3 (cs) 2000-06-14
PA8448801A1 (es) 2000-05-24
ZA982047B (en) 1998-09-28
IL131870A (en) 2006-04-10
UA57772C2 (uk) 2003-07-15
KR20000076236A (ko) 2000-12-26
OA11196A (en) 2003-05-21
TR199902508T2 (xx) 2000-02-21
NO994415L (no) 1999-11-10
EE9900416A (et) 2000-04-17
NO994415D0 (no) 1999-09-10
CA2284163A1 (fr) 1998-09-17
SV1998000038A (es) 1999-02-15
MY117535A (en) 2004-07-31
BG103727A (bg) 2000-04-28
CZ296647B6 (cs) 2006-05-17
HRP980112A2 (en) 1998-12-31
PE58799A1 (es) 1999-07-12
IL131870A0 (en) 2001-03-19
KR100511089B1 (ko) 2005-08-31
IS5176A (is) 1999-09-10
WO1998040357A3 (fr) 1998-11-26
SK122299A3 (en) 2000-05-16
NZ337706A (en) 2001-04-27
HUP0001380A3 (en) 2001-12-28
AP9901648A0 (en) 1999-09-30
JP2001516350A (ja) 2001-09-25
HUP0001380A2 (hu) 2000-09-28
EA002378B1 (ru) 2002-04-25
AR012556A1 (es) 2000-11-08
AU6457598A (en) 1998-09-29

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Legal Events

Date Code Title Description
MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100312