SK4642001A3 - Ureidopiperidine derivatives their preparation and use - Google Patents

Ureidopiperidine derivatives their preparation and use Download PDF

Info

Publication number: SK4642001A3
Authority: SK; Slovakia
Prior art keywords: compound; formula; solvates; salts; preparation
Prior art date: 1998-10-09

Application number

SK464-2001A

Other languages

English (en)

Slovak (sk)

Inventor

Alain Aulombard

Xavier Emonds-Alt

Vincenzo Proietto

Broeck Didier Van

Original Assignee

Sanofi Synthelabo

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-10-09

Filing date

1999-10-04

Publication date

2001-09-11

1999-10-04 Application filed by Sanofi Synthelabo filed Critical Sanofi Synthelabo

2001-09-11 Publication of SK4642001A3 publication Critical patent/SK4642001A3/sk

Links

238000002360 preparation method Methods 0.000 title claims description 30
SKJJGBRWKOFYAD-UHFFFAOYSA-N piperidin-1-ylurea Chemical class NC(=O)NN1CCCCC1 SKJJGBRWKOFYAD-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 162
238000000034 method Methods 0.000 claims abstract description 45
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 6
150000003839 salts Chemical class 0.000 claims description 43
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims description 30
239000012453 solvate Substances 0.000 claims description 25
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 24
201000010099 disease Diseases 0.000 claims description 20
-1 benzoyl halide Chemical class 0.000 claims description 14
239000004480 active ingredient Substances 0.000 claims description 13
238000011282 treatment Methods 0.000 claims description 13
239000002253 acid Substances 0.000 claims description 12
125000000896 monocarboxylic acid group Chemical group 0.000 claims description 10
NHXYSAFTNPANFK-HDMCBQFHSA-N Neurokinin B Chemical compound C([C@@H](C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(N)=O)C(C)C)NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(O)=O)C1=CC=CC=C1 NHXYSAFTNPANFK-HDMCBQFHSA-N 0.000 claims description 9
101800002813 Neurokinin-B Proteins 0.000 claims description 9
239000003814 drug Substances 0.000 claims description 9
LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 8
102000046798 Neurokinin B Human genes 0.000 claims description 7
229910052739 hydrogen Inorganic materials 0.000 claims description 7
239000001257 hydrogen Substances 0.000 claims description 7
150000003053 piperidines Chemical class 0.000 claims description 7
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 6
NQRYJNQNLNOLGT-UHFFFAOYSA-N Piperidine Chemical compound C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims description 6
125000004432 carbon atom Chemical group C* 0.000 claims description 6
239000007858 starting material Substances 0.000 claims description 6
229940079593 drug Drugs 0.000 claims description 5
125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 5
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XWPBINGFFFZAOZ-UHFFFAOYSA-N 3-[1-[3-[1-benzoyl-3-(3,4-dichlorophenyl)piperidin-3-yl]propyl]-4-phenylpiperidin-4-yl]-1,1-dimethylurea Chemical compound C1CC(NC(=O)N(C)C)(C=2C=CC=CC=2)CCN1CCCC(C1)(C=2C=C(Cl)C(Cl)=CC=2)CCCN1C(=O)C1=CC=CC=C1 XWPBINGFFFZAOZ-UHFFFAOYSA-N 0.000 claims description 2
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Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
- C07D211/64—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having an aryl radical as the second substituent in position 4
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/451—Non condensed piperidines, e.g. piperocaine having a carbocyclic group directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Epidemiology (AREA)
Hydrogenated Pyridines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK464-2001A 1998-10-09 1999-10-04 Ureidopiperidine derivatives their preparation and use SK4642001A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9812859A FR2784377B3 (fr)	1998-10-09	1998-10-09	Nouveaux composes derives d'ureidopiperidine, antagonistes selectifs des recepteurs nk3 humains, procede pour leur obtention et compositions pharmaceutiques les contenant
PCT/FR1999/002355 WO2000021931A1 (fr)	1998-10-09	1999-10-04	Derives d'ureidopiperidine comme antagonistes selectifs des recepteurs nk3 humains

Publications (1)

Publication Number	Publication Date
SK4642001A3 true SK4642001A3 (en)	2001-09-11

Family

ID=9531536

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK464-2001A SK4642001A3 (en)	1998-10-09	1999-10-04	Ureidopiperidine derivatives their preparation and use

Country Status (25)

Country	Link
US (1)	US6465489B1 (is)
EP (1)	EP1119552A1 (is)
JP (1)	JP2002527423A (is)
KR (1)	KR20010085903A (is)
CN (1)	CN1133622C (is)
AR (1)	AR029148A1 (is)
AU (1)	AU751592B2 (is)
BR (1)	BR9914397A (is)
CA (1)	CA2346729A1 (is)
CO (1)	CO5180555A1 (is)
DZ (1)	DZ2905A1 (is)
EA (1)	EA003613B1 (is)
EE (1)	EE200100214A (is)
FR (1)	FR2784377B3 (is)
HU (1)	HUP0201709A3 (is)
IL (1)	IL142362A0 (is)
IS (1)	IS5897A (is)
NO (1)	NO20011779L (is)
NZ (1)	NZ510779A (is)
PL (1)	PL347910A1 (is)
SK (1)	SK4642001A3 (is)
TR (1)	TR200101030T2 (is)
TW (1)	TW539669B (is)
WO (1)	WO2000021931A1 (is)
YU (1)	YU26001A (is)

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US6476050B2 (en)	2000-03-14	2002-11-05	Sepracor, Inc.	3-substituted piperidines comprising urea functionality, and methods of use thereof
DE60330794D1 (de) *	2002-07-03	2010-02-11	Glaxo Group Ltd	Substituierte 4-phenylpiperidinamide als tachykininantagonisten und serotoninwiederaufnahmehemmer
US20110144081A1 (en)	2009-12-15	2011-06-16	Henner Knust	Pyrrolidine derivatives
US9554659B2 (en)	2012-10-22	2017-01-31	Uwm Research Foundation, Inc.	Infant sleep pod
USD711152S1 (en)	2013-10-22	2014-08-19	UMW Research Foundation, Inc.	Infant sleep pod
JPWO2020101017A1 (ja) *	2018-11-15	2021-09-30	国立大学法人九州大学	Ｉｌ−３１介在性疾患の予防又は治療剤及び医薬組成物

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IL99320A (en)	1990-09-05	1995-07-31	Sanofi Sa	Arylalkylamines, their preparation and pharmaceutical compositions containing them
FR2676055B1 (fr)	1991-05-03	1993-09-03	Sanofi Elf	Composes polycycliques amines et leurs enantiomeres, procede pour leur preparation et compositions pharmaceutiques les contenant.
FR2688219B1 (fr)	1992-03-03	1994-07-08	Sanofi Elf	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
FR2719311B1 (fr) *	1994-03-18	1998-06-26	Sanofi Sa	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.
FR2738819B1 (fr)	1995-09-14	1997-12-05	Sanofi Sa	Nouveaux composes antagonistes selectifs du recepteur nk3 humain, procede pour leur obtention et compositions pharmaceutiques les contenant
AU4176997A (en)	1996-09-16	1998-04-02	Warner-Lambert Company	3-alkyl-3-phenyl-piperidines

1998
- 1998-10-09 FR FR9812859A patent/FR2784377B3/fr not_active Expired - Lifetime
1999
- 1999-10-04 EP EP99970379A patent/EP1119552A1/fr not_active Withdrawn
- 1999-10-04 AU AU59887/99A patent/AU751592B2/en not_active Ceased
- 1999-10-04 CN CNB998142085A patent/CN1133622C/zh not_active Expired - Fee Related
- 1999-10-04 NZ NZ510779A patent/NZ510779A/en unknown
- 1999-10-04 CA CA002346729A patent/CA2346729A1/en not_active Abandoned
- 1999-10-04 PL PL99347910A patent/PL347910A1/xx not_active Application Discontinuation
- 1999-10-04 IL IL14236299A patent/IL142362A0/xx unknown
- 1999-10-04 JP JP2000575840A patent/JP2002527423A/ja active Pending
- 1999-10-04 EA EA200100299A patent/EA003613B1/ru not_active IP Right Cessation
- 1999-10-04 EE EEP200100214A patent/EE200100214A/xx unknown
- 1999-10-04 HU HU0201709A patent/HUP0201709A3/hu unknown
- 1999-10-04 TR TR2001/01030T patent/TR200101030T2/xx unknown
- 1999-10-04 BR BR9914397-6A patent/BR9914397A/pt not_active IP Right Cessation
- 1999-10-04 YU YU26001A patent/YU26001A/sh unknown
- 1999-10-04 KR KR1020017004456A patent/KR20010085903A/ko not_active Ceased
- 1999-10-04 SK SK464-2001A patent/SK4642001A3/sk unknown
- 1999-10-04 WO PCT/FR1999/002355 patent/WO2000021931A1/fr not_active Ceased
- 1999-10-04 US US09/806,878 patent/US6465489B1/en not_active Expired - Fee Related
- 1999-10-05 TW TW088117155A patent/TW539669B/zh not_active IP Right Cessation
- 1999-10-06 DZ DZ990205A patent/DZ2905A1/xx active
- 1999-10-07 AR ARP990105081A patent/AR029148A1/es not_active Application Discontinuation
- 1999-10-08 CO CO99064055A patent/CO5180555A1/es not_active Application Discontinuation
2001
- 2001-03-16 IS IS5897A patent/IS5897A/is unknown
- 2001-04-06 NO NO20011779A patent/NO20011779L/no unknown

Also Published As

Publication number	Publication date
PL347910A1 (en)	2002-04-22
CN1133622C (zh)	2004-01-07
DZ2905A1 (fr)	2004-03-01
TR200101030T2 (tr)	2001-08-21
CN1329594A (zh)	2002-01-02
NZ510779A (en)	2003-07-25
FR2784377A1 (fr)	2000-04-14
YU26001A (sh)	2003-04-30
BR9914397A (pt)	2001-06-26
EE200100214A (et)	2002-08-15
IS5897A (is)	2001-03-16
NO20011779D0 (no)	2001-04-06
KR20010085903A (ko)	2001-09-07
IL142362A0 (en)	2002-03-10
WO2000021931A1 (fr)	2000-04-20
US6465489B1 (en)	2002-10-15
AR029148A1 (es)	2003-06-18
CA2346729A1 (en)	2000-04-20
HUP0201709A3 (en)	2003-03-28
TW539669B (en)	2003-07-01
CO5180555A1 (es)	2002-07-30
JP2002527423A (ja)	2002-08-27
HUP0201709A2 (en)	2002-09-28
EA003613B1 (ru)	2003-06-26
FR2784377B3 (fr)	2000-11-17
AU5988799A (en)	2000-05-01
EP1119552A1 (fr)	2001-08-01
AU751592B2 (en)	2002-08-22
NO20011779L (no)	2001-06-07
EA200100299A1 (ru)	2001-10-22

Publication	Publication Date	Title
US5942523A (en)	1999-08-24	Compounds which are selective antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools
JP4021477B2 (ja)	2007-12-12	５−ｈｔ４拮抗作用を有するジ−置換１，４−ピペリジンエステル類及びアミド類
CZ287272B6 (en)	2000-10-11	Quaternary basic amide, process of its preparation and pharmaceutical composition in which the amide is comprised
DE69630717T2 (de)	2004-09-23	1-acyl-3-phenyl-3-(3-piperidinopropyl)piperidinderivate als für den menschlichen nk3-rezeptor selektive antagonisten
US20080261976A1 (en)	2008-10-23	Novel piperidinecarboxamide derivatives, method for preparing same and pharmaceutical compositions containing same
SK4642001A3 (en)	2001-09-11	Ureidopiperidine derivatives their preparation and use
US6642233B1 (en)	2003-11-04	1-Phenacyl-3-phenyl-3-(piperidylethyl)piperidine derivatives, process for the preparation thereof and pharmaceutical compositions containing them
HRP20010704A2 (en)	2002-08-31	Novel morpholine derivatives, method for the production thereof and pharmaceutical preparations containing said derivatives
US6294537B1 (en)	2001-09-25	Compounds which are specific antagonists of the human NK3 receptor and their use as medicinal products and diagnostic tools
MXPA01003628A (en)	2001-12-04	Ureidopiperidine derivatives as selective human nk3
HK1060129B (en)	2005-09-23	Novel piperidinecarboxamide derivatives, method for preparing same and pharmaceutical compositions containing same
FR2717478A1 (fr)	1995-09-22	Composés antagonistes sélectifs du récepteur NK3 humain et leur utilisation comme médicaments et outils de diagnostic.