SK8432003A3 - Sulfamidothienopyrimidines and the use of the same as phosphodiesterase v inhibitors - Google Patents

Sulfamidothienopyrimidines and the use of the same as phosphodiesterase v inhibitors Download PDF

Info

Publication number: SK8432003A3
Authority: SK; Slovakia
Prior art keywords: formula; solvates; compound; compounds; treatment
Prior art date: 2000-12-23

Application number

SK843-2003A

Other languages

English (en)

Slovak (sk)

Inventor

Hans-Michael Eggenweiler

Harry Swartz

Pierre Schelling

Norbert Beier

Maria Christadler

Original Assignee

Merck Patent Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2000-12-23

Filing date

2001-12-03

Publication date

2003-10-07

2001-12-03 Application filed by Merck Patent Gmbh filed Critical Merck Patent Gmbh

2003-10-07 Publication of SK8432003A3 publication Critical patent/SK8432003A3/sk

Links

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UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
125000004076 pyridyl group Chemical group 0.000 description 1
150000003246 quinazolines Chemical class 0.000 description 1
125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
102000005962 receptors Human genes 0.000 description 1
108020003175 receptors Proteins 0.000 description 1
229960002917 reteplase Drugs 0.000 description 1
108010051412 reteplase Proteins 0.000 description 1
229960005496 reviparin Drugs 0.000 description 1
238000007363 ring formation reaction Methods 0.000 description 1
229960002055 saruplase Drugs 0.000 description 1
108010073863 saruplase Proteins 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000010898 silica gel chromatography Methods 0.000 description 1
210000002460 smooth muscle Anatomy 0.000 description 1
229940074545 sodium dihydrogen phosphate dihydrate Drugs 0.000 description 1
229940083618 sodium nitroprusside Drugs 0.000 description 1
229910052938 sodium sulfate Inorganic materials 0.000 description 1
GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical class [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 1
235000011152 sodium sulphate Nutrition 0.000 description 1
ZLHQEGFYBMZQGM-RKVLWQGQSA-M sodium;(z)-2-(1,3-benzodioxol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-[(3,4,5-trimethoxyphenyl)methyl]but-2-enoate Chemical compound [Na+].C1=CC(OC)=CC=C1C(=O)C(\CC=1C=C(OC)C(OC)=C(OC)C=1)=C(/C([O-])=O)C1=CC=C(OCO2)C2=C1 ZLHQEGFYBMZQGM-RKVLWQGQSA-M 0.000 description 1
COKFAUSKNMGISZ-BMGIYVBOSA-M sodium;(z)-2-(2,1,3-benzothiadiazol-5-yl)-4-(4-methoxyphenyl)-4-oxo-3-[(3,4,5-trimethoxyphenyl)methyl]but-2-enoate Chemical compound [Na+].C1=CC(OC)=CC=C1C(=O)C(\CC=1C=C(OC)C(OC)=C(OC)C=1)=C(/C([O-])=O)C1=CC2=NSN=C2C=C1 COKFAUSKNMGISZ-BMGIYVBOSA-M 0.000 description 1
239000008347 soybean phospholipid Substances 0.000 description 1
235000019698 starch Nutrition 0.000 description 1
229960005202 streptokinase Drugs 0.000 description 1
239000005720 sucrose Substances 0.000 description 1
150000003460 sulfonic acids Chemical class 0.000 description 1
150000003462 sulfoxides Chemical class 0.000 description 1
239000011593 sulfur Substances 0.000 description 1
229910052717 sulfur Inorganic materials 0.000 description 1
QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid group Chemical class S(O)(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
229960003491 sulodexide Drugs 0.000 description 1
UQZVCDCIMBLVNR-TWYODKAFSA-N sulprostone Chemical compound O[C@@H]1CC(=O)[C@H](C\C=C/CCCC(=O)NS(=O)(=O)C)[C@H]1\C=C\[C@@H](O)COC1=CC=CC=C1 UQZVCDCIMBLVNR-TWYODKAFSA-N 0.000 description 1
229960003400 sulprostone Drugs 0.000 description 1
239000000725 suspension Substances 0.000 description 1
239000006188 syrup Substances 0.000 description 1
235000020357 syrup Nutrition 0.000 description 1
230000009885 systemic effect Effects 0.000 description 1
125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
125000000335 thiazolyl group Chemical group 0.000 description 1
ICRHORQIUXBEPA-UHFFFAOYSA-N thionitrous acid Chemical compound SN=O ICRHORQIUXBEPA-UHFFFAOYSA-N 0.000 description 1
150000003577 thiophenes Chemical group 0.000 description 1
229960005001 ticlopidine Drugs 0.000 description 1
PHWBOXQYWZNQIN-UHFFFAOYSA-N ticlopidine Chemical compound ClC1=CC=CC=C1CN1CC(C=CS2)=C2CC1 PHWBOXQYWZNQIN-UHFFFAOYSA-N 0.000 description 1
229960005062 tinzaparin Drugs 0.000 description 1
229960003425 tirofiban Drugs 0.000 description 1
COKMIXFXJJXBQG-NRFANRHFSA-N tirofiban Chemical compound C1=CC(C[C@H](NS(=O)(=O)CCCC)C(O)=O)=CC=C1OCCCCC1CCNCC1 COKMIXFXJJXBQG-NRFANRHFSA-N 0.000 description 1
210000001519 tissue Anatomy 0.000 description 1
238000011200 topical administration Methods 0.000 description 1
239000000196 tragacanth Substances 0.000 description 1
235000010487 tragacanth Nutrition 0.000 description 1
229940116362 tragacanth Drugs 0.000 description 1
229960002622 triacetin Drugs 0.000 description 1
125000001425 triazolyl group Chemical group 0.000 description 1
229960002485 trolnitrate Drugs 0.000 description 1
HWKQNAWCHQMZHK-UHFFFAOYSA-N trolnitrate Chemical compound [O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O HWKQNAWCHQMZHK-UHFFFAOYSA-N 0.000 description 1
229960005356 urokinase Drugs 0.000 description 1
230000025033 vasoconstriction Effects 0.000 description 1
230000024883 vasodilation Effects 0.000 description 1
230000001196 vasorelaxation Effects 0.000 description 1
235000015112 vegetable and seed oil Nutrition 0.000 description 1
239000008158 vegetable oil Substances 0.000 description 1
229960001722 verapamil Drugs 0.000 description 1
229930003231 vitamin Natural products 0.000 description 1
239000011782 vitamin Substances 0.000 description 1
229940088594 vitamin Drugs 0.000 description 1
235000013343 vitamin Nutrition 0.000 description 1
239000003039 volatile agent Substances 0.000 description 1
229960005080 warfarin Drugs 0.000 description 1
PJVWKTKQMONHTI-UHFFFAOYSA-N warfarin Chemical compound OC=1C2=CC=CC=C2OC(=O)C=1C(CC(=O)C)C1=CC=CC=C1 PJVWKTKQMONHTI-UHFFFAOYSA-N 0.000 description 1
239000000080 wetting agent Substances 0.000 description 1
239000008096 xylene Substances 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Pulmonology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Urology & Nephrology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Rheumatology (AREA)
Ophthalmology & Optometry (AREA)
Hospice & Palliative Care (AREA)
Immunology (AREA)
Pain & Pain Management (AREA)
Vascular Medicine (AREA)
Gastroenterology & Hepatology (AREA)
Gynecology & Obstetrics (AREA)
Physical Education & Sports Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SK843-2003A 2000-12-23 2001-12-03 Sulfamidothienopyrimidines and the use of the same as phosphodiesterase v inhibitors SK8432003A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
DE10064994A DE10064994A1 (de)	2000-12-23	2000-12-23	Sulfamidothienopyrimidine
PCT/EP2001/014102 WO2002051848A2 (de)	2000-12-23	2001-12-03	Sulfamidothienopyrimidine zur verwendung als phosphodiesterase v-hemmer

Publications (1)

Publication Number	Publication Date
SK8432003A3 true SK8432003A3 (en)	2003-10-07

Family

ID=7668967

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK843-2003A SK8432003A3 (en)	2000-12-23	2001-12-03	Sulfamidothienopyrimidines and the use of the same as phosphodiesterase v inhibitors

Country Status (19)

Country	Link
US (1)	US7019013B2 (cs)
EP (1)	EP1353927B1 (cs)
JP (1)	JP4550361B2 (cs)
KR (1)	KR20030062438A (cs)
CN (1)	CN1483035A (cs)
AR (1)	AR035524A1 (cs)
AT (1)	ATE302781T1 (cs)
BR (1)	BR0115996A (cs)
CA (1)	CA2432582C (cs)
CZ (1)	CZ20031815A3 (cs)
DE (2)	DE10064994A1 (cs)
ES (1)	ES2247007T3 (cs)
HU (1)	HUP0302515A3 (cs)
MX (1)	MXPA03005714A (cs)
PL (1)	PL361733A1 (cs)
RU (1)	RU2003122189A (cs)
SK (1)	SK8432003A3 (cs)
WO (1)	WO2002051848A2 (cs)
ZA (1)	ZA200305659B (cs)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US6849638B2 (en) *	2001-04-30	2005-02-01	Bayer Pharmaceuticals Corporation	4-amino-5,6-substituted thiopheno [2,3-d] pyrimidines, pharmaceutical compositions containing the same, and their use in the treatment or prevention of pde7b-mediated diseases and conditions
CN101163706A (zh) *	2005-04-21	2008-04-16	贝林格尔·英格海姆国际有限公司	用于治疗炎性疾病的二氢噻吩并嘧啶
EP1847543A1 (de)	2006-04-19	2007-10-24	Boehringer Ingelheim Pharma GmbH & Co. KG	Dihydrothienopyrimidine zur Behandlung von entzündlichen Erkrankungen
US8080549B2 (en) *	2007-01-12	2011-12-20	Concert Pharmaceuticals, Inc.	Endothelin receptor antagonists
WO2008088727A2 (en)	2007-01-12	2008-07-24	Concert Pharmaceuticals, Inc.	Endothelin receptor antagonists
JP2010516734A (ja)	2007-01-24	2010-05-20	グラクソグループリミテッド	３，５−ジアミノ−６−（２，３−ジクロロフェニル）−１，２，４−トリアジンまたはｒ（−）−２，４−ジアミノ−５−（２，３−ジクロロフェニル）−６−フルオロメチルピリミジンを含む医薬組成物
ES2524910T3 (es)	2007-10-19	2014-12-15	Boehringer Ingelheim International Gmbh	Piperidino-dihidrotienopirimidinas sustituidas
JP5341899B2 (ja)	2007-10-19	2013-11-13	ベーリンガーインゲルハイムインターナショナルゲゼルシャフトミットベシュレンクテルハフツング	ヘテロ環置換ピペラジノ−ジヒドロチエノピリミジン
ATE537175T1 (de)	2007-10-19	2011-12-15	Boehringer Ingelheim Int	Neue piperazino-dihydrothienopyrimidin-derivate
JP6042331B2 (ja)	2010-07-23	2016-12-14	プレジデントアンドフェローズオブハーバードカレッジ	プロテアソーム活性を向上させる三環系化合物
US20130059866A1 (en)	2011-08-24	2013-03-07	Boehringer Ingelheim International Gmbh	Novel piperidino-dihydrothienopyrimidine sulfoxides and their use for treating copd and asthma
US9802954B2 (en)	2011-08-24	2017-10-31	Boehringer Ingelheim International Gmbh	Piperidino-dihydrothienopyrimidine sulfoxides and their use for treating COPD and asthma
EP2806875B1 (en) *	2012-01-25	2017-07-19	Proteostasis Therapeutics, Inc.	Proteasome activity modulating compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE19644228A1 (de) *	1996-10-24	1998-04-30	Merck Patent Gmbh	Thienopyrimidine
DE19752952A1 (de) *	1997-11-28	1999-06-02	Merck Patent Gmbh	Thienopyrimidine
DE19819023A1 (de) *	1998-04-29	1999-11-04	Merck Patent Gmbh	Thienopyrimidine
WO2000059912A1 (en)	1999-03-30	2000-10-12	Nippon Soda Co., Ltd.	Thienopyrimidine compounds and salts thereof and process for the preparation of the same

2000
- 2000-12-23 DE DE10064994A patent/DE10064994A1/de not_active Withdrawn
2001
- 2001-12-03 AT AT01271992T patent/ATE302781T1/de not_active IP Right Cessation
- 2001-12-03 KR KR10-2003-7008265A patent/KR20030062438A/ko not_active Withdrawn
- 2001-12-03 DE DE50107230T patent/DE50107230D1/de not_active Expired - Lifetime
- 2001-12-03 CN CNA018212190A patent/CN1483035A/zh active Pending
- 2001-12-03 PL PL01361733A patent/PL361733A1/xx unknown
- 2001-12-03 US US10/451,183 patent/US7019013B2/en not_active Expired - Fee Related
- 2001-12-03 EP EP01271992A patent/EP1353927B1/de not_active Expired - Lifetime
- 2001-12-03 CZ CZ20031815A patent/CZ20031815A3/cs unknown
- 2001-12-03 ES ES01271992T patent/ES2247007T3/es not_active Expired - Lifetime
- 2001-12-03 SK SK843-2003A patent/SK8432003A3/sk unknown
- 2001-12-03 JP JP2002552942A patent/JP4550361B2/ja not_active Expired - Fee Related
- 2001-12-03 HU HU0302515A patent/HUP0302515A3/hu unknown
- 2001-12-03 RU RU2003122189/04A patent/RU2003122189A/ru not_active Application Discontinuation
- 2001-12-03 CA CA2432582A patent/CA2432582C/en not_active Expired - Fee Related
- 2001-12-03 WO PCT/EP2001/014102 patent/WO2002051848A2/de not_active Ceased
- 2001-12-03 BR BR0115996-8A patent/BR0115996A/pt not_active Application Discontinuation
- 2001-12-03 MX MXPA03005714A patent/MXPA03005714A/es not_active Application Discontinuation
- 2001-12-19 AR ARP010105889A patent/AR035524A1/es not_active Application Discontinuation
2003
- 2003-07-22 ZA ZA200305659A patent/ZA200305659B/en unknown

Also Published As

Publication number	Publication date
ES2247007T3 (es)	2006-03-01
US7019013B2 (en)	2006-03-28
US20040063943A1 (en)	2004-04-01
EP1353927B1 (de)	2005-08-24
WO2002051848A3 (de)	2002-10-24
BR0115996A (pt)	2004-01-06
ZA200305659B (en)	2004-08-27
MXPA03005714A (es)	2003-10-06
KR20030062438A (ko)	2003-07-25
PL361733A1 (en)	2004-10-04
EP1353927A2 (de)	2003-10-22
CN1483035A (zh)	2004-03-17
RU2003122189A (ru)	2004-12-27
CZ20031815A3 (cs)	2003-10-15
DE10064994A1 (de)	2002-07-04
CA2432582C (en)	2011-01-25
WO2002051848A2 (de)	2002-07-04
CA2432582A1 (en)	2002-07-04
ATE302781T1 (de)	2005-09-15
HUP0302515A2 (hu)	2003-11-28
DE50107230D1 (de)	2005-09-29
AR035524A1 (es)	2004-06-02
JP4550361B2 (ja)	2010-09-22
JP2004516329A (ja)	2004-06-03
HUP0302515A3 (en)	2005-06-28

Publication	Publication Date	Title
US20040063730A1 (en)	2004-04-01	Pharmacuetical formulation comprising puyrazolo[4,-3-d]pyrimidines and antithrombotics, calcium antagonists, or prostaglandins or prostaglandin derivatives
US20040034040A1 (en)	2004-02-19	Use of thienopyrimidines
SK8432003A3 (en)	2003-10-07	Sulfamidothienopyrimidines and the use of the same as phosphodiesterase v inhibitors
JP4782376B2 (ja)	2011-09-28	ピリミジン誘導体
JP2004525890A (ja)	2004-08-26	ピラゾロ［４，３−ｄ］ピリミジンおよびエンドセリンレセプターアンタゴニストまたはチエノピリミジンおよびエンドセリンレセプターアンタゴニストを含む医薬製剤
US20040072846A1 (en)	2004-04-15	Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives
JP2004517940A (ja)	2004-06-17	ピラゾロ［４，３−ｄ］ピリミジンおよびニトレートまたはチエノピリミジンおよびニトレートを含む医薬製剤
JP2004513963A (ja)	2004-05-13	ピラゾロ〔４，３−ｄ〕ピリミジンの使用
DE10104802A1 (de)	2002-08-08	Pharmazeutische Formulierungen enthaltend Thienopirimidine und Endothelin-Rezeptor-Antagonisten (1)
SK8032003A3 (en)	2003-11-04	Pharmaceutical formulation containing thienopyrimidines and antithrombotics, calcium antagonists, prostaglandins or prostaglandin derivatives
ZA200302513B (en)	2004-08-24	Thienopyrimidines.
JP2003509511A (ja)	2003-03-11	アミン誘導体
KR20020026011A (ko)	2002-04-04	티에노피리미딘의 용도
DE10104801A1 (de)	2002-08-08	Pharmazeutische Formulierungen enthaltend Thienopirimidine und Endothelin-Rezeptor-Antagonisten (2)