SK50132006A3 - Flukonazolové kapsuly so zlepšeným uvoľňovaním - Google Patents

Flukonazolové kapsuly so zlepšeným uvoľňovaním Download PDF

Info

Publication number: SK50132006A3
Authority: SK; Slovakia
Prior art keywords: fluconazole; capsules; weight; optionally; particles
Prior art date: 2003-07-02

Application number

SK5013-2006A

Other languages

English (en)

Slovak (sk)

Inventor

P�L Fekete

Judit Virgula

Va Furdyga

Husz�R Magdolna Leventiszn�

Imre Klebovich

Nemes Katalin Baloghn�

Original Assignee

Egis Gy�gyszergy�r RT

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2003-07-02

Filing date

2004-06-30

Publication date

2006-05-04

2004-06-30 Application filed by Egis Gy�gyszergy�r RT filed Critical Egis Gy�gyszergy�r RT

2006-05-04 Publication of SK50132006A3 publication Critical patent/SK50132006A3/sk

Links

RFHAOTPXVQNOHP-UHFFFAOYSA-N fluconazole Chemical compound C1=NC=NN1CC(C=1C(=CC(F)=CC=1)F)(O)CN1C=NC=N1 RFHAOTPXVQNOHP-UHFFFAOYSA-N 0.000 title claims abstract description 112
239000002775 capsule Substances 0.000 title claims abstract description 109
229960004884 fluconazole Drugs 0.000 title claims abstract description 99
239000000203 mixture Substances 0.000 claims abstract description 108
239000002245 particle Substances 0.000 claims abstract description 52
239000004480 active ingredient Substances 0.000 claims abstract description 45
GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims abstract description 22
239000008101 lactose Substances 0.000 claims abstract description 21
230000005660 hydrophilic surface Effects 0.000 claims abstract description 18
238000005469 granulation Methods 0.000 claims abstract description 7
230000003179 granulation Effects 0.000 claims abstract description 7
HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims description 38
238000000034 method Methods 0.000 claims description 30
239000004094 surface-active agent Substances 0.000 claims description 30
VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical group O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 28
229920002472 Starch Polymers 0.000 claims description 23
235000019698 starch Nutrition 0.000 claims description 23
239000008107 starch Substances 0.000 claims description 23
239000000945 filler Substances 0.000 claims description 21
238000009472 formulation Methods 0.000 claims description 21
235000019359 magnesium stearate Nutrition 0.000 claims description 19
DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 claims description 17
239000008187 granular material Substances 0.000 claims description 17
239000000314 lubricant Substances 0.000 claims description 17
239000007884 disintegrant Substances 0.000 claims description 16
235000019333 sodium laurylsulphate Nutrition 0.000 claims description 16
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 13
150000001720 carbohydrates Chemical class 0.000 claims description 12
235000014633 carbohydrates Nutrition 0.000 claims description 12
WVDDGKGOMKODPV-UHFFFAOYSA-N hydroxymethyl benzene Natural products OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims description 11
239000000546 pharmaceutical excipient Substances 0.000 claims description 11
238000002360 preparation method Methods 0.000 claims description 11
239000008119 colloidal silica Substances 0.000 claims description 9
238000011049 filling Methods 0.000 claims description 8
235000000346 sugar Nutrition 0.000 claims description 8
238000005507 spraying Methods 0.000 claims description 7
235000019445 benzyl alcohol Nutrition 0.000 claims description 5
150000005846 sugar alcohols Chemical class 0.000 claims description 5
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 4
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims description 4
239000001913 cellulose Substances 0.000 claims description 4
229920002678 cellulose Polymers 0.000 claims description 4
239000008103 glucose Substances 0.000 claims description 4
QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 claims description 4
239000007921 spray Substances 0.000 claims description 4
150000008163 sugars Chemical group 0.000 claims description 4
GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims description 3
229930091371 Fructose Natural products 0.000 claims description 3
239000005715 Fructose Substances 0.000 claims description 3
RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims description 3
235000021355 Stearic acid Nutrition 0.000 claims description 3
229940075614 colloidal silicon dioxide Drugs 0.000 claims description 3
238000005243 fluidization Methods 0.000 claims description 3
239000008172 hydrogenated vegetable oil Substances 0.000 claims description 3
OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 claims description 3
239000008117 stearic acid Substances 0.000 claims description 3
CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims description 2
229930006000 Sucrose Natural products 0.000 claims description 2
229910052784 alkaline earth metal Inorganic materials 0.000 claims description 2
239000003945 anionic surfactant Substances 0.000 claims description 2
239000005720 sucrose Substances 0.000 claims description 2
239000011256 inorganic filler Substances 0.000 claims 4
229910003475 inorganic filler Inorganic materials 0.000 claims 4
239000012766 organic filler Substances 0.000 claims 4
FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical group [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 claims 2
235000019700 dicalcium phosphate Nutrition 0.000 claims 2
229920000881 Modified starch Polymers 0.000 claims 1
150000001342 alkaline earth metals Chemical group 0.000 claims 1
125000000129 anionic group Chemical group 0.000 claims 1
229940095079 dicalcium phosphate anhydrous Drugs 0.000 claims 1
235000019426 modified starch Nutrition 0.000 claims 1
239000012188 paraffin wax Substances 0.000 claims 1
150000003839 salts Chemical class 0.000 claims 1
238000004090 dissolution Methods 0.000 abstract description 43
238000010521 absorption reaction Methods 0.000 abstract description 20
238000000338 in vitro Methods 0.000 abstract description 6
238000001727 in vivo Methods 0.000 abstract description 5
239000003795 chemical substances by application Substances 0.000 abstract description 2
230000036470 plasma concentration Effects 0.000 description 20
229940032147 starch Drugs 0.000 description 17
229940063123 diflucan Drugs 0.000 description 13
239000000243 solution Substances 0.000 description 13
229960001375 lactose Drugs 0.000 description 12
239000003814 drug Substances 0.000 description 11
230000000694 effects Effects 0.000 description 10
229940079593 drug Drugs 0.000 description 9
229910002016 Aerosil® 200 Inorganic materials 0.000 description 8
WSVLPVUVIUVCRA-KPKNDVKVSA-N Alpha-lactose monohydrate Chemical compound O.O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O WSVLPVUVIUVCRA-KPKNDVKVSA-N 0.000 description 7
229960001021 lactose monohydrate Drugs 0.000 description 7
239000012738 dissolution medium Substances 0.000 description 6
238000002474 experimental method Methods 0.000 description 6
238000000265 homogenisation Methods 0.000 description 6
238000012360 testing method Methods 0.000 description 6
229920002261 Corn starch Polymers 0.000 description 5
239000008120 corn starch Substances 0.000 description 5
239000007903 gelatin capsule Substances 0.000 description 5
239000012729 immediate-release (IR) formulation Substances 0.000 description 5
238000007922 dissolution test Methods 0.000 description 4
238000004128 high performance liquid chromatography Methods 0.000 description 4
230000002209 hydrophobic effect Effects 0.000 description 4
239000004615 ingredient Substances 0.000 description 4
238000004519 manufacturing process Methods 0.000 description 4
-1 polyethylene Polymers 0.000 description 4
239000000843 powder Substances 0.000 description 4
239000008213 purified water Substances 0.000 description 4
239000000377 silicon dioxide Substances 0.000 description 4
239000000126 substance Substances 0.000 description 4
238000005516 engineering process Methods 0.000 description 3
238000002156 mixing Methods 0.000 description 3
NOOLISFMXDJSKH-UTLUCORTSA-N (+)-Neomenthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@@H]1O NOOLISFMXDJSKH-UTLUCORTSA-N 0.000 description 2
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 2
FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
NOOLISFMXDJSKH-UHFFFAOYSA-N DL-menthol Natural products CC(C)C1CCC(C)CC1O NOOLISFMXDJSKH-UHFFFAOYSA-N 0.000 description 2
229930195725 Mannitol Natural products 0.000 description 2
229920000168 Microcrystalline cellulose Polymers 0.000 description 2
DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
239000007864 aqueous solution Substances 0.000 description 2
235000013539 calcium stearate Nutrition 0.000 description 2
239000008116 calcium stearate Substances 0.000 description 2
239000007963 capsule composition Substances 0.000 description 2
235000010980 cellulose Nutrition 0.000 description 2
239000011248 coating agent Substances 0.000 description 2
238000000576 coating method Methods 0.000 description 2
RBLGLDWTCZMLRW-UHFFFAOYSA-K dicalcium;phosphate;dihydrate Chemical compound O.O.[Ca+2].[Ca+2].[O-]P([O-])([O-])=O RBLGLDWTCZMLRW-UHFFFAOYSA-K 0.000 description 2
238000001035 drying Methods 0.000 description 2
238000001704 evaporation Methods 0.000 description 2
239000012530 fluid Substances 0.000 description 2
210000004185 liver Anatomy 0.000 description 2
239000000845 maltitol Substances 0.000 description 2
235000010449 maltitol Nutrition 0.000 description 2
VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
229940035436 maltitol Drugs 0.000 description 2
239000000594 mannitol Substances 0.000 description 2
235000010355 mannitol Nutrition 0.000 description 2
229940126601 medicinal product Drugs 0.000 description 2
229940041616 menthol Drugs 0.000 description 2
229940016286 microcrystalline cellulose Drugs 0.000 description 2
235000019813 microcrystalline cellulose Nutrition 0.000 description 2
239000008108 microcrystalline cellulose Substances 0.000 description 2
210000002381 plasma Anatomy 0.000 description 2
229920000036 polyvinylpyrrolidone Polymers 0.000 description 2
235000013855 polyvinylpyrrolidone Nutrition 0.000 description 2
239000000600 sorbitol Substances 0.000 description 2
235000010356 sorbitol Nutrition 0.000 description 2
238000003756 stirring Methods 0.000 description 2
230000001225 therapeutic effect Effects 0.000 description 2
238000005303 weighing Methods 0.000 description 2
238000009736 wetting Methods 0.000 description 2
YCSMVPSDJIOXGN-UHFFFAOYSA-N CCCCCCCCCCCC[Na] Chemical compound CCCCCCCCCCCC[Na] YCSMVPSDJIOXGN-UHFFFAOYSA-N 0.000 description 1
OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
229920002785 Croscarmellose sodium Polymers 0.000 description 1
206010012735 Diarrhoea Diseases 0.000 description 1
DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical class C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
WHNWPMSKXPGLAX-UHFFFAOYSA-N N-Vinyl-2-pyrrolidone Chemical compound C=CN1CCCC1=O WHNWPMSKXPGLAX-UHFFFAOYSA-N 0.000 description 1
206010028813 Nausea Diseases 0.000 description 1
206010034016 Paronychia Diseases 0.000 description 1
239000004698 Polyethylene Substances 0.000 description 1
201000007096 Vulvovaginal Candidiasis Diseases 0.000 description 1
239000002253 acid Substances 0.000 description 1
239000002671 adjuvant Substances 0.000 description 1
LKDRXBCSQODPBY-ZXXMMSQZSA-N alpha-D-fructopyranose Chemical compound OC[C@]1(O)OC[C@@H](O)[C@@H](O)[C@@H]1O LKDRXBCSQODPBY-ZXXMMSQZSA-N 0.000 description 1
229910052782 aluminium Inorganic materials 0.000 description 1
XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
235000010210 aluminium Nutrition 0.000 description 1
238000000540 analysis of variance Methods 0.000 description 1
230000003466 anti-cipated effect Effects 0.000 description 1
230000000843 anti-fungal effect Effects 0.000 description 1
229940121375 antifungal agent Drugs 0.000 description 1
239000012736 aqueous medium Substances 0.000 description 1
229910052791 calcium Inorganic materials 0.000 description 1
239000001506 calcium phosphate Substances 0.000 description 1
229910000389 calcium phosphate Inorganic materials 0.000 description 1
229960001714 calcium phosphate Drugs 0.000 description 1
235000011010 calcium phosphates Nutrition 0.000 description 1
CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 description 1
239000001768 carboxy methyl cellulose Substances 0.000 description 1
CEZCCHQBSQPRMU-UHFFFAOYSA-L chembl174821 Chemical compound [Na+].[Na+].COC1=CC(S([O-])(=O)=O)=C(C)C=C1N=NC1=C(O)C=CC2=CC(S([O-])(=O)=O)=CC=C12 CEZCCHQBSQPRMU-UHFFFAOYSA-L 0.000 description 1
230000000052 comparative effect Effects 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
229960001681 croscarmellose sodium Drugs 0.000 description 1
235000010947 crosslinked sodium carboxy methyl cellulose Nutrition 0.000 description 1
230000003111 delayed effect Effects 0.000 description 1
239000003599 detergent Substances 0.000 description 1
238000011161 development Methods 0.000 description 1
235000014113 dietary fatty acids Nutrition 0.000 description 1
235000019329 dioctyl sodium sulphosuccinate Nutrition 0.000 description 1
201000010099 disease Diseases 0.000 description 1
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
239000006185 dispersion Substances 0.000 description 1
229960000878 docusate sodium Drugs 0.000 description 1
238000001647 drug administration Methods 0.000 description 1
239000013583 drug formulation Substances 0.000 description 1
150000002148 esters Chemical class 0.000 description 1
150000002170 ethers Chemical class 0.000 description 1
230000008020 evaporation Effects 0.000 description 1
239000000194 fatty acid Substances 0.000 description 1
229930195729 fatty acid Natural products 0.000 description 1
238000005429 filling process Methods 0.000 description 1
238000010579 first pass effect Methods 0.000 description 1
229940083666 fluconazole 150 mg Drugs 0.000 description 1
230000037406 food intake Effects 0.000 description 1
235000012631 food intake Nutrition 0.000 description 1
210000001035 gastrointestinal tract Anatomy 0.000 description 1
230000005484 gravity Effects 0.000 description 1
230000036571 hydration Effects 0.000 description 1
238000006703 hydration reaction Methods 0.000 description 1
YWXYYJSYQOXTPL-SLPGGIOYSA-N isosorbide mononitrate Chemical compound [O-][N+](=O)O[C@@H]1CO[C@@H]2[C@@H](O)CO[C@@H]21 YWXYYJSYQOXTPL-SLPGGIOYSA-N 0.000 description 1
239000002609 medium Substances 0.000 description 1
230000004060 metabolic process Effects 0.000 description 1
230000008693 nausea Effects 0.000 description 1
239000002736 nonionic surfactant Substances 0.000 description 1
239000008203 oral pharmaceutical composition Substances 0.000 description 1
230000002572 peristaltic effect Effects 0.000 description 1
239000008194 pharmaceutical composition Substances 0.000 description 1
238000011170 pharmaceutical development Methods 0.000 description 1
239000000049 pigment Substances 0.000 description 1
238000011020 pilot scale process Methods 0.000 description 1
239000004033 plastic Substances 0.000 description 1
229920003023 plastic Polymers 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000001267 polyvinylpyrrolidone Substances 0.000 description 1
229940069328 povidone Drugs 0.000 description 1
230000000284 resting effect Effects 0.000 description 1
238000005070 sampling Methods 0.000 description 1
238000010334 sieve classification Methods 0.000 description 1
239000011734 sodium Substances 0.000 description 1
229910052708 sodium Inorganic materials 0.000 description 1
235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
229940080313 sodium starch Drugs 0.000 description 1
239000007787 solid Substances 0.000 description 1
239000008137 solubility enhancer Substances 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 description 1
238000011269 treatment regimen Methods 0.000 description 1
150000003852 triazoles Chemical class 0.000 description 1
QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5015—Organic compounds, e.g. fats, sugars
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4866—Organic macromolecular compounds

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Epidemiology (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Oncology (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Communicable Diseases (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

SK5013-2006A 2003-07-02 2004-06-30 Flukonazolové kapsuly so zlepšeným uvoľňovaním SK50132006A3 (sk)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
HU0302030A HU227142B1 (en)	2003-07-02	2003-07-02	Capsule of improved release containing fluconazole
PCT/HU2004/000071 WO2005002553A2 (en)	2003-07-02	2004-06-30	Fluconazole capsules with improved release

Publications (1)

Publication Number	Publication Date
SK50132006A3 true SK50132006A3 (sk)	2006-05-04

Family

ID=89981480

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK5013-2006A SK50132006A3 (sk)	2003-07-02	2004-06-30	Flukonazolové kapsuly so zlepšeným uvoľňovaním

Country Status (10)

Country	Link
EP (1)	EP1648451A2 (cs)
CN (1)	CN1812783A (cs)
BG (1)	BG109430A (cs)
CZ (1)	CZ200657A3 (cs)
EA (1)	EA008585B1 (cs)
HU (1)	HU227142B1 (cs)
PL (1)	PL380995A1 (cs)
SK (1)	SK50132006A3 (cs)
UA (1)	UA82532C2 (cs)
WO (1)	WO2005002553A2 (cs)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE10361596A1 (de)	2003-12-24	2005-09-29	Grünenthal GmbH	Verfahren zur Herstellung einer gegen Missbrauch gesicherten Darreichungsform
DE102005005446A1 (de)	2005-02-04	2006-08-10	Grünenthal GmbH	Bruchfeste Darreichungsformen mit retardierter Freisetzung
DE102004032049A1 (de)	2004-07-01	2006-01-19	Grünenthal GmbH	Gegen Missbrauch gesicherte, orale Darreichungsform
GB0900786D0 (en) *	2009-01-19	2009-03-04	Natracine Uk Ltd	Therapeutic compositions
MD3971C2 (ro) *	2009-04-29	2010-06-30	Дмитрий СКУРТУ	Scaun-trenajor
BR112014001091A2 (pt)	2011-07-29	2017-02-14	Gruenenthal Gmbh	comprimido resistente à adulteração que fornece liberação imediata do fármaco
EA201400172A1 (ru)	2011-07-29	2014-06-30	Грюненталь Гмбх	Устойчивая к разрушению таблетка, которая обеспечивает немедленное высвобождение лекарственного средства
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CN113230236A (zh) *	2021-04-29	2021-08-10	山东优杰生物科技有限公司	祛除灰指甲草本贴及其制备方法
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2003
- 2003-07-02 HU HU0302030A patent/HU227142B1/hu not_active IP Right Cessation
2004
- 2004-06-30 EA EA200600085A patent/EA008585B1/ru not_active IP Right Cessation
- 2004-06-30 UA UAA200600919A patent/UA82532C2/uk unknown
- 2004-06-30 WO PCT/HU2004/000071 patent/WO2005002553A2/en not_active Ceased
- 2004-06-30 EP EP04743730A patent/EP1648451A2/en not_active Withdrawn
- 2004-06-30 PL PL380995A patent/PL380995A1/pl not_active IP Right Cessation
- 2004-06-30 CZ CZ20060057A patent/CZ200657A3/cs unknown
- 2004-06-30 SK SK5013-2006A patent/SK50132006A3/sk not_active Application Discontinuation
- 2004-06-30 CN CNA2004800184777A patent/CN1812783A/zh active Pending
2006
- 2006-02-02 BG BG109430A patent/BG109430A/en unknown

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Publication number	Publication date
HU0302030D0 (en)	2003-09-29
HU227142B1 (en)	2010-08-30
BG109430A (en)	2006-11-30
PL380995A1 (pl)	2007-04-16
EA008585B1 (ru)	2007-06-29
EA200600085A1 (ru)	2006-08-25
EP1648451A2 (en)	2006-04-26
CZ200657A3 (cs)	2006-04-12
CN1812783A (zh)	2006-08-02
WO2005002553A3 (en)	2005-03-24
HUP0302030A2 (hu)	2005-03-29
UA82532C2 (uk)	2008-04-25
WO2005002553A2 (en)	2005-01-13

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2012-04-03	FC9A	Refused patent application

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