SMT201300080B - Derivati di carbammati di alchiltiazoli, loro preparazione e loro utilizzo come inibitori dell'enzima faah - Google Patents

Derivati di carbammati di alchiltiazoli, loro preparazione e loro utilizzo come inibitori dell'enzima faah

Info

Publication number: SMT201300080B
Authority: SM; San Marino
Prior art keywords: alkiltiazole; inhibitors; preparation; carbamate derivatives; faah enzyme
Prior art date: 2008-07-23

Application number

SM201300080T

Other languages

English (en)

Italian (it)

Inventor

Ahmed Abouabdellah

Jochen Gorlitzer

Peter Hamley

Antoine Ravet

Original Assignee

Sanofi Sa

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2008-07-23

Filing date

2013-07-15

Publication date

2013-09-06

2013-07-15 Application filed by Sanofi Sa filed Critical Sanofi Sa

2013-09-06 Publication of SMT201300080B publication Critical patent/SMT201300080B/xx

Links

102000004190 Enzymes Human genes 0.000 title 1
108090000790 Enzymes Proteins 0.000 title 1
101150042613 FA2H gene Proteins 0.000 title 1
101150008770 FAAH gene Proteins 0.000 title 1
150000004657 carbamic acid derivatives Chemical class 0.000 title 1
239000003112 inhibitor Substances 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P37/08—Antiallergic agents
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Public Health (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biomedical Technology (AREA)
Physical Education & Sports Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Immunology (AREA)
Rheumatology (AREA)
Orthopedic Medicine & Surgery (AREA)
Communicable Diseases (AREA)
Pain & Pain Management (AREA)
Oncology (AREA)
Epidemiology (AREA)
Urology & Nephrology (AREA)
Hospice & Palliative Care (AREA)
Psychology (AREA)
Pulmonology (AREA)
Hematology (AREA)
Otolaryngology (AREA)
Diabetes (AREA)
Virology (AREA)
Tropical Medicine & Parasitology (AREA)
Child & Adolescent Psychology (AREA)
Psychiatry (AREA)
Obesity (AREA)

SM201300080T 2008-07-23 2013-07-15 Derivati di carbammati di alchiltiazoli, loro preparazione e loro utilizzo come inibitori dell'enzima faah SMT201300080B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0804179A FR2934265B1 (fr)	2008-07-23	2008-07-23	Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique
PCT/FR2009/051457 WO2010010288A2 (fr)	2008-07-23	2009-07-21	Derives de carbamates d'alkylthiazoles, leur preparation et leur application en therapeutique

Publications (1)

Publication Number	Publication Date
SMT201300080B true SMT201300080B (it)	2013-09-06

Family

ID=40289184

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM201300080T SMT201300080B (it)	2008-07-23	2013-07-15	Derivati di carbammati di alchiltiazoli, loro preparazione e loro utilizzo come inibitori dell'enzima faah

Country Status (28)

Country	Link
US (1)	US8912218B2 (de)
EP (1)	EP2344486B1 (de)
JP (1)	JP5452594B2 (de)
KR (1)	KR20110034020A (de)
CN (1)	CN102164920B (de)
AR (1)	AR072593A1 (de)
AU (1)	AU2009274355B2 (de)
BR (1)	BRPI0916385A2 (de)
CA (1)	CA2731789C (de)
CL (1)	CL2011000147A1 (de)
CO (1)	CO6351789A2 (de)
CY (1)	CY1114519T1 (de)
DK (1)	DK2344486T3 (de)
EA (1)	EA018995B1 (de)
ES (1)	ES2413304T3 (de)
FR (1)	FR2934265B1 (de)
HR (1)	HRP20130585T1 (de)
IL (1)	IL210747A0 (de)
MA (1)	MA32579B1 (de)
MX (1)	MX2011000882A (de)
PE (1)	PE20110384A1 (de)
PL (1)	PL2344486T3 (de)
PT (1)	PT2344486E (de)
SI (1)	SI2344486T1 (de)
SM (1)	SMT201300080B (de)
TW (1)	TW201008937A (de)
UY (1)	UY32004A (de)
WO (1)	WO2010010288A2 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2938537B1 (fr)	2008-11-14	2012-10-26	Sanofi Aventis	Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.
FR2941696B1 (fr) *	2009-02-05	2011-04-15	Sanofi Aventis	Derives d'azaspiranyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
FR2945534B1 (fr) *	2009-05-12	2012-11-16	Sanofi Aventis	DERIVES DE CYCLOPENTAL[c]PYRROLE-2-CARBOXYLATES, LEUR PREPARATION ET LEUR APPLICATION EN THERAPEUTIQUE
FR2945533B1 (fr) *	2009-05-12	2011-05-27	Sanofi Aventis	Derives de cyclopenta°c!pyrrolyl-alkylcarbamates d'heterocycles a 5 chainons, leur preparation et leur application en therapeutique
WO2011085216A2 (en)	2010-01-08	2011-07-14	Ironwood Pharmaceuticals, Inc.	Use of faah inhibitors for treating parkinson's disease and restless legs syndrome
WO2011123719A2 (en)	2010-03-31	2011-10-06	Ironwood Pharmaceuticals, Inc.	Use of faah inhibitors for treating abdominal, visceral and pelvic pain
MX2013003019A (es)	2010-09-15	2013-05-28	Hoffmann La Roche	Compuestos de azabenzotiazol, composiciones y metodos de uso.
DE102012018115A1 (de)	2012-09-13	2014-03-13	Matthias Lehr	Aryl-N-(arylalkyl)carbamate als Hemmstoffe der Fatty Acid Amide Hydrolase
DE102013016573A1 (de)	2013-10-04	2015-04-09	Matthias Lehr	1-Tetrazolylpropan-2-one als Inhibitoren von cytosolischer Phospholipase A2 und Fatty Acid Amide Hydrolase, insbesondere geeignet zur topischen Anwendung
WO2020048831A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048830A1 (en)	2018-09-03	2020-03-12	Bayer Aktiengesellschaft	5-aryl-3,9-diazaspiro[5.5]undecan-2-one compounds
WO2020048828A1 (en)	2018-09-03	2020-03-12	Bayer Pharma Aktiengesellschaft	5-heteroaryl-3,9-diazaspiro[5.5]undecane compounds
CN113880774B (zh) *	2020-07-02	2023-12-08	沈阳中化农药化工研发有限公司	一种苯基异恶唑啉类化合物的制备方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
FR2854633B1 (fr) *	2003-05-07	2005-06-24	Sanofi Synthelabo	Derives de piperidinyl-et piperazinyl-alkylcarbamates, leur preparation et leur application en therapeutique
GB0417801D0 (en) *	2004-08-10	2004-09-15	Novartis Ag	Organic compounds
MX2007001634A (es) *	2004-08-11	2007-04-23	Kyorin Seiyaku Kk	Nuevo derivado de acido amino benzoico ciclico.
AR067354A1 (es) *	2007-06-29	2009-10-07	Sunesis Pharmaceuticals Inc	Compuestos utiles como inhibidores de la raf quinasa
FR2938537B1 (fr) *	2008-11-14	2012-10-26	Sanofi Aventis	Derives de carbamates d'alkyl-heterocycles, leur preparation et leur application en therapeutique.

2008
- 2008-07-23 FR FR0804179A patent/FR2934265B1/fr not_active Expired - Fee Related
2009
- 2009-07-21 ES ES09737098T patent/ES2413304T3/es active Active
- 2009-07-21 EA EA201170237A patent/EA018995B1/ru not_active IP Right Cessation
- 2009-07-21 EP EP09737098A patent/EP2344486B1/de active Active
- 2009-07-21 PT PT97370985T patent/PT2344486E/pt unknown
- 2009-07-21 HR HRP20130585AT patent/HRP20130585T1/hr unknown
- 2009-07-21 DK DK09737098.5T patent/DK2344486T3/da active
- 2009-07-21 JP JP2011519216A patent/JP5452594B2/ja not_active Expired - Fee Related
- 2009-07-21 MX MX2011000882A patent/MX2011000882A/es active IP Right Grant
- 2009-07-21 US US13/003,713 patent/US8912218B2/en not_active Expired - Fee Related
- 2009-07-21 CA CA2731789A patent/CA2731789C/fr not_active Expired - Fee Related
- 2009-07-21 PE PE2011000070A patent/PE20110384A1/es not_active Application Discontinuation
- 2009-07-21 SI SI200930624T patent/SI2344486T1/sl unknown
- 2009-07-21 KR KR1020117004019A patent/KR20110034020A/ko not_active Withdrawn
- 2009-07-21 CN CN2009801372742A patent/CN102164920B/zh not_active Expired - Fee Related
- 2009-07-21 WO PCT/FR2009/051457 patent/WO2010010288A2/fr not_active Ceased
- 2009-07-21 PL PL09737098T patent/PL2344486T3/pl unknown
- 2009-07-21 BR BRPI0916385-9A patent/BRPI0916385A2/pt not_active IP Right Cessation
- 2009-07-21 AU AU2009274355A patent/AU2009274355B2/en not_active Ceased
- 2009-07-22 AR ARP090102787A patent/AR072593A1/es not_active Application Discontinuation
- 2009-07-22 TW TW098124759A patent/TW201008937A/zh unknown
- 2009-07-23 UY UY0001032004A patent/UY32004A/es not_active Application Discontinuation
2011
- 2011-01-19 IL IL210747A patent/IL210747A0/en unknown
- 2011-01-20 CO CO11005623A patent/CO6351789A2/es not_active Application Discontinuation
- 2011-01-21 CL CL2011000147A patent/CL2011000147A1/es unknown
- 2011-02-22 MA MA33636A patent/MA32579B1/fr unknown
2013
- 2013-06-27 CY CY20131100519T patent/CY1114519T1/el unknown
- 2013-07-15 SM SM201300080T patent/SMT201300080B/xx unknown

Also Published As

Publication number	Publication date
AU2009274355A1 (en)	2010-01-28
AR072593A1 (es)	2010-09-08
AU2009274355B2 (en)	2014-01-30
US20110212963A1 (en)	2011-09-01
EA201170237A1 (ru)	2011-10-31
JP2011528704A (ja)	2011-11-24
WO2010010288A2 (fr)	2010-01-28
ES2413304T3 (es)	2013-07-16
KR20110034020A (ko)	2011-04-04
CO6351789A2 (es)	2011-12-20
TW201008937A (en)	2010-03-01
HRP20130585T1 (en)	2013-07-31
CN102164920A (zh)	2011-08-24
CN102164920B (zh)	2013-12-25
EP2344486A2 (de)	2011-07-20
US8912218B2 (en)	2014-12-16
FR2934265A1 (fr)	2010-01-29
PT2344486E (pt)	2013-06-27
BRPI0916385A2 (pt)	2018-06-05
MX2011000882A (es)	2011-03-01
JP5452594B2 (ja)	2014-03-26
CL2011000147A1 (es)	2011-06-17
SI2344486T1 (sl)	2013-07-31
PL2344486T3 (pl)	2013-08-30
UY32004A (es)	2010-02-26
FR2934265B1 (fr)	2010-07-30
WO2010010288A3 (fr)	2010-03-18
EA018995B1 (ru)	2013-12-30
CA2731789C (fr)	2016-08-30
DK2344486T3 (da)	2013-07-08
MA32579B1 (fr)	2011-08-01
CA2731789A1 (fr)	2010-01-28
EP2344486B1 (de)	2013-03-27
PE20110384A1 (es)	2011-07-01
CY1114519T1 (el)	2016-10-05
IL210747A0 (en)	2011-03-31

Publication	Publication Date	Title
SMT201300080B (it)	2013-09-06	Derivati di carbammati di alchiltiazoli, loro preparazione e loro utilizzo come inibitori dell'enzima faah
SMT201400114B (it)	2014-11-10	Derivati di 2-arilimidazolo come inibitori dell'enzima pde10a
SMT201500213B (it)	2015-10-30	Alcune triazolopirazine, loro composizioni e metodi d'uso
BRPI0818003A2 (pt)	2019-09-24	inibidores de csf-1r, composições e métodos de uso
SMT201400009B (it)	2014-03-07	Derivati eteroaromatici di ariltriazolo come inibitori dell'enzima pde 10A
BRPI0911688A2 (pt)	2015-07-28	"compostos de pirimidina, composições e métodos de uso"
DK2282994T3 (da)	2013-09-30	3-aminocarbazolforbindelse, farmaceutisk sammensætning indeholdende forbindelsen samt fremstillingsmetode derfor
SMT201400181B (it)	2015-01-15	Composizioni per vasocostrizione e metodi d'uso
PT2963031T (pt)	2019-03-20	Pró-fármacos de tetrahidrocanabinol, composições compreendendo pró-fármacos de tetrahidrocanabinol e métodos de utilização dos mesmos
IL185541A0 (en)	2008-01-06	Benzazole derivatives, compositions, and methods of use as b- secretase inhibitors
SMT201400158B (it)	2015-01-15	Derivati eteroaromatici di fenilimidazolo come inibitori dell'enzima pde10a
CY2014011I1 (el)	2015-12-09	Χορηγηση αναστολεων διπεπτιδυλοπεπτιδασης
FI20080360L (fi)	2009-11-17	Ruostumaton terästuote, tuotteen käyttö ja menetelmä sen valmistamiseksi
BRPI0914343A2 (pt)	2016-07-26	composição, produto, uso da composição e método
BR112012004335A2 (pt)	2015-09-08	composto, composição farmacêutica, e, uso do composto.
EP2252669A4 (de)	2012-10-17	Azeotropartige zusammensetzung aus 1,1,1-trifluor-3-chlorpropen und methylacetat
EP2582664A4 (de)	2014-07-09	Phenylthioacetatverbindungen und -zusammensetzungen sowie verfahren zu ihrer verwendung
SMT201600332B (it)	2016-11-10	Composizioni e metodi per l’aumento dell’attivitàtelomerasica
BRPI0813587A2 (pt)	2014-12-30	Composto, uso do mesmo, e, composição farmacêutica
BRPI0911772A2 (pt)	2017-06-27	composto, composição farmacêutica, e, uso do composto.
DK1720550T3 (da)	2009-08-10	Derivater af piperidinylalkylcarbamater, fremstilling heraf samt anvendelse heraf som inhibitorer for FAAH enzym
BRPI0818121A2 (pt)	2015-11-17	diespiro 1,2,4-trioxolano e seus métodos de fabricação e utilização
EP2320738A4 (de)	2011-08-24	Substituierte aminothiazolderivate sowie pharmazeutische zusammensetzungen damit und verwendung davon
BRPI0923878A2 (pt)	2015-07-28	Inibidores de giyt1 bicíclicos 3.1.0 e métodos de produção e uso dos mesmos.
FR2920774B1 (fr)	2009-10-30	Nouveaux derives de n-phenul acatamide, inhibiteurs de l'enzyme soat-1, compositions pharmaceutiques et cosmetiques les contentant