SMT201400059B - Nuovi derivati di 8-idrossi chinolin-7-carbossammide secondaria - Google Patents

Nuovi derivati di 8-idrossi chinolin-7-carbossammide secondaria

Info

Publication number
SMT201400059B
SMT201400059B SM201400059T SM201400059T SMT201400059B SM T201400059 B SMT201400059 B SM T201400059B SM 201400059 T SM201400059 T SM 201400059T SM 201400059 T SM201400059 T SM 201400059T SM T201400059 B SMT201400059 B SM T201400059B
Authority
SM
San Marino
Prior art keywords
carboxamide
new derivatives
hydroxy quinolin
quinolin
hydroxy
Prior art date
Application number
SM201400059T
Other languages
English (en)
Italian (it)
Inventor
Sordo Simone Del
Federico Mailland
Michela Legora
Stefani Gagliardi
Original Assignee
Polichem Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=42025709&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SMT201400059(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Polichem Sa filed Critical Polichem Sa
Publication of SMT201400059B publication Critical patent/SMT201400059B/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47Quinolines; Isoquinolines
    • A61K31/4709Non-condensed quinolines and containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D215/00Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D405/00Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D409/00Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
SM201400059T 2009-12-29 2014-05-21 Nuovi derivati di 8-idrossi chinolin-7-carbossammide secondaria SMT201400059B (it)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09180895A EP2345641A1 (en) 2009-12-29 2009-12-29 New secondary 8-hydroxyquinoline-7-carboxamide derivatives
PCT/EP2010/070793 WO2011080266A1 (en) 2009-12-29 2010-12-28 New secondary 8-hydroxyquinoline-7-carboxamide derivatives.

Publications (1)

Publication Number Publication Date
SMT201400059B true SMT201400059B (it) 2014-07-07

Family

ID=42025709

Family Applications (1)

Application Number Title Priority Date Filing Date
SM201400059T SMT201400059B (it) 2009-12-29 2014-05-21 Nuovi derivati di 8-idrossi chinolin-7-carbossammide secondaria

Country Status (38)

Country Link
US (1) US8729076B2 (sr)
EP (2) EP2345641A1 (sr)
JP (1) JP5755245B2 (sr)
KR (1) KR20120097407A (sr)
CN (1) CN102712596B (sr)
AU (1) AU2010338269B2 (sr)
BR (1) BR112012015732A2 (sr)
CA (1) CA2783230A1 (sr)
CL (1) CL2012001759A1 (sr)
CO (1) CO6561775A2 (sr)
CY (1) CY1115060T1 (sr)
DK (1) DK2519504T3 (sr)
DO (1) DOP2012000185A (sr)
EA (1) EA020487B1 (sr)
EC (1) ECSP12012008A (sr)
ES (1) ES2460626T3 (sr)
GE (1) GEP20156269B (sr)
GT (1) GT201200214A (sr)
HR (1) HRP20140348T1 (sr)
IL (1) IL220307A (sr)
MA (1) MA33830B1 (sr)
ME (1) ME01748B (sr)
MX (1) MX2012007746A (sr)
MY (1) MY162548A (sr)
NI (1) NI201200115A (sr)
NZ (1) NZ600782A (sr)
PE (1) PE20121804A1 (sr)
PH (1) PH12012501325A1 (sr)
PL (1) PL2519504T3 (sr)
PT (1) PT2519504E (sr)
RS (1) RS53303B (sr)
SG (1) SG181588A1 (sr)
SI (1) SI2519504T1 (sr)
SM (1) SMT201400059B (sr)
TN (1) TN2012000319A1 (sr)
UA (1) UA109422C2 (sr)
WO (1) WO2011080266A1 (sr)
ZA (1) ZA201204349B (sr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2345643A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof
EP2345642A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents
CN104805147B (zh) * 2014-01-26 2018-01-05 上海医药工业研究院 一种二噁英类化合物的制备方法、纯化方法及应用
KR20220148881A (ko) 2020-03-04 2022-11-07 앰플릭스 파마슈티컬스, 인크. 진균 감염 치료에서의 화합물의 용도

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US326328A (en) 1885-09-15 Broiler
US326330A (en) 1885-09-15 Harness-support
DE540842C (de) 1930-08-06 1931-12-28 Chinosol Fabrik Akt Ges Verfahren zur Darstellung der 8-Acetyloxychinolin-7-carbonsaeure
FR2160718A1 (en) * 1971-11-23 1973-07-06 Roussel Uclaf 7-benzyl aminomethyl-8-hydroxy quinolines - bacteriostats and fungistats
DE3426995A1 (de) 1984-07-21 1986-01-30 Dr.Ing.H.C. F. Porsche Ag, 7000 Stuttgart Halterung einer scheibe, vorzugsweise einer windschutzscheibe
WO1996032015A1 (de) 1995-04-08 1996-10-17 Basf Aktiengesellschaft Synergistische fungizide zusammensetzungen aus chinolinderivaten und cytochrom b/c-inhibitors
EP0927164A1 (en) 1996-09-10 1999-07-07 PHARMACIA & UPJOHN COMPANY 8-hydroxy-7-substituted quinolines as anti-viral agents
US6919351B2 (en) 2000-10-12 2005-07-19 Merck & Co., Inc. Aza-and polyaza-naphthalenyl-carboxamides useful as HIV integrase inhibitors
CA2425440C (en) 2000-10-12 2010-04-13 Merck & Co., Inc. Aza- and polyaza-naphthalenyl carboxamides useful as hiv integrase inhibitors
JP3616628B2 (ja) 2001-03-01 2005-02-02 塩野義製薬株式会社 Hivインテグラーゼ阻害活性を有する含窒素芳香族複素環化合物
EP1541558B1 (en) 2002-08-13 2008-08-13 Shionogi & Co., Ltd. Heterocyclic compounds having hiv integrase inhibitory activity
WO2005033079A1 (ja) * 2003-09-30 2005-04-14 Eisai Co., Ltd. ヘテロ環化合物を含有する新規な抗真菌剤
FR2889192A1 (fr) * 2005-07-27 2007-02-02 Cytomics Systems Sa Composes antifongiques, compositions contenant ces composes et leurs utilisations
RU2009106461A (ru) * 2006-07-25 2010-08-27 Энвиво Фармасьютикалз, Инк. (Us) Хинолиновые производные
EP2345642A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. Secondary 8-hydroxyquinoline-7-carboxamide derivatives for use as antifungal agents
EP2345643A1 (en) * 2009-12-29 2011-07-20 Polichem S.A. New tertiary 8-hydroxyquinoline-7-carboxamide derivatives and uses thereof

Also Published As

Publication number Publication date
CY1115060T1 (el) 2016-12-14
JP5755245B2 (ja) 2015-07-29
DK2519504T3 (da) 2014-05-05
BR112012015732A2 (pt) 2019-09-24
EA020487B1 (ru) 2014-11-28
CN102712596B (zh) 2014-04-09
WO2011080266A1 (en) 2011-07-07
IL220307A (en) 2015-04-30
ZA201204349B (en) 2013-08-28
CO6561775A2 (es) 2012-11-15
IL220307A0 (en) 2012-08-30
MA33830B1 (fr) 2012-12-03
EP2345641A1 (en) 2011-07-20
EP2519504A1 (en) 2012-11-07
RS53303B (sr) 2014-08-29
PH12012501325A1 (en) 2013-01-07
AU2010338269B2 (en) 2014-03-06
CA2783230A1 (en) 2011-07-07
NI201200115A (es) 2013-04-22
GT201200214A (es) 2013-09-04
MX2012007746A (es) 2012-08-03
PE20121804A1 (es) 2013-01-17
NZ600782A (en) 2013-11-29
MY162548A (en) 2017-06-15
HK1178525A1 (en) 2013-09-13
AU2010338269A2 (en) 2012-08-02
SG181588A1 (en) 2012-07-30
CN102712596A (zh) 2012-10-03
EA201270672A1 (ru) 2012-12-28
PT2519504E (pt) 2014-04-14
ME01748B (me) 2014-09-20
US8729076B2 (en) 2014-05-20
PL2519504T3 (pl) 2014-08-29
ECSP12012008A (es) 2012-08-31
AU2010338269A1 (en) 2012-07-19
UA109422C2 (xx) 2015-08-25
CL2012001759A1 (es) 2012-12-07
TN2012000319A1 (en) 2013-12-12
US20120316167A1 (en) 2012-12-13
SI2519504T1 (sl) 2014-05-30
JP2013515757A (ja) 2013-05-09
EP2519504B1 (en) 2014-03-19
KR20120097407A (ko) 2012-09-03
ES2460626T3 (es) 2014-05-14
HRP20140348T1 (hr) 2014-05-23
DOP2012000185A (es) 2013-01-15
GEP20156269B (en) 2015-04-14

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