SK48395A3 - Ranitidine chewable tablets - Google Patents

Ranitidine chewable tablets Download PDF

Info

Publication number: SK48395A3
Authority: SK; Slovakia
Prior art keywords: ranitidine; chewable; base; chewable tablet; physiologically acceptable
Prior art date: 1992-10-13

Application number

SK483-95A

Other languages

English (en)

Slovak (sk)

Inventor

Alan Bye

Jill Evans

Paul D Huckle

Laurence F Lacey

Peter J Rue

Original Assignee

Glaxo Group Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1992-10-13

Filing date

1993-10-11

Publication date

1995-11-08

1993-10-11 Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd

1995-11-08 Publication of SK48395A3 publication Critical patent/SK48395A3/sk

Links

VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 title claims abstract description 44
229960000620 ranitidine Drugs 0.000 title claims abstract description 43
239000007910 chewable tablet Substances 0.000 title claims description 24
150000003839 salts Chemical class 0.000 claims description 20
229940068682 chewable tablet Drugs 0.000 claims description 18
239000000203 mixture Substances 0.000 claims description 16
235000013615 non-nutritive sweetener Nutrition 0.000 claims description 15
239000003826 tablet Substances 0.000 claims description 15
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 13
229930006000 Sucrose Natural products 0.000 claims description 13
239000002585 base Substances 0.000 claims description 13
239000005720 sucrose Substances 0.000 claims description 13
239000000796 flavoring agent Substances 0.000 claims description 12
OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims description 7
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 7
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 7
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims description 7
GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims description 7
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 7
GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims description 7
235000013355 food flavoring agent Nutrition 0.000 claims description 7
239000008103 glucose Substances 0.000 claims description 7
239000008101 lactose Substances 0.000 claims description 7
GGWBHVILAJZWKJ-KJEVSKRMSA-N ranitidine hydrochloride Chemical compound [H+].[Cl-].[O-][N+](=O)\C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 GGWBHVILAJZWKJ-KJEVSKRMSA-N 0.000 claims description 5
UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 claims description 4
235000010443 alginic acid Nutrition 0.000 claims description 4
239000000783 alginic acid Substances 0.000 claims description 4
229920000615 alginic acid Polymers 0.000 claims description 4
229960001126 alginic acid Drugs 0.000 claims description 4
150000004781 alginic acids Chemical class 0.000 claims description 4
239000012458 free base Substances 0.000 claims description 4
239000008368 mint flavor Substances 0.000 claims description 4
229960001520 ranitidine hydrochloride Drugs 0.000 claims description 4
235000017557 sodium bicarbonate Nutrition 0.000 claims description 2
229910000030 sodium bicarbonate Inorganic materials 0.000 claims description 2
239000004480 active ingredient Substances 0.000 claims 1
230000002496 gastric effect Effects 0.000 abstract 1
229960004793 sucrose Drugs 0.000 description 9
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 6
235000019634 flavors Nutrition 0.000 description 5
239000011230 binding agent Substances 0.000 description 4
235000019658 bitter taste Nutrition 0.000 description 4
239000008187 granular material Substances 0.000 description 4
239000008194 pharmaceutical composition Substances 0.000 description 4
210000002784 stomach Anatomy 0.000 description 4
KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
235000019359 magnesium stearate Nutrition 0.000 description 3
CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
108010011485 Aspartame Proteins 0.000 description 2
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 2
239000000605 aspartame Substances 0.000 description 2
235000010357 aspartame Nutrition 0.000 description 2
IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 description 2
229960003438 aspartame Drugs 0.000 description 2
239000003814 drug Substances 0.000 description 2
238000001035 drying Methods 0.000 description 2
210000001198 duodenum Anatomy 0.000 description 2
210000004051 gastric juice Anatomy 0.000 description 2
238000005469 granulation Methods 0.000 description 2
230000003179 granulation Effects 0.000 description 2
239000000546 pharmaceutical excipient Substances 0.000 description 2
239000001267 polyvinylpyrrolidone Substances 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
239000000243 solution Substances 0.000 description 2
235000019640 taste Nutrition 0.000 description 2
VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 description 2
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
LNAZSHAWQACDHT-XIYTZBAFSA-N (2r,3r,4s,5r,6s)-4,5-dimethoxy-2-(methoxymethyl)-3-[(2s,3r,4s,5r,6r)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxy-6-[(2r,3r,4s,5r,6r)-4,5,6-trimethoxy-2-(methoxymethyl)oxan-3-yl]oxyoxane Chemical compound CO[C@@H]1[C@@H](OC)[C@H](OC)[C@@H](COC)O[C@H]1O[C@H]1[C@H](OC)[C@@H](OC)[C@H](O[C@H]2[C@@H]([C@@H](OC)[C@H](OC)O[C@@H]2COC)OC)O[C@@H]1COC LNAZSHAWQACDHT-XIYTZBAFSA-N 0.000 description 1
OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 description 1
LARJDTRRRDBHNV-UHFFFAOYSA-N 1-n'-[2-[[5-[(dimethylamino)methyl]furan-2-yl]methylsulfanyl]ethyl]-1-n-methyl-2-nitroethane-1,1-diamine Chemical compound [O-][N+](=O)CC(NC)NCCSCC1=CC=C(CN(C)C)O1 LARJDTRRRDBHNV-UHFFFAOYSA-N 0.000 description 1
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 description 1
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
239000001856 Ethyl cellulose Substances 0.000 description 1
ZZSNKZQZMQGXPY-UHFFFAOYSA-N Ethyl cellulose Chemical compound CCOCC1OC(OC)C(OCC)C(OCC)C1OC1C(O)C(O)C(OC)C(CO)O1 ZZSNKZQZMQGXPY-UHFFFAOYSA-N 0.000 description 1
VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 description 1
208000032974 Gagging Diseases 0.000 description 1
108010010803 Gelatin Proteins 0.000 description 1
229920002907 Guar gum Polymers 0.000 description 1
229920000084 Gum arabic Polymers 0.000 description 1
CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 1
206010020710 Hyperphagia Diseases 0.000 description 1
206010061218 Inflammation Diseases 0.000 description 1
229920000881 Modified starch Polymers 0.000 description 1
206010038776 Retching Diseases 0.000 description 1
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 1
239000004141 Sodium laurylsulphate Substances 0.000 description 1
235000021355 Stearic acid Nutrition 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 description 1
208000025865 Ulcer Diseases 0.000 description 1
239000002250 absorbent Substances 0.000 description 1
238000010521 absorption reaction Methods 0.000 description 1
235000010489 acacia gum Nutrition 0.000 description 1
239000000205 acacia gum Substances 0.000 description 1
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
229940072107 ascorbate Drugs 0.000 description 1
235000010323 ascorbic acid Nutrition 0.000 description 1
239000011668 ascorbic acid Substances 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
239000008116 calcium stearate Substances 0.000 description 1
235000013539 calcium stearate Nutrition 0.000 description 1
239000002775 capsule Substances 0.000 description 1
NMGSERJNPJZFFC-UHFFFAOYSA-N carbonic acid;sulfuric acid Chemical compound OC(O)=O.OS(O)(=O)=O NMGSERJNPJZFFC-UHFFFAOYSA-N 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
229940001468 citrate Drugs 0.000 description 1
238000007906 compression Methods 0.000 description 1
230000006835 compression Effects 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000007884 disintegrant Substances 0.000 description 1
201000006549 dyspepsia Diseases 0.000 description 1
235000005686 eating Nutrition 0.000 description 1
210000003238 esophagus Anatomy 0.000 description 1
MVPICKVDHDWCJQ-UHFFFAOYSA-N ethyl 3-pyrrolidin-1-ylpropanoate Chemical compound CCOC(=O)CCN1CCCC1 MVPICKVDHDWCJQ-UHFFFAOYSA-N 0.000 description 1
235000019325 ethyl cellulose Nutrition 0.000 description 1
229920001249 ethyl cellulose Polymers 0.000 description 1
239000000945 filler Substances 0.000 description 1
239000012467 final product Substances 0.000 description 1
235000003599 food sweetener Nutrition 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000008369 fruit flavor Substances 0.000 description 1
229940050411 fumarate Drugs 0.000 description 1
239000008273 gelatin Substances 0.000 description 1
229920000159 gelatin Polymers 0.000 description 1
235000019322 gelatine Nutrition 0.000 description 1
235000011852 gelatine desserts Nutrition 0.000 description 1
229940049654 glyceryl behenate Drugs 0.000 description 1
125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
239000000665 guar gum Substances 0.000 description 1
235000010417 guar gum Nutrition 0.000 description 1
229960002154 guar gum Drugs 0.000 description 1
239000000938 histamine H1 antagonist Substances 0.000 description 1
239000008172 hydrogenated vegetable oil Substances 0.000 description 1
239000001866 hydroxypropyl methyl cellulose Substances 0.000 description 1
235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 description 1
229920003088 hydroxypropyl methyl cellulose Polymers 0.000 description 1
UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 description 1
230000004054 inflammatory process Effects 0.000 description 1
239000004615 ingredient Substances 0.000 description 1
239000007937 lozenge Substances 0.000 description 1
229940037627 magnesium lauryl sulfate Drugs 0.000 description 1
HBNDBUATLJAUQM-UHFFFAOYSA-L magnesium;dodecyl sulfate Chemical compound [Mg+2].CCCCCCCCCCCCOS([O-])(=O)=O.CCCCCCCCCCCCOS([O-])(=O)=O HBNDBUATLJAUQM-UHFFFAOYSA-L 0.000 description 1
VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 description 1
229920000609 methyl cellulose Polymers 0.000 description 1
239000001923 methylcellulose Substances 0.000 description 1
235000010981 methylcellulose Nutrition 0.000 description 1
239000002480 mineral oil Substances 0.000 description 1
150000007522 mineralic acids Chemical class 0.000 description 1
210000004877 mucosa Anatomy 0.000 description 1
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
150000007524 organic acids Chemical class 0.000 description 1
235000005985 organic acids Nutrition 0.000 description 1
235000020830 overeating Nutrition 0.000 description 1
238000004806 packaging method and process Methods 0.000 description 1
239000000843 powder Substances 0.000 description 1
239000002516 radical scavenger Substances 0.000 description 1
238000010992 reflux Methods 0.000 description 1
239000011347 resin Substances 0.000 description 1
229920005989 resin Polymers 0.000 description 1
235000019204 saccharin Nutrition 0.000 description 1
CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 1
229940081974 saccharin Drugs 0.000 description 1
239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 1
239000000741 silica gel Substances 0.000 description 1
229910002027 silica gel Inorganic materials 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
239000004299 sodium benzoate Substances 0.000 description 1
235000010234 sodium benzoate Nutrition 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
235000019333 sodium laurylsulphate Nutrition 0.000 description 1
229940045902 sodium stearyl fumarate Drugs 0.000 description 1
239000002904 solvent Substances 0.000 description 1
239000008117 stearic acid Substances 0.000 description 1
239000000126 substance Substances 0.000 description 1
229940086735 succinate Drugs 0.000 description 1
KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 description 1
229960004016 sucrose syrup Drugs 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000003765 sweetening agent Substances 0.000 description 1
208000011580 syndromic disease Diseases 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
229940095064 tartrate Drugs 0.000 description 1
XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/34—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide
- A61K31/341—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Physiology (AREA)
Nutrition Science (AREA)
Zoology (AREA)
Bioinformatics & Cheminformatics (AREA)
Chemical Kinetics & Catalysis (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicinal Preparation (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Saccharide Compounds (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

SK483-95A 1992-10-13 1993-10-11 Ranitidine chewable tablets SK48395A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
GB929221414A GB9221414D0 (en)	1992-10-13	1992-10-13	Pharmaceutical compositions
PCT/EP1993/002763 WO1994008560A1 (en)	1992-10-13	1993-10-11	Ranitidine chewable tablets

Publications (1)

Publication Number	Publication Date
SK48395A3 true SK48395A3 (en)	1995-11-08

Family

ID=10723323

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK483-95A SK48395A3 (en)	1992-10-13	1993-10-11	Ranitidine chewable tablets

Country Status (25)

Country	Link
US (1)	US5593685A (cs)
EP (2)	EP0664697B1 (cs)
JP (1)	JP2918691B2 (cs)
KR (1)	KR950703327A (cs)
AT (1)	ATE166572T1 (cs)
AU (1)	AU676690B2 (cs)
BG (1)	BG99567A (cs)
CA (1)	CA2147000A1 (cs)
CZ (1)	CZ94495A3 (cs)
DE (1)	DE69318844T2 (cs)
ES (1)	ES2117718T3 (cs)
GB (1)	GB9221414D0 (cs)
HU (2)	HUT72497A (cs)
IL (1)	IL107255A (cs)
MX (1)	MX9306333A (cs)
NO (1)	NO951432L (cs)
NZ (1)	NZ256681A (cs)
OA (1)	OA10144A (cs)
PH (1)	PH31433A (cs)
PL (1)	PL174359B1 (cs)
SG (1)	SG49850A1 (cs)
SK (1)	SK48395A3 (cs)
TW (1)	TW271405B (cs)
WO (1)	WO1994008560A1 (cs)
ZA (1)	ZA937544B (cs)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5622980A (en) *	1993-08-17	1997-04-22	Applied Analytical Industries, Inc.	Oral compositions of H2-antagonists
GB9418530D0 (en) *	1994-09-14	1994-11-02	Glaxo Group Ltd	Medicaments
US5538737A (en) *	1994-11-30	1996-07-23	Applied Analytical Industries, Inc.	Oral compositions of H2 -antagonists
WO1997016159A1 (en) *	1995-10-30	1997-05-09	Warner-Lambert Company	Enhanced anti-inflammatory oral composition containing h2 receptor antagonist and antimicrobial oils
DE19639343C2 (de) *	1996-09-25	1998-10-08	Suedzucker Ag	Komprimate, enthaltend ein Süßungsmittelgemisch
US6949264B1 (en)	1996-11-27	2005-09-27	Wm. Wrigley Jr. Company	Nutraceuticals or nutritional supplements and method of making
GB9715423D0 (en) *	1997-07-23	1997-09-24	Glaxo Group Ltd	Aqueous compositions
US6086920A (en) *	1998-08-12	2000-07-11	Fuisz Technologies Ltd.	Disintegratable microspheres
US6586023B1 (en)	1998-12-15	2003-07-01	Wm. Wrigley Jr. Company	Process for controlling release of active agents from a chewing gum coating and product thereof
US6531114B1 (en)	1999-04-06	2003-03-11	Wm. Wrigley Jr. Company	Sildenafil citrate chewing gum formulations and methods of using the same
US6627234B1 (en)	1998-12-15	2003-09-30	Wm. Wrigley Jr. Company	Method of producing active agent coated chewing gum products
US7163705B2 (en) *	1998-12-15	2007-01-16	Wm. Wrigley Jr. Company	Coated chewing gum product and method of making
US6270807B1 (en)	1999-03-02	2001-08-07	L. Perrigo Company	Taste-masked pharmaceutical composition
US6773716B2 (en)	1999-04-06	2004-08-10	Wm. Wrigley Jr. Company	Over-coated chewing gum formulations
US6322806B1 (en)	1999-04-06	2001-11-27	Wm. Wrigley Jr. Company	Over-coated chewing gum formulations including tableted center
US7935362B2 (en) *	1999-04-06	2011-05-03	Wm. Wrigley Jr. Company	Over-coated product including consumable center and medicament
US6355265B1 (en)	1999-04-06	2002-03-12	Wm. Wrigley Jr. Company	Over-coated chewing gum formulations
US20020159956A1 (en) *	1999-04-06	2002-10-31	Ream Ronald L.	Over-coated chewing gum formulations
US6426090B1 (en) *	1999-04-06	2002-07-30	Wm. Wrigley Jr. Company	Over-coated product including tableted center and medicament
US6541048B2 (en)	1999-09-02	2003-04-01	Wm. Wrigley Jr. Company	Coated chewing gum products containing an acid blocker and process of preparing
US6645535B2 (en)	1999-09-02	2003-11-11	Wm. Wrigley Jr. Company	Method of making coated chewing gum products containing various antacids
US6663849B1 (en)	2000-09-01	2003-12-16	Wm. Wrigley Jr. Company	Antacid chewing gum products coated with high viscosity materials
US6569472B1 (en)	2000-09-01	2003-05-27	Wm. Wrigley Jr. Company	Coated chewing gum products containing antacid and method of making
US9387168B2 (en)	1999-09-20	2016-07-12	Jack Barreca	Chewing gum with tomatidine
US9253991B2 (en)	1999-09-20	2016-02-09	Jack Barreca	Chewing gum with B vitamins
WO2001021147A1 (en) *	1999-09-20	2001-03-29	Mastercare	Diet and weight control gum and sucker
US6572900B1 (en)	2000-06-09	2003-06-03	Wm. Wrigley, Jr. Company	Method for making coated chewing gum products including a high-intensity sweetener
US7115288B2 (en) *	2000-06-09	2006-10-03	Wm. Wrigley Jr. Company	Method for making coated chewing gum products with a coating including an aldehyde flavor and a dipeptide sweetener
US6444241B1 (en)	2000-08-30	2002-09-03	Wm. Wrigley Jr. Company	Caffeine coated chewing gum product and process of making
US6579545B2 (en)	2000-12-22	2003-06-17	Wm. Wrigley Jr. Company	Coated chewing gum products containing an antigas agent
JP5412966B2 (ja) *	2009-06-08	2014-02-12	ライオン株式会社	粒状製剤
CN109010303B (zh) *	2017-06-09	2021-05-07	苏州科伦药物研究有限公司	一种盐酸雷尼替丁胶囊的工业制备方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE68903605T2 (de) *	1988-05-04	1993-04-01	Smith Kline French Lab	Kautablette.
IL90245A (en) *	1988-05-11	1994-04-12	Glaxo Group Ltd	Resin adsorbate comprising ranitidine together with a synthetic cation exchange resin, its preparation and pharmaceutical compositions containing it
NL8902338A (nl) *	1988-09-20	1990-04-17	Glaxo Group Ltd	Farmaceutische preparaten.
US5084278A (en) *	1989-06-02	1992-01-28	Nortec Development Associates, Inc.	Taste-masked pharmaceutical compositions
NZ235877A (en) *	1989-11-02	1992-09-25	Mcneil Ppc Inc	Composition comprising acetaminophen or nsaid and an h 1 or h 2 receptor blocker and/or proton pump inhibitor for treating overindulgence
US5075114A (en) *	1990-05-23	1991-12-24	Mcneil-Ppc, Inc.	Taste masking and sustained release coatings for pharmaceuticals
CA2052679C (en) *	1990-08-30	1997-12-02	Edward J. Roche	Rotogranulations and taste masking coatings for preparation of chewable pharmaceutical tablets
BR9205827A (pt) *	1991-04-04	1994-06-28	Procter & Gamble	Composições farmacêuticas ingeriveis para tratamento de distúrbios do trato gastrintestinal superior
SK121193A3 (en) *	1991-04-04	1994-07-06	Procter & Gamble	Chewable antacid compositions
JP2948317B2 (ja) *	1991-05-28	1999-09-13	マクニール―ピーピーシー・インコーポレーテツド	噛める薬物投与用組成物
CA2068402C (en) *	1991-06-14	1998-09-22	Michael R. Hoy	Taste mask coatings for preparation of chewable pharmaceutical tablets
CA2079934C (en) *	1991-10-15	2002-09-03	Edward J. Roche	Taste mask coatings for preparing chewable pharmaceutical tablets
US5229137A (en) *	1992-05-06	1993-07-20	Brigham And Women's Hospital, Inc.	Methods and pharmaceutical compositions for treating episodic heartburn

1992
- 1992-10-13 GB GB929221414A patent/GB9221414D0/en active Pending
1993
- 1993-10-11 EP EP93922535A patent/EP0664697B1/en not_active Expired - Lifetime
- 1993-10-11 DE DE69318844T patent/DE69318844T2/de not_active Expired - Fee Related
- 1993-10-11 PH PH47062A patent/PH31433A/en unknown
- 1993-10-11 EP EP97200896A patent/EP0788789A1/en not_active Withdrawn
- 1993-10-11 HU HU9501053A patent/HUT72497A/hu unknown
- 1993-10-11 KR KR1019950701396A patent/KR950703327A/ko not_active Withdrawn
- 1993-10-11 AT AT93922535T patent/ATE166572T1/de not_active IP Right Cessation
- 1993-10-11 SK SK483-95A patent/SK48395A3/sk unknown
- 1993-10-11 AU AU51434/93A patent/AU676690B2/en not_active Ceased
- 1993-10-11 PL PL93308356A patent/PL174359B1/pl unknown
- 1993-10-11 SG SG1996007570A patent/SG49850A1/en unknown
- 1993-10-11 CZ CZ95944A patent/CZ94495A3/cs unknown
- 1993-10-11 ES ES93922535T patent/ES2117718T3/es not_active Expired - Lifetime
- 1993-10-11 CA CA002147000A patent/CA2147000A1/en not_active Abandoned
- 1993-10-11 US US08/411,664 patent/US5593685A/en not_active Expired - Fee Related
- 1993-10-11 NZ NZ256681A patent/NZ256681A/xx unknown
- 1993-10-11 JP JP6509592A patent/JP2918691B2/ja not_active Expired - Lifetime
- 1993-10-11 WO PCT/EP1993/002763 patent/WO1994008560A1/en not_active Ceased
- 1993-10-12 IL IL10725593A patent/IL107255A/en not_active IP Right Cessation
- 1993-10-12 MX MX9306333A patent/MX9306333A/es unknown
- 1993-10-12 ZA ZA937544A patent/ZA937544B/xx unknown
- 1993-10-12 TW TW082108415A patent/TW271405B/zh active
1995
- 1995-04-11 OA OA60638A patent/OA10144A/en unknown
- 1995-04-12 BG BG99567A patent/BG99567A/xx unknown
- 1995-04-12 NO NO951432A patent/NO951432L/no unknown
- 1995-06-28 HU HU95P/P00520P patent/HU211847A9/hu unknown

Also Published As

Publication number	Publication date
AU5143493A (en)	1994-05-09
NO951432D0 (no)	1995-04-12
JP2918691B2 (ja)	1999-07-12
NO951432L (no)	1995-05-12
DE69318844T2 (de)	1998-10-15
ATE166572T1 (de)	1998-06-15
PH31433A (en)	1998-11-03
ZA937544B (en)	1994-04-21
PL174359B1 (pl)	1998-07-31
JPH08502272A (ja)	1996-03-12
EP0664697B1 (en)	1998-05-27
MX9306333A (es)	1995-01-31
HUT72497A (en)	1996-05-28
IL107255A0 (en)	1994-01-25
EP0788789A1 (en)	1997-08-13
US5593685A (en)	1997-01-14
CA2147000A1 (en)	1994-04-28
EP0664697A1 (en)	1995-08-02
BG99567A (en)	1995-12-29
CZ94495A3 (en)	1995-10-18
HU9501053D0 (en)	1995-06-28
WO1994008560A1 (en)	1994-04-28
NZ256681A (en)	1997-10-24
ES2117718T3 (es)	1998-08-16
GB9221414D0 (en)	1992-11-25
AU676690B2 (en)	1997-03-20
SG49850A1 (en)	1998-06-15
HU211847A9 (en)	1995-12-28
PL308356A1 (en)	1995-07-24
KR950703327A (ko)	1995-09-20
IL107255A (en)	1998-07-15
TW271405B (cs)	1996-03-01
DE69318844D1 (de)	1998-07-02
OA10144A (en)	1996-12-18

Publication	Publication Date	Title
SK48395A3 (en)	1995-11-08	Ranitidine chewable tablets
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AU2002300238B2 (en)	2003-01-02	Process for manufacturing bite-dispersion tablets
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KR20040098009A (ko)	2004-11-18	구강 내 속붕괴성 정제
JPH02500747A (ja)	1990-03-15	医薬組成物
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US5468504A (en)	1995-11-21	Effervescent pharmaceutical compositions
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EP2491930A1 (en)	2012-08-29	Pharmaceutical combination of betahistine and trimetazidine
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EP2481395A1 (en)	2012-08-01	Sachet, effervescent tablet and dry syrup of otilonium
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