SK87398A3 - Use of ginkgo biloba extracts for the preparation of pharmaceutical compositions, and method of cosmetic treatment using a ginkgo biloba extract - Google Patents

Use of ginkgo biloba extracts for the preparation of pharmaceutical compositions, and method of cosmetic treatment using a ginkgo biloba extract Download PDF

Info

Publication number: SK87398A3
Authority: SK; Slovakia
Prior art keywords: ginkgo biloba; composition; extract; cells; use according
Prior art date: 1996-10-22

Application number

SK873-98A

Other languages

English (en)

Slovak (sk)

Inventor

Dominique Castelli

Laurence Friteau

Gerd Ries

Original Assignee

Roc Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1996-10-22

Filing date

1997-10-21

Publication date

2000-01-18

1997-10-21 Application filed by Roc Sa filed Critical Roc Sa

2000-01-18 Publication of SK87398A3 publication Critical patent/SK87398A3/sk

Links

238000011282 treatment Methods 0.000 title claims abstract description 12
238000002360 preparation method Methods 0.000 title claims abstract description 11
238000000034 method Methods 0.000 title claims abstract description 10
239000002537 cosmetic Substances 0.000 title claims abstract description 6
235000020686 ginkgo biloba extract Nutrition 0.000 title claims description 9
239000009429 Ginkgo biloba extract Substances 0.000 title claims description 7
229940068052 ginkgo biloba extract Drugs 0.000 title claims description 7
239000008194 pharmaceutical composition Substances 0.000 title description 2
239000000203 mixture Substances 0.000 claims abstract description 21
235000008100 Ginkgo biloba Nutrition 0.000 claims abstract description 18
244000194101 Ginkgo biloba Species 0.000 claims abstract description 14
239000004480 active ingredient Substances 0.000 claims abstract description 10
238000000605 extraction Methods 0.000 claims abstract description 6
239000000284 extract Substances 0.000 claims description 26
208000010668 atopic eczema Diseases 0.000 claims description 9
235000007586 terpenes Nutrition 0.000 claims description 8
150000003505 terpenes Chemical class 0.000 claims description 7
201000004624 Dermatitis Diseases 0.000 claims description 5
230000000694 effects Effects 0.000 claims description 5
GAMYVSCDDLXAQW-AOIWZFSPSA-N Thermopsosid Natural products O(C)c1c(O)ccc(C=2Oc3c(c(O)cc(O[C@H]4[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O4)c3)C(=O)C=2)c1 GAMYVSCDDLXAQW-AOIWZFSPSA-N 0.000 claims description 4
229930003944 flavone Natural products 0.000 claims description 4
235000011949 flavones Nutrition 0.000 claims description 4
VHBFFQKBGNRLFZ-UHFFFAOYSA-N vitamin p Natural products O1C2=CC=CC=C2C(=O)C=C1C1=CC=CC=C1 VHBFFQKBGNRLFZ-UHFFFAOYSA-N 0.000 claims description 4
206010015150 Erythema Diseases 0.000 claims description 3
150000002212 flavone derivatives Chemical class 0.000 claims description 3
206010025135 lupus erythematosus Diseases 0.000 claims description 3
208000024891 symptom Diseases 0.000 claims description 3
208000030507 AIDS Diseases 0.000 claims description 2
206010003645 Atopy Diseases 0.000 claims description 2
206010020751 Hypersensitivity Diseases 0.000 claims description 2
201000009053 Neurodermatitis Diseases 0.000 claims description 2
241000721454 Pemphigus Species 0.000 claims description 2
206010051246 Photodermatosis Diseases 0.000 claims description 2
201000004681 Psoriasis Diseases 0.000 claims description 2
208000024780 Urticaria Diseases 0.000 claims description 2
206010047642 Vitiligo Diseases 0.000 claims description 2
231100000321 erythema Toxicity 0.000 claims description 2
210000004400 mucous membrane Anatomy 0.000 claims description 2
208000017983 photosensitivity disease Diseases 0.000 claims description 2
230000002062 proliferating effect Effects 0.000 claims 2
230000001225 therapeutic effect Effects 0.000 claims 2
230000000699 topical effect Effects 0.000 claims 2
206010040914 Skin reaction Diseases 0.000 claims 1
201000005404 rubella Diseases 0.000 claims 1
231100000430 skin reaction Toxicity 0.000 claims 1
230000035483 skin reaction Effects 0.000 claims 1
230000002519 immonomodulatory effect Effects 0.000 abstract description 6
230000037307 sensitive skin Effects 0.000 abstract description 3
210000004027 cell Anatomy 0.000 description 31
210000001744 T-lymphocyte Anatomy 0.000 description 20
210000001339 epidermal cell Anatomy 0.000 description 19
IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 15
210000003491 skin Anatomy 0.000 description 14
210000002510 keratinocyte Anatomy 0.000 description 13
210000002540 macrophage Anatomy 0.000 description 13
210000004698 lymphocyte Anatomy 0.000 description 12
239000000047 product Substances 0.000 description 12
210000001821 langerhans cell Anatomy 0.000 description 10
108090000978 Interleukin-4 Proteins 0.000 description 9
230000000735 allogeneic effect Effects 0.000 description 9
230000035755 proliferation Effects 0.000 description 9
PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 description 8
108010036949 Cyclosporine Proteins 0.000 description 8
239000000427 antigen Substances 0.000 description 8
108091007433 antigens Proteins 0.000 description 8
102000036639 antigens Human genes 0.000 description 8
229960001265 ciclosporin Drugs 0.000 description 8
229930182912 cyclosporin Natural products 0.000 description 8
229930105110 Cyclosporin A Natural products 0.000 description 7
101000878605 Homo sapiens Low affinity immunoglobulin epsilon Fc receptor Proteins 0.000 description 7
CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 6
LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
102100038007 Low affinity immunoglobulin epsilon Fc receptor Human genes 0.000 description 6
238000003501 co-culture Methods 0.000 description 6
238000004519 manufacturing process Methods 0.000 description 6
239000000126 substance Substances 0.000 description 6
101000950648 Homo sapiens Malectin Proteins 0.000 description 5
102100037750 Malectin Human genes 0.000 description 5
REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 description 5
230000000172 allergic effect Effects 0.000 description 5
230000000638 stimulation Effects 0.000 description 5
XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 5
YXHVCZZLWZYHSA-UHFFFAOYSA-N (Z)-6-[8-pentadecenyl]salicylic acid Natural products CCCCCCC=CCCCCCCCC1=CC=CC(O)=C1C(O)=O YXHVCZZLWZYHSA-UHFFFAOYSA-N 0.000 description 4
IQFYYKKMVGJFEH-OFKYTIFKSA-N 1-[(2r,4s,5r)-4-hydroxy-5-(tritiooxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO[3H])O[C@H]1N1C(=O)NC(=O)C(C)=C1 IQFYYKKMVGJFEH-OFKYTIFKSA-N 0.000 description 4
241000218628 Ginkgo Species 0.000 description 4
235000011201 Ginkgo Nutrition 0.000 description 4
230000028993 immune response Effects 0.000 description 4
238000010348 incorporation Methods 0.000 description 4
MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 description 4
210000003819 peripheral blood mononuclear cell Anatomy 0.000 description 4
239000002904 solvent Substances 0.000 description 4
108090000695 Cytokines Proteins 0.000 description 3
102000004127 Cytokines Human genes 0.000 description 3
XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
YXHVCZZLWZYHSA-FPLPWBNLSA-N Ginkgoic acid Chemical compound CCCCCC\C=C/CCCCCCCC1=CC=CC(O)=C1C(O)=O YXHVCZZLWZYHSA-FPLPWBNLSA-N 0.000 description 3
206010061218 Inflammation Diseases 0.000 description 3
102100040247 Tumor necrosis factor Human genes 0.000 description 3
230000007123 defense Effects 0.000 description 3
238000002474 experimental method Methods 0.000 description 3
210000000987 immune system Anatomy 0.000 description 3
230000006698 induction Effects 0.000 description 3
230000004054 inflammatory process Effects 0.000 description 3
235000005875 quercetin Nutrition 0.000 description 3
229960001285 quercetin Drugs 0.000 description 3
108020003175 receptors Proteins 0.000 description 3
102000005962 receptors Human genes 0.000 description 3
230000004044 response Effects 0.000 description 3
238000012360 testing method Methods 0.000 description 3
IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical class N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
IWEIJEPIYMAGTH-UHFFFAOYSA-N Bilobetin Chemical compound COC1=CC=C(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)C=C1C1=C(O)C=C(O)C(C(C=2)=O)=C1OC=2C1=CC=C(O)C=C1 IWEIJEPIYMAGTH-UHFFFAOYSA-N 0.000 description 2
108010073816 IgE Receptors Proteins 0.000 description 2
102000009438 IgE Receptors Human genes 0.000 description 2
108090001090 Lectins Proteins 0.000 description 2
102000004856 Lectins Human genes 0.000 description 2
LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 2
ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 description 2
HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 description 2
IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
230000004913 activation Effects 0.000 description 2
-1 aliphatic alcohols Chemical class 0.000 description 2
230000009285 allergic inflammation Effects 0.000 description 2
238000006243 chemical reaction Methods 0.000 description 2
229930002875 chlorophyll Natural products 0.000 description 2
235000019804 chlorophyll Nutrition 0.000 description 2
ATNHDLDRLWWWCB-AENOIHSZSA-M chlorophyll a Chemical compound C1([C@@H](C(=O)OC)C(=O)C2=C3C)=C2N2C3=CC(C(CC)=C3C)=[N+]4C3=CC3=C(C=C)C(C)=C5N3[Mg-2]42[N+]2=C1[C@@H](CCC(=O)OC\C=C(/C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)[C@H](C)C2=C5 ATNHDLDRLWWWCB-AENOIHSZSA-M 0.000 description 2
201000010099 disease Diseases 0.000 description 2
208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
210000002615 epidermis Anatomy 0.000 description 2
229930184727 ginkgolide Natural products 0.000 description 2
230000003054 hormonal effect Effects 0.000 description 2
230000007124 immune defense Effects 0.000 description 2
230000001900 immune effect Effects 0.000 description 2
238000000338 in vitro Methods 0.000 description 2
230000028709 inflammatory response Effects 0.000 description 2
230000002401 inhibitory effect Effects 0.000 description 2
230000003993 interaction Effects 0.000 description 2
IYRMWMYZSQPJKC-UHFFFAOYSA-N kaempferol Chemical compound C1=CC(O)=CC=C1C1=C(O)C(=O)C2=C(O)C=C(O)C=C2O1 IYRMWMYZSQPJKC-UHFFFAOYSA-N 0.000 description 2
239000002523 lectin Substances 0.000 description 2
150000002632 lipids Chemical class 0.000 description 2
239000002609 medium Substances 0.000 description 2
150000002828 nitro derivatives Chemical class 0.000 description 2
150000002829 nitrogen Chemical class 0.000 description 2
230000004783 oxidative metabolism Effects 0.000 description 2
108090000765 processed proteins & peptides Proteins 0.000 description 2
108090000623 proteins and genes Proteins 0.000 description 2
230000001105 regulatory effect Effects 0.000 description 2
239000000243 solution Substances 0.000 description 2
239000011550 stock solution Substances 0.000 description 2
210000001519 tissue Anatomy 0.000 description 2
239000001993 wax Substances 0.000 description 2
MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 description 1
TWCMVXMQHSVIOJ-UHFFFAOYSA-N Aglycone of yadanzioside D Natural products COC(=O)C12OCC34C(CC5C(=CC(O)C(O)C5(C)C3C(O)C1O)C)OC(=O)C(OC(=O)C)C24 TWCMVXMQHSVIOJ-UHFFFAOYSA-N 0.000 description 1
206010027654 Allergic conditions Diseases 0.000 description 1
201000004384 Alopecia Diseases 0.000 description 1
235000001271 Anacardium Nutrition 0.000 description 1
241000693997 Anacardium Species 0.000 description 1
200000000007 Arterial disease Diseases 0.000 description 1
PLMKQQMDOMTZGG-UHFFFAOYSA-N Astrantiagenin E-methylester Natural products CC12CCC(O)C(C)(CO)C1CCC1(C)C2CC=C2C3CC(C)(C)CCC3(C(=O)OC)CCC21C PLMKQQMDOMTZGG-UHFFFAOYSA-N 0.000 description 1
DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
SHZGCJCMOBCMKK-UHFFFAOYSA-N D-mannomethylose Natural products CC1OC(O)C(O)C(O)C1O SHZGCJCMOBCMKK-UHFFFAOYSA-N 0.000 description 1
208000001840 Dandruff Diseases 0.000 description 1
UBSCDKPKWHYZNX-UHFFFAOYSA-N Demethoxycapillarisin Natural products C1=CC(O)=CC=C1OC1=CC(=O)C2=C(O)C=C(O)C=C2O1 UBSCDKPKWHYZNX-UHFFFAOYSA-N 0.000 description 1
229920001917 Ficoll Polymers 0.000 description 1
208000003098 Ganglion Cysts Diseases 0.000 description 1
WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
102100031547 HLA class II histocompatibility antigen, DO alpha chain Human genes 0.000 description 1
101000866278 Homo sapiens HLA class II histocompatibility antigen, DO alpha chain Proteins 0.000 description 1
208000035154 Hyperesthesia Diseases 0.000 description 1
XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 1
SHZGCJCMOBCMKK-JFNONXLTSA-N L-rhamnopyranose Chemical compound C[C@@H]1OC(O)[C@H](O)[C@H](O)[C@H]1O SHZGCJCMOBCMKK-JFNONXLTSA-N 0.000 description 1
PNNNRSAQSRJVSB-UHFFFAOYSA-N L-rhamnose Natural products CC(O)C(O)C(O)C(O)C=O PNNNRSAQSRJVSB-UHFFFAOYSA-N 0.000 description 1
241000201282 Limonium Species 0.000 description 1
108700018351 Major Histocompatibility Complex Proteins 0.000 description 1
208000001940 Massive Hepatic Necrosis Diseases 0.000 description 1
206010030113 Oedema Diseases 0.000 description 1
229920002565 Polyethylene Glycol 400 Polymers 0.000 description 1
229920001991 Proanthocyanidin Polymers 0.000 description 1
229930186743 Quercetol Natural products 0.000 description 1
208000003782 Raynaud disease Diseases 0.000 description 1
208000012322 Raynaud phenomenon Diseases 0.000 description 1
206010039793 Seborrhoeic dermatitis Diseases 0.000 description 1
206010070834 Sensitisation Diseases 0.000 description 1
206010040830 Skin discomfort Diseases 0.000 description 1
206010040844 Skin exfoliation Diseases 0.000 description 1
OUUQCZGPVNCOIJ-UHFFFAOYSA-M Superoxide Chemical compound [O-][O] OUUQCZGPVNCOIJ-UHFFFAOYSA-M 0.000 description 1
208000005400 Synovial Cyst Diseases 0.000 description 1
230000006052 T cell proliferation Effects 0.000 description 1
206010043189 Telangiectasia Diseases 0.000 description 1
108060008682 Tumor Necrosis Factor Proteins 0.000 description 1
241000700605 Viruses Species 0.000 description 1
201000006083 Xeroderma Pigmentosum Diseases 0.000 description 1
206010048222 Xerosis Diseases 0.000 description 1
239000013543 active substance Substances 0.000 description 1
230000003321 amplification Effects 0.000 description 1
230000003266 anti-allergic effect Effects 0.000 description 1
230000030741 antigen processing and presentation Effects 0.000 description 1
210000000612 antigen-presenting cell Anatomy 0.000 description 1
230000000890 antigenic effect Effects 0.000 description 1
238000013459 approach Methods 0.000 description 1
238000003149 assay kit Methods 0.000 description 1
WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
210000000481 breast Anatomy 0.000 description 1
244000309466 calf Species 0.000 description 1
150000001720 carbohydrates Chemical class 0.000 description 1
231100000504 carcinogenesis Toxicity 0.000 description 1
230000020411 cell activation Effects 0.000 description 1
230000001413 cellular effect Effects 0.000 description 1
239000003795 chemical substances by application Substances 0.000 description 1
238000004891 communication Methods 0.000 description 1
150000001875 compounds Chemical class 0.000 description 1
238000002316 cosmetic surgery Methods 0.000 description 1
125000000332 coumarinyl group Chemical class O1C(=O)C(=CC2=CC=CC=C12)* 0.000 description 1
230000016396 cytokine production Effects 0.000 description 1
230000001472 cytotoxic effect Effects 0.000 description 1
230000007423 decrease Effects 0.000 description 1
230000007812 deficiency Effects 0.000 description 1
201000001981 dermatomyositis Diseases 0.000 description 1
230000035618 desquamation Effects 0.000 description 1
231100000676 disease causative agent Toxicity 0.000 description 1
229940079593 drug Drugs 0.000 description 1
239000003814 drug Substances 0.000 description 1
230000004064 dysfunction Effects 0.000 description 1
230000008451 emotion Effects 0.000 description 1
210000003979 eosinophil Anatomy 0.000 description 1
150000007946 flavonol Chemical group 0.000 description 1
HVQAJTFOCKOKIN-UHFFFAOYSA-N flavonol Natural products O1C2=CC=CC=C2C(=O)C(O)=C1C1=CC=CC=C1 HVQAJTFOCKOKIN-UHFFFAOYSA-N 0.000 description 1
235000011957 flavonols Nutrition 0.000 description 1
210000003953 foreskin Anatomy 0.000 description 1
238000009472 formulation Methods 0.000 description 1
239000012737 fresh medium Substances 0.000 description 1
230000006870 function Effects 0.000 description 1
230000002068 genetic effect Effects 0.000 description 1
239000008103 glucose Substances 0.000 description 1
230000003676 hair loss Effects 0.000 description 1
239000008233 hard water Substances 0.000 description 1
229910001385 heavy metal Inorganic materials 0.000 description 1
PFOARMALXZGCHY-UHFFFAOYSA-N homoegonol Natural products C1=C(OC)C(OC)=CC=C1C1=CC2=CC(CCCO)=CC(OC)=C2O1 PFOARMALXZGCHY-UHFFFAOYSA-N 0.000 description 1
229930195733 hydrocarbon Natural products 0.000 description 1
150000002430 hydrocarbons Chemical class 0.000 description 1
206010020718 hyperplasia Diseases 0.000 description 1
230000036737 immune function Effects 0.000 description 1
208000026278 immune system disease Diseases 0.000 description 1
230000036039 immunity Effects 0.000 description 1
230000002163 immunogen Effects 0.000 description 1
230000000495 immunoinflammatory effect Effects 0.000 description 1
230000007233 immunological mechanism Effects 0.000 description 1
239000002955 immunomodulating agent Substances 0.000 description 1
229940121354 immunomodulator Drugs 0.000 description 1
230000002584 immunomodulator Effects 0.000 description 1
210000004969 inflammatory cell Anatomy 0.000 description 1
230000002757 inflammatory effect Effects 0.000 description 1
230000005764 inhibitory process Effects 0.000 description 1
239000003999 initiator Substances 0.000 description 1
238000002955 isolation Methods 0.000 description 1
235000008777 kaempferol Nutrition 0.000 description 1
IQPNAANSBPBGFQ-UHFFFAOYSA-N luteolin Chemical compound C=1C(O)=CC(O)=C(C(C=2)=O)C=1OC=2C1=CC=C(O)C(O)=C1 IQPNAANSBPBGFQ-UHFFFAOYSA-N 0.000 description 1
LRDGATPGVJTWLJ-UHFFFAOYSA-N luteolin Natural products OC1=CC(O)=CC(C=2OC3=CC(O)=CC(O)=C3C(=O)C=2)=C1 LRDGATPGVJTWLJ-UHFFFAOYSA-N 0.000 description 1
235000009498 luteolin Nutrition 0.000 description 1
239000000463 material Substances 0.000 description 1
230000007246 mechanism Effects 0.000 description 1
229940127554 medical product Drugs 0.000 description 1
230000004048 modification Effects 0.000 description 1
238000012986 modification Methods 0.000 description 1
210000001616 monocyte Anatomy 0.000 description 1
210000005087 mononuclear cell Anatomy 0.000 description 1
UXOUKMQIEVGVLY-UHFFFAOYSA-N morin Natural products OC1=CC(O)=CC(C2=C(C(=O)C3=C(O)C=C(O)C=C3O2)O)=C1 UXOUKMQIEVGVLY-UHFFFAOYSA-N 0.000 description 1
239000013642 negative control Substances 0.000 description 1
230000010309 neoplastic transformation Effects 0.000 description 1
230000000926 neurological effect Effects 0.000 description 1
210000000440 neutrophil Anatomy 0.000 description 1
229910052757 nitrogen Inorganic materials 0.000 description 1
238000003199 nucleic acid amplification method Methods 0.000 description 1
210000000056 organ Anatomy 0.000 description 1
230000001717 pathogenic effect Effects 0.000 description 1
231100000915 pathological change Toxicity 0.000 description 1
230000036285 pathological change Effects 0.000 description 1
210000005259 peripheral blood Anatomy 0.000 description 1
239000011886 peripheral blood Substances 0.000 description 1
230000002093 peripheral effect Effects 0.000 description 1
150000008442 polyphenolic compounds Chemical class 0.000 description 1
235000013824 polyphenols Nutrition 0.000 description 1
239000013641 positive control Substances 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000002265 prevention Effects 0.000 description 1
102000004196 processed proteins & peptides Human genes 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
230000009467 reduction Effects 0.000 description 1
239000013557 residual solvent Substances 0.000 description 1
230000002207 retinal effect Effects 0.000 description 1
210000004761 scalp Anatomy 0.000 description 1
208000008742 seborrheic dermatitis Diseases 0.000 description 1
230000035945 sensitivity Effects 0.000 description 1
230000008313 sensitization Effects 0.000 description 1
210000002966 serum Anatomy 0.000 description 1
150000004354 sesquiterpene derivatives Chemical group 0.000 description 1
230000004936 stimulating effect Effects 0.000 description 1
239000006228 supernatant Substances 0.000 description 1
230000020382 suppression by virus of host antigen processing and presentation of peptide antigen via MHC class I Effects 0.000 description 1
239000000725 suspension Substances 0.000 description 1
208000009056 telangiectasis Diseases 0.000 description 1
229940104230 thymidine Drugs 0.000 description 1
238000002054 transplantation Methods 0.000 description 1
230000006433 tumor necrosis factor production Effects 0.000 description 1
238000010792 warming Methods 0.000 description 1

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/16—Ginkgophyta, e.g. Ginkgoaceae (Ginkgo family)
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9771—Ginkgophyta, e.g. Ginkgoaceae [Ginkgo family]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/007—Preparations for dry skin

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Natural Medicines & Medicinal Plants (AREA)
Pharmacology & Pharmacy (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Botany (AREA)
Biotechnology (AREA)
Epidemiology (AREA)
Mycology (AREA)
Microbiology (AREA)
Immunology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Alternative & Traditional Medicine (AREA)
Medical Informatics (AREA)
Dermatology (AREA)
Birds (AREA)
Pulmonology (AREA)
Transplantation (AREA)
Medicines Containing Plant Substances (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Cosmetics (AREA)

SK873-98A 1996-10-22 1997-10-21 Use of ginkgo biloba extracts for the preparation of pharmaceutical compositions, and method of cosmetic treatment using a ginkgo biloba extract SK87398A3 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9612822A FR2754714B1 (fr)	1996-10-22	1996-10-22	Nouvelles utilisations d'extraits de ginkgo biloba pour la preparation de compositions pharmaceutiques,et methode de traitement cosmetique mettant en oeuvre un extrait de ginkgo biloba
PCT/IB1997/001319 WO1998017295A1 (en)	1996-10-22	1997-10-21	Use of ginkgo biloba extracts for the preparation of pharmaceutical compositions, and method of cosmetic treatment using a ginkgo biloba extract

Publications (1)

Publication Number	Publication Date
SK87398A3 true SK87398A3 (en)	2000-01-18

Family

ID=9496869

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SK873-98A SK87398A3 (en)	1996-10-22	1997-10-21	Use of ginkgo biloba extracts for the preparation of pharmaceutical compositions, and method of cosmetic treatment using a ginkgo biloba extract

Country Status (17)

Country	Link
EP (1)	EP0877619B1 (de)
JP (1)	JP2000517345A (de)
KR (1)	KR19990076619A (de)
CN (1)	CN1211925A (de)
AR (1)	AR010019A1 (de)
AT (1)	ATE219371T1 (de)
AU (1)	AU743822B2 (de)
BR (1)	BR9706889A (de)
CA (1)	CA2240997A1 (de)
CZ (1)	CZ195398A3 (de)
DE (1)	DE69713484T2 (de)
EA (1)	EA000974B1 (de)
ES (1)	ES2176786T3 (de)
FR (1)	FR2754714B1 (de)
PL (1)	PL327540A1 (de)
SK (1)	SK87398A3 (de)
WO (1)	WO1998017295A1 (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
KR100436384B1 (ko) *	2001-08-24	2004-06-18	조천호	천연식물 추출물로 이루어진 피부개선 화장료 조성물
FR2831443B1 (fr) *	2001-10-30	2005-02-11	Oreal	Utilisation d'extraits vegetaux pour ameliorer la fonction barriere de la peau
FR2846242A1 (fr) *	2003-01-17	2004-04-30	Oreal	Utilisation cosmetique et/ou dermatologique d'au moins un extrait de ginkgo biloba en tant qu'agent blanchissant
EP1543823A1 (de) *	2003-12-19	2005-06-22	Johnson & Johnson Consumer France SAS	Gingkoextrakt enthaltende kosmetische Zubereitungen zur Verbesserung des Hautglanzes
FR2911782A1 (fr) *	2007-01-31	2008-08-01	Jacqueline Martin	Comment guerir du sida avec mentha pulegium et ginkgo biloba
JP2009256270A (ja) *	2008-04-18	2009-11-05	Maruzen Pharmaceut Co Ltd	インスリン様成長因子−１発現促進剤
CN102641353B (zh) *	2012-05-15	2014-07-02	何超文	一种富含植物黄酮类物质的生发素
CN106880529A (zh) *	2017-03-30	2017-06-23	辽宁吉瑞生物科技有限公司	一种含银杏提取液的化妆品及其生产工艺
PL234670B1 (pl) *	2017-11-18	2020-03-31	Inst Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk	Zastosowanie wyciągu z liści miłorzębu japońskiego Ginkgo biloba
CN112843080A (zh) *	2021-02-09	2021-05-28	安徽九华华源药业有限公司	抗甲3型流感病毒的组合物及其制备方法
FR3129084B1 (fr) *	2021-11-16	2025-05-23	Larboretum	Composition cosmétique

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JPS6239521A (ja) *	1985-08-14	1987-02-20	Kuraray Co Ltd	免疫増強剤
FR2634380B1 (fr) *	1988-07-19	1990-10-12	Beljanski Mirko	Regulateur biologique, actif dans diverses pathologies
JP3076620B2 (ja) *	1991-04-19	2000-08-14	株式会社コーセー	皮膚外用剤

1996
- 1996-10-22 FR FR9612822A patent/FR2754714B1/fr not_active Expired - Fee Related
1997
- 1997-10-21 CA CA002240997A patent/CA2240997A1/en not_active Abandoned
- 1997-10-21 EP EP97943121A patent/EP0877619B1/de not_active Expired - Lifetime
- 1997-10-21 KR KR1019980704722A patent/KR19990076619A/ko not_active Ceased
- 1997-10-21 PL PL97327540A patent/PL327540A1/xx unknown
- 1997-10-21 AR ARP970104864A patent/AR010019A1/es unknown
- 1997-10-21 EA EA199800589A patent/EA000974B1/ru not_active IP Right Cessation
- 1997-10-21 AU AU44704/97A patent/AU743822B2/en not_active Ceased
- 1997-10-21 AT AT97943121T patent/ATE219371T1/de not_active IP Right Cessation
- 1997-10-21 ES ES97943121T patent/ES2176786T3/es not_active Expired - Lifetime
- 1997-10-21 JP JP10519167A patent/JP2000517345A/ja active Pending
- 1997-10-21 WO PCT/IB1997/001319 patent/WO1998017295A1/en not_active Ceased
- 1997-10-21 DE DE69713484T patent/DE69713484T2/de not_active Expired - Lifetime
- 1997-10-21 BR BR9706889-6A patent/BR9706889A/pt not_active Application Discontinuation
- 1997-10-21 CZ CZ981953A patent/CZ195398A3/cs unknown
- 1997-10-21 CN CN97192462A patent/CN1211925A/zh active Pending
- 1997-10-21 SK SK873-98A patent/SK87398A3/sk unknown

Also Published As

Publication number	Publication date
DE69713484T2 (de)	2003-01-30
WO1998017295A1 (en)	1998-04-30
CA2240997A1 (en)	1998-04-30
FR2754714B1 (fr)	1999-01-22
EP0877619B1 (de)	2002-06-19
EA000974B1 (ru)	2000-08-28
EA199800589A1 (ru)	1998-12-24
EP0877619A1 (de)	1998-11-18
AR010019A1 (es)	2000-05-17
CN1211925A (zh)	1999-03-24
BR9706889A (pt)	1999-12-28
JP2000517345A (ja)	2000-12-26
ES2176786T3 (es)	2002-12-01
PL327540A1 (en)	1998-12-21
ATE219371T1 (de)	2002-07-15
DE69713484D1 (de)	2002-07-25
CZ195398A3 (cs)	1998-11-11
AU4470497A (en)	1998-05-15
KR19990076619A (ko)	1999-10-15
AU743822B2 (en)	2002-02-07
FR2754714A1 (fr)	1998-04-24

Publication	Publication Date	Title
KR100544570B1 (ko)	2006-01-24	민감성 피부를 치료하는 조성물을 제조하기 위한 복합체의 사용방법, 제조 방법 및 저알레르기성 조성물
EP2365819B1 (de)	2019-04-03	Extrakt von oberirdische teile von hafer, der vor erscheinen der ähren geerntet wurde
JPH08283172A (ja)	1996-10-29	活性酸素消去剤及びこれを含有する皮膚外用剤
JPH11180879A (ja)	1999-07-06	バラ科植物エキスの用途
KR101015702B1 (ko)	2011-02-22	해조추출물을 포함하는 염증 및 피부자극 개선 및 완화용조성물
JP4401617B2 (ja)	2010-01-20	脂肪性物質を基材とする脂溶性剤中にコートおよび／またはマイクロカプセル化されたＣｕｃｕｍｉｓｍｅｌｏ抽出物
AU743822B2 (en)	2002-02-07	Use of ginkgo biloba extracts for the preparation of pharmaceutical comp ositions, and method of cosmetic treatment using a ginkgo biloba extract
KR100702327B1 (ko)	2007-03-30	자극완화 효과를 갖는 동백꽃 추출물을 함유하는 화장료조성물
WO1989010114A1 (en)	1989-11-02	Composition for promoting hair growth in androgenetic alopecia and method thereof
US20240325482A1 (en)	2024-10-03	Novel composition comprising nepeta cataria-derived exosomes as active ingredient
KR100794360B1 (ko)	2008-01-15	항염 및 항알레르기 효과를 갖는 문주란 추출물을함유하는 화장료 조성물
US20020041908A1 (en)	2002-04-11	Iridacea extracts for stimulating the immune system
US20050037028A1 (en)	2005-02-17	Skin perparation for external use containing purpuricenus temminckii frass as the active ingredient
KR20100137295A (ko)	2010-12-30	Ｔｓｌｐ 저해능에 의한 아토피 피부염 개선능을 가지는 한방 조성물
KR102034436B1 (ko)	2019-10-18	베트남 후피향 추출물을 포함하는 아토피 피부염 치료 및 예방용 조성물
Hassan et al.	2021	The Use of Pentoxifylline Topical in the Treatment of Alopecia in Rats
HK1019047A (en)	2000-01-21	Use of ginkgo biloba extracts for the preparation of pharmaceutical compositions, and method of cosmetic treatment using a ginkgo biloba extract
AU633823B2 (en)	1993-02-11	Anti-allergic plant extract
JP3494845B2 (ja)	2004-02-09	アレルギー性疾患予防・治療剤
KR101648467B1 (ko)	2016-08-17	약용식물 추출물을 함유하여 염증 및 피부 자극을 완화시키는 화장료 조성물
KR20100048969A (ko)	2010-05-11	저 자극 효과를 갖는 여주 추출물을 함유하는 화장료조성물