SMAP201100010A - Composizioni e metodi di uso di anticorpi terapeutici. - Google Patents

Composizioni e metodi di uso di anticorpi terapeutici.

Info

Publication number: SMAP201100010A
Authority: SM; San Marino
Prior art keywords: compositions; methods; antibodies; therapeutic antibodies; baffr
Prior art date: 2008-07-17

Application number

SM201100010T

Other languages

English (en)

Other versions

SMP201100010B (it

Inventor

Christoph Heusser

Julia Neugebauer

Eveline Schaadt

Stefanie Urlinger

Maximilian Woisetschlaeger

Original Assignee

Novartis Ag

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-17

Filing date

2011-02-17

Publication date

2011-05-06

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41073830&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMAP201100010(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-02-17 Application filed by Novartis Ag filed Critical Novartis Ag

2011-05-06 Publication of SMAP201100010A publication Critical patent/SMAP201100010A/it

2011-09-09 Publication of SMP201100010B publication Critical patent/SMP201100010B/it

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/74—Inducing cell proliferation
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Immunology (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Biochemistry (AREA)
Physical Education & Sports Medicine (AREA)
Rheumatology (AREA)
Transplantation (AREA)
Oncology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Hematology (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Orthopedic Medicine & Surgery (AREA)
Peptides Or Proteins (AREA)
Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Micro-Organisms Or Cultivation Processes Thereof (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

SM201100010T 2008-07-17 2011-02-17 Composizioni e metodi di uso di anticorpi terapeutici SMP201100010B (it)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
EP08160671		2008-07-17
EP09160326		2009-05-15
PCT/EP2009/059030 WO2010007082A1 (en)	2008-07-17	2009-07-15	Compositions and methods of use for therapeutic antibodies

Publications (2)

Publication Number	Publication Date
SMAP201100010A true SMAP201100010A (it)	2011-05-06
SMP201100010B SMP201100010B (it)	2011-09-09

Family

ID=41073830

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM201100010T SMP201100010B (it)	2008-07-17	2011-02-17	Composizioni e metodi di uso di anticorpi terapeutici

Country Status (40)

Country	Link
US (3)	US8106163B2 (it)
EP (1)	EP2315780B8 (it)
JP (2)	JP5767109B2 (it)
KR (2)	KR101314369B1 (it)
CN (1)	CN102119174B (it)
AR (1)	AR072749A1 (it)
AU (1)	AU2009272771B2 (it)
BR (1)	BRPI0915928B8 (it)
CA (1)	CA2730063C (it)
CL (1)	CL2011000086A1 (it)
CR (1)	CR11863A (it)
CU (1)	CU23878B1 (it)
CY (1)	CY1116800T1 (it)
DK (1)	DK2315780T3 (it)
DO (1)	DOP2011000016A (it)
EA (1)	EA024492B1 (it)
EC (1)	ECSP11010761A (it)
ES (1)	ES2547270T3 (it)
GE (1)	GEP20146129B (it)
HR (1)	HRP20151227T1 (it)
HU (1)	HUE025778T2 (it)
IL (1)	IL210485A (it)
JO (1)	JO3149B1 (it)
MA (1)	MA32481B1 (it)
MX (1)	MX2011000616A (it)
MY (1)	MY158980A (it)
NI (1)	NI201100017A (it)
NZ (1)	NZ590057A (it)
PE (1)	PE20110563A1 (it)
PL (1)	PL2315780T3 (it)
PT (1)	PT2315780E (it)
RS (1)	RS54299B1 (it)
SG (1)	SG193805A1 (it)
SI (1)	SI2315780T1 (it)
SM (1)	SMP201100010B (it)
SV (1)	SV2011003807A (it)
TW (1)	TWI508742B (it)
UY (1)	UY31987A (it)
WO (1)	WO2010007082A1 (it)
ZA (1)	ZA201008952B (it)

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EP2222846B1 (en) *	2007-08-10	2017-05-03	Protelix, Inc.	Universal fibronectin type iii binding-domain libraries
US8470966B2 (en)	2007-08-10	2013-06-25	Protelica, Inc.	Universal fibronectin type III binding-domain libraries
US8680019B2 (en) *	2007-08-10	2014-03-25	Protelica, Inc.	Universal fibronectin Type III binding-domain libraries
US9458240B2 (en) *	2010-12-10	2016-10-04	Novartis Pharma Ag	Anti-BAFFR antibody formulations
JP2012153788A (ja) *	2011-01-25	2012-08-16	Nitto Denko Corp	光学用粘着シート
HUE028603T2 (en) *	2011-05-13	2016-12-28	Ganymed Pharmaceuticals Ag	Antibodies for treatment of cancer expressing claudin 6
US9216219B2 (en)	2012-06-12	2015-12-22	Novartis Ag	Anti-BAFFR antibody formulation
US10435474B2 (en)	2013-12-24	2019-10-08	Ossianix, Inc.	Baff selective binding compounds and related methods
EA033604B1 (ru)	2014-01-31	2019-11-08	Boehringer Ingelheim Int	Молекула анти-baff антитела, фармацевтическая композиция, содержащая эту молекулу, способы ее применения и кодирующий ее изолированный полинуклеотид
MA41044A (fr)	2014-10-08	2017-08-15	Novartis Ag	Compositions et procédés d'utilisation pour une réponse immunitaire accrue et traitement contre le cancer
UY36351A (es)	2014-10-14	2016-06-01	Novartis Ag	Moléculas de anticuerpo que se unen a pd-l1 y usos de las mismas
MA41459A (fr)	2015-02-03	2017-12-12	Als Therapy Development Inst	Anticorps anti-cd40l et méthodes pour traiter des maladies ou des troubles liés aux cd40l
CN108025051B (zh)	2015-07-29	2021-12-24	诺华股份有限公司	包含抗pd-1抗体分子的联合疗法
EP3316902A1 (en)	2015-07-29	2018-05-09	Novartis AG	Combination therapies comprising antibody molecules to tim-3
LT3317301T (lt)	2015-07-29	2021-07-26	Novartis Ag	Kombinuotos terapijos, apimančios antikūno molekules prieš lag-3
ES2986067T3 (es)	2015-12-17	2024-11-08	Novartis Ag	Moléculas de anticuerpos frente a PD-1 y usos de las mismas
JP7132123B2 (ja)	2016-02-10	2022-09-06	ノバルティスアーゲー	原発性シェーグレン症候群の治療のためのｐｉ３ｋの活性阻害剤または機能阻害剤の使用
EP3464374B1 (en) *	2016-06-06	2025-08-06	City of Hope	Baff-r antibodies and uses thereof
BR112019012354A2 (pt)	2016-12-21	2019-11-26	Teneobio, Inc.	anticorpos apenas de cadeia pesada anti-bcma
US11197928B2 (en)	2017-01-13	2021-12-14	Board Of Regents, The University Of Texas System	Sustained production of high affinity antigen specific antibody by high dose BAFF receptor-targeting mAb-siRNA conjugate
MA50435A (fr) *	2017-05-24	2020-09-02	Als Therapy Development Inst	Anticorps anti-ligand anti-cd40 thérapeutiques
CN110891971B (zh) *	2017-06-20	2024-01-12	特尼奥生物股份有限公司	仅有重链的抗bcma抗体
SG11202011597RA (en) *	2018-07-20	2020-12-30	Teneobio Inc	Heavy chain antibodies binding to cd19
MX2021011464A (es) *	2019-03-29	2021-10-22	Chugai Pharmaceutical Co Ltd	Inhibidor que contiene anticuerpo del receptor anti-interleucina 6 (il-6) para inhibir el deterioro de la funcion de la barrera hemato-encefalica (bbb).
TWI905099B (zh)	2019-05-21	2025-11-21	瑞士商諾華公司	Cd19 結合分子及其用途
EP4055047A1 (en) *	2019-11-06	2022-09-14	Novartis AG	Treatment for sjögren's syndrome
CN112813099A (zh) *	2019-11-15	2021-05-18	上海细胞治疗集团有限公司	一种在活化的t细胞中具有高活性的启动子
CN116096414A (zh) *	2020-08-04	2023-05-09	诺华股份有限公司	Cll的治疗
WO2022031567A1 (en)	2020-08-04	2022-02-10	Novartis Ag	Treatment of b cell malignancies
CN118459585A (zh) *	2020-09-07	2024-08-09	白先宏	Baff-r结合分子及其应用
WO2022097061A1 (en)	2020-11-06	2022-05-12	Novartis Ag	Anti-cd19 agent and b cell targeting agent combination therapy for treating b cell malignancies
CN115073598B (zh) *	2021-03-15	2024-02-20	盛禾(中国)生物制药有限公司	一种抗baffr抗体及其应用
EP4334351A1 (en)	2021-05-04	2024-03-13	Novartis AG	Treatment for systemic lupus erythematosus using anti-baffr antibodies
CN117203240A (zh)	2021-05-04	2023-12-08	诺华股份有限公司	使用抗baffr抗体治疗狼疮肾炎
CA3233246A1 (en) *	2021-09-29	2023-04-06	Dragonfly Therapeutics, Inc.	Antibodies targeting baff-r and use thereof
TW202440636A (zh)	2023-03-21	2024-10-16	美商傳記５５有限公司	Ｃｄ１９／ｃｄ３８多特異性抗體
WO2025058962A1 (en) *	2023-09-11	2025-03-20	Absci Corporation	High-throughput methods for kinetic characterization, quantifying and optimizing antibodies and antibody fragments expression in bacteria
WO2025131888A1 (en)	2023-12-19	2025-06-26	Basf Se	Modified alkoxylated polyalkylene imines or modified alkoxylated polyamines
WO2025221674A1 (en) *	2024-04-15	2025-10-23	Eli Lilly And Company	Baffr x cd3 bispecific antibodies and methods of use

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KR20090016772A (ko) *	1999-08-17	2009-02-17	바이오겐 아이덱 엠에이 인코포레이티드	Ｂａｆｆ 수용체(ｂｃｍａ), 면역조절제
UA83458C2 (uk)	2000-09-18	2008-07-25	Байоджен Айдек Ма Інк.	Виділений поліпептид baff-r (рецептор фактора активації в-клітин сімейства tnf)
CN101120021A (zh) *	2004-12-31	2008-02-06	基因技术公司	结合br3的多肽及其用途
US20100166741A1 (en) *	2006-07-13	2010-07-01	Genentech , Inc.	Altered br-3 binding polypeptides

2009
- 2009-07-15 MX MX2011000616A patent/MX2011000616A/es active IP Right Grant
- 2009-07-15 KR KR1020117001052A patent/KR101314369B1/ko active Active
- 2009-07-15 CA CA2730063A patent/CA2730063C/en active Active
- 2009-07-15 DK DK09797499.2T patent/DK2315780T3/en active
- 2009-07-15 UY UY0001031987A patent/UY31987A/es active IP Right Grant
- 2009-07-15 SI SI200931293T patent/SI2315780T1/sl unknown
- 2009-07-15 RS RS20150667A patent/RS54299B1/sr unknown
- 2009-07-15 PE PE2011000038A patent/PE20110563A1/es active IP Right Grant
- 2009-07-15 NZ NZ590057A patent/NZ590057A/xx unknown
- 2009-07-15 KR KR1020137019574A patent/KR101545795B1/ko active Active
- 2009-07-15 HR HRP20151227TT patent/HRP20151227T1/hr unknown
- 2009-07-15 PL PL09797499T patent/PL2315780T3/pl unknown
- 2009-07-15 ES ES09797499.2T patent/ES2547270T3/es active Active
- 2009-07-15 CN CN200980127408.2A patent/CN102119174B/zh active Active
- 2009-07-15 GE GEAP200912063A patent/GEP20146129B/en unknown
- 2009-07-15 AU AU2009272771A patent/AU2009272771B2/en active Active
- 2009-07-15 SG SG2013062567A patent/SG193805A1/en unknown
- 2009-07-15 WO PCT/EP2009/059030 patent/WO2010007082A1/en not_active Ceased
- 2009-07-15 EP EP09797499.2A patent/EP2315780B8/en active Active
- 2009-07-15 AR ARP090102678A patent/AR072749A1/es active IP Right Grant
- 2009-07-15 BR BRPI0915928A patent/BRPI0915928B8/pt active IP Right Grant
- 2009-07-15 PT PT97974992T patent/PT2315780E/pt unknown
- 2009-07-15 JP JP2011517915A patent/JP5767109B2/ja active Active
- 2009-07-15 US US12/503,175 patent/US8106163B2/en active Active
- 2009-07-15 HU HUE09797499A patent/HUE025778T2/en unknown
- 2009-07-15 MY MYPI2010005960A patent/MY158980A/en unknown
- 2009-07-15 EA EA201100191A patent/EA024492B1/ru not_active IP Right Cessation
- 2009-07-16 JO JOP/2009/0267A patent/JO3149B1/ar active
- 2009-07-16 TW TW098124126A patent/TWI508742B/zh active
2010
- 2010-12-13 ZA ZA2010/08952A patent/ZA201008952B/en unknown
- 2010-12-21 CR CR11863A patent/CR11863A/es unknown
2011
- 2011-01-06 IL IL210485A patent/IL210485A/en active IP Right Grant
- 2011-01-14 MA MA33525A patent/MA32481B1/fr unknown
- 2011-01-14 CL CL2011000086A patent/CL2011000086A1/es unknown
- 2011-01-14 NI NI201100017A patent/NI201100017A/es unknown
- 2011-01-14 DO DO2011000016A patent/DOP2011000016A/es unknown
- 2011-01-17 CU CUP2011000013A patent/CU23878B1/es active IP Right Grant
- 2011-01-17 SV SV2011003807A patent/SV2011003807A/es unknown
- 2011-01-17 EC EC2011010761A patent/ECSP11010761A/es unknown
- 2011-02-17 SM SM201100010T patent/SMP201100010B/it unknown
- 2011-12-15 US US13/326,514 patent/US9340620B2/en active Active
- 2011-12-15 US US13/326,569 patent/US9382326B2/en active Active
2015
- 2015-04-10 JP JP2015081099A patent/JP6077587B2/ja active Active
- 2015-10-19 CY CY20151100934T patent/CY1116800T1/el unknown

Also Published As

Publication number	Publication date
IL210485A (en)	2015-03-31
BRPI0915928B1 (pt)	2020-10-20
JP5767109B2 (ja)	2015-08-19
US8106163B2 (en)	2012-01-31
ZA201008952B (en)	2012-01-25
KR101314369B1 (ko)	2013-10-10
RS54299B1 (sr)	2016-02-29
JP2015133983A (ja)	2015-07-27
CY1116800T1 (el)	2017-03-15
PE20110563A1 (es)	2011-08-29
CU23878B1 (es)	2013-04-19
HK1150839A1 (en)	2012-01-13
CA2730063A1 (en)	2010-01-21
NI201100017A (es)	2012-08-17
TW201006493A (en)	2010-02-16
BRPI0915928A2 (pt)	2015-11-03
SI2315780T1 (sl)	2015-11-30
BRPI0915928B8 (pt)	2021-05-25
SMP201100010B (it)	2011-09-09
ECSP11010761A (es)	2011-02-28
WO2010007082A1 (en)	2010-01-21
KR20110020914A (ko)	2011-03-03
CA2730063C (en)	2017-04-18
CL2011000086A1 (es)	2011-07-01
TWI508742B (zh)	2015-11-21
PL2315780T3 (pl)	2016-01-29
CU20110013A7 (es)	2012-06-21
JO3149B1 (ar)	2017-09-20
EP2315780B1 (en)	2015-08-19
JP2011527896A (ja)	2011-11-10
IL210485A0 (en)	2011-03-31
EA201100191A1 (ru)	2011-08-30
US9382326B2 (en)	2016-07-05
SV2011003807A (es)	2011-03-23
JP6077587B2 (ja)	2017-02-08
US20120195913A1 (en)	2012-08-02
MX2011000616A (es)	2011-02-24
AU2009272771A1 (en)	2010-01-21
SG193805A1 (en)	2013-10-30
KR101545795B1 (ko)	2015-08-19
MA32481B1 (fr)	2011-07-03
CR11863A (es)	2011-02-11
ES2547270T3 (es)	2015-10-05
UY31987A (es)	2010-02-26
GEP20146129B (en)	2014-08-11
NZ590057A (en)	2012-08-31
PT2315780E (pt)	2015-11-30
CN102119174B (zh)	2015-01-21
EA024492B1 (ru)	2016-09-30
EP2315780A1 (en)	2011-05-04
HRP20151227T1 (hr)	2015-12-18
AU2009272771B2 (en)	2012-09-20
HUE025778T2 (en)	2016-05-30
US9340620B2 (en)	2016-05-17
DOP2011000016A (es)	2011-02-15
US20100021452A1 (en)	2010-01-28
MY158980A (en)	2016-11-30
CN102119174A (zh)	2011-07-06
EP2315780B8 (en)	2015-09-23
US20120183529A1 (en)	2012-07-19
DK2315780T3 (en)	2015-10-19
KR20130098432A (ko)	2013-09-04
AR072749A1 (es)	2010-09-15

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