SK7222003A3 - Substituted 2-phenylaminoimidazoline phenyl ketone derivatives as IP antagonists - Google Patents

Substituted 2-phenylaminoimidazoline phenyl ketone derivatives as IP antagonists Download PDF

Info

Publication number: SK7222003A3
Authority: SK; Slovakia
Prior art keywords: phenyl; group; dihydro; ylamino; imidazol
Prior art date: 2000-11-14

Application number

SK722-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Alam Jahangir

Original Assignee

Hoffmann La Roche

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-11-14

Filing date

2001-11-05

Publication date

2004-05-04

2001-11-05 Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche

2004-05-04 Publication of SK7222003A3 publication Critical patent/SK7222003A3/sk

Links

239000005557 antagonist Substances 0.000 title description 4
XSDRNCZRJVKAFM-UHFFFAOYSA-N diphenylmethanone;n-phenyl-4,5-dihydro-1h-imidazol-2-amine Chemical class N1CCN=C1NC1=CC=CC=C1.C=1C=CC=CC=1C(=O)C1=CC=CC=C1 XSDRNCZRJVKAFM-UHFFFAOYSA-N 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 171
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230000036407 pain Effects 0.000 claims abstract description 27
108091006335 Prostaglandin I receptors Proteins 0.000 claims abstract description 21
150000003839 salts Chemical class 0.000 claims abstract description 20
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 15
239000012453 solvate Substances 0.000 claims abstract description 14
208000001953 Hypotension Diseases 0.000 claims abstract description 13
239000002464 receptor antagonist Substances 0.000 claims abstract description 13
229940044551 receptor antagonist Drugs 0.000 claims abstract description 13
SYSQUGFVNFXIIT-UHFFFAOYSA-N n-[4-(1,3-benzoxazol-2-yl)phenyl]-4-nitrobenzenesulfonamide Chemical class C1=CC([N+](=O)[O-])=CC=C1S(=O)(=O)NC1=CC=C(C=2OC3=CC=CC=C3N=2)C=C1 SYSQUGFVNFXIIT-UHFFFAOYSA-N 0.000 claims abstract description 10
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-1 methylenedioxy, ethylenedioxy Chemical group 0.000 claims description 154
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 48
125000001424 substituent group Chemical group 0.000 claims description 32
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125000000623 heterocyclic group Chemical group 0.000 claims description 17
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UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 8
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125000003854 p-chlorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1Cl 0.000 claims description 3
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125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 2
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LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 claims description 2
FFTOAWSXCAZUOD-UHFFFAOYSA-N 1-[4-[4-(4,5-dihydro-1h-imidazol-2-ylamino)phenyl]-2-fluoro-4-methoxycyclohexa-1,5-dien-1-yl]propan-1-one Chemical compound C1=CC(C(=O)CC)=C(F)CC1(OC)C(C=C1)=CC=C1NC1=NCCN1 FFTOAWSXCAZUOD-UHFFFAOYSA-N 0.000 claims 1
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YOJXNFYWBMGZEK-UHFFFAOYSA-N propyl 4-[4-[3-[4-(4,5-dihydro-1h-imidazol-2-ylamino)phenyl]propanoyl]phenyl]piperazine-1-carboxylate Chemical compound C1CN(C(=O)OCCC)CCN1C1=CC=C(C(=O)CCC=2C=CC(NC=3NCCN=3)=CC=2)C=C1 YOJXNFYWBMGZEK-UHFFFAOYSA-N 0.000 description 1
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UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
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IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
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CWXPZXBSDSIRCS-UHFFFAOYSA-N tert-butyl piperazine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1CCNCC1 CWXPZXBSDSIRCS-UHFFFAOYSA-N 0.000 description 1
YJBKVPRVZAQTPY-UHFFFAOYSA-J tetrachlorostannane;dihydrate Chemical compound O.O.Cl[Sn](Cl)(Cl)Cl YJBKVPRVZAQTPY-UHFFFAOYSA-J 0.000 description 1
MLGCXEBRWGEOQX-UHFFFAOYSA-N tetradifon Chemical compound C1=CC(Cl)=CC=C1S(=O)(=O)C1=CC(Cl)=C(Cl)C=C1Cl MLGCXEBRWGEOQX-UHFFFAOYSA-N 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
238000002560 therapeutic procedure Methods 0.000 description 1
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125000005297 thienyloxy group Chemical group S1C(=CC=C1)O* 0.000 description 1
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CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 1
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Classifications

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- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
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- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5377—1,4-Oxazines, e.g. morpholine not condensed and containing further heterocyclic rings, e.g. timolol
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- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
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- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
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- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Pulmonology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Diabetes (AREA)
Immunology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Hydrogenated Pyridines (AREA)

SK722-2003A 2000-11-14 2001-11-05 Substituted 2-phenylaminoimidazoline phenyl ketone derivatives as IP antagonists SK7222003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US24888800P	2000-11-14	2000-11-14
PCT/EP2001/012776 WO2002040453A1 (en)	2000-11-14	2001-11-05	Substituted 2-phenylaminoimidazoline phenyl ketone derivatives as ip antagonists

Publications (1)

Publication Number	Publication Date
SK7222003A3 true SK7222003A3 (en)	2004-05-04

Family

ID=22941114

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK722-2003A SK7222003A3 (en)	2000-11-14	2001-11-05	Substituted 2-phenylaminoimidazoline phenyl ketone derivatives as IP antagonists

Country Status (29)

Country	Link
EP (1)	EP1339694B1 (pl)
JP (1)	JP4108474B2 (pl)
KR (1)	KR100562605B1 (pl)
CN (1)	CN1267423C (pl)
AR (1)	AR035502A1 (pl)
AT (1)	ATE305002T1 (pl)
AU (1)	AU2180802A (pl)
BG (1)	BG107814A (pl)
BR (1)	BR0115291A (pl)
CA (1)	CA2427900A1 (pl)
CZ (1)	CZ20031596A3 (pl)
DE (1)	DE60113563T2 (pl)
EC (1)	ECSP034602A (pl)
ES (1)	ES2248413T3 (pl)
HU (1)	HUP0303156A3 (pl)
IL (1)	IL155436A0 (pl)
MA (1)	MA26958A1 (pl)
MX (1)	MXPA03004073A (pl)
NO (1)	NO20032142L (pl)
NZ (1)	NZ525330A (pl)
PA (1)	PA8532201A1 (pl)
PE (1)	PE20020602A1 (pl)
PL (1)	PL362549A1 (pl)
RU (1)	RU2284995C2 (pl)
SK (1)	SK7222003A3 (pl)
UY (1)	UY27023A1 (pl)
WO (1)	WO2002040453A1 (pl)
YU (1)	YU37203A (pl)
ZA (1)	ZA200303413B (pl)

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KR100777876B1 (ko) *	2003-05-01	2007-11-28	에프. 호프만-라 로슈 아게	프로스타글란딘 ｉ2(ｉｐ) 길항제로서 이미다졸린-2-일아미노페닐 아마이드
JP2007521276A (ja) *	2003-06-25	2007-08-02	スミスクライン・ビーチャム・コーポレイション	Ｎｋ−２およびｎｋ−３として用いるための４−カルボキサミドキノリン誘導体
MXPA06000269A (es) *	2003-07-09	2006-04-07	Hoffmann La Roche	Tiofenilaminoimidazolinas.
JP2009524619A (ja) *	2006-01-27	2009-07-02	エフ．ホフマン−ラロシュアーゲー	Ｃｎｓ障害の処置のための２−イミダゾールの使用
AU2007312390B2 (en)	2006-10-19	2013-03-28	F. Hoffmann-La Roche Ag	Aminomethyl-4-imidazoles
AU2007316257A1 (en)	2006-11-02	2008-05-08	F. Hoffmann-La Roche Ag	Substituted 2-imidazoles as modulators of the trace amine associated receptors
WO2008058867A2 (en)	2006-11-16	2008-05-22	F. Hoffmann-La Roche Ag	Substituted 4-imidazoles
KR101189348B1 (ko)	2006-12-13	2012-10-09	에프. 호프만-라 로슈 아게	미량 아민 결합 수용체(ｔａａｒ)에 대한 리간드로서의 신규한 2-이미다졸
US20080146523A1 (en)	2006-12-18	2008-06-19	Guido Galley	Imidazole derivatives
ES2510546T3 (es)	2007-02-02	2014-10-21	F. Hoffmann-La Roche Ag	Nuevas 2-aminooxazolinas como ligandos TAAR1 para trastornos del SNC
MX2009008465A (es)	2007-02-15	2009-08-20	Hoffmann La Roche	Nuevas 2-aminooxazolinas como ligandos de taar1.
CN101687812A (zh)	2007-07-02	2010-03-31	弗·哈夫曼-拉罗切有限公司	对痕量胺相关受体(taar)具有良好亲和性的2-咪唑啉化合物
KR101150628B1 (ko)	2007-07-03	2012-05-31	에프. 호프만-라 로슈 아게	4-이미다졸린 및 항우울제로서 이의 용도
CN101765587A (zh)	2007-07-27	2010-06-30	弗·哈夫曼-拉罗切有限公司	作为taar配体的2-氮杂环丁烷甲胺类和2-吡咯烷甲胺类
KR101167773B1 (ko)	2007-08-03	2012-07-24	에프. 호프만-라 로슈 아게	Ｔａａｒ１ 리간드로서의 피리딘카복스아마이드 및 벤즈아마이드 유도체
US8242153B2 (en)	2008-07-24	2012-08-14	Hoffmann-La Roche Inc.	4,5-dihydro-oxazol-2YL derivatives
US8354441B2 (en)	2009-11-11	2013-01-15	Hoffmann-La Roche Inc.	Oxazoline derivatives
EP2513064B1 (en)	2009-12-17	2018-07-04	Katholieke Universiteit Leuven K.U. Leuven R&D	Compounds, compositions and methods for controlling biofilms
US9452980B2 (en)	2009-12-22	2016-09-27	Hoffmann-La Roche Inc.	Substituted benzamides
WO2014143592A1 (en)	2013-03-12	2014-09-18	Allergan, Inc.	Inhibition of neovascularization by inhibition of prostanoid ip receptors
WO2014143591A1 (en)	2013-03-12	2014-09-18	Allergan, Inc.	Inhibition of neovascularization by simultaneous inhibition of prostanoid ip and ep4 receptors
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2001
- 2001-11-05 MX MXPA03004073A patent/MXPA03004073A/es active IP Right Grant
- 2001-11-05 HU HU0303156A patent/HUP0303156A3/hu unknown
- 2001-11-05 YU YU37203A patent/YU37203A/sh unknown
- 2001-11-05 SK SK722-2003A patent/SK7222003A3/sk unknown
- 2001-11-05 WO PCT/EP2001/012776 patent/WO2002040453A1/en not_active Ceased
- 2001-11-05 DE DE60113563T patent/DE60113563T2/de not_active Expired - Fee Related
- 2001-11-05 EP EP01996531A patent/EP1339694B1/en not_active Expired - Lifetime
- 2001-11-05 PL PL01362549A patent/PL362549A1/pl unknown
- 2001-11-05 CN CNB018187471A patent/CN1267423C/zh not_active Expired - Fee Related
- 2001-11-05 CA CA002427900A patent/CA2427900A1/en not_active Abandoned
- 2001-11-05 JP JP2002542781A patent/JP4108474B2/ja not_active Expired - Fee Related
- 2001-11-05 AT AT01996531T patent/ATE305002T1/de not_active IP Right Cessation
- 2001-11-05 AU AU2180802A patent/AU2180802A/xx not_active Withdrawn
- 2001-11-05 IL IL15543601A patent/IL155436A0/xx unknown
- 2001-11-05 ES ES01996531T patent/ES2248413T3/es not_active Expired - Lifetime
- 2001-11-05 NZ NZ525330A patent/NZ525330A/en unknown
- 2001-11-05 CZ CZ20031596A patent/CZ20031596A3/cs unknown
- 2001-11-05 BR BR0115291-2A patent/BR0115291A/pt not_active IP Right Cessation
- 2001-11-05 RU RU2003115426/04A patent/RU2284995C2/ru not_active IP Right Cessation
- 2001-11-05 KR KR1020037006504A patent/KR100562605B1/ko not_active Expired - Fee Related
- 2001-11-09 PE PE2001001118A patent/PE20020602A1/es not_active Application Discontinuation
- 2001-11-13 UY UY27023A patent/UY27023A1/es not_active Application Discontinuation
- 2001-11-13 AR ARP010105280A patent/AR035502A1/es not_active Application Discontinuation
- 2001-11-13 PA PA20018532201A patent/PA8532201A1/es unknown
2003
- 2003-05-02 ZA ZA200303413A patent/ZA200303413B/en unknown
- 2003-05-12 MA MA27154A patent/MA26958A1/fr unknown
- 2003-05-13 EC EC2003004602A patent/ECSP034602A/es unknown
- 2003-05-13 NO NO20032142A patent/NO20032142L/no not_active Application Discontinuation
- 2003-05-14 BG BG107814A patent/BG107814A/bg unknown

Also Published As

Publication number	Publication date
YU37203A (sh)	2006-05-25
CN1474813A (zh)	2004-02-11
PA8532201A1 (es)	2002-08-26
JP2004513940A (ja)	2004-05-13
CN1267423C (zh)	2006-08-02
EP1339694B1 (en)	2005-09-21
PE20020602A1 (es)	2002-07-08
JP4108474B2 (ja)	2008-06-25
MXPA03004073A (es)	2003-09-04
NO20032142D0 (no)	2003-05-13
ES2248413T3 (es)	2006-03-16
UY27023A1 (es)	2002-06-20
ZA200303413B (en)	2004-08-02
KR20030065512A (ko)	2003-08-06
PL362549A1 (pl)	2004-11-02
DE60113563T2 (de)	2006-07-13
BG107814A (bg)	2004-02-27
CA2427900A1 (en)	2002-05-23
AR035502A1 (es)	2004-06-02
ECSP034602A (es)	2003-06-25
NO20032142L (no)	2003-05-13
HUP0303156A2 (hu)	2004-01-28
IL155436A0 (en)	2003-11-23
NZ525330A (en)	2004-10-29
CZ20031596A3 (cs)	2004-01-14
KR100562605B1 (ko)	2006-03-17
BR0115291A (pt)	2003-08-19
RU2284995C2 (ru)	2006-10-10
HUP0303156A3 (en)	2004-03-29
DE60113563D1 (de)	2006-02-02
MA26958A1 (fr)	2004-12-20
WO2002040453A1 (en)	2002-05-23
EP1339694A1 (en)	2003-09-03
AU2180802A (en)	2002-05-27
ATE305002T1 (de)	2005-10-15

Publication	Publication Date	Title
EP1339694B1 (en)	2005-09-21	Substituted 2-phenylaminoimidazoline phenyl ketone derivatives as ip antagonists
HUP0104364A2 (hu)	2002-04-29	Pirrolidinszármazékok, CCR-3 receptor antagonisták és ezeket tartalmazó gyógyszerkészítmények
US7671235B2 (en)	2010-03-02	Tetralin and indane derivatives and uses thereof
JP3971299B2 (ja)	2007-09-05	α−１アドレナリン作動性拮抗薬としてのキナゾリン誘導体
US6417186B1 (en)	2002-07-09	Substituted-phenyl ketone derivatives as IP antagonists
US6903086B2 (en)	2005-06-07	Alkoxycarbonylamino benzoic acid or alkoxycarbonylamino tetrazolyl phenyl derivatives as IP antagonists
CZ278198A3 (cs)	1999-04-14	2-(Arylfenyl)aminoimidazolinové deriváty
US7078401B2 (en)	2006-07-18	Thiophenylaminoimidazolines as IP antagonists
EP1368345B1 (en)	2006-03-22	Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as ip antagonists
KR100777876B1 (ko)	2007-11-28	프로스타글란딘 ｉ2(ｉｐ) 길항제로서 이미다졸린-2-일아미노페닐 아마이드
AU2002221808B2 (en)	2007-09-27	Substituted 2-phenylaminoimidazoline Phenyl Ketone Derivatives as IP Antagonists
FR2558835A1 (fr)	1985-08-02	Derives d'hydantoine, leur procede de production et medicament les contenant
AU2002221808A1 (en)	2002-08-01	Substituted 2-phenylaminoimidazoline Phenyl Ketone Derivatives as IP Antagonists
MX2008015511A (es)	2008-12-18	Derivados de arilsulfonilnaftaleno y usos de los mismos.
HK1061847A (en)	2004-10-08	Substituted 2-phenylaminoimidazoline phenyl ketone derivatives as ip antagonists
AU2002253060A1 (en)	2002-09-19	Alkoxycarbonylamino heteroaryl carboxylic acid derivatives as IP antagonists