SK4542002A3 - Synergistic combinations of an NK1 receptor antagonist and a GABA structural analog - Google Patents

Synergistic combinations of an NK1 receptor antagonist and a GABA structural analog Download PDF

Info

Publication number: SK4542002A3
Authority: SK; Slovakia
Prior art keywords: receptor antagonist; pain; combination; gaba analog; gabapentin
Prior art date: 1999-10-07

Application number

SK454-2002A

Other languages

English (en)

Slovak (sk)

Inventor

John Hughes

Lakhbir Singh

Original Assignee

Warner Lambert Co

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1999-10-07

Filing date

2000-10-05

Publication date

2003-09-11

2000-10-05 Application filed by Warner Lambert Co filed Critical Warner Lambert Co

2003-09-11 Publication of SK4542002A3 publication Critical patent/SK4542002A3/sk

Links

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239000011701 zinc Substances 0.000 description 1
229910052725 zinc Inorganic materials 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
- A61K31/404—Indoles, e.g. pindolol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/32—Alcohol-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Epidemiology (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Virology (AREA)
Addiction (AREA)
AIDS & HIV (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK454-2002A 1999-10-07 2000-10-05 Synergistic combinations of an NK1 receptor antagonist and a GABA structural analog SK4542002A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US15827199P	1999-10-07	1999-10-07
PCT/EP2000/009858 WO2001024792A1 (fr)	1999-10-07	2000-10-05	Complexes medicamenteux d'antagoniste de recepteur nk1 et d'analogue structurel gaba

Publications (1)

Publication Number	Publication Date
SK4542002A3 true SK4542002A3 (en)	2003-09-11

Family

ID=22567369

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK454-2002A SK4542002A3 (en)	1999-10-07	2000-10-05	Synergistic combinations of an NK1 receptor antagonist and a GABA structural analog

Country Status (38)

Country	Link
EP (2)	EP1221950B1 (fr)
JP (2)	JP2003510356A (fr)
KR (1)	KR20020060192A (fr)
CN (1)	CN1387434A (fr)
AP (1)	AP2002002501A0 (fr)
AR (1)	AR029646A1 (fr)
AT (1)	ATE269072T1 (fr)
AU (2)	AU7663300A (fr)
BG (1)	BG106548A (fr)
BR (1)	BR0014598A (fr)
CA (1)	CA2385930A1 (fr)
CO (1)	CO5280195A1 (fr)
CR (1)	CR6614A (fr)
CZ (1)	CZ20021116A3 (fr)
DE (1)	DE60011650T2 (fr)
DK (1)	DK1221950T3 (fr)
EA (1)	EA004266B1 (fr)
EE (1)	EE200200185A (fr)
ES (1)	ES2220542T3 (fr)
GT (1)	GT200000166A (fr)
HR (1)	HRP20020286A2 (fr)
HU (1)	HUP0203466A3 (fr)
IL (1)	IL148965A0 (fr)
IS (1)	IS6318A (fr)
MA (1)	MA26826A1 (fr)
MX (1)	MXPA02003484A (fr)
NO (1)	NO20021625D0 (fr)
NZ (1)	NZ517949A (fr)
OA (1)	OA12063A (fr)
PA (1)	PA8504301A1 (fr)
PE (1)	PE20010708A1 (fr)
PL (1)	PL357498A1 (fr)
PT (1)	PT1221950E (fr)
SK (1)	SK4542002A3 (fr)
TR (1)	TR200200913T2 (fr)
UY (1)	UY26376A1 (fr)
WO (2)	WO2001024792A1 (fr)
ZA (1)	ZA200202675B (fr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6001876A (en)	1996-07-24	1999-12-14	Warner-Lambert Company	Isobutylgaba and its derivatives for the treatment of pain
US8048917B2 (en)	2005-04-06	2011-11-01	Xenoport, Inc.	Prodrugs of GABA analogs, compositions and uses thereof
CN1662231A (zh) *	2002-04-24	2005-08-31	柏树生物科学公司	包括应激相关障碍在内的功能性躯体障碍的预防与治疗
US20060039968A1 (en) *	2002-10-08	2006-02-23	Ramalingam Manikandan	Gabapentin tablets and method for their preparation
WO2004084881A1 (fr) *	2003-03-21	2004-10-07	Dynogen Pharmaceuticals, Inc.	METHODES DE TRAITEMENT DE TROUBLES INTESTINAUX FONCTIONNELS UTILISANT DES MODULATEURS DE LA SOUS-UNITE &dollar;G(A)2&dollar;G(D) DES CANAUX CALCIQUES AVEC DES MODULATEURS DES MUSCLES LISSES
EP1492519B1 (fr) *	2003-03-21	2006-11-15	Dynogen Pharmaceuticals, Inc.	Methodes de traitement de troubles des voies urinaires inferieures utilisant des des agents antimuscariniques et des modulateurs des canaux calciques de la sous-unite alpha-2-delta
WO2004084880A1 (fr) *	2003-03-21	2004-10-07	Dynogen Pharmaceuticals, Inc.	Methodes de traitement de la douleur a l'aide de modulateurs des muscles lisses et de modulateurs de la sous-unite $g(a)2$g(d) des canaux calciques
EP1543831A1 (fr) *	2003-12-18	2005-06-22	Pfizer GmbH Arzneimittelwerk Gödecke	Composition de pregabaline
DE102007019071A1 (de) *	2007-04-23	2008-10-30	Ratiopharm Gmbh	Stabilisierte pharmazeutische Zusammensetzung enthaltend Pregabalin
MX2013000946A (es)	2010-07-30	2013-02-27	Toray Industries	Agente terapeutico o agente profilactico para el dolor neuropatico.
EP3753410A3 (fr) *	2010-09-28	2021-04-28	The Regents Of The University Of California	Combinaisons comprenants des agonistes dans le traitement de la hyperglycemie
ES3064256T3 (en) *	2019-03-26	2026-04-23	Orion Corp	Pregabalin formulations and use thereof
WO2022234110A1 (fr) *	2021-05-07	2022-11-10	Plus Vitech, S.L.	Dérivés d'acide gamma-aminobutyrique destinée à être utilisée en cancérothérapie

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5025035A (en) *	1990-10-12	1991-06-18	Warner-Lambert Company	Method of treating depression
US5792796A (en) *	1994-07-27	1998-08-11	Warner-Lambert Company	Methods for treating anxiety and panic
US5510381A (en) *	1995-05-15	1996-04-23	Warner-Lambert Company	Method of treatment of mania and bipolar disorder
DE69736390T2 (de) *	1996-10-07	2007-07-26	Merck Sharp & Dohme Ltd., Hoddesdon	Zns-penetrierende nk-1 rezeptorantagonisten als antidepressivum und / oder anxiolytikum
WO1998024439A1 (fr) *	1996-12-02	1998-06-11	Merck Sharp & Dohme Limited	Utilisation d'antagonistes du recepteur nk-1 dans le traitement des etats anxieux severes

2000
- 2000-01-05 AP APAP/P/2002/002501A patent/AP2002002501A0/en unknown
- 2000-10-05 DE DE60011650T patent/DE60011650T2/de not_active Expired - Fee Related
- 2000-10-05 DK DK00966138T patent/DK1221950T3/da active
- 2000-10-05 HU HU0203466A patent/HUP0203466A3/hu unknown
- 2000-10-05 MX MXPA02003484A patent/MXPA02003484A/es active IP Right Grant
- 2000-10-05 TR TR2002/00913T patent/TR200200913T2/xx unknown
- 2000-10-05 CZ CZ20021116A patent/CZ20021116A3/cs unknown
- 2000-10-05 BR BR0014598-0A patent/BR0014598A/pt not_active Application Discontinuation
- 2000-10-05 KR KR1020027004462A patent/KR20020060192A/ko not_active Withdrawn
- 2000-10-05 WO PCT/EP2000/009858 patent/WO2001024792A1/fr not_active Ceased
- 2000-10-05 OA OA1200200107A patent/OA12063A/en unknown
- 2000-10-05 CA CA002385930A patent/CA2385930A1/fr not_active Abandoned
- 2000-10-05 NZ NZ517949A patent/NZ517949A/en unknown
- 2000-10-05 EE EEP200200185A patent/EE200200185A/xx unknown
- 2000-10-05 AU AU76633/00A patent/AU7663300A/en not_active Abandoned
- 2000-10-05 ES ES00966138T patent/ES2220542T3/es not_active Expired - Lifetime
- 2000-10-05 CN CN00813906A patent/CN1387434A/zh active Pending
- 2000-10-05 SK SK454-2002A patent/SK4542002A3/sk unknown
- 2000-10-05 EP EP00966138A patent/EP1221950B1/fr not_active Expired - Lifetime
- 2000-10-05 IL IL14896500A patent/IL148965A0/xx unknown
- 2000-10-05 AT AT00966138T patent/ATE269072T1/de not_active IP Right Cessation
- 2000-10-05 PT PT00966138T patent/PT1221950E/pt unknown
- 2000-10-05 JP JP2001527791A patent/JP2003510356A/ja not_active Withdrawn
- 2000-10-05 HR HR20020286A patent/HRP20020286A2/hr not_active Application Discontinuation
- 2000-10-05 PL PL00357498A patent/PL357498A1/xx not_active Application Discontinuation
- 2000-10-05 EA EA200200303A patent/EA004266B1/ru not_active IP Right Cessation
- 2000-10-06 GT GT200000166A patent/GT200000166A/es unknown
- 2000-10-06 CO CO00076105A patent/CO5280195A1/es not_active Application Discontinuation
- 2000-10-06 PE PE2000001069A patent/PE20010708A1/es not_active Application Discontinuation
- 2000-10-06 UY UY26376A patent/UY26376A1/es not_active Application Discontinuation
- 2000-10-06 AR ARP000105296A patent/AR029646A1/es not_active Application Discontinuation
- 2000-10-06 PA PA20008504301A patent/PA8504301A1/es unknown
- 2000-10-09 AU AU16962/01A patent/AU1696201A/en not_active Abandoned
- 2000-10-09 EP EP00979495A patent/EP1233766A1/fr not_active Withdrawn
- 2000-10-09 WO PCT/EP2000/010084 patent/WO2001024791A1/fr not_active Ceased
- 2000-10-09 JP JP2001527790A patent/JP2003510355A/ja not_active Withdrawn
2002
- 2002-03-21 IS IS6318A patent/IS6318A/is unknown
- 2002-03-22 BG BG106548A patent/BG106548A/xx unknown
- 2002-04-05 ZA ZA200202675A patent/ZA200202675B/xx unknown
- 2002-04-05 CR CR6614A patent/CR6614A/es not_active Application Discontinuation
- 2002-04-05 NO NO20021625A patent/NO20021625D0/no not_active Application Discontinuation
- 2002-04-05 MA MA26587A patent/MA26826A1/fr unknown

Also Published As

Publication number	Publication date
HRP20020286A2 (en)	2003-08-31
PT1221950E (pt)	2004-08-31
GT200000166A (es)	2002-03-30
CN1387434A (zh)	2002-12-25
CA2385930A1 (fr)	2001-04-12
NO20021625L (no)	2002-04-05
CO5280195A1 (es)	2003-05-30
JP2003510356A (ja)	2003-03-18
WO2001024791A1 (fr)	2001-04-12
JP2003510355A (ja)	2003-03-18
WO2001024792A9 (fr)	2002-09-06
AU7663300A (en)	2001-05-10
TR200200913T2 (tr)	2002-09-23
UY26376A1 (es)	2000-12-29
WO2001024792A1 (fr)	2001-04-12
IL148965A0 (en)	2002-11-10
BG106548A (en)	2002-12-29
AR029646A1 (es)	2003-07-10
DE60011650T2 (de)	2005-07-14
PE20010708A1 (es)	2001-07-27
EE200200185A (et)	2003-04-15
ZA200202675B (en)	2003-04-15
AU1696201A (en)	2001-05-10
EP1221950B1 (fr)	2004-06-16
EP1221950A1 (fr)	2002-07-17
NZ517949A (en)	2003-08-29
EP1233766A1 (fr)	2002-08-28
HUP0203466A3 (en)	2005-03-29
OA12063A (en)	2006-05-03
NO20021625D0 (no)	2002-04-05
AP2002002501A0 (en)	2002-06-30
IS6318A (is)	2002-03-21
MXPA02003484A (es)	2004-09-10
DK1221950T3 (da)	2004-09-20
ATE269072T1 (de)	2004-07-15
HUP0203466A2 (hu)	2003-02-28
CZ20021116A3 (cs)	2003-05-14
DE60011650D1 (de)	2004-07-22
EA004266B1 (ru)	2004-02-26
KR20020060192A (ko)	2002-07-16
CR6614A (es)	2003-12-04
PA8504301A1 (es)	2002-08-26
ES2220542T3 (es)	2004-12-16
BR0014598A (pt)	2002-06-11
MA26826A1 (fr)	2004-12-20
EA200200303A1 (ru)	2002-08-29
PL357498A1 (en)	2004-07-26

Publication	Publication Date	Title
JP4977297B2 (ja)	2012-07-18	トラマドール物質及び抗痙攣薬を含んで成る組成物
US6936601B2 (en)	2005-08-30	Compositions for treating pain
EA000976B1 (ru)	2000-08-28	Композиция для снятия боли и способ снятия боли
NZ509260A (en)	2003-09-26	Pharmaceutical composition containing valsartan and a calcium channel blocker
CZ187097A3 (cs)	1998-01-14	Farmaceutický prostředek
SK4862000A3 (en)	2001-01-18	The use of 5-ht3 receptor antagonists
EP1221950B1 (fr)	2004-06-16	Complexes medicamenteux d'antagoniste de recepteur nk1 et d'analogue structurel gaba
BG63190B1 (bg)	2001-06-29	Използване на оптически чист (+) норцисаприд за лечение на емезис и смущения на централната нервна система
JP2575569B2 (ja)	1997-01-29	薬物従属症及び禁断症状の治療に関するグリシン／ｎｍｄａレセプターリガンドの用法
BG106279A (bg)	2002-08-30	Лечение на нервни разстройства
US4312879A (en)	1982-01-26	Clonidine and lofexidine as antidiarrheal agents
US5441963A (en)	1995-08-15	Potentiation of NMDA antagonists
JPH02502545A (ja)	1990-08-16	抗ひきつけ剤組成物および方法のためのデキストロメトルファン相乗的協力剤
CA2593854A1 (fr)	2006-08-10	Composes organiques
MXPA01010749A (es)	2002-08-20	Metodo para tratar la neurodegeneracion.
CA1209047A (fr)	1986-08-05	Compose therapeutique contenant un analogue du piracetam
US4363809A (en)	1982-12-14	Organic compounds
US3904758A (en)	1975-09-09	Method of increasing wakefulness
CZ367598A3 (cs)	1999-05-12	Použití substituovaného azaspiranu
HK1036758B (en)	2008-07-18	Antihypertensive combination of valsartan and calcium channel blocker