SMT201400013B - Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici - Google Patents

Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici

Info

Publication number: SMT201400013B
Authority: SM; San Marino
Prior art keywords: tieno; ampk; activators; therapeutic uses; dione
Prior art date: 2009-12-29

Application number

SM201400013T

Other languages

English (en)

Inventor

Daniel Cravo

Sophie Hallakou-Bozec

Sebastien Bolze

Franck Lepifre

Laurent Faveriel

Jean-Denis Durand

Christine Charon

Original Assignee

Poxel

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2009-12-29

Filing date

2014-01-29

Publication date

2014-05-07

2014-01-29 Application filed by Poxel filed Critical Poxel

2014-05-07 Publication of SMT201400013B publication Critical patent/SMT201400013B/it

Links

101100321932 Rattus norvegicus Prkaa2 gene Proteins 0.000 title 1
239000012190 activator Substances 0.000 title 1
WUVXRNGXQRVRLV-UHFFFAOYSA-N pyridine-2,3-dione Chemical compound O=C1C=CC=NC1=O WUVXRNGXQRVRLV-UHFFFAOYSA-N 0.000 title 1
230000001225 therapeutic effect Effects 0.000 title 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Animal Behavior & Ethology (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Chemical Kinetics & Catalysis (AREA)
Diabetes (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Obesity (AREA)
Hematology (AREA)
Endocrinology (AREA)
Emergency Medicine (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Child & Adolescent Psychology (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

SM201400013T 2009-12-29 2014-01-29 Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici SMT201400013B (it)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
EP09306344		2009-12-29
PCT/EP2010/070811 WO2011080277A1 (en)	2009-12-29	2010-12-28	Thieno [2,3-b] pyridinedione activators of ampk and therapeutic uses thereof

Publications (1)

Publication Number	Publication Date
SMT201400013B true SMT201400013B (it)	2014-05-07

Family

ID=41691577

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SM201400013T SMT201400013B (it)	2009-12-29	2014-01-29	Attivatori di ampk tieno[2,3-B] piridina dione e loro impieghi terapeutici

Country Status (24)

Country	Link
US (1)	US9365584B2 (it)
EP (1)	EP2519527B1 (it)
JP (1)	JP5559894B2 (it)
KR (1)	KR101469002B1 (it)
CN (1)	CN102803269B (it)
AU (1)	AU2010338280B2 (it)
BR (1)	BR112012016330B8 (it)
CA (1)	CA2784553C (it)
CY (1)	CY1114952T1 (it)
DK (1)	DK2519527T3 (it)
EA (1)	EA020588B1 (it)
ES (1)	ES2445537T3 (it)
HR (1)	HRP20140035T1 (it)
IL (1)	IL220432A (it)
ME (1)	ME01558B (it)
MX (1)	MX2012007548A (it)
PL (1)	PL2519527T3 (it)
PT (1)	PT2519527E (it)
RS (1)	RS53282B (it)
SI (1)	SI2519527T1 (it)
SM (1)	SMT201400013B (it)
TW (1)	TWI574968B (it)
WO (1)	WO2011080277A1 (it)
ZA (1)	ZA201205604B (it)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
MX370976B (es) *	2011-11-11	2020-01-10	Gilead Apollo Llc	Inhibidores de acetil coa carboxilasa (acc) y usos de los mismos.
US8889730B2 (en)	2012-04-10	2014-11-18	Pfizer Inc.	Indole and indazole compounds that activate AMPK
JP6064062B2 (ja)	2013-03-15	2017-01-18	ファイザー・インク	Ａｍｐｋを活性化させるインダゾール化合物
EP3089748A4 (en)	2014-01-02	2017-09-27	Massachusetts Eye & Ear Infirmary	Treating ocular neovascularization
WO2017011917A1 (en) *	2015-07-23	2017-01-26	Thrasos Therapeutics Inc.	Methods for treating and preventing polycystic kidney diseases (pkd) using amp-activated protein kinase (ampk) modulators and activators
AR106472A1 (es)	2015-10-26	2018-01-17	Gilead Apollo Llc	Inhibidores de acc y usos de los mismos
US20170166582A1 (en)	2015-11-25	2017-06-15	Gilead Apollo, Llc	Pyrazole acc inhibitors and uses thereof
CN108347939B (zh)	2015-11-25	2021-09-28	吉利德阿波罗公司	含有2,4-二氧代-1,4-二氢噻吩并[2,3-d]嘧啶的衍生物的杀真菌组合物
PL3380479T3 (pl)	2015-11-25	2023-05-08	Gilead Apollo, Llc	Triazolowe inhibitory acc i ich zastosowania
EP3380478B1 (en)	2015-11-25	2020-12-23	Gilead Apollo, LLC	Ester acc inhibitors and uses thereof
CA3155220C (en)	2016-03-02	2024-01-16	Gilead Apollo, Llc	Solid forms of a thienopyrimidinedione acc inhibitor and methods for production thereof
WO2018045969A1 (zh) *	2016-09-07	2018-03-15	法玛科技顾问股份有限公司	活化腺苷单磷酸活化蛋白激酶之化合物
ES2982801T3 (es)	2017-03-28	2024-10-17	Gilead Sciences Inc	Combinaciones terapéuticas para el tratamiento de las enfermedades hepáticas
WO2019185413A1 (en)	2018-03-27	2019-10-03	Basf Se	Pesticidal substituted cyclopropyl derivatives
MX2022014505A (es)	2020-05-19	2022-12-13	Kallyope Inc	Activadores de la ampk.
CA3183575A1 (en)	2020-06-26	2021-12-30	Iyassu Sebhat	Ampk activators
CN116322663A (zh)	2020-09-30	2023-06-23	比奥维拉迪维治疗股份有限公司	Ampk激活剂及其使用方法
AU2022391025A1 (en)	2021-11-19	2024-06-06	The Brigham And Women's Hospital, Inc.	Bifunctional chimeric molecules for labeling of kinases with target binding moieties and methods of use thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7119205B2 (en) *	2003-05-16	2006-10-10	Abbott Laboratories	Thienopyridones as AMPK activators for the treatment of diabetes and obesity
KR101630466B1 (ko) *	2008-04-11	2016-06-14	메르크 파텐트 게엠베하	Ａｍｐ-활성화 단백질 키나아제(ａｍｐｋ) 활성화제로서의 티에노피리돈 유도체

2010
- 2010-12-28 PT PT108007667T patent/PT2519527E/pt unknown
- 2010-12-28 ES ES10800766.7T patent/ES2445537T3/es active Active
- 2010-12-28 TW TW099146432A patent/TWI574968B/zh not_active IP Right Cessation
- 2010-12-28 US US13/519,407 patent/US9365584B2/en not_active Expired - Fee Related
- 2010-12-28 EA EA201200975A patent/EA020588B1/ru not_active IP Right Cessation
- 2010-12-28 EP EP10800766.7A patent/EP2519527B1/en active Active
- 2010-12-28 DK DK10800766.7T patent/DK2519527T3/da active
- 2010-12-28 HR HRP20140035AT patent/HRP20140035T1/hr unknown
- 2010-12-28 AU AU2010338280A patent/AU2010338280B2/en not_active Ceased
- 2010-12-28 SI SI201030501T patent/SI2519527T1/sl unknown
- 2010-12-28 BR BR112012016330A patent/BR112012016330B8/pt not_active IP Right Cessation
- 2010-12-28 MX MX2012007548A patent/MX2012007548A/es active IP Right Grant
- 2010-12-28 KR KR1020127018478A patent/KR101469002B1/ko not_active Expired - Fee Related
- 2010-12-28 RS RS20140028A patent/RS53282B/sr unknown
- 2010-12-28 PL PL10800766T patent/PL2519527T3/pl unknown
- 2010-12-28 ME MEP-2014-10A patent/ME01558B/me unknown
- 2010-12-28 JP JP2012546437A patent/JP5559894B2/ja not_active Expired - Fee Related
- 2010-12-28 CA CA2784553A patent/CA2784553C/en not_active Expired - Fee Related
- 2010-12-28 CN CN201080064452.6A patent/CN102803269B/zh not_active Expired - Fee Related
- 2010-12-28 WO PCT/EP2010/070811 patent/WO2011080277A1/en not_active Ceased
2012
- 2012-06-14 IL IL220432A patent/IL220432A/en active IP Right Grant
- 2012-07-25 ZA ZA2012/05604A patent/ZA201205604B/en unknown
2014
- 2014-01-24 CY CY20141100066T patent/CY1114952T1/el unknown
- 2014-01-29 SM SM201400013T patent/SMT201400013B/it unknown

Also Published As

Publication number	Publication date
CA2784553A1 (en)	2011-07-07
PT2519527E (pt)	2014-02-17
PL2519527T3 (pl)	2014-06-30
EP2519527B1 (en)	2013-12-18
KR20120120232A (ko)	2012-11-01
US9365584B2 (en)	2016-06-14
KR101469002B1 (ko)	2014-12-04
ME01558B (me)	2014-04-20
MX2012007548A (es)	2012-07-23
EA020588B1 (ru)	2014-12-30
CN102803269A (zh)	2012-11-28
CA2784553C (en)	2014-08-19
IL220432A (en)	2015-02-26
ES2445537T3 (es)	2014-03-03
DK2519527T3 (da)	2014-01-27
BR112012016330B1 (pt)	2021-03-23
SI2519527T1 (sl)	2014-06-30
TW201144318A (en)	2011-12-16
US20130053401A1 (en)	2013-02-28
JP2013515758A (ja)	2013-05-09
EP2519527A1 (en)	2012-11-07
BR112012016330A2 (pt)	2018-04-03
CN102803269B (zh)	2016-01-13
RS53282B (sr)	2014-08-29
BR112012016330B8 (pt)	2021-05-25
JP5559894B2 (ja)	2014-07-23
HRP20140035T1 (hr)	2014-02-14
AU2010338280B2 (en)	2013-08-22
AU2010338280A1 (en)	2012-07-26
EA201200975A1 (ru)	2012-12-28
CY1114952T1 (el)	2016-12-14
ZA201205604B (en)	2013-05-29
WO2011080277A1 (en)	2011-07-07
TWI574968B (zh)	2017-03-21

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IL211891A0 (en)	2011-06-30	Pyrazolo pyridine derivatives, compositions comprising the same and uses thereof
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IL201264A0 (en)	2010-05-31	Neuraminic acid derivatives and methods of manufacturing the same
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BRPI0818121A2 (pt)	2015-11-17	diespiro 1,2,4-trioxolano e seus métodos de fabricação e utilização