SK285190B6 - Kryštálová modifikácia proti plesniam a farmaceutický prostriedok s jej obsahom - Google Patents

Kryštálová modifikácia proti plesniam a farmaceutický prostriedok s jej obsahom Download PDF

Info

Publication number: SK285190B6
Authority: SK; Slovakia
Prior art keywords: vwd; crystal modification; triazol; weak; modification
Prior art date: 1997-10-07

Application number

SK512-2000A

Other languages

English (en)

Slovak (sk)

Other versions

SK5122000A3 (en

Inventor

David R. Andrews

William Leong

Anantha R. Sudhakar

Original Assignee

Schering Corporation

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-10-07

Filing date

1998-10-05

Publication date

2006-08-03

1998-10-05 Application filed by Schering Corporation filed Critical Schering Corporation

2000-09-12 Publication of SK5122000A3 publication Critical patent/SK5122000A3/sk

2006-08-03 Publication of SK285190B6 publication Critical patent/SK285190B6/sk

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 11
230000000843 anti-fungal effect Effects 0.000 title description 5
229940121375 antifungal agent Drugs 0.000 title description 5
150000001875 compounds Chemical class 0.000 claims abstract description 24
241000124008 Mammalia Species 0.000 claims abstract description 6
238000012986 modification Methods 0.000 claims description 68
230000004048 modification Effects 0.000 claims description 68
239000013078 crystal Substances 0.000 claims description 50
125000004215 2,4-difluorophenyl group Chemical group [H]C1=C([H])C(*)=C(F)C([H])=C1F 0.000 claims description 16
125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims description 16
IOLCXVTUBQKXJR-UHFFFAOYSA-M potassium bromide Chemical compound [K+].[Br-] IOLCXVTUBQKXJR-UHFFFAOYSA-M 0.000 claims description 14
239000000843 powder Substances 0.000 claims description 12
238000002329 infrared spectrum Methods 0.000 claims description 8
-1 1H-1,2,4- triazol-1-ylmethyl Chemical group 0.000 claims description 7
239000003814 drug Substances 0.000 claims description 4
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 3
239000003937 drug carrier Substances 0.000 claims description 2
238000004519 manufacturing process Methods 0.000 claims description 2
MDTUWBLTRPRXBX-UHFFFAOYSA-N 1,2,4-triazol-3-one Chemical compound O=C1N=CN=N1 MDTUWBLTRPRXBX-UHFFFAOYSA-N 0.000 claims 1
241000233866 Fungi Species 0.000 claims 1
230000006806 disease prevention Effects 0.000 claims 1
206010017533 Fungal infection Diseases 0.000 abstract description 7
208000031888 Mycoses Diseases 0.000 abstract description 7
238000000034 method Methods 0.000 abstract description 7
239000000243 solution Substances 0.000 description 19
OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
238000002360 preparation method Methods 0.000 description 12
239000007787 solid Substances 0.000 description 12
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 12
239000003826 tablet Substances 0.000 description 11
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 9
239000004480 active ingredient Substances 0.000 description 9
239000000203 mixture Substances 0.000 description 9
238000009835 boiling Methods 0.000 description 8
239000002904 solvent Substances 0.000 description 7
239000002775 capsule Substances 0.000 description 6
239000000047 product Substances 0.000 description 6
239000007858 starting material Substances 0.000 description 6
238000003756 stirring Methods 0.000 description 6
238000001757 thermogravimetry curve Methods 0.000 description 5
239000000969 carrier Substances 0.000 description 4
238000002844 melting Methods 0.000 description 4
230000008018 melting Effects 0.000 description 4
NSPMIYGKQJPBQR-UHFFFAOYSA-N 4H-1,2,4-triazole Chemical compound C=1N=CNN=1 NSPMIYGKQJPBQR-UHFFFAOYSA-N 0.000 description 3
DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
239000012458 free base Substances 0.000 description 3
239000003517 fume Substances 0.000 description 3
239000007788 liquid Substances 0.000 description 3
239000012299 nitrogen atmosphere Substances 0.000 description 3
238000000425 proton nuclear magnetic resonance spectrum Methods 0.000 description 3
239000000725 suspension Substances 0.000 description 3
238000002076 thermal analysis method Methods 0.000 description 3
238000002834 transmittance Methods 0.000 description 3
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 2
FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
239000003429 antifungal agent Substances 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
239000001768 carboxy methyl cellulose Substances 0.000 description 2
229940110456 cocoa butter Drugs 0.000 description 2
235000019868 cocoa butter Nutrition 0.000 description 2
238000002425 crystallisation Methods 0.000 description 2
230000008025 crystallization Effects 0.000 description 2
239000000796 flavoring agent Substances 0.000 description 2
235000019634 flavors Nutrition 0.000 description 2
238000011194 good manufacturing practice Methods 0.000 description 2
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
239000000463 material Substances 0.000 description 2
125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 2
229920000609 methyl cellulose Polymers 0.000 description 2
239000001923 methylcellulose Substances 0.000 description 2
235000010981 methylcellulose Nutrition 0.000 description 2
231100000252 nontoxic Toxicity 0.000 description 2
230000003000 nontoxic effect Effects 0.000 description 2
239000002674 ointment Substances 0.000 description 2
230000000704 physical effect Effects 0.000 description 2
230000005855 radiation Effects 0.000 description 2
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 2
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 2
239000011877 solvent mixture Substances 0.000 description 2
238000001228 spectrum Methods 0.000 description 2
239000000126 substance Substances 0.000 description 2
239000000829 suppository Substances 0.000 description 2
239000000375 suspending agent Substances 0.000 description 2
239000012049 topical pharmaceutical composition Substances 0.000 description 2
SNTWKPAKVQFCCF-UHFFFAOYSA-N 2,3-dihydro-1h-triazole Chemical compound N1NC=CN1 SNTWKPAKVQFCCF-UHFFFAOYSA-N 0.000 description 1
241000416162 Astragalus gummifer Species 0.000 description 1
OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
239000004375 Dextrin Substances 0.000 description 1
229920001353 Dextrin Polymers 0.000 description 1
238000005033 Fourier transform infrared spectroscopy Methods 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
239000005909 Kieselgur Substances 0.000 description 1
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 1
239000004264 Petrolatum Substances 0.000 description 1
239000002202 Polyethylene glycol Substances 0.000 description 1
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
229920002472 Starch Polymers 0.000 description 1
229920001615 Tragacanth Polymers 0.000 description 1
238000002441 X-ray diffraction Methods 0.000 description 1
239000002253 acid Substances 0.000 description 1
238000007605 air drying Methods 0.000 description 1
239000007900 aqueous suspension Substances 0.000 description 1
239000002585 base Substances 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
239000011230 binding agent Substances 0.000 description 1
230000037396 body weight Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
239000003086 colorant Substances 0.000 description 1
229910052802 copper Inorganic materials 0.000 description 1
239000010949 copper Substances 0.000 description 1
239000012043 crude product Substances 0.000 description 1
235000019425 dextrin Nutrition 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
238000001938 differential scanning calorimetry curve Methods 0.000 description 1
239000003085 diluting agent Substances 0.000 description 1
238000004090 dissolution Methods 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000000839 emulsion Substances 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
230000002538 fungal effect Effects 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
239000008103 glucose Substances 0.000 description 1
239000008187 granular material Substances 0.000 description 1
239000010439 graphite Substances 0.000 description 1
229910002804 graphite Inorganic materials 0.000 description 1
239000008240 homogeneous mixture Substances 0.000 description 1
239000012535 impurity Substances 0.000 description 1
239000008101 lactose Substances 0.000 description 1
230000007774 longterm Effects 0.000 description 1
239000000314 lubricant Substances 0.000 description 1
ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
239000001095 magnesium carbonate Substances 0.000 description 1
229910000021 magnesium carbonate Inorganic materials 0.000 description 1
235000019359 magnesium stearate Nutrition 0.000 description 1
GBMDVOWEEQVZKZ-UHFFFAOYSA-N methanol;hydrate Chemical compound O.OC GBMDVOWEEQVZKZ-UHFFFAOYSA-N 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
235000010446 mineral oil Nutrition 0.000 description 1
238000002156 mixing Methods 0.000 description 1
239000001814 pectin Substances 0.000 description 1
235000010987 pectin Nutrition 0.000 description 1
229920001277 pectin Polymers 0.000 description 1
235000019271 petrolatum Nutrition 0.000 description 1
229940066842 petrolatum Drugs 0.000 description 1
239000000825 pharmaceutical preparation Substances 0.000 description 1
229940127557 pharmaceutical product Drugs 0.000 description 1
229920001223 polyethylene glycol Polymers 0.000 description 1
238000000634 powder X-ray diffraction Methods 0.000 description 1
239000003755 preservative agent Substances 0.000 description 1
239000008213 purified water Substances 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
150000003839 salts Chemical class 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
239000007909 solid dosage form Substances 0.000 description 1
239000003381 stabilizer Substances 0.000 description 1
239000008107 starch Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
239000008174 sterile solution Substances 0.000 description 1
238000003860 storage Methods 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
239000000454 talc Substances 0.000 description 1
229910052623 talc Inorganic materials 0.000 description 1
239000002562 thickening agent Substances 0.000 description 1
230000000699 topical effect Effects 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
238000002211 ultraviolet spectrum Methods 0.000 description 1
239000011345 viscous material Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Communicable Diseases (AREA)
Pharmacology & Pharmacy (AREA)
Oncology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Agricultural Chemicals And Associated Chemicals (AREA)

SK512-2000A 1997-10-07 1998-10-05 Kryštálová modifikácia proti plesniam a farmaceutický prostriedok s jej obsahom SK285190B6 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US94618397A	1997-10-07	1997-10-07
PCT/US1998/020476 WO1999018097A1 (fr)	1997-10-07	1998-10-05	Olymorphe antifongique cristallin

Publications (2)

Publication Number	Publication Date
SK5122000A3 SK5122000A3 (en)	2000-09-12
SK285190B6 true SK285190B6 (sk)	2006-08-03

Family

ID=25484068

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK512-2000A SK285190B6 (sk)	1997-10-07	1998-10-05	Kryštálová modifikácia proti plesniam a farmaceutický prostriedok s jej obsahom

Country Status (30)

Country	Link
EP (1)	EP1021439B1 (fr)
JP (4)	JP2001519346A (fr)
KR (1)	KR100626109B1 (fr)
CN (1)	CN1125067C (fr)
AR (1)	AR015947A1 (fr)
AT (1)	ATE263163T1 (fr)
AU (1)	AU759982B2 (fr)
BR (1)	BR9812866A (fr)
CA (1)	CA2305803C (fr)
CO (1)	CO4970829A1 (fr)
CZ (1)	CZ299835B6 (fr)
DE (1)	DE69822859T2 (fr)
DK (1)	DK1021439T3 (fr)
ES (1)	ES2217594T3 (fr)
HU (1)	HU225233B1 (fr)
ID (1)	ID29290A (fr)
IL (1)	IL135331A (fr)
IN (1)	IN1998CH02232A (fr)
MX (1)	MX225999B (fr)
MY (1)	MY130126A (fr)
NO (1)	NO318827B1 (fr)
NZ (1)	NZ503662A (fr)
PE (1)	PE120499A1 (fr)
PH (1)	PH11998002606B1 (fr)
PL (1)	PL189317B1 (fr)
PT (1)	PT1021439E (fr)
SK (1)	SK285190B6 (fr)
TW (1)	TW589310B (fr)
WO (1)	WO1999018097A1 (fr)
ZA (1)	ZA989063B (fr)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
EP2130540A1 (fr) *	2008-06-02	2009-12-09	Sandoz AG	Compositions pharmaceutiques contenant une forme cristalline du posaconazole
EP2141159A1 (fr) *	2008-07-03	2010-01-06	Sandoz AG	Formule cristalline de posaconazole
WO2011003992A1 (fr)	2009-07-09	2011-01-13	Sandoz Ag	Forme cristalline du posaconazole
CN102906087B (zh)	2010-05-19	2016-03-23	桑多斯股份公司	制备手性三唑酮的方法
JP5955837B2 (ja)	2010-05-19	2016-07-20	サンド・アクチエンゲゼルシヤフト	ポサコナゾール及びポサコナゾール中間体の精製
EP2571847B1 (fr)	2010-05-19	2016-09-21	Sandoz AG	Procédé de préparation de hydrazides chiraux
AU2011254657B2 (en)	2010-05-19	2016-02-04	Sandoz Ag	Preparation of posaconazole intermediates
CA2838051C (fr)	2011-06-16	2019-09-24	Sandoz Ag	Procede pour la preparation d'un compose chiral
EP2758385B1 (fr) *	2011-09-19	2018-03-28	MSN Laboratories Limited	Procédé pour la préparation de médicament antifongique triazole, ses intermédiaires et polymorphes de celui-ci
CA2919290A1 (fr)	2013-07-25	2015-01-29	Sandoz Ag	Procede ameliore pour la preparation de la forme cristalline iv du posaconazole
ITMI20132117A1 (it) *	2013-12-18	2015-06-19	Djada Pharmaceutical Sa	Una forma cristallina di posaconazolo
ITMI20132114A1 (it)	2013-12-18	2015-06-19	Djada Pharmaceutical Sa	Una forma cristallina di posaconazolo
ITMI20132115A1 (it) *	2013-12-18	2015-06-19	Djada Pharmaceutical Sa	Una forma cristallina di posaconazolo
ITMI20132118A1 (it) *	2013-12-18	2015-06-19	Djada Pharmaceutical Sa	Una forma cristallina di posaconazolo
CN111825717A (zh)	2014-10-21	2020-10-27	阿瑞雅德制药公司	5-氯-n4-[2-(二甲基磷酰基)苯基]-n2-{2-甲氧基-4-[4-(4-甲基哌嗪-1-基)哌啶-1-基]苯基}嘧啶-2,4-二胺的晶形
CN104387374A (zh) *	2014-10-21	2015-03-04	江苏恒盛药业有限公司	泊沙康唑晶型i的制备工艺
CN104370894A (zh) *	2014-10-21	2015-02-25	江苏恒盛药业有限公司	无定型泊沙康唑的制备工艺
US11058682B2 (en)	2015-08-08	2021-07-13	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Gastro-resistant formulation containing posaconazole
CN108473467B (zh)	2015-12-24	2021-08-13	武田药品工业株式会社	共结晶、其制造方法及含有共结晶的药物
EP3210599B1 (fr)	2016-02-26	2024-08-28	Alfred E. Tiefenbacher (GmbH & Co. KG)	Formulation gastro-résistante contenant du posaconazole et un inhibiteur de précipitation polymère
CN105949278B (zh) *	2016-03-30	2019-12-06	南京曼杰生物科技有限公司	一种取代的四氢呋喃水溶性衍生物及其应用
WO2017032908A1 (fr)	2016-07-08	2017-03-02	Synthon B.V.	Composition pharmaceutique comprenant du posaconazole amorphe
TR201620462A2 (tr)	2016-12-31	2018-07-23	Abdi Ibrahim Ilac Sanayi Ve Ticaret Anonim Sirketi	POSAKONAZOL İÇEREN FARMASÖTİK BİLEŞİMLER ve ÜRETİM YÖNTEMİ
TR201722493A2 (tr)	2017-12-28	2019-07-22	Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi	Posakonazol i̇çeren kati farmasöti̇k kompozi̇syon
WO2022034232A1 (fr)	2020-08-13	2022-02-17	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Formulation à haute résistance entérosoluble contenant du posaconazole
US20240390363A1 (en)	2021-11-25	2024-11-28	Alfred E. Tiefenbacher (Gmbh & Co. Kg)	Granules containing posaconazole
EP4091604B1 (fr)	2021-11-25	2024-04-03	Alfred E. Tiefenbacher (GmbH & Co. KG)	Granules contenant du posaconazole

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IL103558A0 (en) *	1991-10-30	1993-03-15	Schering Corp	Tri-substituted tetrahydrofuran antifungals
PL181193B1 (pl) *	1993-12-21	2001-06-29	Schering Corp	Nowe pochodne tetrahydrofuranowe o działaniu przeciwgrzybicznym, kompozycja farmaceutyczna do leczenia infekcji grzybiczych oraz sposób wytwarzania tych związków
SG48386A1 (en) *	1994-01-24	1998-04-17	Janssen Pharmaceutica Nv	Watersoluble azole antifungals
US5625064A (en) *	1995-04-19	1997-04-29	Schering Corporation	Process for the preparation of triazolones
HUP9701690A3 (en) *	1995-06-02	1998-04-28	Schering Corp Kenilwort	Tetrahydrofuran derivatives as antifungals and pharmaceutical compositions containing the same

1998
- 1998-10-05 KR KR20007003709A patent/KR100626109B1/ko not_active Expired - Lifetime
- 1998-10-05 AT AT98951994T patent/ATE263163T1/de active
- 1998-10-05 AR ARP980104957A patent/AR015947A1/es not_active Application Discontinuation
- 1998-10-05 DK DK98951994T patent/DK1021439T3/da active
- 1998-10-05 EP EP98951994A patent/EP1021439B1/fr not_active Expired - Lifetime
- 1998-10-05 HU HU0004899A patent/HU225233B1/hu unknown
- 1998-10-05 ID IDW20000632A patent/ID29290A/id unknown
- 1998-10-05 CO CO98057733A patent/CO4970829A1/es unknown
- 1998-10-05 PE PE1998000942A patent/PE120499A1/es not_active IP Right Cessation
- 1998-10-05 PL PL98339659A patent/PL189317B1/pl unknown
- 1998-10-05 ES ES98951994T patent/ES2217594T3/es not_active Expired - Lifetime
- 1998-10-05 ZA ZA989063A patent/ZA989063B/xx unknown
- 1998-10-05 WO PCT/US1998/020476 patent/WO1999018097A1/fr not_active Ceased
- 1998-10-05 JP JP2000514908A patent/JP2001519346A/ja not_active Withdrawn
- 1998-10-05 CZ CZ20001264A patent/CZ299835B6/cs not_active IP Right Cessation
- 1998-10-05 SK SK512-2000A patent/SK285190B6/sk not_active IP Right Cessation
- 1998-10-05 CN CN98811886A patent/CN1125067C/zh not_active Expired - Lifetime
- 1998-10-05 BR BR9812866-3A patent/BR9812866A/pt not_active Application Discontinuation
- 1998-10-05 PT PT98951994T patent/PT1021439E/pt unknown
- 1998-10-05 DE DE69822859T patent/DE69822859T2/de not_active Expired - Lifetime
- 1998-10-05 IL IL13533198A patent/IL135331A/xx not_active IP Right Cessation
- 1998-10-05 NZ NZ503662A patent/NZ503662A/xx not_active IP Right Cessation
- 1998-10-05 CA CA002305803A patent/CA2305803C/fr not_active Expired - Lifetime
- 1998-10-05 AU AU97803/98A patent/AU759982B2/en not_active Expired
- 1998-10-06 MY MYPI98004576A patent/MY130126A/en unknown
- 1998-10-06 IN IN2232CH1998 patent/IN1998CH02232A/en unknown
- 1998-10-06 TW TW087116562A patent/TW589310B/zh not_active IP Right Cessation
- 1998-10-06 PH PH11998002606A patent/PH11998002606B1/en unknown
2000
- 2000-04-06 MX MXPA00003404 patent/MX225999B/es active IP Right Grant
- 2000-04-06 NO NO20001779A patent/NO318827B1/no not_active IP Right Cessation
2008
- 2008-01-04 JP JP2008000110A patent/JP2008106075A/ja not_active Withdrawn
2012
- 2012-05-18 JP JP2012114725A patent/JP2012153730A/ja active Pending
- 2012-05-18 JP JP2012114724A patent/JP2012153729A/ja active Pending

Also Published As

Publication number	Publication date
JP2008106075A (ja)	2008-05-08
PL339659A1 (en)	2001-01-02
IL135331A (en)	2005-08-31
MY130126A (en)	2007-06-29
CZ299835B6 (cs)	2008-12-10
JP2012153730A (ja)	2012-08-16
IL135331A0 (en)	2001-05-20
CO4970829A1 (es)	2000-11-07
NZ503662A (en)	2002-10-25
NO20001779L (no)	2000-06-06
NO318827B1 (no)	2005-05-09
ATE263163T1 (de)	2004-04-15
CZ20001264A3 (cs)	2000-08-16
DE69822859T2 (de)	2005-01-27
JP2012153729A (ja)	2012-08-16
MXPA00003404A (es)	2000-11-01
ZA989063B (en)	1999-04-06
AU9780398A (en)	1999-04-27
AR015947A1 (es)	2001-05-30
PL189317B1 (pl)	2005-07-29
KR20010030959A (ko)	2001-04-16
PE120499A1 (es)	1999-12-04
CA2305803A1 (fr)	1999-04-15
WO1999018097A1 (fr)	1999-04-15
IN1998CH02232A (fr)	2005-03-04
ID29290A (id)	2001-08-16
HUP0004899A2 (hu)	2002-02-28
NO20001779D0 (no)	2000-04-06
AU759982B2 (en)	2003-05-01
EP1021439B1 (fr)	2004-03-31
HK1029588A1 (en)	2001-04-06
KR100626109B1 (ko)	2006-09-20
CN1281449A (zh)	2001-01-24
HUP0004899A3 (en)	2002-03-28
PH11998002606B1 (en)	2006-08-10
PT1021439E (pt)	2004-07-30
MX225999B (es)	2005-02-02
HU225233B1 (en)	2006-08-28
TW589310B (en)	2004-06-01
JP2001519346A (ja)	2001-10-23
CA2305803C (fr)	2009-12-22
DK1021439T3 (da)	2004-05-10
ES2217594T3 (es)	2004-11-01
EP1021439A1 (fr)	2000-07-26
DE69822859D1 (de)	2004-05-06
BR9812866A (pt)	2000-08-08
SK5122000A3 (en)	2000-09-12
CN1125067C (zh)	2003-10-22

Legal Events

Date

Code

Title

Description

2013-01-02

TC4A

Change of owner's name

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, NJ, US

Effective date: 20121108

2018-12-03

MK4A

Expiry of patent

Expiry date: 20181005

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