SK288036B6 - Antibody that binds to AILIM, or a part of said antibody, for use in supressing, treating or preventing Crohn's disease - Google Patents

Antibody that binds to AILIM, or a part of said antibody, for use in supressing, treating or preventing Crohn's disease Download PDF

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Publication number
SK288036B6
SK288036B6 SK1330-2003A SK13302003A SK288036B6 SK 288036 B6 SK288036 B6 SK 288036B6 SK 13302003 A SK13302003 A SK 13302003A SK 288036 B6 SK288036 B6 SK 288036B6
Authority
SK
Slovakia
Prior art keywords
antibody
ailim
cells
human
mouse
Prior art date
Application number
SK1330-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK13302003A3 (sk
Inventor
Mamoru Watanabe
Original Assignee
Japan Tobacco Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Japan Tobacco Inc filed Critical Japan Tobacco Inc
Publication of SK13302003A3 publication Critical patent/SK13302003A3/sk
Publication of SK288036B6 publication Critical patent/SK288036B6/sk

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Steroid Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
SK1330-2003A 2001-03-27 2002-02-18 Antibody that binds to AILIM, or a part of said antibody, for use in supressing, treating or preventing Crohn's disease SK288036B6 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2001089158 2001-03-27
JP2002019291A JP4210454B2 (ja) 2001-03-27 2002-01-29 炎症性腸疾患治療剤
PCT/JP2002/001361 WO2002076504A1 (fr) 2001-03-27 2002-02-18 Remedes contre les affections intestinales inflammatoires

Publications (2)

Publication Number Publication Date
SK13302003A3 SK13302003A3 (sk) 2004-07-07
SK288036B6 true SK288036B6 (en) 2013-01-02

Family

ID=26612136

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1330-2003A SK288036B6 (en) 2001-03-27 2002-02-18 Antibody that binds to AILIM, or a part of said antibody, for use in supressing, treating or preventing Crohn's disease

Country Status (18)

Country Link
US (2) US7465444B2 (fr)
EP (1) EP1374902B1 (fr)
JP (1) JP4210454B2 (fr)
KR (1) KR100602940B1 (fr)
CN (1) CN1291757C (fr)
AT (1) ATE510562T1 (fr)
AU (1) AU2002232222B8 (fr)
BR (1) BR0208446A (fr)
CA (1) CA2441577C (fr)
CZ (1) CZ20032692A3 (fr)
HU (1) HU229378B1 (fr)
IL (2) IL158088A0 (fr)
MX (1) MXPA03008760A (fr)
NO (1) NO332316B1 (fr)
NZ (1) NZ528554A (fr)
RU (1) RU2281118C2 (fr)
SK (1) SK288036B6 (fr)
WO (1) WO2002076504A1 (fr)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
DE19821060A1 (de) * 1997-09-23 1999-04-15 Bundesrepublik Deutschland Let Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
US8017113B2 (en) * 2003-03-12 2011-09-13 Rappaport Family Institute For Research In The Medical Sciences Compositions and methods for diagnosing and treating an inflammation
WO2004080273A2 (fr) * 2003-03-12 2004-09-23 Rappaport Family Institute For Research In The Medical Sciences Compositions et procedes pour le diagnostic et le traitement du cancer de la prostate
ES2442386T3 (es) * 2004-04-23 2014-02-11 Bundesrepublik Deutschland Letztvertreten Durch Das Robert Koch-Institut Vertreten Durch Seinen Pr Método para el tratamiento de condiciones mediadas por células T por la disminución de las células positivas de ICOS in vivo.
DK1915398T3 (en) * 2005-07-18 2016-07-04 Amgen Inc Humane anti-B7RP1 neutraliserende antistoffer
AU2013203437A1 (en) * 2005-07-18 2013-05-02 Amgen Inc. Human anti-B7RP1 neutralizing antibodies
US9244059B2 (en) 2007-04-30 2016-01-26 Immutep Parc Club Orsay Cytotoxic anti-LAG-3 monoclonal antibody and its use in the treatment or prevention of organ transplant rejection and autoimmune disease
RU2593939C2 (ru) 2008-11-13 2016-08-10 Ногра Фарма Лимитед Антисмысловые композиции и способы их получения и применения
MX373443B (es) * 2011-03-31 2020-05-20 Inst Nat Sante Rech Med Anticuerpos dirigidos contra icos y usos de los mismos.
WO2012174338A2 (fr) * 2011-06-15 2012-12-20 Glaxosmithkline Llc Procédé de sélection d'indications thérapeutiques
MD480Z (ro) * 2011-07-07 2012-09-30 Elvira Andon Metoda de tratament al colitei ulceroase nespecifice acute
US9458246B2 (en) 2013-03-13 2016-10-04 Amgen Inc. Proteins specific for BAFF and B7RP1
PH12022550138A1 (en) 2013-03-13 2023-03-06 Amgen Inc Proteins specific for baff and b7rp1 and uses thereof
US10280221B2 (en) 2013-03-15 2019-05-07 Glaxosmithkline Intellectual Property Development Limited Anti-LAG-3 binding proteins
MA41414A (fr) 2015-01-28 2017-12-05 Centre Nat Rech Scient Protéines de liaison agonistes d' icos
MX2018002610A (es) 2015-09-02 2018-09-27 Immutep Sas Anticuerpos anti-lag-3.
JP6411676B2 (ja) 2015-12-03 2018-10-24 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited Stingの調節因子としての環状プリンジヌクレオチド
WO2017098421A1 (fr) 2015-12-08 2017-06-15 Glaxosmithkline Intellectual Property Development Limited Composés benzothiadiazine
WO2017153952A1 (fr) 2016-03-10 2017-09-14 Glaxosmithkline Intellectual Property Development Limited Dérivés de 5-sulfamoyl-2-hydroxybenzamide
KR20180132783A (ko) 2016-04-07 2018-12-12 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 단백질 조절제로서 유용한 헤테로사이클릭 아미드
CN113549110B (zh) 2016-04-07 2024-08-16 葛兰素史密斯克莱知识产权发展有限公司 用作蛋白质调节剂的杂环酰胺
MX2018013519A (es) 2016-05-05 2019-03-14 Glaxosmithkline Ip No 2 Ltd Inhibidores del potenciador del homologo zeste 2.
AU2017300123A1 (en) 2016-07-20 2019-01-31 Glaxosmithkline Intellectual Property Development Limited Isoquinoline derivatives as PERK inhibitors
EP3585782A1 (fr) 2017-02-27 2020-01-01 GlaxoSmithKline Intellectual Property Development Limited Amides hétérocycliques en tant qu'inhibiteurs de kinase
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
US20200181275A1 (en) 2017-06-09 2020-06-11 Glaxosmithkline Intellectual Property Development Limited Combination therapy with icos agonist and ox40 agonist to treat cancer
EP3635010A1 (fr) 2017-06-09 2020-04-15 GlaxoSmithKline Intellectual Property Development Limited Polythérapie avec un agoniste icos et un agoniste ox40 pour traiter le cancer
CA3066048A1 (fr) 2017-06-09 2018-12-13 Glaxosmithkline Intellectual Property Development Limited Polytherapie
WO2019021208A1 (fr) 2017-07-27 2019-01-31 Glaxosmithkline Intellectual Property Development Limited Dérivés d'indazole utiles en tant qu'inhibiteurs de perk
WO2019053617A1 (fr) 2017-09-12 2019-03-21 Glaxosmithkline Intellectual Property Development Limited Composés chimiques
JP2020533380A (ja) 2017-09-14 2020-11-19 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 癌の組合せ治療
WO2019069270A1 (fr) 2017-10-05 2019-04-11 Glaxosmithkline Intellectual Property Development Limited Modulateurs de stimulateur des gènes (sting) de l'interféron
EP3692033A1 (fr) 2017-10-05 2020-08-12 GlaxoSmithKline Intellectual Property Development Limited Modulateurs de stimulateur des gènes (sting) d'interféron utiles dans le traitement du vih
GB201807924D0 (en) 2018-05-16 2018-06-27 Ctxt Pty Ltd Compounds
JP2021525713A (ja) 2018-05-31 2021-09-27 グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッドGlaxosmithkline Intellectual Property Development Limited 癌を治療するためのii型タンパク質アルギニンメチルトランスフェラーゼ阻害剤及びicos結合タンパク質の組合せ
BR112020023459A2 (pt) 2018-05-31 2021-02-23 Glaxosmithkline Intellectual Property Development Limited terapia combinada com proteínas de ligação a icos e inibidores de arginina metiltransferase
MA52889A (fr) 2018-06-15 2021-04-21 Flagship Pioneering Innovations V Inc Augmentation de l'activité immunitaire par modulation de facteurs de signalisation post-cellulaires
WO2020031087A1 (fr) 2018-08-06 2020-02-13 Glaxosmithkline Intellectual Property Development Limited Polythérapie
AU2019366321A1 (en) 2018-10-22 2021-05-13 Glaxosmithkline Intellectual Property Development Limited Dosing
EP3962493A2 (fr) 2019-05-03 2022-03-09 Flagship Pioneering Innovations V, Inc. Métodes de modulation de l'activité immunitaire
GB201910305D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
GB201910304D0 (en) 2019-07-18 2019-09-04 Ctxt Pty Ltd Compounds
WO2021018941A1 (fr) 2019-07-31 2021-02-04 Glaxosmithkline Intellectual Property Development Limited Méthodes de traitement du cancer
WO2021046293A1 (fr) 2019-09-06 2021-03-11 Glaxosmithkline Intellectual Property Development Limited Schéma posologique pour le traitement du cancer avec un anticorps agoniste anti-icos et du trémélimumab
WO2021043961A1 (fr) 2019-09-06 2021-03-11 Glaxosmithkline Intellectual Property Development Limited Schéma posologique pour le traitement du cancer avec un anticorps agoniste anti-icos et une chimiothérapie
BR112022005787A2 (pt) 2019-09-27 2022-06-21 Glaxosmithkline Ip Dev Ltd Proteínas de ligação a antígeno
US20230114107A1 (en) 2019-12-17 2023-04-13 Flagship Pioneering Innovations V, Inc. Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly
WO2021119753A1 (fr) 2019-12-18 2021-06-24 Ctxt Pty Limited Composés
US20230131598A1 (en) 2020-04-14 2023-04-27 Glaxosmithkline Intellectual Property Development Limited Combination treatment for cancer
WO2021209357A1 (fr) 2020-04-14 2021-10-21 Glaxosmithkline Intellectual Property Development Limited Traitement combiné pour le cancer impliquant des anticorps anti-icos et anti-pd1, impliquant éventuellement en outre des anticorps anti-tim3
CN115461362A (zh) 2020-04-14 2022-12-09 葛兰素史密斯克莱知识产权发展有限公司 基于ICOS抗体和PD-L1抗体TGF-β受体融合蛋白的癌症组合疗法
EP4172323A1 (fr) 2020-06-29 2023-05-03 Flagship Pioneering Innovations V, Inc. Virus modifiés pour favoriser la thanotransmission et leur utilisation dans le traitement du cancer
CA3212345A1 (fr) 2021-03-02 2022-09-09 Glaxosmithkline Intellectual Property Development Limited Pyridines substituees utiles en tant qu'inhibiteurs de la dnmt1
EP4305627A4 (fr) * 2021-03-12 2025-07-02 Adaptive Biotechnologies Corp Méthodes relatives au récepteur des lymphocytes t associés à la maladie de crohn
US20220325287A1 (en) 2021-03-31 2022-10-13 Flagship Pioneering Innovations V, Inc. Thanotransmission polypeptides and their use in treating cancer
WO2022208353A1 (fr) 2021-03-31 2022-10-06 Glaxosmithkline Intellectual Property Development Limited Protéines de liaison à l'antigène et leurs combinaisons
TW202313682A (zh) 2021-05-18 2023-04-01 英商凱麥博有限公司 抗icos抗體之用途
KR20240026507A (ko) 2021-06-29 2024-02-28 플래그쉽 파이어니어링 이노베이션스 브이, 인크. 타노트랜스미션을 촉진시키도록 엔지니어링된 면역 세포 및 이의 용도
US20250340641A1 (en) 2022-05-18 2025-11-06 Kymab Limited Uses of anti-icos antibodies
WO2024077191A1 (fr) 2022-10-05 2024-04-11 Flagship Pioneering Innovations V, Inc. Molécules d'acide nucléique codant pour des trif et des polypeptides supplémentaires et leur utilisation dans le traitement du cancer
US20240269251A1 (en) 2023-01-09 2024-08-15 Flagship Pioneering Innovations V, Inc. Genetic switches and their use in treating cancer

Family Cites Families (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5075109A (en) * 1986-10-24 1991-12-24 Southern Research Institute Method of potentiating an immune response
US5506126A (en) * 1988-02-25 1996-04-09 The General Hospital Corporation Rapid immunoselection cloning method
US6075181A (en) * 1990-01-12 2000-06-13 Abgenix, Inc. Human antibodies derived from immunized xenomice
US6641809B1 (en) * 1990-03-26 2003-11-04 Bristol-Myers Squibb Company Method of regulating cellular processes mediated by B7 and CD28
US5770197A (en) * 1991-06-27 1998-06-23 Bristol-Myers Squibb Company Methods for regulating the immune response using B7 binding molecules and IL4-binding molecules
JP3162438B2 (ja) 1991-09-12 2001-04-25 住友製薬株式会社 高感度特異的抗体測定法
US5484892A (en) * 1993-05-21 1996-01-16 Dana-Farber Cancer Institute, Inc. Monoclonal antibodies that block ligand binding to the CD22 receptor in mature B cells
US6719972B1 (en) 1994-06-03 2004-04-13 Repligen Corporation Methods of inhibiting T cell proliferation or IL-2 accumulation with CTLA4- specific antibodies
US5747461A (en) * 1994-07-26 1998-05-05 Markov; Angel K. Synergistic administration of cyclosporine and fructose diphosphate
RU2089179C1 (ru) * 1995-12-14 1997-09-10 Закрытое акционерное общество "ВАМ" Стимулятор эндогенной продукции цитокинов и гепопоэтических факторов и способ его использования
US5914112A (en) * 1996-01-23 1999-06-22 Genentech, Inc. Anti-CD18 antibodies in stroke
ES2183131T3 (es) 1996-01-23 2003-03-16 Genentech Inc Anticuerpos anti-cd18 utilizados contra el ictus cerebral.
BR9711499A (pt) 1996-09-18 1999-08-24 Zetesis Spa Uso de prote¡nas como agentes contra doen-as auto-imunes
EP1878748A2 (fr) * 1996-11-08 2008-01-16 Biogen Idec Inc. Identification d'interactions de liaisons uniques entre certains anticorps et les antigènes costimulants humains B7.1 et B7.2
WO1998037415A1 (fr) 1997-02-20 1998-08-27 The Regents Of The University Of California ANTIGENE DE LA VESICULE SECRETRICE DE pANCA DE LA RECTO-COLITE HEMORRAGIQUE
JP3521382B2 (ja) 1997-02-27 2004-04-19 日本たばこ産業株式会社 細胞間接着及びシグナル伝達を媒介する細胞表面分子
US7112655B1 (en) 1997-02-27 2006-09-26 Japan Tobacco, Inc. JTT-1 protein and methods of inhibiting lymphocyte activation
WO2001032675A1 (fr) 1999-10-29 2001-05-10 Human Genome Sciences, Inc. 32 proteines humaines secretees
IL132240A0 (en) 1997-04-07 2001-03-19 Genentech Inc Anti-vegf antibodies
DE19821060A1 (de) * 1997-09-23 1999-04-15 Bundesrepublik Deutschland Let Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung
CA2305350C (fr) 1997-09-23 2015-04-07 Bundesrepublik Deutschland Letztvertreten Durch Den Direktor Des Robert-Koch-Instituts Polypeptide costimulant de lymphocytes t, anticorps monoclonaux, leur preparation et leur utilisation
JPH11228442A (ja) 1998-02-09 1999-08-24 Cypros Pharmaceut Corp 臓器移植後のシクロスポリン投与量を低減するためのフルクトース二リン酸の使用
AU767241B2 (en) * 1998-09-14 2003-11-06 Qiang Xu Immunosuppressive agents
JP2000154151A (ja) 1998-09-14 2000-06-06 Kyo Jo 免疫抑制剤
CA2346496A1 (fr) * 1998-10-07 2000-04-13 Millennium Pharmaceuticals, Inc. Nouvelles molecules specifiques de th2 et leurs utilisations
US6658450B1 (en) * 1999-01-29 2003-12-02 Avaya Technology Corp. Method and system for memory resident transient storage of data associated with a plurality of collaborating computer processes
US7708993B2 (en) * 1999-02-03 2010-05-04 Amgen Inc. Polypeptides involved in immune response
EP2332978B1 (fr) 1999-02-03 2014-04-02 Amgen, Inc Nouveaux polypeptides impliqués dans la réponse immunitaire
CA2373256A1 (fr) 1999-05-06 2000-11-16 Genetics Institute, Inc. Emploi de molecules de co-stimulation solubles favorisant les reponses immunitaires
AU6615500A (en) 1999-07-28 2001-02-19 Genetics Institute Inc. Preventing immune-mediated abortion by inhibiting costimulation
WO2001012658A2 (fr) 1999-08-11 2001-02-22 Isis Innovations Limited Acides nucleiques, polypeptides, analyses, moyens et techniques therapeutiques
JP4210454B2 (ja) 2001-03-27 2009-01-21 日本たばこ産業株式会社 炎症性腸疾患治療剤
JP3871503B2 (ja) 1999-08-30 2007-01-24 日本たばこ産業株式会社 免疫性疾患治療剤
CA2383800A1 (fr) 1999-09-03 2001-03-15 Human Genome Sciences Inc. 52 proteines humaines secretees
PT1218504E (pt) 1999-09-21 2007-10-22 Genetics Inst Llc Novas moléculas gl50 e suas utilizações
AU2001245396A1 (en) 2000-03-02 2001-09-12 Mayo Foundation For Medical Education And Research Hb7-h2, a novel co-stimulatory molecule
JP3597140B2 (ja) 2000-05-18 2004-12-02 日本たばこ産業株式会社 副刺激伝達分子ailimに対するヒトモノクローナル抗体及びその医薬用途
EP2042596B1 (fr) 2000-11-28 2015-02-11 Amgen Inc. Nouveaux polypeptides impliqués dans la réponse immunitaire
JP4212278B2 (ja) 2001-03-01 2009-01-21 日本たばこ産業株式会社 移植片拒絶反応抑制剤
US7428905B2 (en) * 2004-07-30 2008-09-30 R.J. Reynolds Tobacco Company Method of making smokeable tobacco substitute filler having an increased fill value

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JP2002356443A (ja) 2002-12-13
ATE510562T1 (de) 2011-06-15
CA2441577A1 (fr) 2002-10-03
BR0208446A (pt) 2004-03-02
AU2002232222B8 (en) 2006-05-18
US20090155273A1 (en) 2009-06-18
EP1374902A1 (fr) 2004-01-02
NO20034312D0 (no) 2003-09-26
NO332316B1 (no) 2012-08-27
KR20030085567A (ko) 2003-11-05
RU2281118C2 (ru) 2006-08-10
NZ528554A (en) 2007-08-31
US20040131608A1 (en) 2004-07-08
US7465444B2 (en) 2008-12-16
SK13302003A3 (sk) 2004-07-07
CN1537017A (zh) 2004-10-13
NO20034312L (no) 2003-11-24
CN1291757C (zh) 2006-12-27
HUP0303622A2 (hu) 2004-01-28
EP1374902A4 (fr) 2005-09-28
HU229378B1 (en) 2013-11-28
WO2002076504A1 (fr) 2002-10-03
CZ20032692A3 (cs) 2004-09-15
EP1374902B1 (fr) 2011-05-25
IL158088A0 (en) 2004-03-28
CA2441577C (fr) 2013-01-08
RU2003131330A (ru) 2005-05-10
HUP0303622A3 (en) 2008-11-28
JP4210454B2 (ja) 2009-01-21
KR100602940B1 (ko) 2006-07-19
AU2002232222B2 (en) 2006-01-19
IL158088A (en) 2013-06-27
US8052972B2 (en) 2011-11-08
MXPA03008760A (es) 2004-02-17

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