SK6982003A3 - NMDA receptor agonist pharmaceutical compositions - Google Patents

NMDA receptor agonist pharmaceutical compositions Download PDF

Info

Publication number: SK6982003A3
Authority: SK; Slovakia
Prior art keywords: pharmaceutical composition; disease; hydroxy; pharmaceutically acceptable; free
Prior art date: 2000-12-13

Application number

SK698-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Jinyang Hong

Yesook Kim

Original Assignee

Pfizer Prod Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-13

Filing date

2001-12-05

Publication date

2004-08-03

2001-12-05 Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc

2004-08-03 Publication of SK6982003A3 publication Critical patent/SK6982003A3/sk

Links

239000008194 pharmaceutical composition Substances 0.000 title claims abstract description 33
239000003706 n methyl dextro aspartic acid receptor stimulating agent Substances 0.000 title abstract 2
QEMSVZNTSXPFJA-HNAYVOBHSA-N 1-[(1s,2s)-1-hydroxy-1-(4-hydroxyphenyl)propan-2-yl]-4-phenylpiperidin-4-ol Chemical compound C1([C@H](O)[C@H](C)N2CCC(O)(CC2)C=2C=CC=CC=2)=CC=C(O)C=C1 QEMSVZNTSXPFJA-HNAYVOBHSA-N 0.000 claims abstract description 20
238000000034 method Methods 0.000 claims abstract description 17
210000003169 central nervous system Anatomy 0.000 claims abstract description 12
208000024827 Alzheimer disease Diseases 0.000 claims abstract description 11
208000019695 Migraine disease Diseases 0.000 claims abstract description 9
206010027599 migraine Diseases 0.000 claims abstract description 9
208000006011 Stroke Diseases 0.000 claims abstract description 8
238000001356 surgical procedure Methods 0.000 claims abstract description 8
206010046543 Urinary incontinence Diseases 0.000 claims abstract description 7
206010015037 epilepsy Diseases 0.000 claims abstract description 7
208000015122 neurodegenerative disease Diseases 0.000 claims abstract description 7
208000005314 Multi-Infarct Dementia Diseases 0.000 claims abstract description 6
208000002193 Pain Diseases 0.000 claims abstract description 6
201000004810 Vascular dementia Diseases 0.000 claims abstract description 6
230000000302 ischemic effect Effects 0.000 claims abstract description 6
208000030507 AIDS Diseases 0.000 claims abstract description 5
208000013016 Hypoglycemia Diseases 0.000 claims abstract description 5
208000018737 Parkinson disease Diseases 0.000 claims abstract description 5
206010039966 Senile dementia Diseases 0.000 claims abstract description 5
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239000002249 anxiolytic agent Substances 0.000 claims abstract description 5
230000000949 anxiolytic effect Effects 0.000 claims abstract description 5
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239000000203 mixture Substances 0.000 claims description 48
239000000872 buffer Substances 0.000 claims description 22
150000003839 salts Chemical class 0.000 claims description 20
229910052760 oxygen Inorganic materials 0.000 claims description 18
XEEYBQQBJWHFJM-UHFFFAOYSA-N iron Substances [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 13
QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 12
239000001301 oxygen Substances 0.000 claims description 12
JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims description 11
FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims description 10
239000002738 chelating agent Substances 0.000 claims description 10
229910021645 metal ion Inorganic materials 0.000 claims description 10
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
RGHHSNMVTDWUBI-UHFFFAOYSA-N 4-hydroxybenzaldehyde Chemical compound OC1=CC=C(C=O)C=C1 RGHHSNMVTDWUBI-UHFFFAOYSA-N 0.000 claims description 9
229910052742 iron Inorganic materials 0.000 claims description 9
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 8
239000007864 aqueous solution Substances 0.000 claims description 8
239000007857 degradation product Substances 0.000 claims description 8
-1 iron ion Chemical class 0.000 claims description 8
JPVYNHNXODAKFH-UHFFFAOYSA-N Cu2+ Chemical compound [Cu+2] JPVYNHNXODAKFH-UHFFFAOYSA-N 0.000 claims description 7
229910001431 copper ion Inorganic materials 0.000 claims description 7
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 7
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 6
KDYFGRWQOYBRFD-UHFFFAOYSA-N succinic acid Chemical compound OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 claims description 6
QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims description 5
150000001450 anions Chemical class 0.000 claims description 5
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239000001384 succinic acid Substances 0.000 claims description 3
FEWJPZIEWOKRBE-UHFFFAOYSA-N Tartaric acid Natural products [H+].[H+].[O-]C(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-N 0.000 claims description 2
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239000011975 tartaric acid Substances 0.000 claims description 2
235000002906 tartaric acid Nutrition 0.000 claims description 2
YMOKTQJGQCFJHR-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;formic acid Chemical compound OC=O.OC(=O)C(O)C(O)C(O)=O YMOKTQJGQCFJHR-UHFFFAOYSA-N 0.000 claims 1
BDDLHHRCDSJVKV-UHFFFAOYSA-N 7028-40-2 Chemical compound CC(O)=O.CC(O)=O.CC(O)=O.CC(O)=O BDDLHHRCDSJVKV-UHFFFAOYSA-N 0.000 claims 1
206010012289 Dementia Diseases 0.000 abstract description 4
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239000000523 sample Substances 0.000 description 7
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IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 4
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 description 4
208000012902 Nervous system disease Diseases 0.000 description 4
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HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 4
DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
239000004480 active ingredient Substances 0.000 description 4
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238000002474 experimental method Methods 0.000 description 4
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HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 4
239000008215 water for injection Substances 0.000 description 4
BWSIKGOGLDNQBZ-LURJTMIESA-N (2s)-2-(methoxymethyl)pyrrolidin-1-amine Chemical compound COC[C@@H]1CCCN1N BWSIKGOGLDNQBZ-LURJTMIESA-N 0.000 description 3
KQKFQBTWXOGINC-UHFFFAOYSA-N 4-phenylpiperidin-4-ol Chemical compound C=1C=CC=CC=1C1(O)CCNCC1 KQKFQBTWXOGINC-UHFFFAOYSA-N 0.000 description 3
RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 3
102000004868 N-Methyl-D-Aspartate Receptors Human genes 0.000 description 3
108090001041 N-Methyl-D-Aspartate Receptors Proteins 0.000 description 3
HOKKHZGPKSLGJE-UHFFFAOYSA-N N-methyl-D-aspartic acid Natural products CNC(C(O)=O)CC(O)=O HOKKHZGPKSLGJE-UHFFFAOYSA-N 0.000 description 3
238000005481 NMR spectroscopy Methods 0.000 description 3
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239000003153 chemical reaction reagent Substances 0.000 description 3
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239000003085 diluting agent Substances 0.000 description 3
238000002360 preparation method Methods 0.000 description 3
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JLVSRWOIZZXQAD-UHFFFAOYSA-N 2,3-disulfanylpropane-1-sulfonic acid Chemical compound OS(=O)(=O)CC(S)CS JLVSRWOIZZXQAD-UHFFFAOYSA-N 0.000 description 2
101001053395 Arabidopsis thaliana Acid beta-fructofuranosidase 4, vacuolar Proteins 0.000 description 2
IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 2
QXNVGIXVLWOKEQ-UHFFFAOYSA-N Disodium Chemical compound [Na][Na] QXNVGIXVLWOKEQ-UHFFFAOYSA-N 0.000 description 2
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QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 description 2
230000001154 acute effect Effects 0.000 description 2
229910052786 argon Inorganic materials 0.000 description 2
WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
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238000001990 intravenous administration Methods 0.000 description 2
229910052751 metal Inorganic materials 0.000 description 2
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LKGCPYOBWLSCTK-UHFFFAOYSA-N methanesulfonic acid;trihydrate Chemical compound O.O.O.CS(O)(=O)=O LKGCPYOBWLSCTK-UHFFFAOYSA-N 0.000 description 2
239000003703 n methyl dextro aspartic acid receptor blocking agent Substances 0.000 description 2
238000007254 oxidation reaction Methods 0.000 description 2
229960003330 pentetic acid Drugs 0.000 description 2
ACTRVOBWPAIOHC-XIXRPRMCSA-N succimer Chemical compound OC(=O)[C@@H](S)[C@@H](S)C(O)=O ACTRVOBWPAIOHC-XIXRPRMCSA-N 0.000 description 2
229940124597 therapeutic agent Drugs 0.000 description 2
229940044613 1-propanol Drugs 0.000 description 1
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238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 1
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IPDWABJNXLNLRA-UHFFFAOYSA-N 2,3-dihydroxybutanedioic acid;2-hydroxypropane-1,2,3-tricarboxylic acid Chemical compound OC(=O)C(O)C(O)C(O)=O.OC(=O)CC(O)(C(O)=O)CC(O)=O IPDWABJNXLNLRA-UHFFFAOYSA-N 0.000 description 1
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DEFVIWRASFVYLL-UHFFFAOYSA-N ethylene glycol bis(2-aminoethyl)tetraacetic acid Chemical compound OC(=O)CN(CC(O)=O)CCOCCOCCN(CC(O)=O)CC(O)=O DEFVIWRASFVYLL-UHFFFAOYSA-N 0.000 description 1
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BPFBNAXGHSFGDC-UHFFFAOYSA-N n'-(2-aminoethyl)-n'-[2-[bis(2-aminoethyl)amino]ethyl]ethane-1,2-diamine Chemical compound NCCN(CCN)CCN(CCN)CCN BPFBNAXGHSFGDC-UHFFFAOYSA-N 0.000 description 1
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Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/02—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
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SK698-2003A 2000-12-13 2001-12-05 NMDA receptor agonist pharmaceutical compositions SK6982003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US25537200P	2000-12-13	2000-12-13
PCT/IB2001/002359 WO2002047685A2 (en)	2000-12-13	2001-12-05	Nmda receptor agonist pharmaceutical compositions

Publications (1)

Publication Number	Publication Date
SK6982003A3 true SK6982003A3 (en)	2004-08-03

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ID=22968017

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK698-2003A SK6982003A3 (en)	2000-12-13	2001-12-05	NMDA receptor agonist pharmaceutical compositions

Country Status (41)

Country	Link
US (2)	US6635270B2 (is)
EP (1)	EP1347760B1 (is)
JP (1)	JP2004515529A (is)
KR (1)	KR100533407B1 (is)
CN (1)	CN1273135C (is)
AP (1)	AP1235A (is)
AR (1)	AR035607A1 (is)
AT (1)	ATE296629T1 (is)
AU (2)	AU1845402A (is)
BG (1)	BG107788A (is)
BR (1)	BR0116085A (is)
CA (1)	CA2431172A1 (is)
CZ (1)	CZ20031543A3 (is)
DE (1)	DE60111265T2 (is)
DO (1)	DOP2001000300A (is)
DZ (1)	DZ3484A1 (is)
EA (1)	EA006489B1 (is)
EC (1)	ECSP034655A (is)
EE (1)	EE200300284A (is)
ES (1)	ES2239648T3 (is)
GE (1)	GEP20053568B (is)
HR (1)	HRP20030473A2 (is)
HU (1)	HUP0400645A2 (is)
IL (1)	IL155810A0 (is)
IS (1)	IS6811A (is)
MA (1)	MA26970A1 (is)
MX (1)	MXPA03005257A (is)
NO (1)	NO20032678L (is)
NZ (1)	NZ525742A (is)
OA (1)	OA12414A (is)
PA (1)	PA8534901A1 (is)
PE (1)	PE20020710A1 (is)
PL (1)	PL362080A1 (is)
PT (1)	PT1347760E (is)
SK (1)	SK6982003A3 (is)
TN (1)	TNSN01173A1 (is)
UA (1)	UA73619C2 (is)
UY (1)	UY27068A1 (is)
WO (1)	WO2002047685A2 (is)
YU (1)	YU41103A (is)
ZA (1)	ZA200303892B (is)

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TW200901974A (en) *	2007-01-16	2009-01-16	Wyeth Corp	Compounds, compositions, and methods of making and using them
CN101317844B (zh) *	2007-06-08	2010-11-17	章劲夫	化合物(+)-5-甲基-10，11-二氢-5H-二苯并〔a，d〕环庚烯-5，10-亚胺在制备避孕药物中的应用
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US8951968B2 (en)	2009-10-05	2015-02-10	Northwestern University	Methods of treating depression and other related diseases
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KR20150110586A (ko)	2013-01-29	2015-10-02	노렉스, 인크.	스피로-락탐 nmda 수용체 조절인자 및 그의 용도
EA032649B1 (ru)	2013-01-29	2019-06-28	Аптиникс Инк.	Спиролактамные модуляторы nmda-рецептора и их применение
US9877959B2 (en)	2013-12-23	2018-01-30	Samyang Biopharmaceuticals Corporation	Pharmaceutical composition containing palonosetron
WO2017201285A1 (en)	2016-05-19	2017-11-23	Aptinyx Inc.	Spiro-lactam nmda receptor modulators and uses thereof
BR112018073663A2 (pt)	2016-05-19	2019-04-30	Aptinyx Inc.	moduladores de receptores nmda spiro-lactâmicos e seus usos
SG10202101055VA (en)	2016-08-01	2021-03-30	Aptinyx Inc	Spiro-lactam nmda receptor modulators and uses thereof
EP3490994B8 (en)	2016-08-01	2024-03-13	Tenacia Biotechnology (Hong Kong) Co., Limited	Spiro-lactam and bis-spiro-lactam nmda receptor modulators and uses thereof
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JP2019527232A (ja)	2016-08-01	2019-09-26	アプティニックスインコーポレイテッド	スピロ−ラクタムｎｍｄａ修飾因子及びこれを用いた方法
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2001
- 2001-05-12 UA UA2003065485A patent/UA73619C2/uk unknown
- 2001-12-05 KR KR10-2003-7007874A patent/KR100533407B1/ko not_active Expired - Fee Related
- 2001-12-05 AT AT01270205T patent/ATE296629T1/de not_active IP Right Cessation
- 2001-12-05 EE EEP200300284A patent/EE200300284A/xx unknown
- 2001-12-05 EP EP01270205A patent/EP1347760B1/en not_active Expired - Lifetime
- 2001-12-05 YU YU41103A patent/YU41103A/sh unknown
- 2001-12-05 OA OA1200300145A patent/OA12414A/en unknown
- 2001-12-05 ES ES01270205T patent/ES2239648T3/es not_active Expired - Lifetime
- 2001-12-05 BR BR0116085-0A patent/BR0116085A/pt not_active IP Right Cessation
- 2001-12-05 DZ DZ013484A patent/DZ3484A1/fr active
- 2001-12-05 US US10/010,827 patent/US6635270B2/en not_active Expired - Fee Related
- 2001-12-05 WO PCT/IB2001/002359 patent/WO2002047685A2/en not_active Ceased
- 2001-12-05 NZ NZ525742A patent/NZ525742A/en unknown
- 2001-12-05 MX MXPA03005257A patent/MXPA03005257A/es active IP Right Grant
- 2001-12-05 PL PL01362080A patent/PL362080A1/xx not_active Application Discontinuation
- 2001-12-05 CN CNB018203922A patent/CN1273135C/zh not_active Expired - Fee Related
- 2001-12-05 PT PT01270205T patent/PT1347760E/pt unknown
- 2001-12-05 GE GE5171A patent/GEP20053568B/en unknown
- 2001-12-05 AU AU1845402A patent/AU1845402A/xx active Pending
- 2001-12-05 HR HR20030473A patent/HRP20030473A2/hr not_active Application Discontinuation
- 2001-12-05 DE DE60111265T patent/DE60111265T2/de not_active Expired - Fee Related
- 2001-12-05 CZ CZ20031543A patent/CZ20031543A3/cs unknown
- 2001-12-05 HU HU0400645A patent/HUP0400645A2/hu unknown
- 2001-12-05 SK SK698-2003A patent/SK6982003A3/sk unknown
- 2001-12-05 JP JP2002549256A patent/JP2004515529A/ja active Pending
- 2001-12-05 AU AU2002218454A patent/AU2002218454B2/en not_active Ceased
- 2001-12-05 IL IL15581001A patent/IL155810A0/xx unknown
- 2001-12-05 EA EA200300514A patent/EA006489B1/ru not_active IP Right Cessation
- 2001-12-05 CA CA002431172A patent/CA2431172A1/en not_active Abandoned
- 2001-12-10 DO DO2001000300A patent/DOP2001000300A/es unknown
- 2001-12-11 AR ARP010105748A patent/AR035607A1/es unknown
- 2001-12-11 PE PE2001001235A patent/PE20020710A1/es not_active Application Discontinuation
- 2001-12-12 UY UY27068A patent/UY27068A1/es not_active Application Discontinuation
- 2001-12-12 TN TNTNSN01173A patent/TNSN01173A1/fr unknown
- 2001-12-13 AP APAP/P/2001/002376A patent/AP1235A/en active
- 2001-12-13 PA PA20018534901A patent/PA8534901A1/es unknown
2003
- 2003-05-08 IS IS6811A patent/IS6811A/is unknown
- 2003-05-09 BG BG107788A patent/BG107788A/bg unknown
- 2003-05-20 ZA ZA200303892A patent/ZA200303892B/en unknown
- 2003-06-03 MA MA27191A patent/MA26970A1/fr unknown
- 2003-06-12 NO NO20032678A patent/NO20032678L/no not_active Application Discontinuation
- 2003-06-13 EC EC2003004655A patent/ECSP034655A/es unknown
- 2003-08-19 US US10/643,441 patent/US20040039022A1/en not_active Abandoned

Also Published As

Publication number	Publication date
ES2239648T3 (es)	2005-10-01
EP1347760B1 (en)	2005-06-01
GEP20053568B (en)	2005-07-11
DOP2001000300A (es)	2002-05-30
IL155810A0 (en)	2003-12-23
PT1347760E (pt)	2005-09-30
AP2001002376A0 (en)	2001-12-31
KR20030070060A (ko)	2003-08-27
HUP0400645A2 (hu)	2004-06-28
EA006489B1 (ru)	2005-12-29
ATE296629T1 (de)	2005-06-15
EP1347760A2 (en)	2003-10-01
JP2004515529A (ja)	2004-05-27
MXPA03005257A (es)	2003-09-25
YU41103A (sh)	2006-05-25
ZA200303892B (en)	2004-05-20
EE200300284A (et)	2003-10-15
DZ3484A1 (fr)	2002-06-20
NO20032678D0 (no)	2003-06-12
PL362080A1 (en)	2004-10-18
BG107788A (bg)	2004-01-30
TNSN01173A1 (fr)	2005-11-10
AR035607A1 (es)	2004-06-16
WO2002047685A3 (en)	2002-08-15
DE60111265T2 (de)	2006-05-04
AU1845402A (en)	2002-06-24
DE60111265D1 (de)	2005-07-07
US20020111366A1 (en)	2002-08-15
AP1235A (en)	2004-01-06
WO2002047685A2 (en)	2002-06-20
HK1059575A1 (en)	2004-07-09
HRP20030473A2 (en)	2005-04-30
PE20020710A1 (es)	2002-08-09
UA73619C2 (en)	2005-08-15
CZ20031543A3 (cs)	2004-06-16
OA12414A (en)	2006-04-18
US20040039022A1 (en)	2004-02-26
NZ525742A (en)	2005-07-29
EA200300514A1 (ru)	2003-10-30
KR100533407B1 (ko)	2005-12-02
NO20032678L (no)	2003-06-12
CN1273135C (zh)	2006-09-06
ECSP034655A (es)	2003-07-25
PA8534901A1 (es)	2002-08-26
MA26970A1 (fr)	2004-12-20
CA2431172A1 (en)	2002-06-20
AU2002218454B2 (en)	2005-10-27
UY27068A1 (es)	2002-07-31
CN1479617A (zh)	2004-03-03
IS6811A (is)	2003-05-08
US6635270B2 (en)	2003-10-21
BR0116085A (pt)	2003-12-23

Legal Events

Date	Code	Title	Description
2010-04-07	FB9A	Suspension of patent application procedure

Publication	Publication Date	Title
SK6982003A3 (en)	2004-08-03	NMDA receptor agonist pharmaceutical compositions
AU2002218454A1 (en)	2002-08-29	NMDA receptor agonist pharmaceutical compositions
EP3110399B1 (en)	2018-01-10	Process for producing a stable low concentration, injectable solution of noradrenaline
SK1682002A3 (en)	2002-06-04	Aqueous formulation containing moxifloxacin and sodium chloride, method of producing and use thereof
CA2378425C (en)	2009-11-24	Aqueous pharmaceutical formulation of moxifloxacin or salts thereof
EP1352654B1 (en)	2006-03-01	Famotidine injections
EP2804597B1 (en)	2016-04-20	Aqueous paracetamol composition for injection
EP1294369B1 (en)	2005-09-07	NOVEL FORMULATIONS OF $g(a)-2,4-DISULFOPHENYL-N-TERT-BUTYLNITRONE
WO2023072714A1 (en)	2023-05-04	Phytonadione for parenteral administration
WO2004098614A1 (ja)	2004-11-18	メチルコバラミン含有凍結乾燥製剤及びその製造方法
KR20220062368A (ko)	2022-05-16	p-보로노페닐알라닌을 함유하는 주사액제의 석출 방지 방법
HK1059575B (en)	2006-12-08	Nmda receptor agonist pharmaceutical compositions
WO2024151603A1 (en)	2024-07-18	Hydromorphone formulations for multi-dose products
EP4456898A1 (en)	2024-11-06	Hydralazine compositions and methods
HK1101347A1 (en)	2007-10-18	Fasudil-containing preparation and method of improving stability thereof
HK1051649B (en)	2006-04-07	NOVEL FORMULATIONS OF α-2,4-DISULFOPHENYL-N-TERT-BUTYLNITRONE